{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:54:39Z","timestamp":1784346879450,"version":"3.55.0"},"reference-count":132,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.drudis.2023.103850","type":"journal-article","created":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T18:39:31Z","timestamp":1701628771000},"page":"103850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Potential molecular pathways of angiotensin receptor blockers in the brain toward cognitive improvement in dementia"],"prefix":"10.1016","volume":"29","author":[{"given":"Varnita","family":"Karmakar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bapi","family":"Gorain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2023.103850_b0005","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.drudis.2023.103850_b0010","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1016\/S2468-2667(21)00277-2","article-title":"Forecasting the prevalence of dementia","volume":"7","author":"Schwarzinger","year":"2022","journal-title":"Lancet Public Heal"},{"key":"10.1016\/j.drudis.2023.103850_b0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5535\/arm.22027","article-title":"Dementia epidemiology fact sheet 2022","volume":"46","author":"Shin","year":"2022","journal-title":"Ann Rehabil Med"},{"key":"10.1016\/j.drudis.2023.103850_b0020","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1177\/0269881106068299","article-title":"Clinical practice with anti-dementia drugs: A consensus statement from British Association for Psychopharmacology","volume":"20","author":"Burns","year":"2006","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.drudis.2023.103850_b0025","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.bbrc.2020.01.123","article-title":"Natural and synthetic drugs used for the treatment of the dementia","volume":"524","author":"Dembitsky","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.drudis.2023.103850_b0030","article-title":"Recent advances in the endogenous brain renin-angiotensin system and drugs acting on it","volume":"2021","author":"Urmila","year":"2021","journal-title":"J Renin-Angiotensin-Aldosterone Syst JRAAS"},{"key":"10.1016\/j.drudis.2023.103850_b0035","doi-asserted-by":"crossref","first-page":"10139","DOI":"10.3390\/ijms221810139","article-title":"Brain renin\u2013angiotensin system as novel and potential therapeutic target for alzheimer\u2019s disease","volume":"22","author":"Loera-Valencia","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2023.103850_b0040","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.colsurfb.2013.12.016","article-title":"Nanoemulsion strategy for olmesartan medoxomil improves oral absorption and extended antihypertensive activity in hypertensive rats","volume":"115","author":"Gorain","year":"2014","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.drudis.2023.103850_b0045","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.jamda.2020.12.019","article-title":"Antihypertensive medication classes and the risk of dementia: A systematic review and network meta-analysis","volume":"22","author":"den Brok","year":"2021","journal-title":"J Am Med Dir Assoc"},{"key":"10.1016\/j.drudis.2023.103850_b0050","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1161\/HYPERTENSIONAHA.122.19378","article-title":"Angiotensin Receptor Blockers Are Associated With a Lower Risk of Progression From Mild Cognitive Impairment to Dementia","volume":"79","author":"Deng","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.drudis.2023.103850_b0055","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3233\/JAD-181035","article-title":"Contributions by the Brain Renin-Angiotensin System to Memory, Cognition, and Alzheimer\u2019s Disease","volume":"67","author":"Wright","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.drudis.2023.103850_b0060","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1002\/jnr.22441","article-title":"An angiotensin II type 1 receptor blocker can preserve endothelial function and attenuate brain ischemic damage in spontaneously hypertensive rats","volume":"88","author":"Oyama","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.drudis.2023.103850_b0065","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/CS20120078","article-title":"AT1 receptor blockers as treatments for inflammatory brain disorders","volume":"123","author":"Saavedra","year":"2012","journal-title":"Clin Sci"},{"key":"10.1016\/j.drudis.2023.103850_b0070","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/01.HYP.35.1.409","article-title":"The brain renin-angiotensin system modulates angiotensin II\u2013induced hypertension and cardiac hypertrophy","volume":"35","author":"Baltatu","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.drudis.2023.103850_b0075","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41440-020-0396-2","article-title":"A colorful view of the brain renin-angiotensin system","volume":"43","author":"Sigmund","year":"2020","journal-title":"Hypertens