{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:40:38Z","timestamp":1772811638451,"version":"3.50.1"},"reference-count":123,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.drudis.2023.103574","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T18:58:10Z","timestamp":1680202690000},"page":"103574","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Demystifying the potential of inhibitors targeting DNA topoisomerases in unicellular protozoan parasites"],"prefix":"10.1016","volume":"28","author":[{"given":"Swati","family":"Lamba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2023.103574_b0005","doi-asserted-by":"crossref","first-page":"e704","DOI":"10.1016\/S2214-109X(16)30168-1","article-title":"Health in times of uncertainty in the eastern Mediterranean region, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"4","author":"Mokdad","year":"2016","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.drudis.2023.103574_b0010","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12879-015-0807-1","article-title":"Outbreak of Cryptosporidium hominis following river flooding in the city of Halle (Saale), Germany, August 2013","volume":"15","author":"Gertler","year":"2015","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.drudis.2023.103574_b0015","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1017\/S0950268819000232","article-title":"An apple a day: an outbreak of cryptosporidiosis in Norway associated with self\u2013pressed apple juice","volume":"147","author":"Robertson","year":"2019","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.drudis.2023.103574_b0020","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1017\/S0031182016002134","article-title":"Leishmania infantum: illness, transmission profile and risk factors for asymptomatic infection in an endemic metropolis in Brazil","volume":"144","author":"Dos Santos Marques","year":"2017","journal-title":"Parasitology"},{"key":"10.1016\/j.drudis.2023.103574_b0025","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0140-6736(18)33044-7","article-title":"Leishmaniasis","volume":"393","author":"Abdoli","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.drudis.2023.103574_b0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ddr.21907","article-title":"Road-map of pre-clinical treatment for Visceral Leishmaniasis","volume":"83","author":"Mazire","year":"2022","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.drudis.2023.103574_b0035","doi-asserted-by":"crossref","first-page":"7579","DOI":"10.3390\/molecules27217579","article-title":"Antileishmanial activities of medicinal herbs and phytochemicals in vitro and in vivo: an update for the years 2015 to 2021","volume":"27","author":"Hassan","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2023.103574_b0040","doi-asserted-by":"crossref","first-page":"1091961","DOI":"10.3389\/fimmu.2022.1091961","article-title":"Host\u2013parasite interactions during Plasmodium infection: Implications for immunotherapies","volume":"13","author":"Chandley","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.drudis.2023.103574_b0045","doi-asserted-by":"crossref","first-page":"17050","DOI":"10.1038\/nrdp.2017.50","article-title":"Malaria","volume":"3","author":"Phillips","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.drudis.2023.103574_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.621699","article-title":"Epidemiology of trypanosomiasis in wildlife\u2013implications for humans at the wildlife interface in Africa","volume":"8","author":"Kasozi","year":"2021","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.drudis.2023.103574_b0055","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1017\/S0031182016001268","article-title":"The animal trypanosomiases and their chemotherapy: a review","volume":"143","author":"Giordani","year":"2016","journal-title":"Parasitology"},{"key":"10.1016\/j.drudis.2023.103574_b0060","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.actatropica.2017.08.032","article-title":"Animal African trypanosomiasis in Nigeria: a long way from elimination\/eradication","volume":"176","author":"Isaac","year":"2017","journal-title":"Acta Trop"},{"key":"10.1016\/j.drudis.2023.103574_b0065","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.actatropica.2015.03.014","article-title":"In vivo experimental drug resistance study in Trypanosoma vivax isolates from tsetse infested and non-tsetse infested areas of Northwest Ethiopia","volume":"146","author":"Dagnachew","year":"2015","journal-title":"Acta Trop"},{"key":"10.1016\/j.drudis.2023.103574_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bjid.2023.102743","article-title":"Epoxy-\u03b1-lapachone (2,2-Dimethyl-3,4-dihydro-spiropyran-10,2\u2019-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites","volume":"27","author":"Peixoto","year":"2023","journal-title":"Braz