{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:17:29Z","timestamp":1788898649728,"version":"build-2803163510"},"reference-count":131,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016279","name":"Mahatma Gandhi University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.drudis.2023.103802","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T12:04:48Z","timestamp":1697544288000},"page":"103802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Anti-amyloid potential of some phytochemicals against A\u03b2-peptide and \u03b1-synuclein, tau, prion, and Huntingtin protein"],"prefix":"10.1016","volume":"28","author":[{"given":"Jenat Pazheparambil","family":"Jerom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sooryalekshmi","family":"Madhukumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raveendran Harikumaran","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunilkumar Puthenpurackal","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2023.103802_b0005","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1021\/acs.accounts.6b00524","article-title":"Supramolecular hydrogels based on DNA self-assembly","volume":"50","author":"Shao","year":"2017","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.drudis.2023.103802_b0010","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1073\/pnas.1800038115","article-title":"RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome","volume":"115","author":"Van Treeck","year":"2018","journal-title":"PNAS"},{"key":"10.1016\/j.drudis.2023.103802_b0015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/10717544.2020.1716878","article-title":"Self-assembled chitosan\/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery","volume":"27","author":"Ma","year":"2020","journal-title":"Drug Deliv"},{"key":"10.1016\/j.drudis.2023.103802_b0020","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.3390\/polym13162603","article-title":"Protein, (poly)peptide, and amino acid-based nanostructures prepared via polymerization-induced self-assembly","volume":"13","author":"Varlas","year":"2021","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.drudis.2023.103802_b0025","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1021\/jp5077388","article-title":"Self-assembly of phenylalanine-based molecules","volume":"119","author":"German","year":"2014","journal-title":"J Phys Chem"},{"key":"10.1016\/j.drudis.2023.103802_b0030","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1021\/acschemneuro.8b00310","article-title":"Amyloid like structures formed by single amino acid self-assemblies of cysteine and methionine","volume":"10","author":"Gour","year":"2019","journal-title":"ACS Chem Nerosci"},{"key":"10.1016\/j.drudis.2023.103802_b0035","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ijch.201600076","article-title":"Formation of apoptosis inducing amyloid fibrils by tryptophan","volume":"57","author":"Shaham-Niv","year":"2017","journal-title":"Isr J Chem"},{"key":"10.1016\/j.drudis.2023.103802_b0040","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3390\/molecules23061273","article-title":"Antibodies towards tyrosine amyloid-like fibrils allow toxicity modulation and cellular imaging of the assemblies","volume":"23","author":"Zaguri","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2023.103802_b0045","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3390\/ijms21031129","article-title":"Interaction of A\u03b2 42 with membranes triggers the self-assembly into oligomers","volume":"21","author":"Banerjee","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2023.103802_b0050","first-page":"282","article-title":"Observation of an \u03b1-synuclein liquid droplet state and its maturation into Lewy body-like assemblies","volume":"13","author":"Hardenberg","year":"2021","journal-title":"J Mol Cell Biol"},{"key":"10.1016\/j.drudis.2023.103802_b0055","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1073\/pnas.96.8.4604","article-title":"Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington\u2019s disease pathology","volume":"96","author":"Scherzinger","year":"1999","journal-title":"PNAS"},{"key":"10.1016\/j.drudis.2023.103802_b0060","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1523\/JNEUROSCI.4385-04.2005","article-title":"Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice","volume":"25","author":"Vijayvergiya","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.drudis.2023.103802_b0065","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0531-5565(03)00004-4","article-title":"Islet amyloid polypeptide and type 2 diabetes","volume":"38","author":"Marzban","year":"2003","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.drudis.2023.103802_b0070","first-page":"39","article-title":"Transthyretin cardiac amyloidosis: pathogenesis, treatments, and emerging role in heart failure with preserved ejection fraction","volume":"2014","author":"Ton","year":"2014","journal-title":"Clin Med Insights Cardiol"},{"key":"10.1016\/j.drudis.2023.103802_b0075","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nature20814","article-title":"Structural variation in amyloid-\u03b2 fibrils from Alzheimer\u2019s disease clinical