{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:24:35Z","timestamp":1793399075612,"version":"4.5.0"},"reference-count":128,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.drudis.2024.104062","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T18:21:02Z","timestamp":1718216462000},"page":"104062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Selenium-containing compounds: a new hope for innovative treatments in Alzheimer\u2019s disease and Parkinson\u2019s disease"],"prefix":"10.1016","volume":"29","author":[{"given":"Patryk","family":"Pyka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Garbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Fioravanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Hittinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadwiga","family":"Handzlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Zwergel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-7377","authenticated-orcid":false,"given":"Cecilia","family":"Battistelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2024.104062_b0005","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.drudis.2020.10.014","article-title":"The innovative potential of selenium-containing agents for fighting cancer and viral infections","volume":"26","author":"Ali","year":"2021","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.drudis.2024.104062_b0010","doi-asserted-by":"crossref","first-page":"2191165","DOI":"10.1080\/14756366.2023.2191165","article-title":"Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors","volume":"38","author":"Astrain-Redin","year":"2023","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0015","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.3390\/molecules27144328","article-title":"New organoselenium (NSAIDs-selenourea and isoselenocyanate) derivatives as potential antiproliferative agents: synthesis, biological evaluation and in silico calculations","volume":"27","author":"Nie","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2024.104062_b0020","doi-asserted-by":"crossref","first-page":"12952","DOI":"10.3390\/ijms222312952","article-title":"The effect of organoselenium compounds on histone deacetylase inhibition and their potential for cancer therapy","volume":"22","author":"Adimulam","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2024.104062_b0025","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jtemb.2014.06.017","article-title":"Effects of selenium compounds on proliferation and epigenetic marks of breast cancer cells","volume":"28","author":"de Miranda","year":"2014","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.drudis.2024.104062_b0030","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1038\/bjc.2014.85","article-title":"Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models","volume":"110","author":"Cao","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.drudis.2024.104062_b0035","series-title":"New frontiers in organoselenium compounds","first-page":"99","article-title":"Bioactive organoselenium compounds and therapeutic perspectives","author":"Lenard\u00e3o","year":"2018"},{"key":"10.1016\/j.drudis.2024.104062_b0040","doi-asserted-by":"crossref","first-page":"20913","DOI":"10.1039\/C5DT02130H","article-title":"Computer-assisted designed \u2018selenoxy-chinolin\u2019: a new catalytic mechanism of the GPx-like cycle and inhibition of metal-free and metal-associated A\u03b2 aggregation","volume":"44","author":"Wang","year":"2015","journal-title":"Dalton Trans"},{"key":"10.1016\/j.drudis.2024.104062_b0045","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.3892\/mmr.2017.6377","article-title":"Health risk assessment of environmental selenium: emerging evidence and challenges (Review)","volume":"15","author":"Vinceti","year":"2017","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.drudis.2024.104062_b0050","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3390\/molecules23030628","article-title":"Selenides and diselenides: a review of their anticancer and chemopreventive activity","volume":"23","author":"Alvarez-Perez","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2024.104062_b0055","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202300705","article-title":"Current small molecule-based medicinal chemistry approaches for neurodegeneration therapeutics","volume":"19","author":"Sanghai","year":"2024","journal-title":"ChemMedChem"},{"key":"10.1016\/j.drudis.2024.104062_b0060","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1089\/ars.2006.1363","article-title":"Seleno-L-methionine protects against beta-amyloid and iron\/hydrogen peroxide-mediated neuron death","volume":"9","author":"Xiong","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.drudis.2024.104062_b0065","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3390\/antiox11020251","article-title":"The role of selenium in pathologies: an updated review","volume":"11","author":"Barchielli","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.drudis.2024.104062_b0070","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2741\/E605","article-title":"Genetics of familial and sporadic Alzheimer's disease","volume":"5","author":"Piaceri","year":"2013","journal-title":"Front Biosci"},{"key":"10.1016\/j.drudis.2024.104062_b0075","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glae023","article-title":"Changes