Res"},{"key":"10.1016\/j.drudis.2023.103850_b0080","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/HYPERTENSIONAHA.117.08550","article-title":"How is the brain Renin-angiotensin system regulated?","volume":"70","author":"Nakagawa","year":"2017","journal-title":"Hypertens (Dallas, Tex 1979)"},{"key":"10.1016\/j.drudis.2023.103850_b0085","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/jcbfm.2011.133","article-title":"Direct stimulation of angiotensin II type 2 receptor enhances spatial memory","volume":"32","author":"Jing","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.drudis.2023.103850_b0090","doi-asserted-by":"crossref","first-page":"33238","DOI":"10.1074\/jbc.M002615200","article-title":"A human homolog of angiotensin-converting enzyme: Cloning and functional expression as a captopril-insensitive carboxypeptidase","volume":"275","author":"Tipnis","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.drudis.2023.103850_b0095","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1210\/en.2004-0443","article-title":"The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis","volume":"145","author":"Douglas","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.drudis.2023.103850_b0100","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1\u20137) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.drudis.2023.103850_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.586314","article-title":"Brain Renin\u2013angiotensin system at the intersect of physical and cognitive frailty","volume":"14","author":"Cosarderelioglu","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.drudis.2023.103850_b0110","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/jpet.118.248831","article-title":"Molecular basis of the brain renin angiotensin system in cardiovascular and neurologic disorders: uncovering a key role for the astroglial angiotensin type 1 receptor AT1R","volume":"366","author":"Haspula","year":"2018","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.drudis.2023.103850_b0115","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1042\/CS20180236","article-title":"Angiotensin generation in the brain: a re-evaluation","volume":"132","author":"Uijl","year":"2018","journal-title":"Clin Sci"},{"key":"10.1016\/j.drudis.2023.103850_b0120","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1152\/physiol.00002.2008","article-title":"An intracellular renin-angiotensin system in neurons: Fact, hypothesis, or fantasy","volume":"23","author":"Grobe","year":"2008","journal-title":"Physiology"},{"key":"10.1016\/j.drudis.2023.103850_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-019-1011-2","article-title":"The Renin-angiotensin system in the central nervous system and its role in blood pressure regulation","volume":"22","author":"Nakagawa","year":"2020","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.drudis.2023.103850_b0130","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cmet.2010.09.011","article-title":"The brain renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance","volume":"12","author":"Grobe","year":"2010","journal-title":"Cell Metab"},{"key":"10.1016\/j.drudis.2023.103850_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175623","article-title":"ACE2\/ANG-(1\u20137)\/Mas receptor axis activation prevents inflammation and improves cognitive functions in streptozotocin induced rat model of Alzheimer\u2019s disease-like phenotypes","volume":"946","author":"Tiwari","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.drudis.2023.103850_b0140","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.neuron.2022.03.008","article-title":"Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer\u2019s disease","volume":"110","author":"Sadick","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.drudis.2023.103850_b0145","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12012-022-09730-0","article-title":"AT1 Receptors: Their Actions from Hypertension to Cognitive Impairment","volume":"22","author":"Wu","year":"2022","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.drudis.2023.103850_b0150","doi-asserted-by":"crossref","first-page":"268","DOI":"10.37349\/emed.2021.00046","article-title":"Angiotensin-(1\u20137) and Mas receptor in the brain","volume":"2","author":"Rukavina Mikusic","year":"2021","journal-title":"Explor Med"},{"key":"10.1016\/j.drudis.2023.103850_b0155","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1161\/HYPERTENSIONAHA.117.09923","article-title":"Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism","volume":"70","author":"Shinohara","year":"2017","journal-title":"Hypertens (Dallas, Tex 1979)"},{"key":"10.1016\/j.drudis.2023.103850_b0160","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s11064-018-2679-4","article-title":"ACE2 in brain physiology and pathophysiology: Evidence from transgenic animal models","volume":"44","author":"Alenina","year":"2019","journal-title":"Neurochem Res"},{"key":"10.1016\/j.drudis.2023.103850_b0165","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/sj.ki.5000321","article-title":"ACE and ACE2: Their