subtypes","volume":"541","author":"Quiang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2023.103802_b0080","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1021\/acschemneuro.8b00003","article-title":"Blocking the thiol at cysteine-322 destabilizes tau protein and prevents its oligomer formation","volume":"9","author":"Chen","year":"2018","journal-title":"ACS Chem Nerosci"},{"key":"10.1016\/j.drudis.2023.103802_b0085","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4161\/cib.3.2.10964","article-title":"The regulation of synaptic function by \u03b1-synuclein","volume":"3","author":"Bellani","year":"2010","journal-title":"Commun Integr Biol"},{"key":"10.1016\/j.drudis.2023.103802_b0090","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.nbd.2017.07.009","article-title":"The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases","volume":"109","author":"Cremades","year":"2017","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.drudis.2023.103802_b0095","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"\u03b1 -Synuclein in filamentous inclusions of Lewy bodies from Parkinson\u2019s disease and dementia with Lewy bodies","volume":"95","author":"Spillantini","year":"1998","journal-title":"PNAS"},{"key":"10.1016\/j.drudis.2023.103802_b0100","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1080\/10408398.2015.1077195","article-title":"Curcumin an active component of turmeric (Curcuma longa) and its effects on health","volume":"57","author":"Kocaadam","year":"2017","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.drudis.2023.103802_b0105","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/jnr.20025","article-title":"Curcumin has potent anti-amyloidogenic effects for Alzheimer\u2019s \u03b2-amyloid fibrils in vitro","volume":"75","author":"Ono","year":"2004","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.drudis.2023.103802_b0110","doi-asserted-by":"crossref","first-page":"10624","DOI":"10.1021\/bi2012383","article-title":"Black tea theaflavins inhibit formation of toxic amyloid-\u03b2 and \u03b1-synuclein fibrils","volume":"50","author":"Grelle","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.drudis.2023.103802_b0115","doi-asserted-by":"crossref","first-page":"19643","DOI":"10.1039\/D0CP02459G","article-title":"Destabilization potential of phenolics on A\u03b2 fibril: mechanistic insights from molecular dynamics simulation","volume":"22","author":"Gupta","year":"2020","journal-title":"PCCP"},{"key":"10.1016\/j.drudis.2023.103802_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2021.107557","article-title":"Amyloid \u03b2 fibrils disruption by kolaviron: Molecular docking and extended molecular dynamics simulation studies","volume":"94","author":"Adewole","year":"2021","journal-title":"Comput Biol Chem"},{"key":"10.1016\/j.drudis.2023.103802_b0125","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1016\/j.bmcl.2014.05.008","article-title":"Naturally occurring polyphenolic inhibitors of amyloid beta aggregation","volume":"24","author":"Churches","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.drudis.2023.103802_b0130","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1021\/bi1000855","article-title":"Destabilizing Alzheimer\u2019s A\u03b2 42 protofibrils with morin: Mechanistic insights from molecular dynamics simulations","volume":"49","author":"Lemkul","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.drudis.2023.103802_b0135","first-page":"193","article-title":"Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer\u2019s \u03b2-amyloid fibrils in vitro","volume":"1690","author":"Ono","year":"2004","journal-title":"BBA"},{"key":"10.1016\/j.drudis.2023.103802_b0140","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.bbrc.2005.08.148","article-title":"Ferulic acid destabilizes preformed \u03b2-amyloid fibrils in vitro","volume":"336","author":"Ono","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.drudis.2023.103802_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcn.2017.12.003","article-title":"Trans \u03b5-viniferin is an amyloid- \u03b2 disaggregating and anti-inflammatory drug in a mouse primary cellular model of Alzheimer\u2019s disease","volume":"88","author":"Vion","year":"2018","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.drudis.2023.103802_b0150","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1046\/j.1471-4159.2002.00904.x","article-title":"Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer\u2019s \u03b2 -amyloid fibrils in vitro","volume":"81","author":"Ono","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.drudis.2023.103802_b0155","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/jnr.21476","article-title":"Multifunction of myricetin on A\u03b2: Neuroprotection via a conformational change of A-beta and reduction of A-beta via the interference of secretases","volume":"86","author":"Shimmyo","year":"2008","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.drudis.2023.103802_b0160","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/j.bbagen.2018.07.019","article-title":"Menadione sodium bisulfite inhibits the toxic aggregation of amyloid-\u03b2 (1\u201342)","volume":"1862","author":"Zhang","year":"2018","journal-title":"Biochem