in expression of key genes in Alzheimer's disease: a specific brain tissue change","volume":"79","author":"Rasmussen","year":"2024","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.drudis.2024.104062_b0080","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.2147\/IJN.S200490","article-title":"Alzheimer's disease: pathogenesis, diagnostics, and therapeutics","volume":"14","author":"Tiwari","year":"2019","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.drudis.2024.104062_b0085","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1177\/000348949009900407","article-title":"Human leukocyte antigens -A, -B, -C, and -DR and nasopharyngeal carcinoma in northern China","volume":"99","author":"Zhu","year":"1990","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.drudis.2024.104062_b0090","first-page":"1126","article-title":"Alpha, beta-and gamma-secretases in Alzheimer's disease","volume":"4","author":"Epis","year":"2012","journal-title":"Front Biosci"},{"key":"10.1016\/j.drudis.2024.104062_b0095","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbadis.2004.09.008","article-title":"Tau pathology in Alzheimer disease and other tauopathies","volume":"1739","author":"Iqbal","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.drudis.2024.104062_b0100","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.4103\/1673-5374.385847","article-title":"Targeting tau in Alzheimer's disease: from mechanisms to clinical therapy","volume":"19","author":"Ye","year":"2024","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.drudis.2024.104062_b0105","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1194\/jlr.R075481","article-title":"Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-beta and other amyloidogenic proteins","volume":"58","author":"Huynh","year":"2017","journal-title":"J Lipid Res"},{"key":"10.1016\/j.drudis.2024.104062_b0110","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3390\/ijerph16030337","article-title":"Occupational exposures and neurodegenerative diseases: a systematic literature review and meta-analyses","volume":"16","author":"Gunnarsson","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.drudis.2024.104062_b0115","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1007\/s12035-016-0357-6","article-title":"Epigenetics in Alzheimer's disease: perspective of DNA methylation","volume":"55","author":"Qazi","year":"2018","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.drudis.2024.104062_b0120","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3233\/JAD-141755","article-title":"Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain","volume":"44","author":"Rueli","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.drudis.2024.104062_b0125","doi-asserted-by":"crossref","first-page":"13578","DOI":"10.1039\/C9CP02613D","article-title":"Revealing the mechanistic pathway of cholinergic inhibition of Alzheimer's disease by donepezil: a metadynamics simulation study","volume":"21","author":"Ghosh","year":"2019","journal-title":"Phys Chem Chem Phys"},{"key":"10.1016\/j.drudis.2024.104062_b0130","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2174\/1570159X18666200807130637","article-title":"Neurodegenerative pathways in Alzheimer's disease: a review","volume":"19","author":"Ramachandran","year":"2021","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.drudis.2024.104062_b0135","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00424-010-0809-1","article-title":"Glutamate receptors, neurotoxicity and neurodegeneration","volume":"460","author":"Lau","year":"2010","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.drudis.2024.104062_b0140","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.3390\/ijms25073733","article-title":"Targeting N-methyl-d-aspartate receptors in neurodegenerative diseases","volume":"25","author":"Carles","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2024.104062_b0145","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jneuroim.2008.09.012","article-title":"Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells","volume":"205","author":"Ojala","year":"2008","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.drudis.2024.104062_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/alzrt24","article-title":"Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy","volume":"2","author":"Zotova","year":"2010","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.drudis.2024.104062_b0155","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.3389\/fnins.2019.01444","article-title":"Interplay between mitochondrial oxidative disorders and proteostasis in Alzheimer's disease","volume":"13","author":"Llanos-Gonzalez","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1016\/j.drudis.2024.104062_b0160","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3934\/Neuroscience.2021005","article-title":"The biological pathways of Alzheimer disease: a review","volume":"8","author":"Calabro","year":"2021","journal-title":"AIMS Neurosci"},{"key":"10.1016\/j.drudis.2024.104062_b0165","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.mad.2005.09.016","article-title":"Neurotransmitter deficits in behavioural and psychological symptoms of Alzheimer's