role to balance the expression of angiotensin II and angiotensin-(1\u20137)","volume":"70","author":"Chappel","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.drudis.2023.103850_b0170","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11040908","article-title":"Multiple aspects of inappropriate action of renin\u2013angiotensin, vasopressin, and oxytocin systems in neuropsychiatric and neurodegenerative diseases","volume":"11","author":"Szczepanska-Sadowska","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.drudis.2023.103850_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/102602","article-title":"Renin angiotensin system in cognitive function and dementia","volume":"2013","author":"Bodiga","year":"2013","journal-title":"Asian J Neurosci"},{"key":"10.1016\/j.drudis.2023.103850_b0180","doi-asserted-by":"crossref","first-page":"fcac338","DOI":"10.1093\/braincomms\/fcac338","article-title":"Acetylcholine and noradrenaline differentially regulate hippocampus-dependent spatial learning and memory","volume":"5","author":"De Leo","year":"2022","journal-title":"Brain Commun"},{"key":"10.1016\/j.drudis.2023.103850_b0185","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0196-9781(98)00044-8","article-title":"Angiotensin II inhibits long-term potentiation within the lateral nucleus of the amygdala through AT1 receptors","volume":"19","author":"Von Bohlen Und Halbach","year":"1998","journal-title":"Peptides"},{"key":"10.1016\/j.drudis.2023.103850_b0190","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/169649","article-title":"Roles of brain angiotensin II in cognitive function and dementia","volume":"2012","author":"Mogi","year":"2012","journal-title":"Int J Hypertens"},{"key":"10.1016\/j.drudis.2023.103850_b0195","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.yexcr.2015.06.010","article-title":"Angiotensin-(1\u20137) counteracts angiotensin II-induced dysfunction in cerebral endothelial cells via modulating Nox2\/ROS and PI3K\/NO pathways","volume":"336","author":"Xiao","year":"2015","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.drudis.2023.103850_b0200","first-page":"1","article-title":"Angiotensin-converting enzyme 2 is reduced in Alzheimer\u2019s disease in association with increasing amyloid-\u03b2 and tau pathology","volume":"8","author":"Kehoe","year":"2016","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"10.1016\/j.drudis.2023.103850_b0205","doi-asserted-by":"crossref","first-page":"636754","DOI":"10.3389\/fnins.2021.636754","article-title":"Circulating angiotensin-(1\u20137) is reduced in Alzheimer\u2019s disease patients and correlates with white matter abnormalities: Results from a pilot study","volume":"15","author":"Ribeiro","year":"2021","journal-title":"Front Neurosci"},{"key":"10.1016\/j.drudis.2023.103850_b0210","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.kint.2018.10.042","article-title":"The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome","volume":"95","author":"Ramkumar","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.drudis.2023.103850_b0215","first-page":"1","article-title":"Memory is preserved in older adults taking AT1 receptor blockers","volume":"9","author":"Ho","year":"2017","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"10.1016\/j.drudis.2023.103850_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2017.08.055","article-title":"The stimulation of the Ang II\/AT1R axis causes this impairment, emphasising a critical connection between molecular interactions and cognitive function. Also, ACE overexpression, another classic RAS route, causes cell death, exacerbation of inflammation","volume":"46","author":"Farag","year":"2017","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.drudis.2023.103850_b0225","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.590855","article-title":"From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase","volume":"11","author":"Hallberg","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.drudis.2023.103850_b0230","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1055\/s-0035-1555115","article-title":"The impact of age on cognition","volume":"36","author":"Murman","year":"2015","journal-title":"Semin Hear"},{"key":"10.1016\/j.drudis.2023.103850_b0235","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbr.2016.05.008","article-title":"Molecular and cellular aspects of age-related cognitive decline and Alzheimer\u2019s disease","volume":"322","author":"Hullinger","year":"2017","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.drudis.2023.103850_b0240","doi-asserted-by":"crossref","first-page":"12246","DOI":"10.3390\/ijms241512246","article-title":"The amyloid cascade hypothesis 2.0 for Alzheimer\u2019s disease and aging-associated cognitive decline: From molecular basis to effective therapy","volume":"24","author":"Volloch","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2023.103850_b0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022682","article-title":"ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function","volume":"6","author":"Xia","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.drudis.2023.103850_b0250","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1161\/HYPERTENSIONAHA.110.155895","article-title":"Aging