J Infect Dis"},{"key":"10.1016\/j.drudis.2023.103574_b0075","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0020-7519(00)00137-5","article-title":"Human babesiosis: an emerging tick-borne disease","volume":"30","author":"Kjemtrup","year":"2000","journal-title":"Int J Parasitol"},{"issue":"Suppl.","key":"10.1016\/j.drudis.2023.103574_b0080","doi-asserted-by":"crossref","first-page":"S247","DOI":"10.1017\/S0031182004005190","article-title":"Babesiosis of cattle","volume":"129","author":"Bock","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/j.drudis.2023.103574_b0085","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.vetpar.2018.03.001","article-title":"Antiprotozoal treatment of canine babesiosis","volume":"254","author":"Baneth","year":"2018","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.drudis.2023.103574_b0090","first-page":"52","article-title":"Babesia odocoilei as a cause of mortality in captive cervids in Canada","volume":"59","author":"Mathieu","year":"2018","journal-title":"Can Vet J"},{"key":"10.1016\/j.drudis.2023.103574_b0095","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ijpara.2018.11.007","article-title":"Human babesiosis","volume":"49","author":"Krause","year":"2019","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.drudis.2023.103574_b0100","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1645\/0022-3395(2001)087[0373:DAEOTY]2.0.CO;2","article-title":"Description and epidemiology of Theileria youngi n. sp. from a northern Californian dusky-footed woodrat (Neotoma Fuscipes) population","volume":"87","author":"Kjemtrup","year":"2001","journal-title":"J Parasitol"},{"key":"10.1016\/j.drudis.2023.103574_b0105","doi-asserted-by":"crossref","first-page":"806","DOI":"10.7589\/0090-3558-41.4.806","article-title":"Theileriosis in a white-tailed deer (Odocoileus virginianus) fawn","volume":"41","author":"Yabsley","year":"2005","journal-title":"J Wildl Dis"},{"key":"10.1016\/j.drudis.2023.103574_b0110","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1177\/1040638713501173","article-title":"Merogonic stages of Theileria cervi in mule deer (Odocoileus hemionus)","volume":"25","author":"Wood","year":"2013","journal-title":"J Vet Diagn Invest"},{"key":"10.1016\/j.drudis.2023.103574_b0115","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.2174\/092986712799828355","article-title":"Current advances in detection and treatment of babesiosis","volume":"19","author":"Mosqueda","year":"2012","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.drudis.2023.103574_b0120","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-0-387-77570-8_9","article-title":"DNA topoisomerases of Leishmania: the potential targets for anti-leishmanial therapy","volume":"625","author":"Das","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.drudis.2023.103574_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115158","article-title":"DNA topoisomerases in the unicellular protozoan parasites: unwinding the mystery","volume":"203","author":"Lamba","year":"2022","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.drudis.2023.103574_b0130","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.tibs.2018.12.001","article-title":"DNA Topoisomerases in unicellular pathogens: structure, function, and druggability","volume":"44","author":"Chowdhury","year":"2019","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.drudis.2023.103574_b0135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.21775\/cimb.031.045","article-title":"DNA Topoisomerases of kinetoplastid parasites: brief overview and recent perspectives","volume":"31","author":"Saha","year":"2019","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.drudis.2023.103574_b0140","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1365-2958.2006.05428.x","article-title":"Topoisomerases of kinetoplastid parasites: why so fascinating?","volume":"62","author":"Das","year":"2006","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.drudis.2023.103574_b0145","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/BF03401792","article-title":"Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis","volume":"6","author":"Mittra","year":"2000","journal-title":"Mol Med"},{"key":"10.1016\/j.drudis.2023.103574_b0150","doi-asserted-by":"crossref","first-page":"15387","DOI":"10.1073\/pnas.242259599","article-title":"The mechanism of topoisomerase I poisoning by a camptothecin analog","volume":"99","author":"Staker","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.drudis.2023.103574_b0155","doi-asserted-by":"crossref","first-page":"16335","DOI":"10.1074\/jbc.M412417200","article-title":"N-terminal region of the large subunit of Leishmania donovani bisubunit topoisomerase I is involved in DNA relaxation and interaction with the smaller