disease","volume":"127","author":"Lanari","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.drudis.2024.104062_b0170","article-title":"A common molecular and cellular pathway in developing Alzheimer and cancer","volume":"37","author":"Ali","year":"2024","journal-title":"Biochem Biophys Rep"},{"key":"10.1016\/j.drudis.2024.104062_b0175","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrneurol.2016.81","article-title":"The mTOR signalling cascade: paving new roads to cure neurological disease","volume":"12","author":"Crino","year":"2016","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.drudis.2024.104062_b0180","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1101\/gad.836900","article-title":"A common enzyme connects notch signaling and Alzheimer's disease","volume":"14","author":"Kopan","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.drudis.2024.104062_b0185","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s11033-020-05326-5","article-title":"Ebselen reversed peripheral oxidative stress induced by a mouse model of sporadic Alzheimer's disease","volume":"47","author":"Klann","year":"2020","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.drudis.2024.104062_b0190","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1021\/acschemneuro.0c00549","article-title":"Se-methylselenocysteine (SMC) improves cognitive deficits by attenuating synaptic and metabolic abnormalities in Alzheimer's mice model: a proteomic study","volume":"12","author":"Du","year":"2021","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.drudis.2024.104062_b0195","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pnpbp.2015.10.008","article-title":"Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test","volume":"65","author":"Pinto Brod","year":"2016","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.drudis.2024.104062_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174499","article-title":"Protective effects of octylseleno-xylofuranoside in a streptozotocin-induced mouse model of Alzheimer's disease","volume":"910","author":"Baldinotti","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.drudis.2024.104062_b0205","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1016\/j.bmc.2017.11.019","article-title":"Organoselenium compounds from purines: synthesis of 6-arylselanylpurines with antioxidant and anticholinesterase activities and memory improvement effect","volume":"25","author":"Duarte","year":"2017","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0210","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s11011-021-00703-w","article-title":"Effect of a purine derivative containing selenium to improve memory decline and anxiety through modulation of the cholinergic system and Na+\/K+-ATPase in an Alzheimer's disease model","volume":"36","author":"Pinz","year":"2021","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.drudis.2024.104062_b0215","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1021\/acs.jmedchem.3c02148","article-title":"First-in-class selenium-containing potent serotonin receptor 5-HT6 agents with a beneficial neuroprotective profile against Alzheimer's disease","volume":"67","author":"Pyka","year":"2024","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0220","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cbi.2018.08.004","article-title":"Selenothymidine protects against biochemical and behavioral alterations induced by ICV-STZ model of dementia in mice","volume":"294","author":"Thome","year":"2018","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.drudis.2024.104062_b0225","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1021\/acschemneuro.8b00034","article-title":"Effect of sodium selenate on hippocampal proteome of 3xTg-AD mice-exploring the antioxidant dogma of selenium against Alzheimer's disease","volume":"9","author":"Iqbal","year":"2018","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.drudis.2024.104062_b0230","doi-asserted-by":"crossref","first-page":"282","DOI":"10.2174\/1570159X14666151223100011","article-title":"Selenium in the therapy of neurological diseases. Where is it going?","volume":"14","author":"Dominiak","year":"2016","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.drudis.2024.104062_b0235","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s10072-011-0880-1","article-title":"Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment","volume":"33","author":"Khan","year":"2012","journal-title":"Neurol Sci"},{"key":"10.1016\/j.drudis.2024.104062_b0240","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1128\/MCB.23.3.916-922.2003","article-title":"The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice","volume":"23","author":"Nonn","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.drudis.2024.104062_b0245","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/ana.20741","article-title":"1,026 experimental treatments in acute stroke","volume":"59","author":"O'Collins","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.drudis.2024.104062_b0250","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000015908","article-title":"Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial","volume":"9","author":"Ogawa","year":"1999","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.drudis.2024.104062_b0255","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3233\/JAD-131892","article-title":"Differences