and the renin-angiotensin system","volume":"60","author":"Conti","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.drudis.2023.103850_b0255","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The Pathobiology of Vascular Dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.drudis.2023.103850_b0260","doi-asserted-by":"crossref","first-page":"e4764","DOI":"10.1371\/journal.pone.0004764","article-title":"Identification of ischemic regions in a rat model of stroke","volume":"4","author":"Popp","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.drudis.2023.103850_b0265","doi-asserted-by":"crossref","DOI":"10.3390\/v15040908","article-title":"Multifactorial white matter damage in the acute phase and pre-existing conditions may drive cognitive dysfunction after SARS-CoV-2 infection: Neuropathology-based evidence","volume":"15","author":"Gelpi","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.drudis.2023.103850_b0270","first-page":"1","article-title":"Local and systemic hypoxia as inductors of increased aluminum and iron brain accumulation promoting the onset of Alzheimer\u2019s disease","author":"Cirovic","year":"2023","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.drudis.2023.103850_b0275","doi-asserted-by":"crossref","first-page":"1070743","DOI":"10.3389\/fped.2023.1070743","article-title":"Neonatal asphyxia as an inflammatory disease: Reactive oxygen species and cytokines","volume":"11","author":"Okazaki","year":"2023","journal-title":"Front Pediatr"},{"key":"10.1016\/j.drudis.2023.103850_b0280","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/01.STR.0000121642.53822.58","article-title":"Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats","volume":"35","author":"Stenman","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.drudis.2023.103850_b0285","doi-asserted-by":"crossref","first-page":"R519","DOI":"10.1152\/ajpregu.00222.2020","article-title":"Role of angiotensin II in chronic intermittent hypoxia-induced hypertension and cognitive decline","volume":"320","author":"Marciante","year":"2021","journal-title":"Am J Physiol \u2013 Regul Integr Comp Physiol"},{"key":"10.1016\/j.drudis.2023.103850_b0290","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrneurol.2010.148","article-title":"Decision-making cognition in neurodegenerative diseases","volume":"6","author":"Gleichgerrcht","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.drudis.2023.103850_b0295","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.sjbs.2020.01.026","article-title":"Role of brain renin angiotensin system in neurodegeneration: An update","volume":"27","author":"Abiodun","year":"2020","journal-title":"Saudi J Biol Sci"},{"key":"10.1016\/j.drudis.2023.103850_b0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2010.10.001","article-title":"Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications","volume":"36","author":"Saavedra","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.drudis.2023.103850_b0305","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s00213-018-4950-4","article-title":"Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression","volume":"235","author":"Levy","year":"2018","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.drudis.2023.103850_b0310","article-title":"A review on neuroinflammatory pathway mediating through Ang-II\/AT1 receptors and a novel approach for the treatment of cerebral ischemia in combination with ARB\u2019s and ceftriaxone","author":"Rao","year":"2023","journal-title":"https:\/\/doi.org\/101177\/09727531231182554"},{"key":"10.1016\/j.drudis.2023.103850_b0315","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26123724","article-title":"Role of monoamine oxidase activity in alzheimer\u2019s disease: An insight into the therapeutic potential of inhibitors","volume":"26","author":"Behl","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2023.103850_b0320","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1089\/ars.2010.3208","article-title":"Reactive oxygen species in the regulation of synaptic plasticity and memory","volume":"14","author":"Massaad","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.drudis.2023.103850_b0325","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s11357-022-00639-8","article-title":"Angiotensin receptor blocker use is associated with upregulation of the memory-protective angiotensin type 4 receptor (AT4R) in the postmortem brains of individuals without cognitive impairment","volume":"45","author":"Cosarderelioglu","year":"2023","journal-title":"GeroScience"},{"key":"10.1016\/j.drudis.2023.103850_b0330","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nature07141","article-title":"Acetylcholine contributes through muscarinic receptors to attentional modulation in