subunit","volume":"280","author":"Das","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.drudis.2023.103574_b0160","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/sj.cdd.4401435","article-title":"Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani","volume":"11","author":"Sen","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.drudis.2023.103574_b0165","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1128\/AAC.49.4.1441-1446.2005","article-title":"Topoisomerase I amino acid substitutions, Gly185Arg and Asp325Glu, confer camptothecin resistance in Leishmania donovani","volume":"49","author":"Marquis","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2023.103574_b0170","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00786-18","article-title":"Activity of AROMATHECINS against African TRYPANOSOMES","volume":"62","author":"Nenortas","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2023.103574_b0175","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bcp.2017.05.002","article-title":"Voacamine alters Leishmania ultrastructure and kills parasite by poisoning unusual bi-subunit topoisomerase IB","volume":"138","author":"Chowdhury","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.drudis.2023.103574_b0180","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/BF03402104","article-title":"Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy","volume":"9","author":"Chowdhury","year":"2003","journal-title":"Mol Med"},{"key":"10.1016\/j.drudis.2023.103574_b0185","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00688-17","article-title":"Efficacy of a binuclear cyclopalladated compound therapy for cutaneous leishmaniasis in the murine model of infection with Leishmania amazonensis and its inhibitory effect on topoisomerase 1B","volume":"61","author":"Vel\u00e1squez","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2023.103574_b0190","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/phrev.phrev_31_16","article-title":"Review of Holarrhena antidysenterica (L.) Wall. ex A. DC.: pharmacognostic, pharmacological, and toxicological perspective","volume":"11","author":"Jamadagni","year":"2017","journal-title":"Pharmacogn Rev"},{"key":"10.1016\/j.drudis.2023.103574_b0195","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1021\/acsinfecdis.2c00562","article-title":"Holanamine, a steroidal alkaloid from the bark of Holarrhena pubescens Wall. ex G. Don inhibits the growth of Leishmania donovani by targeting DNA topoisomerase 1B","volume":"9","author":"Goel","year":"2023","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.drudis.2023.103574_b0200","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chemphyslip.2013.05.002","article-title":"Recent developments in the antiprotozoal and anticancer activities of the 2-alkynoic fatty acids","volume":"172\u2013173","author":"Carballeira","year":"2013","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.drudis.2023.103574_b0205","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2174\/1568026618666180516125056","article-title":"First total synthesis of \u03c9-phenyl \u03b46 fatty acids and their leishmanicidal and anticancer properties","volume":"18","author":"Carballeira","year":"2018","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.drudis.2023.103574_b0210","doi-asserted-by":"crossref","first-page":"26603","DOI":"10.1038\/srep26603","article-title":"Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors","volume":"6","author":"Mamidala","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2023.103574_b0215","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11745-015-4114-9","article-title":"Novel very long-chain \u03b1-methoxylated \u03945,9 fatty acids from the sponge Asteropus niger are effective inhibitors of topoisomerases IB","volume":"51","author":"Carballeira","year":"2016","journal-title":"Lipids"},{"key":"10.1016\/j.drudis.2023.103574_b0220","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1021\/jm800259e","article-title":"Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors","volume":"51","author":"Cinelli","year":"2008","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2023.103574_b0225","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1186\/s12917-019-2153-9","article-title":"Antiparasitic effect of synthetic aromathecins on Leishmania infantum","volume":"15","author":"Reguera","year":"2019","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.drudis.2023.103574_b0230","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ejmech.2016.09.017","article-title":"Antileishmanial effect of new indeno-1,5-naphthyridines, selective inhibitors of Leishmania infantum type IB DNA topoisomerase","volume":"124","author":"Tejer\u00eda","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2023.103574_b0235","doi-asserted-by":"crossref","first-page":"586","DOI":"10.4269\/ajtmh.1996.55.586","article-title":"The efficacy of pentamidine