in nutritional status between very mild Alzheimer's disease patients and healthy controls","volume":"41","author":"Olde Rikkert","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.drudis.2024.104062_b0260","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s13311-018-0662-z","article-title":"Supranutritional sodium selenate supplementation delivers selenium to the central nervous system: results from a randomized controlled pilot trial in Alzheimer's disease","volume":"16","author":"Cardoso","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.drudis.2024.104062_b0265","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bbi.2023.12.024","article-title":"Maternal selenium dietary supplementation alters sociability and reinforcement learning deficits induced by in utero exposure to maternal immune activation in mice","volume":"116","author":"Gillespie","year":"2024","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.drudis.2024.104062_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112011","article-title":"Altered dietary selenium influences brain iron content and behavioural outcomes","volume":"372","author":"Sharma","year":"2019","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.drudis.2024.104062_b0275","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neuroscience.2014.07.068","article-title":"Diphenyl-diselenide suppresses amyloid-\u03b2 peptide in Caenorhabditis elegans model of Alzheimer's disease","volume":"278","author":"Zamberlan","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.drudis.2024.104062_b0280","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jnutbio.2012.06.012","article-title":"Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer's type model in rats","volume":"24","author":"Pinton","year":"2013","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.drudis.2024.104062_b0285","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bbr.2013.03.034","article-title":"p, p'-Methoxyl-diphenyl diselenide protects against amyloid-\u03b2 induced cytotoxicity in vitro and improves memory deficits in vivo","volume":"247","author":"Pinton","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.drudis.2024.104062_b0290","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/10715762.2021.1882678","article-title":"Redox reactions of organoselenium compounds: implication in their biological activity","volume":"55","author":"Singh","year":"2021","journal-title":"Free Radic Res"},{"key":"10.1016\/j.drudis.2024.104062_b0295","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.3390\/ma15062068","article-title":"Attachment of chiral functional groups to modify the activity of new GPx mimetics","volume":"15","author":"Laskowska","year":"2022","journal-title":"Materials"},{"key":"10.1016\/j.drudis.2024.104062_b0300","doi-asserted-by":"crossref","first-page":"7349","DOI":"10.3390\/molecules28217349","article-title":"Recent advances in the synthesis and antioxidant activity of low molecular mass organoselenium molecules","volume":"28","author":"Anghinoni","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2024.104062_b0305","doi-asserted-by":"crossref","first-page":"14698","DOI":"10.1039\/D3RA02475J","article-title":"Facile synthesis of chiral phenylselenides as novel antioxidants and cytotoxic agents","volume":"13","author":"Laskowska","year":"2023","journal-title":"RSC Adv"},{"key":"10.1016\/j.drudis.2024.104062_b0310","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3390\/antiox11071231","article-title":"Novel organoselenium redox modulators with potential anticancer, antimicrobial, and antioxidant activities","volume":"11","author":"Sak","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.drudis.2024.104062_b0315","doi-asserted-by":"crossref","first-page":"69","DOI":"10.24820\/ark.5550190.p011.908","article-title":"Organoselenium compounds as antioxidants","volume":"2023","author":"Joule","year":"2022","journal-title":"Arkivoc"},{"key":"10.1016\/j.drudis.2024.104062_b0320","series-title":"Encyclopedia of biological chemistry","first-page":"399","article-title":"Glutathione peroxidases","author":"Ursini","year":"2013"},{"key":"10.1016\/j.drudis.2024.104062_b0325","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1021\/cn500119g","article-title":"Design, synthesis, and evaluation of multitarget-directed selenium-containing clioquinol derivatives for the treatment of Alzheimer's disease","volume":"5","author":"Wang","year":"2014","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.drudis.2024.104062_b0330","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1016\/j.bmc.2016.08.017","article-title":"Synthesis and evaluation of 8-hydroxyquinolin derivatives substituted with (benzo[d][1,2]selenazol-3(2H)-one) as effective inhibitor of metal-induced A\u03b2 aggregation and antioxidant","volume":"24","author":"Wang","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0335","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1021\/acschemneuro.1c00478","article-title":"Structure dependent differential modulation of A\u03b2 fibrillization by selenadiazole-based inhibitors","volume":"12","author":"Kalsoom","year":"2021","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.drudis.2024.104062_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104171","article-title":"Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds \u2013 determination of their carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and alpha-glycosidase inhibition properties","volume":"103","author":"Gulcin","year":"2020","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0345","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.1016\/j.bmcl.2013.10.034","article-title":"Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity","volume":"23","author":"Mao","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.drudis.2024.104062_b0350","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.ejmech.2017.06.048","article-title":"New tacrine dimers with antioxidant linkers as dual drugs: anti-Alzheimer's and antiproliferative agents","volume":"138","author":"Roldan-Pena","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0355","doi-asserted-by":"crossref","first-page":"9089","DOI":"10.1021\/jm401047q","article-title":"Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen","volume":"56","author":"Luo","year":"2013","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0360","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.bmc.2013.12.066","article-title":"Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease","volume":"22","author":"Luo","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0365","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1039\/C5MD00274E","article-title":"Tricyclic phenothiazine and phenoselenazine derivatives as potential multi-targeting agents to treat Alzheimer's disease","volume":"6","author":"Tin","year":"2015","journal-title":"MedChemComm"},{"key":"10.1016\/j.drudis.2024.104062_b0370","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/antiox12010139","article-title":"Seleno-analogs of scaffolds resembling natural products a novel warhead toward dual compounds","volume":"12","author":"Astrain-Redin","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.drudis.2024.104062_b0375","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.1016\/j.bmc.2016.09.031","article-title":"Synthesis and evaluation of dihydropyrimidinone-derived selenoesters as multi-targeted directed compounds against Alzheimer's disease","volume":"24","author":"Barbosa","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0380","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neuro.2021.10.012","article-title":"Dihydropyrimidinone-derived selenoesters efficacy and safety in an in vivo model of A\u03b2 aggregation","volume":"88","author":"Pereira","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.drudis.2024.104062_b0385","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1016\/j.bmc.2018.10.022","article-title":"Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer's disease","volume":"26","author":"Hu","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0390","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/npp.2009.197","article-title":"Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease","volume":"35","author":"Kilgore","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.drudis.2024.104062_b0395","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/emmm.201201923","article-title":"Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease","volume":"5","author":"Govindarajan","year":"2013","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.drudis.2024.104062_b0400","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd4360","article-title":"Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders","volume":"13","author":"Falkenberg","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.drudis.2024.104062_b0405","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1006\/bbrc.1995.2149","article-title":"O-linked N-acetylglucosamine is upregulated in Alzheimer brains","volume":"213","author":"Griffith","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.drudis.2024.104062_b0410","doi-asserted-by":"crossref","first-page":"7058","DOI":"10.1016\/j.bmc.2010.08.010","article-title":"OGA inhibition by GlcNAc-selenazoline","volume":"18","author":"Kim","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0415","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.carres.2006.03.004","article-title":"Enzymatic characterization of O-GlcNAcase isoforms using a fluorogenic GlcNAc substrate","volume":"341","author":"Kim","year":"2006","journal-title":"Carbohydr Res"},{"key":"10.1016\/j.drudis.2024.104062_b0420","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejmech.2017.04.033","article-title":"The computer-aided discovery of novel family of the 5-HT6 serotonin receptor ligands among derivatives of 4-benzyl-1,3,5-triazine","volume":"135","author":"Lazewska","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0425","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.3390\/molecules23102529","article-title":"Computer-aided studies for novel arylhydantoin 1,3,5-triazine derivatives as 5-HT6 serotonin receptor ligands with antidepressive-like, anxiolytic and antiobesity action in vivo","volume":"23","author":"Kurczab","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2024.104062_b0430","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ejmech.2019.06.022","article-title":"Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6","volume":"178","author":"Ali","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112529","article-title":"Chlorine