Biophys Acta Gen Subj"},{"key":"10.1016\/j.drudis.2023.103802_b0165","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s11062-019-09801-z","article-title":"Effects of eugenol on Alzheimer\u2019s disease-like manifestations in insulin and A\u03b2-induced rat models","volume":"51","author":"Taheri","year":"2019","journal-title":"Neurophysiology"},{"key":"10.1016\/j.drudis.2023.103802_b0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059155","article-title":"Ginsenoside Rg1 decreases A\u03b2 1\u201342 level by upregulating PPAR c and IDE expression in the hippocampus of a rat model of Alzheimer\u2019s disease","volume":"8","author":"Quan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.drudis.2023.103802_b0175","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.neuroscience.2010.04.041","article-title":"Valproic acid enhances microglial phagocytosis of amyloid \u03b21-42","volume":"169","author":"Smith","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.drudis.2023.103802_b0180","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/jnr.23244","article-title":"Baicalein reduces \u03b2-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer\u2019s disease transgenic mouse model","volume":"1246","author":"Zhang","year":"2013","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.drudis.2023.103802_b0185","doi-asserted-by":"crossref","first-page":"9862","DOI":"10.1038\/srep09862","article-title":"Curcumin pyrazole and its derivative (N-(3-nitrophenylpyrazole) curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of wild type and mutant \u03b1-synuclein","volume":"5","author":"Ahsan","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2023.103802_b0190","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00401-007-0332-4","article-title":"Curcumin inhibits aggregation of \u03b1-synuclein","volume":"115","author":"Pandey","year":"2008","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.drudis.2023.103802_b0195","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40035-019-0159-7","article-title":"Dihydromyricetin and salvianolic acid B inhibit \u03b1-synuclein aggregation and enhance chaperone-mediated autophagy","volume":"8","author":"Wu","year":"2019","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.drudis.2023.103802_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2019.112112","article-title":"Inhibitory effect of euphorbia tannins on \u03b1-synuclein aggregation in aqueous solutions","volume":"299","author":"Sekowski","year":"2020","journal-title":"J Mol Liq"},{"key":"10.1016\/j.drudis.2023.103802_b0205","doi-asserted-by":"crossref","first-page":"11769","DOI":"10.1021\/acs.jafc.9b04558","article-title":"Brazilin inhibits \u03b1-synuclein fibrillogenesis, disrupts mature fibrils, and protects against amyloid-induced cytotoxicity","volume":"67","author":"Zhao","year":"2019","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.drudis.2023.103802_b0210","article-title":"Tannic acid inhibits \u03b1-synuclein amyloid fibril formation via binding to the monomer N-terminal domain","volume":"5","author":"Stoeber","year":"2021","journal-title":"BioRxiv"},{"key":"10.1016\/j.drudis.2023.103802_b0215","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.3390\/molecules24162940","article-title":"Complex of EGCG with Cu (II) suppresses amyloid aggregation and Cu (II)-induced cytotoxicity of \u03b1-synuclein","volume":"24","author":"Teng","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2023.103802_b0220","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fchem.2018.00181","article-title":"Exploring the structural diversity in inhibitors of \u03b1-synuclein amyloidogenic folding, aggregation, and neurotoxicity","volume":"6","author":"Das","year":"2018","journal-title":"Front Chem"},{"key":"10.1016\/j.drudis.2023.103802_b0225","doi-asserted-by":"crossref","first-page":"H2336","DOI":"10.1111\/1750-3841.13016","article-title":"Cuminaldehyde as the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on \u03b1-synuclein fibrillation and cytotoxicity","volume":"80","author":"Morshedi","year":"2015","journal-title":"J Food Sci"},{"key":"10.1016\/j.drudis.2023.103802_b0230","doi-asserted-by":"crossref","first-page":"3723567","DOI":"10.1155\/2022\/3723567","article-title":"Ferulic acid exerts neuroprotective effects via autophagy induction in C. elegans and cellular models of Parkinson\u2019s disease","volume":"2022","author":"Long","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.drudis.2023.103802_b0235","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neurobiolaging.2019.07.003","article-title":"Tyrosol a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson\u2019s disease","volume":"82","author":"Garcia-Moreno","year":"2019","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.drudis.2023.103802_b0240","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.bfopcu.2017.09.001","article-title":"Effect of myricetin on the transgenic drosophila model of Parkinson\u2019s disease","volume":"55","author":"Ara","year":"2017","journal-title":"Bull Fac Pharmacy, Cairo Univ"},{"key":"10.1016\/j.drudis.2023.103802_b0245","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jep.2016.10.040","article-title":"Baicalein