in the treatment of early-late stage Trypanosoma brucei gambiense trypanosomiasis","volume":"55","author":"Doua","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.drudis.2023.103574_b0240","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/toxsci\/kfs238","article-title":"A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models","volume":"130","author":"Harrill","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.drudis.2023.103574_b0245","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1021\/bi952162r","article-title":"A crystallographic and spectroscopic study of the complex between d(CGCGAATTCGCG)2 and 2,5-bis(4-guanylphenyl)furan, an analogue of berenil. Structural origins of enhanced DNA-binding affinity","volume":"35","author":"Laughton","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.drudis.2023.103574_b0250","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1073\/pnas.87.3.950","article-title":"Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs","volume":"87","author":"Shapiro","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.drudis.2023.103574_b0255","doi-asserted-by":"crossref","first-page":"6828","DOI":"10.1128\/AAC.01129-16","article-title":"Antileishmanial mechanism of diamidines involves targeting kinetoplasts","volume":"60","author":"Yang","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2023.103574_b0260","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1021\/np50091a004","article-title":"Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Cyclea barbata","volume":"56","author":"Lin","year":"1993","journal-title":"J Nat Prod"},{"key":"10.1016\/j.drudis.2023.103574_b0265","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3987\/COM-89-S2","article-title":"A new bisbenzylisoquinoline alkaloid from Phaeanthus vietnamensis and its antibacterial activity","volume":"30","author":"Sedmera","year":"1990","journal-title":"Heterocycles"},{"key":"10.1016\/j.drudis.2023.103574_b0270","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1515\/znc-2003-7-813","article-title":"Cytotoxic benzophenanthridine and benzylisoquinoline alkaloids from Argemone mexicana","volume":"58","author":"Chang","year":"2003","journal-title":"Z Naturforsch C J Biosci"},{"key":"10.1016\/j.drudis.2023.103574_b0275","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fitote.2015.11.021","article-title":"A new bisbenzylisoquinoline alkaloid isolated from Thalictrum foliolosum, as a potent inhibitor of DNA topoisomerase IB of Leishmania donovani","volume":"109","author":"Kumar","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.drudis.2023.103574_b0280","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejmech.2018.04.033","article-title":"Substituted 1,5-naphthyridine derivatives as novel antileishmanial agents. Synthesis and biological evaluation","volume":"152","author":"Tejer\u00eda","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2023.103574_b0285","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbrc.2021.07.019","article-title":"Discovery of Leishmania donovani topoisomerase IB selective inhibitors by targeting protein-protein interactions between the large and small subunits","volume":"569","author":"Lee","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.drudis.2023.103574_b0290","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/molecules19010204","article-title":"Recent syntheses of 1,2,3,4-tetrahydroquinolines, 2,3-dihydro-4(1H)-quinolinones and 4(1H)-quinolinones using domino reactions","volume":"19","author":"Nammalwar","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2023.103574_b0295","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1007\/s11164-016-2794-2","article-title":"Synthesis and therapeutic potential of quinoline derivatives","volume":"43","author":"Narwal","year":"2017","journal-title":"Res Chem Int"},{"key":"10.1016\/j.drudis.2023.103574_b0300","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejmech.2018.02.058","article-title":"Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity","volume":"149","author":"Alonso","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2023.103574_b0305","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejmech.2018.10.065","article-title":"Antileishmanial activity of new hybrid tetrahydroquinoline and quinoline derivatives with phosphorus substituents","volume":"162","author":"Tejer\u00eda","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2023.103574_b0310","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1515\/znc-2008-9-1011","article-title":"Antiproliferative effects of a series of cyclic imides on primary endothelial cells and a leukemia cell line","volume":"63","author":"Yunesa","year":"2008","journal-title":"Z Naturforsch C J Biosci"},{"key":"10.1016\/j.drudis.2023.103574_b0315","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ejmech.2006.12.003","article-title":"Novel