V1","volume":"454","author":"Herrero","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2023.103850_b0335","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/jnc.14052","article-title":"Cholinergic modulation of the hippocampal region and memory function","volume":"142","author":"Haam","year":"2017","journal-title":"J Neurochem"},{"key":"10.1016\/j.drudis.2023.103850_b0340","doi-asserted-by":"crossref","first-page":"20210004","DOI":"10.1042\/NS20210004","article-title":"Targeting the M1 muscarinic acetylcholine receptor in Alzheimer\u2019s disease","volume":"6","author":"Dwomoh","year":"2022","journal-title":"Neuronal Signal"},{"key":"10.1016\/j.drudis.2023.103850_b0345","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-3-642-23274-9_7","article-title":"Muscarinic receptor pharmacology and circuitry for the modulation of cognition","volume":"208","author":"Bubser","year":"2012","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.drudis.2023.103850_b0350","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/aps.2009.37","article-title":"Neuronal nicotinic receptors as novel targets for inflammation and neuroprotection: mechanistic considerations and clinical relevance","volume":"30","author":"Bencherif","year":"2009","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.drudis.2023.103850_b0355","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1111\/bph.13769","article-title":"Hippocampal \u03b17 nicotinic ACh receptors contribute to modulation of depression-like behaviour in C57BL\/6J mice","volume":"175","author":"Mineur","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2023.103850_b0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ph14020166","article-title":"Losartan improves memory, neurogenesis and cell motility in transgenic Alzheimer\u2019s mice","volume":"14","author":"Drews","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.drudis.2023.103850_b0365","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/1470320313516173","article-title":"Anti-stress and nootropic activity of drugs affecting the renin-angiotensin system in rats based on indirect biochemical evidence","volume":"16","author":"Anil Kumar","year":"2015","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"10.1016\/j.drudis.2023.103850_b0370","first-page":"85","article-title":"Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease","volume":"25","author":"Wang","year":"2008","journal-title":"Hipertension"},{"key":"10.1016\/j.drudis.2023.103850_b0375","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1179\/1743132813Y.0000000295","article-title":"The effects of valsartan on cognitive deficits induced by aluminum trichloride and D-galactose in mice","volume":"36","author":"Yang","year":"2014","journal-title":"Neurol Res"},{"key":"10.1016\/j.drudis.2023.103850_b0380","article-title":"Comparing the neuroprotective effects of telmisartan, perindopril, and nebivolol against lipopolysaccharide-induced injury in neuron-like cells","volume":"14","author":"\u015een","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.drudis.2023.103850_b0385","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2012.10.017","article-title":"PPAR\u03b3 activation prevents impairments in spatial memory and neurogenesis following transient illness","volume":"29","author":"Ormerod","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.drudis.2023.103850_b0390","first-page":"6","article-title":"Localization of PPAR isotypes in the adult mouse and human brain","author":"Warden","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2023.103850_b0395","first-page":"9","article-title":"The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function","author":"Gray","year":"2012","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.drudis.2023.103850_b0400","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10571-017-0554-5","article-title":"Roles of peroxisome proliferator-activated receptor-gamma on brain and peripheral inflammation","volume":"38","author":"Villapol","year":"2018","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.drudis.2023.103850_b0405","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1093\/brain\/awv172","article-title":"Neurorestoration after traumatic brain injury through angiotensin II receptor blockage","volume":"138","author":"Villapol","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.drudis.2023.103850_b0410","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.vph.2006.05.002","article-title":"Molecular activation of PPAR\u03b3 by angiotensin II type 1-receptor antagonists","volume":"45","author":"Erbe","year":"2006","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.drudis.2023.103850_b0415","first-page":"9","article-title":"Involvement of PPAR-\u03b3 in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson\u2019s disease","author":"Garrido-Gil","year":"2012","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.drudis.2023.103850_b0420","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jjcc.2012.08.004","article-title":"Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor\/tropomyosin-related