attenuates \u03b1-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo","volume":"194","author":"Hung","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.drudis.2023.103802_b0250","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.neuropharm.2018.09.042","article-title":"Rosmarinic acid protects against MPTP-induced toxicity and inhibits iron-induced \u03b1-synuclein aggregation","volume":"144","author":"Qu","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.drudis.2023.103802_b0255","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3233\/JAD-170351","article-title":"Curcumin inhibits Tau aggregation and disintegrates preformed Tau filaments in vitro","volume":"60","author":"Rane","year":"2017","journal-title":"J Alzheimer\u2019s Dis"},{"key":"10.1016\/j.drudis.2023.103802_b0260","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.neuint.2011.02.010","article-title":"Oleuropein and derivatives from olives as Tau aggregation inhibitors","volume":"58","author":"Daccache","year":"2011","journal-title":"Neurochem Int"},{"key":"10.1016\/j.drudis.2023.103802_b0265","first-page":"1","article-title":"The prenylflavonoid xanthohumol reduces Alzheimer-like changes and modulates multiple pathogenic molecular pathways in the Neuro2a\/APPswe cell model of AD","volume":"9","author":"Huang","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.drudis.2023.103802_b0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2016.00598","article-title":"Resveratrol attenuates formaldehyde induced hyperphosphorylation of Tau protein and cytotoxicity in N2a Cells","volume":"10","author":"He","year":"2017","journal-title":"Front Neurosci"},{"key":"10.1016\/j.drudis.2023.103802_b0275","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijbiomac.2019.07.081","article-title":"Nanobiocatalyst facilitated aglycosidic quercetin as a potent inhibitor of tau protein aggregation","volume":"138","author":"Kumar","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.drudis.2023.103802_b0280","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1038\/s41598-020-60773-1","article-title":"Basic limonoid modulates chaperone mediated proteostasis and dissolve Tau fibrils","volume":"10","author":"Gorantla","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2023.103802_b0285","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1080\/14756366.2017.1347783","article-title":"Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to \u03b2 sheet in tau protein linked to Alzheimer\u2019s disease","volume":"32","author":"Cornejo","year":"2017","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.drudis.2023.103802_b0290","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1021\/bi400240c","article-title":"Molecular hairpin: a possible model for inhibition of tau aggregation by tannic acid","volume":"52","author":"Yao","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.drudis.2023.103802_b0295","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1515\/tnsci-2018-0010","article-title":"Effects of resveratrol and morin on insoluble tau in tau transgenic mice","volume":"9","author":"Yu","year":"2018","journal-title":"Transl Neurosci"},{"key":"10.1016\/j.drudis.2023.103802_b0300","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1021\/np100572z","article-title":"The diarylheptanoid (+) a R, 11 S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein Tau","volume":"74","author":"Jones","year":"2011","journal-title":"J Nat Prod"},{"key":"10.1016\/j.drudis.2023.103802_b0305","doi-asserted-by":"crossref","first-page":"28419","DOI":"10.1038\/srep28419","article-title":"Structural transitions in full-length human prion protein detected by xenon as probe and spin labeling of the N-terminal domain","volume":"6","author":"Narayanan","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2023.103802_b0310","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3390\/pathogens2030506","article-title":"Curcumin reduces amyloid fibrillation of prion protein and decreases reactive oxidative stress","volume":"2","author":"Lin","year":"2013","journal-title":"Pathogens"},{"key":"10.1016\/j.drudis.2023.103802_b0315","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1007\/s12035-015-9464-z","article-title":"Treatment of SMB-S15 Cells with resveratrol efficiently removes the PrPSc accumulation in vitro and prion infectivity in vivo","volume":"53","author":"Wang","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.drudis.2023.103802_b0320","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijbiomac.2021.01.045","article-title":"Ellagic acid and pentagalloylglucose are potential inhibitors of prion protein fibrillization","volume":"172","author":"Yan","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.drudis.2023.103802_b0325","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1016\/j.bbamem.2016.06.019","article-title":"Bacoside-A, an anti-amyloid natural substance, inhibits membrane disruption by the amyloidogenic determinant of prion protein through accelerating fibril formation","volume":"1858","author":"Malishev","year":"2016","journal-title":"BBA"},{"key":"10.1016\/j.drudis.2023.103802_b0330","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1021\/acsomega.9b02375","article-title":"Harmine