and versatile methodology for synthesis of cyclic imides and evaluation of their cytotoxic, DNA binding, apoptotic inducing activities and molecular modeling study","volume":"42","author":"Abdel-Aziz","year":"2007","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2023.103574_b0320","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/1573406415666190430144950","article-title":"Synthesis of new cyclic imides derived from safrole, structure- and ligand-based approaches to evaluate potential new multitarget agents against species of Leishmania","volume":"16","author":"de Sousa Luis","year":"2020","journal-title":"Med Chem"},{"key":"10.1016\/j.drudis.2023.103574_b0325","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3390\/ph14080784","article-title":"Hybrid quinolinyl phosphonates as heterocyclic carboxylate isosteres: synthesis and biological evaluation against topoisomerase 1B (TOP1B)","volume":"14","author":"Selas","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.drudis.2023.103574_b0330","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ijpddr.2019.10.004","article-title":"Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB","volume":"11","author":"P\u00e9rez-Pertejo","year":"2019","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.drudis.2023.103574_b0335","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0031-9422(00)95005-2","article-title":"Triterpenes and flavonoids from Combretum leprosum","volume":"32","author":"Facundo","year":"1993","journal-title":"Phytochemistry"},{"key":"10.1016\/j.drudis.2023.103574_b0340","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1590\/S0103-50532011000500017","article-title":"Activity of the Lupane isolated from Combretum leprosum against Leishmania amazonensis promastigotes","volume":"22","author":"Teles","year":"2011","journal-title":"J Brazi Chem Soc"},{"key":"10.1016\/j.drudis.2023.103574_b0345","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12906-015-0681-9","article-title":"A lupane-triterpene isolated from Combretum leprosum Mart. fruit extracts that interferes with the intracellular development of Leishmania (L.) amazonensis in vitro","volume":"15","author":"Teles","year":"2015","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.drudis.2023.103574_b0350","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1186\/s12859-014-0416-9","article-title":"Unique features of apicoplast DNA gyrases from Toxoplasma gondii and Plasmodium falciparum","volume":"15","author":"Nagano","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.drudis.2023.103574_b0355","doi-asserted-by":"crossref","first-page":"e0026721","DOI":"10.1128\/AAC.00267-21","article-title":"Inhibitory compounds targeting Plasmodium falciparum Gyrase B","volume":"65","author":"Pakosz","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2023.103574_b0360","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1093\/nar\/gkp239","article-title":"Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites","volume":"37","author":"Baum","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.drudis.2023.103574_b0365","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.exppara.2016.03.008","article-title":"Inhibition of Plasmodium falciparum proliferation in vitro by double-stranded RNA nanoparticle against malaria topoisomerase II","volume":"164","author":"Attasart","year":"2016","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.drudis.2023.103574_b0370","doi-asserted-by":"crossref","first-page":"14640","DOI":"10.1021\/acsomega.9b02130","article-title":"Identification of trans-2-cis-8-Matricaria-ester from the essential oil of Erigeron multiradiatus and evaluation of its antileishmanial potential by in vitro and in silico approaches","volume":"4","author":"Chandra Pandey","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.drudis.2023.103574_b0375","doi-asserted-by":"crossref","first-page":"11940","DOI":"10.1038\/s41598-018-30405-w","article-title":"Isobenzofuranone derivative JVPH3, an inhibitor of L. donovani topoisomerase II, disrupts mitochondrial architecture in trypanosomatid parasites","volume":"8","author":"Chowdhury","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2023.103574_b0380","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/cbdd.13835","article-title":"Ursolic and betulinic semisynthetic derivatives show activity against CQ-resistant Plasmodium falciparum isolated from Amazonia","volume":"97","author":"Sol Sol de Medeiros","year":"2021","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.drudis.2023.103574_b0385","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s11101-015-9405-5","article-title":"Biosynthesis and biotechnological production of anti-cancer drug Camptothecin","volume":"14","author":"Kai","year":"2015","journal-title":"Phytochem Rev"},{"issue":"Suppl. 