kinase B in hippocampus of hypertensive rats","volume":"60","author":"Kishi","year":"2012","journal-title":"J Cardiol"},{"key":"10.1016\/j.drudis.2023.103850_b0425","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1161\/01.CIR.0000127955.36250.65","article-title":"Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity","volume":"109","author":"Schupp","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.drudis.2023.103850_b0430","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3390\/ijms24032345","article-title":"Pharmacological utility of PPAR modulation for angiogenesis in cardiovascular disease","volume":"24","author":"Wagner","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2023.103850_b0435","first-page":"11","article-title":"The protective effects of peroxisome proliferator-activated receptor gamma in cerebral ischemia-reperfusion injury","author":"Ding","year":"2020","journal-title":"Front Neurol"},{"key":"10.1016\/j.drudis.2023.103850_b0440","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.bbadis.2015.12.016","article-title":"Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer\u2019s disease","volume":"1862","author":"Nelson","year":"2016","journal-title":"Biochim Biophys Acta \u2013 Mol Basis Dis"},{"key":"10.1016\/j.drudis.2023.103850_b0445","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1161\/01.STR.0000027274.03779.F3","article-title":"Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist","volume":"33","author":"Ito","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.drudis.2023.103850_b0450","first-page":"13","article-title":"The effect of candesartan alone and its combination with estrogen on post-traumatic Brain injury outcomes in female rats","author":"Hajmohammadi","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1016\/j.drudis.2023.103850_b0455","first-page":"536","article-title":"Blockade of central angiotensin II AT1 receptor protects the brain from ischemia\/reperfusion injury in normotensive rats","volume":"39","author":"Panahpour","year":"2014","journal-title":"Iran J Med Sci"},{"key":"10.1016\/j.drudis.2023.103850_b0460","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci10030153","article-title":"The role of sartans in the treatment of stroke and subarachnoid hemorrhage: A narrative review of preclinical and clinical studies","volume":"10","author":"Wanderer","year":"2020","journal-title":"Brain Sci"},{"key":"10.1016\/j.drudis.2023.103850_b0465","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1111\/j.1476-5381.2010.01167.x","article-title":"Role of angiotensin II receptor subtype activation in cognitive function and ischaemic brain damage","volume":"163","author":"Horiuchi","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2023.103850_b0470","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-neuro-071714-033835","article-title":"Neuronal and vascular interactions","volume":"38","author":"Andreone","year":"2015","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.drudis.2023.103850_b0475","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s11011-021-00728-1","article-title":"Manifestation of renin angiotensin system modulation in traumatic brain injury","volume":"36","author":"Mirzahosseini","year":"2021","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.drudis.2023.103850_b0480","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/hr.2014.51","article-title":"Valsartan ameliorates the constitutive adipokine expression pattern in mature adipocytes: a role for inverse agonism of the angiotensin II type 1 receptor in obesity","volume":"37","author":"Hasan","year":"2014","journal-title":"Hypertens Res"},{"key":"10.1016\/j.drudis.2023.103850_b0485","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1152\/physiol.00036.2020","article-title":"Angiotensin receptor blockers are not just for hypertension anymore","volume":"36","author":"Saavedra","year":"2021","journal-title":"Physiology"},{"key":"10.1016\/j.drudis.2023.103850_b0490","doi-asserted-by":"crossref","DOI":"10.3390\/cells10061309","article-title":"Neuroprotective Natural Products for Alzheimer\u2019s Disease","volume":"10","author":"Chen","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.drudis.2023.103850_b0495","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/HYPERTENSIONAHA.108.123612","article-title":"Continuous activation of renin-angiotensin system impairs cognitive function in renin\/angiotensinogen transgenic mice","volume":"53","author":"Inaba","year":"2009","journal-title":"Hypertens (Dallas, Tex 1979)"},{"key":"10.1016\/j.drudis.2023.103850_b0500","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1161\/STROKEAHA.110.583948","article-title":"Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-\u03b3 activation in mice with chronic cerebral