acts as an indirect inhibitor of intracellular protein aggregation","volume":"5","author":"Jain","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.drudis.2023.103802_b0335","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1007\/s12264-019-00421-5","article-title":"Gedunin degrades aggregates of mutant huntingtin protein and intranuclear inclusions via the proteasomal pathway in neurons and fibroblasts from patients with Huntington\u2019s disease","volume":"35","author":"Yang","year":"2019","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.drudis.2023.103802_b0340","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.freeradbiomed.2003.11.023","article-title":"Flavonoid permeability across an in situ model of the blood-brain barrier","volume":"36","author":"Youdim","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.drudis.2023.103802_b0345","first-page":"645","article-title":"Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits by decreasing brain tissue inflammation in rats","volume":"23","author":"Falahieh","year":"2020","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.drudis.2023.103802_b0350","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1055\/s-2002-34401","article-title":"Transport of amentoflavone across the blood-brain barrier in vitro","volume":"68","author":"Gutmann","year":"2002","journal-title":"Planta Med"},{"key":"10.1016\/j.drudis.2023.103802_b0355","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1021\/acsami.8b20594","article-title":"Nano-curcumin simultaneously protects the blood \u2212 brain barrier and reduces M1 microglial activation during cerebral ischemia \u2212 reperfusion injury","volume":"11","author":"Wang","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.drudis.2023.103802_b0360","doi-asserted-by":"crossref","first-page":"e0212663","DOI":"10.1371\/journal.pone.0212663","article-title":"Trans \u03b5 viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model","volume":"14","author":"Caillaud","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.drudis.2023.103802_b0365","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1093\/jn\/134.11.3083","article-title":"Ferulic acid is quickly absorbed from rat stomach as the free form and then conjugated mainly in liver","volume":"134","author":"Zhao","year":"2004","journal-title":"J Nutr"},{"key":"10.1016\/j.drudis.2023.103802_b0370","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.addr.2021.01.019","article-title":"Overcoming barriers by local drug delivery with liposomes","volume":"174","author":"Antimisiaris","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.drudis.2023.103802_b0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114181","article-title":"Targeting organic cation transporters at the blood-brain barrier to treat ischemic stroke in rats","volume":"357","author":"Stanton","year":"2022","journal-title":"Exp Neurol"},{"key":"10.1016\/j.drudis.2023.103802_b0380","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.jsps.2022.10.004","article-title":"An update on the novel and approved drugs for Alzheimer disease","volume":"30","author":"Alhazmi","year":"2022","journal-title":"Saudi Pharm J"},{"key":"10.1016\/j.drudis.2023.103802_b0385","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/ana.25513","article-title":"Target engagement in an Alzheimer trial: crenezumab lowers amyloid \u03b2 oligomers in cerebrospinal fluid","volume":"86","author":"Yang","year":"2019","journal-title":"Ann Neurol"},{"key":"10.1016\/j.drudis.2023.103802_b0390","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.trci.2019.02.005","article-title":"The Alzheimer\u2019s prevention initiative generation program: study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer\u2019 s disease","volume":"5","author":"Lopez","year":"2019","journal-title":"Alzheimers Dement (NY)"},{"key":"10.1016\/j.drudis.2023.103802_b0395","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1182\/blood.2019004460","article-title":"Daratumumab plus CyBorD for patients with newly diagnosed AL amyloidosis: safety run-in results of ANDROMEDA","volume":"136","author":"Palladini","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.drudis.2023.103802_b0400","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13195-021-00813-8","article-title":"A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer\u2019s disease with lecanemab, an anti-A\u03b2 protofibril antibody","volume":"13","author":"Swanson","year":"2021","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.drudis.2023.103802_b0405","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1212\/WNL.0b013e3182309fa5","article-title":"A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease","volume":"77","author":"Salloway","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.drudis.2023.103802_b0410","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2023.103802_b0415","doi-asserted-by":"crossref","first-page":"W257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.drudis.2023.103802_b0420","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1471-4159.2007.04613.x","article-title":"Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model","volume":"102","author":"Garcia-Alloza","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.drudis.2023.103802_b0425","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbrc.2021.08.049","article-title":"Inhibition