5","key":"10.1016\/j.drudis.2023.103574_b0390","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1634\/theoncologist.7-suppl_5-46","article-title":"Emerging role of topotecan in front-line treatment of carcinoma of the ovary","volume":"7","author":"Coleman","year":"2002","journal-title":"Oncologist"},{"key":"10.1016\/j.drudis.2023.103574_b0395","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0006-2952(95)00215-L","article-title":"Antitrypanosomal activity of camptothecin analogs. Structure-activity correlations","volume":"50","author":"Bodley","year":"1995","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.drudis.2023.103574_b0400","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/sj.cdd.4400952","article-title":"Programmed cell death in the unicellular protozoan parasite Leishmania","volume":"9","author":"Lee","year":"2002","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.drudis.2023.103574_b0405","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/0042-6822(72)90153-5","article-title":"Camptothecin: mechanism of inhibition of adenovirus formation","volume":"48","author":"Horwitz","year":"1972","journal-title":"Virology"},{"key":"10.1016\/j.drudis.2023.103574_b0410","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.antiviral.2017.04.008","article-title":"Antiviral screen identifies EV71 inhibitors and reveals camptothecin-target, DNA topoisomerase 1 as a novel EV71 host factor","volume":"143","author":"Wu","year":"2017","journal-title":"Antiviral Res"},{"key":"10.1016\/j.drudis.2023.103574_b0415","doi-asserted-by":"crossref","first-page":"e91191","DOI":"10.1371\/journal.pone.0091191","article-title":"Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum","volume":"9","author":"Cortopassi","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.drudis.2023.103574_b0420","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1073\/pnas.92.9.3726","article-title":"Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania","volume":"92","author":"Bodley","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.drudis.2023.103574_b0425","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.drudis.2006.06.014","article-title":"Targeting atypical trypanosomatid DNA topoisomerase I","volume":"11","author":"Bala\u00f1a-Fouce","year":"2006","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.drudis.2023.103574_b0430","first-page":"81","article-title":"Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani","volume":"565","author":"Das","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.drudis.2023.103574_b0435","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.biochi.2007.07.015","article-title":"Structural insights on the small subunit of DNA topoisomerase I from the unicellular parasite Leishmania donovani","volume":"89","author":"D\u00edaz Gonz\u00e1lez","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.drudis.2023.103574_b0440","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.bcp.2008.06.019","article-title":"Mutational study of the \u2018catalytic tetrad\u2019 of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: role of Asp-353 and Asn-221 in camptothecin resistance","volume":"76","author":"Diaz-Gonz\u00e1lez","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.drudis.2023.103574_b0445","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.ttbdis.2018.04.019","article-title":"The effects of nitidine chloride and camptothecin on the growth of Babesia and Theileria parasites","volume":"9","author":"Tayebwa","year":"2018","journal-title":"Ticks Tick Borne Dis"},{"key":"10.1016\/j.drudis.2023.103574_b0450","doi-asserted-by":"crossref","first-page":"9645","DOI":"10.1002\/chem.201104071","article-title":"Multicomponent reaction to construct spirocyclic oxindoles with a Michael (triple Michael)\/cyclization cascade sequence as the key step","volume":"18","author":"Li","year":"2012","journal-title":"Chemistry"},{"key":"10.1016\/j.drudis.2023.103574_b0455","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1128\/AAC.00352-16","article-title":"A novel spirooxindole derivative inhibits the growth of Leishmania donovani parasites both in vitro and in vivo by targeting type IB topoisomerase","volume":"60","author":"Saha","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2023.103574_b0460","doi-asserted-by":"crossref","first-page":"e4918","DOI":"10.1371\/journal.pone.0004918","article-title":"HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis","volume":"4","author":"Santos","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.drudis.2023.103574_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2021.102287","article-title":"The HIV-1 protease inhibitor Amprenavir targets Leishmania donovani topoisomerase I and induces oxidative stress-mediated programmed cell death","volume":"82","author":"Roy","year":"2021","journal-title":"Parasitol