hypoperfusion","volume":"41","author":"Washida","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.drudis.2023.103850_b0505","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11481-011-9287-2","article-title":"Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system","volume":"7","author":"Montgomery","year":"2011","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.1016\/j.drudis.2023.103850_b0510","doi-asserted-by":"crossref","first-page":"e0201719","DOI":"10.1371\/journal.pone.0201719","article-title":"Differential effects of angiotensin II type I receptor blockers on reducing intraocular pressure and TGF\u03b2 signaling in the mouse retina","volume":"13","author":"Hazlewood","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.drudis.2023.103850_b0515","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.717157","article-title":"Kynurenic acid and its synthetic derivatives protect against sepsis-associated neutrophil activation and brain mitochondrial dysfunction in rats","volume":"12","author":"Poles","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.drudis.2023.103850_b0520","doi-asserted-by":"crossref","first-page":"10592","DOI":"10.1523\/JNEUROSCI.1107-14.2014","article-title":"Reduction of brain kynurenic acid improves cognitive function","volume":"34","author":"Kozak","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.drudis.2023.103850_b0525","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1021\/acs.jmedchem.5b00461","article-title":"Challenges and opportunities in the discovery of new therapeutics targeting the kynurenine pathway","volume":"58","author":"Dounay","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2023.103850_b0530","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s12640-017-9781-2","article-title":"Angiotensin II type 1 receptor blockers inhibit KAT II activity in the brain-Its possible clinical applications","volume":"32","author":"Zakrocka","year":"2017","journal-title":"Neurotox Res"},{"key":"10.1016\/j.drudis.2023.103850_b0535","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/npp.2010.39","article-title":"Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior","volume":"35","author":"Potter","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.drudis.2023.103850_b0540","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00210-018-1572-7","article-title":"Angiotensin II type 1 receptor blockers decrease kynurenic acid production in rat kidney in vitro","volume":"392","author":"Zakrocka","year":"2019","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.drudis.2023.103850_b0545","doi-asserted-by":"crossref","first-page":"14396","DOI":"10.3390\/ijms232214396","article-title":"Emerging role of NLRP3 inflammasome and pyroptosis in liver transplantation","volume":"23","author":"Lucas-Ruiz","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2023.103850_b0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101907","article-title":"The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases","volume":"87","author":"Possemato","year":"2023","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.drudis.2023.103850_b0555","doi-asserted-by":"crossref","first-page":"13075","DOI":"10.1096\/fj.201900439","article-title":"Inflammasome-mediated innate immunity in Alzheimer\u2019s disease","volume":"33","author":"Venegas","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.drudis.2023.103850_b0560","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1021\/acschemneuro.1c00831","article-title":"Novel small-molecule inhibitor of NLRP3 inflammasome reverses cognitive impairment in an Alzheimer\u2019s disease model","volume":"13","author":"Haseeb","year":"2022","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.drudis.2023.103850_b0565","first-page":"13","article-title":"Repositioning of the Angiotensin II Receptor Antagonist Candesartan as an Anti-Inflammatory Agent With NLRP3 Inflammasome Inhibitory Activity","author":"Lin","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.drudis.2023.103850_b0570","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbi.2016.02.022","article-title":"NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice","volume":"56","author":"Xu","year":"2016","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.drudis.2023.103850_b0575","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3892\/etm.2022.11146","article-title":"Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation","volume":"23","author":"Yan","year":"2022","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.drudis.2023.103850_b0580","doi-asserted-by":"crossref","first-page":"7007","DOI":"10.2147\/JIR.S343575","article-title":"Angiotensin-(1\u20137) analogue AVE0991 modulates astrocyte-mediated neuroinflammation via lncRNA SNHG14\/miR-223-3p\/NLRP3 pathway and offers neuroprotection in a transgenic mouse model of Alzheimer\u2019s disease","volume":"14","author":"Duan","year":"2021","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.drudis.2023.103850_b0585","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.15788","article-title":"Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer\u2019s disease","author":"Jha","year":"2023","journal-title":"J Neurochem"},{"key":"10.1016\/j.drudis.2023.103850_b0590","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0304-3940(86)90204-1","article-title":"Angiotensin