of \u03b1-synuclein aggregation by AM17, a synthetic resveratrol derivative","volume":"574","author":"Chau","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.drudis.2023.103802_b0430","doi-asserted-by":"crossref","first-page":"7722","DOI":"10.1021\/acs.jafc.6b03217","article-title":"Protocatechuic acid: inhibition of fibril formation, destabilization of pre-formed fibrils of amyloid-\u03b2 and \u03b1 -synuclein, and neuroprotection","volume":"64","author":"Hornedo-Ortega","year":"2016","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.drudis.2023.103802_b0435","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jsps.2018.02.001","article-title":"The possible mechanisms of protocatechuic acid-induced central analgesia","volume":"26","author":"Arslan","year":"2018","journal-title":"Saudi Pharm J"},{"key":"10.1016\/j.drudis.2023.103802_b0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110817","article-title":"Melatonin, protocatechuic acid and hydroxytyrosol effects on vitagenes system against \u03b1-synuclein toxicity","volume":"134","author":"Gallardo-Fern\u00e1ndez","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.drudis.2023.103802_b0445","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1080\/1028415X.2017.1354543","article-title":"Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: review on the basis of in vitro and in vivo studies in rodents and humans","volume":"22","author":"Krzysztoforska","year":"2019","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.drudis.2023.103802_b0450","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3390\/antiox11040629","article-title":"An olive-derived extract 20% rich in hydroxytyrosol prevents \u03b2-Amyloid aggregation and oxidative stress, two features of Alzheimer disease, via SKN-1\/NRF2 and HSP-16.2 in Caenorhabditis elegans","volume":"11","author":"Romero-M\u00e1rquez","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.drudis.2023.103802_b0455","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/mnfr.201100436","article-title":"Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake","volume":"56","author":"Serra","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.drudis.2023.103802_b0460","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.fct.2018.06.059","article-title":"Protective effects of hydroxytyrosol against \u03b1-synuclein toxicity on PC12 cells and fibril formation","volume":"120","author":"Hornedo-Ortega","year":"2018","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.drudis.2023.103802_b0465","doi-asserted-by":"crossref","first-page":"8122","DOI":"10.1039\/D0FO01511C","article-title":"Amyloid \u03b2 fibrils disruption by oleuropein aglycone: long-time molecular dynamics simulation to gain insight into the mechanism of action of this polyphenol from extra virgin olive oil","volume":"11","author":"Brogi","year":"2020","journal-title":"Food Funct"},{"key":"10.1016\/j.drudis.2023.103802_b0470","doi-asserted-by":"crossref","first-page":"5010741","DOI":"10.1155\/2018\/5010741","article-title":"Benefit of Oleuropein Aglycone for Alzheimer\u2019s disease by promoting autophagy","volume":"2018","author":"Cordero","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.drudis.2023.103802_b0475","doi-asserted-by":"crossref","first-page":"7865","DOI":"10.1039\/C9FO02133G","article-title":"Function and protects cells against tau aggregates","volume":"10","author":"Zhang","year":"2019","journal-title":"Food Funct"},{"key":"10.1016\/j.drudis.2023.103802_b0480","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3233\/JAD-190098","article-title":"Tyrosol reduces amyloid-\u03b2 oligomer neurotoxicity and alleviates synaptic, oxidative, and cognitive disturbances in Alzheimer\u2019s disease model mice","volume":"70","author":"Taniguchi","year":"2019","journal-title":"J Alzheimer\u2019s Dis"},{"key":"10.1016\/j.drudis.2023.103802_b0485","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/nu8060333","article-title":"Salvianolic acid B inhibits A\u03b2 generation by modulating BACE1 activity in SH-SY5Y-APPsw cells","volume":"8","author":"Tang","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.drudis.2023.103802_b0490","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.toxrep.2018.02.017","article-title":"Ellagic acid attenuates arsenic induced neuro-inflammation and mitochondrial dysfunction associated apoptosis","volume":"5","author":"Firdaus","year":"2018","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.drudis.2023.103802_b0495","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1021\/acschemneuro.1c00001","article-title":"Ellagic acid inhibits \u03b1-synuclein aggregation at multiple stages and reduces its cytotoxicity","volume":"12","author":"Kumar","year":"2021","journal-title":"ACS Chem Nerosci"},{"key":"10.1016\/j.drudis.2023.103802_b0500","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bpj.2020.05.033","article-title":"The