Int"},{"key":"10.1016\/j.drudis.2023.103574_b0470","first-page":"787","article-title":"Anti-cancer copper salicylaldoxime complex inhibits topoisomerase II catalytic activity","volume":"10","author":"Jayaraju","year":"2001","journal-title":"Curr Sci"},{"key":"10.1016\/j.drudis.2023.103574_b0475","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.exppara.2017.02.010","article-title":"Copper salisylaldoxime (CuSAL) imparts protective efficacy against visceral leishmaniasis by targeting Leishmania donovani topoisomerase IB","volume":"175","author":"Singh","year":"2017","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.drudis.2023.103574_b0480","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/1099-1573(200102)15:1<30::AID-PTR680>3.0.CO;2-T","article-title":"Biological activities of the plant-derived bisindole voacamine with reference to malaria","volume":"15","author":"Ramanitrahasimbola","year":"2001","journal-title":"Phytother Res"},{"key":"10.1016\/j.drudis.2023.103574_b0485","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1016\/j.bmcl.2015.07.032","article-title":"Interfacial inhibitors","volume":"25","author":"Pommier","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.drudis.2023.103574_b0490","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1128\/AAC.00499-12","article-title":"Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis","volume":"56","author":"Bala\u00f1a-Fouce","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2023.103574_b0495","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijpddr.2019.09.005","article-title":"Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum","volume":"11","author":"Guti\u00e9rrez-Corbo","year":"2019","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.drudis.2023.103574_b0500","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1517\/13543776.2011.604314","article-title":"Tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibitors","volume":"21","author":"Huang","year":"2011","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.drudis.2023.103574_b0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102711","article-title":"Old drug repurposing for neglected disease: Pyronaridine as a promising candidate for the treatment of Echinococcus granulosus infections","volume":"54","author":"Li","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.drudis.2023.103574_b0510","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1874104501105010011","article-title":"Acridine and acridinones: old and new structures with antimalarial activity","volume":"5","author":"Vald\u00e9s","year":"2011","journal-title":"Open Med Chem J"},{"key":"10.1016\/j.drudis.2023.103574_b0515","doi-asserted-by":"crossref","first-page":"13023","DOI":"10.3390\/ijms160613023","article-title":"Synthesis, DNA binding, and antiproliferative activity of novel acridine-thiosemicarbazone derivatives","volume":"16","author":"de Almeida","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2023.103574_b0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.128289","article-title":"In vitro anti-Leishmania activity and molecular docking of spiro\u2013acridine compounds as potential multitarget agents against Leishmania infantum","volume":"49","author":"Almeida","year":"2021","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.drudis.2023.103574_b0525","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1128\/AAC.39.12.2606","article-title":"Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy","volume":"39","author":"Gakunju","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2023.103574_b0530","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3892\/ijmm.2013.1358","article-title":"Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1\/STAT3 signaling pathway","volume":"32","author":"Liao","year":"2013","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.drudis.2023.103574_b0535","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jep.2012.08.041","article-title":"Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells","volume":"144","author":"Wang","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.drudis.2023.103574_b0540","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1021\/tx00036a010","article-title":"Inhibition of topoisomerase I function by nitidine and fagaronine","volume":"6","author":"Wang","year":"1993","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.drudis.2023.103574_b0545","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1105\/tpc.107.054361","article-title":"MIDGET unravels functions of the Arabidopsis topoisomerase VI complex in DNA endoreduplication, chromatin condensation, and transcriptional silencing","volume":"19","author":"Kirik","year":"2007","journal-title":"Plant Cell"},{"key":"10.1016\/j.drudis.2023.103574_b0550","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1128\/AAC.02519-13","article-title":"Radicicol