II binding sites in the anteroventral-third ventricle (AV3V) area and related structures of the rat brain","volume":"67","author":"Shigematsu","year":"1986","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.drudis.2023.103850_b0595","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mce.2009.02.005","article-title":"New aspects of rapid aldosterone signaling","volume":"308","author":"Grossmann","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.drudis.2023.103850_b0600","doi-asserted-by":"crossref","first-page":"31","DOI":"10.21315\/mjms2018.25.4.3","article-title":"Hormonal influences on cognitive function","volume":"25","author":"Ali","year":"2018","journal-title":"Malays J Med Sci"},{"key":"10.1016\/j.drudis.2023.103850_b0605","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.bbi.2009.04.012","article-title":"In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland","volume":"23","author":"S\u00e1nchez-Lemus","year":"2009","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.drudis.2023.103850_b0610","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/sj.npp.1300921","article-title":"A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding","volume":"31","author":"Saavedra","year":"2005","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.drudis.2023.103850_b0615","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.yhbeh.2015.06.022","article-title":"Estrogen-cholinergic interactions: Implications for cognitive Aging","volume":"74","author":"Newhouse","year":"2015","journal-title":"Horm Behav"},{"key":"10.1016\/j.drudis.2023.103850_b0620","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/advances\/nmab145","article-title":"Perspective: estrogen and the risk of cognitive decline: A missing choline(rgic) link?","volume":"13","author":"Bortz","year":"2022","journal-title":"Adv Nutr"},{"key":"10.1016\/j.drudis.2023.103850_b0625","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s10571-009-9368-4","article-title":"Anti-inflammatory effects of angiotensin receptor blockers in the brain and the periphery","volume":"29","author":"Benicky","year":"2009","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.drudis.2023.103850_b0630","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-022-02496-w","article-title":"The role of Toll-like receptors and neuroinflammation in Parkinson\u2019s disease","volume":"19","author":"Heidari","year":"2022","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.drudis.2023.103850_b0635","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/s41598-018-19807-y","article-title":"Plasma MCP-1 and cognitive decline in patients with Alzheimer\u2019s disease and mild cognitive impairment: A two-year follow-up study","volume":"8","author":"Lee","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2023.103850_b0640","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s40120-022-00350-y","article-title":"Long-Term Health Outcomes of Lecanemab in Patients with Early Alzheimer\u2019s Disease Using Simulation Modeling","volume":"11","author":"Tahami Monfared","year":"2022","journal-title":"Neurol Ther"},{"key":"10.1016\/j.drudis.2023.103850_b0645","first-page":"1","article-title":"Memantine for dementia","volume":"2019","author":"McShane","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.drudis.2023.103850_b0650","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1136\/bmj.321.7274.1445","article-title":"Efficacy and safety of galantamine in patients with mild to moderate Alzheimer\u2019s disease: multicentre randomised controlled trial","volume":"321","author":"Wilcock","year":"2000","journal-title":"BMJ Br Med J"},{"key":"10.1016\/j.drudis.2023.103850_b0655","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/bmj.b5465","article-title":"Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis","volume":"340","author":"Li","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.drudis.2023.103850_b0660","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/hr.2012.105","article-title":"Effects of telmisartan on the cerebral circulation of hypertensive patients with chronic-stage stroke","volume":"35","author":"Deguchi","year":"2012","journal-title":"Hypertens Res"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644623003665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644623003665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T13:11:39Z","timestamp":1761225099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644623003665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":132,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S1359644623003665"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2023.103850","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential molecular pathways of angiotensin receptor blockers in the brain toward cognitive improvement in dementia","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2023.103850","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103850"}}