effect of (-)-epigallocatechin-3-gallate on the amyloid-\u03b2 secondary structure","volume":"119","author":"Acharya","year":"2020","journal-title":"Biophys J"},{"key":"10.1016\/j.drudis.2023.103802_b0505","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.febslet.2014.11.026","article-title":"The green tea polyphenol (-) epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios","volume":"589","author":"Wobst","year":"2015","journal-title":"FEBS Lett"},{"key":"10.1016\/j.drudis.2023.103802_b0510","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3389\/fnins.2018.00735","article-title":"Phenylindanes in brewed coffee inhibit amyloid-beta and Tau aggregation","volume":"12","author":"Mancini","year":"2018","journal-title":"Front Neurosci"},{"key":"10.1016\/j.drudis.2023.103802_b0515","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.2174\/1570159X19666210111155110","article-title":"Chlorogenic acid improves PTSD-like symptoms and associated mechanisms","volume":"19","author":"Chen","year":"2021","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.drudis.2023.103802_b0520","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.3390\/nu12051531","article-title":"Presence of caffeic acid in cerebrospinal fluid: evidence that dietary polyphenols can cross the blood-brain barrier in humans","volume":"12","author":"Grabska-Kobylecka","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.drudis.2023.103802_b0525","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.biochi.2014.11.011","article-title":"Anti-fibrillation potency of caffeic acid against an anti-depressant induced fibrillogenesis of human \u03b1-synuclein: implications for Parkinson\u2019s disease","volume":"108","author":"Fazili","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.drudis.2023.103802_b0530","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1021\/acsomega.1c06565","article-title":"Analysis of the molecular mechanism of punicalagin in the treatment of Alzheimer\u2019s disease by computer-aided drug research technology","volume":"7","author":"Xu","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.drudis.2023.103802_b0535","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4062\/biomolther.2019.113","article-title":"Polyphenolic biflavonoids inhibit amyloid-\u03b2 fibrillation and disaggregate preformed amyloid-\u03b2 fibrils","volume":"28","author":"Choi","year":"2020","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.drudis.2023.103802_b0540","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.3390\/ijms22083829","article-title":"Quercetin attenuates brain oxidative alterations induced by iron oxide nanoparticles in rats","volume":"22","author":"Dora","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2023.103802_b0545","first-page":"2872","article-title":"Oxidized quercetin inhibits \u03b1-synuclein fibrillization","volume":"1830","author":"Zhu","year":"2013","journal-title":"BBA"},{"key":"10.1016\/j.drudis.2023.103802_b0550","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.4103\/1673-5374.197141","article-title":"Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer\u2019s disease","volume":"11","author":"Ramezani","year":"2016","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.drudis.2023.103802_b0555","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jmb.2008.08.039","article-title":"Structural characteristics of \u03b1-synuclein oligomers stabilized by the flavonoid baicalein","volume":"383","author":"Hong","year":"2008","journal-title":"J Mol Biol"},{"key":"10.1016\/j.drudis.2023.103802_b0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2020.113198","article-title":"Silybin as a potent inhibitor of \u03b1-synuclein aggregation and associated cytotoxicity against neuroblastoma cells induced by zinc oxide nanoparticles","volume":"310","author":"Khodabandeh","year":"2020","journal-title":"J Mol Liq"},{"key":"10.1016\/j.drudis.2023.103802_b0565","article-title":"Natural alkaloid harmine promotes degradation of \u03b1-synuclein via PKA-mediated ubiquitin-proteasome system activation","volume":"61","author":"Cui-Zan","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.drudis.2023.103802_b0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113554","article-title":"Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3 \u03b2\/DYRK1A dual inhibitors for the treatment of Alzheimer\u2019s disease","volume":"222","author":"Liu","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2023.103802_b0575","doi-asserted-by":"crossref","first-page":"40744","DOI":"10.1038\/srep40744","article-title":"Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis","volume":"7","author":"Dubey","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2023.103802_b0580","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1021\/cn400051e","article-title":"Tanshinones inhibit amyloid aggregation by amyloid-\u03b2 peptide, disaggregate amyloid fibrils, and protect cultured cells","volume":"4","author":"Wang","year":"2013","journal-title":"ACS Chem Nerosci"},{"key":"10.1016\/j.drudis.2023.103802_b0585","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1039\/C5FO00664C","article-title":"Inhibition