confers mid-schizont arrest by inhibiting mitochondrial replication in Plasmodium falciparum","volume":"58","author":"Chalapareddy","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2023.103574_b0555","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1093\/nar\/gkl567","article-title":"Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol","volume":"34","author":"Corbett","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.drudis.2023.103574_b0560","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00025-15","article-title":"Radicicol-mediated inhibition of topoisomerase VIB-VIA activity of the human malaria parasite Plasmodium falciparum","volume":"1","author":"Chalapareddy","year":"2016","journal-title":"mSphere"},{"key":"10.1016\/j.drudis.2023.103574_b0565","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1080\/07391102.2021.1891970","article-title":"Molecular docking and molecular dynamics simulation identify a novel Radicicol derivative that predicts exclusive binding to Plasmodium falciparum Topoisomerase VIB","volume":"40","author":"Bansod","year":"2022","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.drudis.2023.103574_b0570","doi-asserted-by":"crossref","first-page":"e23398","DOI":"10.1002\/bip.23398","article-title":"Pyronaridine: An update of its pharmacological activities and mechanisms of action","volume":"112","author":"Bailly","year":"2021","journal-title":"Biopolymers"},{"key":"10.1016\/j.drudis.2023.103574_b0575","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ejmech.2018.01.017","article-title":"In vitro antiplasmodial efficacy of synthetic coumarin-triazole analogs","volume":"145","author":"Yadav","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2023.103574_b0580","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1128\/AAC.37.4.839","article-title":"Mechanism of action of quinolones against Escherichia coli DNA gyrase","volume":"37","author":"Yoshida","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2023.103574_b0585","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nrd2199","article-title":"How many drug targets are there?","volume":"5","author":"Overington","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.drudis.2023.103574_b0590","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exppara.2015.12.016","article-title":"Evaluation of in vitro inhibitory effect of enoxacin on Babesia and Theileria parasites","volume":"161","author":"Omar","year":"2016","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.drudis.2023.103574_b0595","first-page":"269","article-title":"In-vitro and in-vivo activities of phenolic compounds against cutaneous leishmaniasis","volume":"10","author":"Monzote","year":"2016","journal-title":"Records Nat Products"},{"key":"10.1016\/j.drudis.2023.103574_b0600","first-page":"153","article-title":"A derivative of cinnamic acid, methyl-4-hydroxycinnamate modulates inflammatory cytokine levels in malaria-infected mice through inhibition of gsk3\u03b2","volume":"30","author":"Sudi","year":"2018","journal-title":"Malaysian Appl Biol"},{"key":"10.1016\/j.drudis.2023.103574_b0605","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.3390\/molecules25143178","article-title":"Alkyl and aryl derivatives based on p\u2013coumaric acid modification and inhibitory action against Leishmania braziliensis and Plasmodium falciparum","volume":"25","author":"Lopes","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2023.103574_b0610","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00904-18","article-title":"Leishmanicidal activity of isoselenocyanate derivatives","volume":"63","author":"Fern\u00e1ndez-Rubio","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2023.103574_b0615","doi-asserted-by":"crossref","first-page":"e22265","DOI":"10.1096\/fj.202101668RR","article-title":"TDP1 knockout Leishmania donovani accumulate topoisomerase-1-linked DNA damage and are hypersensitive to clinically used antileishmanial drugs","volume":"36","author":"Chowdhury","year":"2022","journal-title":"FASEB J"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644623000909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644623000909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T13:05:30Z","timestamp":1761224730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644623000909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":123,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S1359644623000909"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2023.103574","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Demystifying the potential of inhibitors targeting DNA topoisomerases in unicellular protozoan parasites","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2023.103574","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103574"}}