effects of tanshinone on the aggregation of \u03b1-synuclein","volume":"7","author":"Ji","year":"2015","journal-title":"Food Funct"},{"key":"10.1016\/j.drudis.2023.103802_b0590","first-page":"7631801","article-title":"Tanshinone IIA alleviates the AD phenotypes in APP and PS1 transgenic mice","volume":"2016","author":"Li","year":"2016","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.drudis.2023.103802_b0595","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.nbd.2014.11.007","article-title":"Neurobiology of disease ginsenoside Rb1 inhibits fibrillation and toxicity of \u03b1-synuclein and disaggregates preformed fibrils","volume":"74","author":"Ardah","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.drudis.2023.103802_b0600","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/acschemneuro.6b00438","article-title":"Bacoside-A, an Indian traditional-medicine substance, inhibits \u03b2 amyloid cytotoxicity, fibrillation, and membrane interactions","volume":"8","author":"Malishe","year":"2017","journal-title":"ACS Chem Nerosci"},{"key":"10.1016\/j.drudis.2023.103802_b0605","article-title":"Bacopa monnieri, a neuroprotective lead in Alzheimer disease: a review on its properties, mechanisms of action, and preclinical and clinical studies","volume":"13","author":"Manap","year":"2019","journal-title":"Drug Target Insights"},{"key":"10.1016\/j.drudis.2023.103802_b0610","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2010.02.006","article-title":"Neuroprotective effects of cyanidin 3-O-glucopyranoside on amyloid \u03b2 (25\u201335) oligomer-induced toxicity","volume":"473","author":"Tarozzi","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.drudis.2023.103802_b0615","doi-asserted-by":"crossref","first-page":"22815","DOI":"10.1038\/srep22815","article-title":"Determination of cyanidin 3-glucoside in rat brain, liver and kidneys by UPLC\/MS-MS and its application to a short-term pharmacokinetic study","volume":"6","author":"Fornasaro","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2023.103802_b0620","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1039\/C9FO00316A","article-title":"Cyanidin-3-O-glucoside inhibits A\u03b2-40 fibrillogenesis, disintegrates preformed fibrils, and reduces amyloid cytotoxicity","volume":"11","author":"Liu","year":"2020","journal-title":"Food Funct"},{"key":"10.1016\/j.drudis.2023.103802_b0625","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/nu8060367","article-title":"Piceatannol and other wine stilbenes: a pool of inhibitors against \u03b1 -synuclein aggregation and cytotoxicity","volume":"8","author":"Temsamani","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.drudis.2023.103802_b0630","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/abbs\/gmt074","article-title":"PP2 and piceatannol inhibit PrP106-126-induced iNOS activation mediated by CD36 in BV2 microglia","volume":"45","author":"Zhang","year":"2013","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.drudis.2023.103802_b0635","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/ptr.5824","article-title":"Inhibition of prion propagation by 3, 4-Dimethoxycinnamic acid","volume":"31","author":"Zanyatkin","year":"2017","journal-title":"Phytother Res"},{"key":"10.1016\/j.drudis.2023.103802_b0640","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuint.2012.10.001","article-title":"Vitamins K interact with N-terminus \u03b1-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and \u03b1-synuclein","volume":"62","author":"Da Silva","year":"2013","journal-title":"Neurochem Int"},{"key":"10.1016\/j.drudis.2023.103802_b0645","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0006-8993(97)00292-8","article-title":"Menadione induced tau dephosphorylation in cultured human neuroblastoma cells","volume":"760","author":"Ko","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.drudis.2023.103802_b0650","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.bbrc.2015.12.043","article-title":"\u03b1-Synuclein aggregation, seeding and inhibition by scyllo-inositol","volume":"469","author":"Ibrahim","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.drudis.2023.103802_b0655","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1074\/jbc.M113.501635","article-title":"scyllo-inositol promotes robust mutant huntingtin protein degradation","volume":"289","author":"Lai","year":"2014","journal-title":"J Biol Chem"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644623003185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644623003185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T13:09:13Z","timestamp":1761224953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644623003185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":131,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1359644623003185"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2023.103802","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-amyloid potential of some phytochemicals against A\u03b2-peptide and \u03b1-synuclein, tau, prion, and Huntingtin protein","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2023.103802","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103802"}}