substituents and linker topology as factors of 5-HT6R activity for novel highly active 1,3,5-triazine derivatives with procognitive properties in vivo","volume":"203","author":"Sudol","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105695","article-title":"An exit beyond the pharmacophore model for 5-HT6R agents \u2013 a new strategy to gain dual 5-HT6\/5-HT(2A) action for triazine derivatives with procognitive potential","volume":"121","author":"Kucwaj-Brysz","year":"2022","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113441","article-title":"Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer's disease","volume":"219","author":"Qu","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0450","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.4103\/1673-5374.387967","article-title":"\u03b1-Synuclein pathology from the body to the brain: so many seeds so close to the central soil","volume":"19","author":"Yang","year":"2024","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.drudis.2024.104062_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134296","article-title":"Oxidative stress and Parkinson's disease: conflict of oxidant-antioxidant systems","volume":"709","author":"Hemmati-Dinarvand","year":"2019","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.drudis.2024.104062_b0460","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pneurobio.2013.04.004","article-title":"Mitochondrial dysfunction and oxidative stress in Parkinson's disease","volume":"106\u2013107","author":"Subramaniam","year":"2013","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.drudis.2024.104062_b0465","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","article-title":"Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC","volume":"94","author":"Do Van","year":"2016","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.drudis.2024.104062_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103138","article-title":"Fragment-based drug discovery and biological evaluation of novel cannabinol-based inhibitors of oxytosis\/ferroptosis for neurological disorders","volume":"72","author":"Liang","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.drudis.2024.104062_b0475","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.freeradbiomed.2012.05.040","article-title":"Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders","volume":"53","author":"Wilhelmus","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.drudis.2024.104062_b0480","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1002\/mds.23218","article-title":"Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed","volume":"25","author":"Shahar","year":"2010","journal-title":"Mov Disord"},{"key":"10.1016\/j.drudis.2024.104062_b0485","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejphar.2016.11.054","article-title":"Involvement of BDNF\/TrkB signaling in the effect of diphenyl diselenide on motor function in a Parkinson's disease rat model","volume":"795","author":"Sampaio","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.drudis.2024.104062_b0490","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/exnr.2000.7516","article-title":"The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease","volume":"166","author":"Moussaoui","year":"2000","journal-title":"Exp Neurol"},{"key":"10.1016\/j.drudis.2024.104062_b0495","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5625\/lar.2015.31.4.155","article-title":"Modeling Parkinson's disease in the common marmoset (Callithrix jacchus): overview of models, methods, and animal care","volume":"31","author":"Yun","year":"2015","journal-title":"Lab Anim Res"},{"key":"10.1016\/j.drudis.2024.104062_b0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153733","article-title":"N-\u03b3-(L-glutamyl)-L-selenomethionine shows neuroprotective effects against Parkinson's disease associated with SKN-1\/Nrf2 and TRXR-1 in Caenorhabditis elegans","volume":"92","author":"Chang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.drudis.2024.104062_b0505","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ejphar.2016.03.039","article-title":"4-Phenylselenyl-7-chloroquinoline, a new quinoline derivative containing selenium, has potential antinociceptive and anti-inflammatory actions","volume":"780","author":"Pinz","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.drudis.2024.104062_b0510","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/fcp.12295","article-title":"Further analysis of acute antinociceptive and anti-inflammatory actions of 4-phenylselenyl-7-chloroquinoline in mice","volume":"31","author":"Silva","year":"2017","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.drudis.2024.104062_b0515","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jtemb.2018.10.015","article-title":"7-chloro-4-(phenylselanyl) quinoline prevents dopamine depletion in a Drosophila melanogaster model of Parkinson's-like disease","volume":"54","author":"de Freitas Couto","year":"2019","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.drudis.2024.104062_b0520","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.biopha.2018.06.049","article-title":"Current advances of pharmacological properties of 7-chloro-4-(phenylselanyl) quinoline: prevention of cognitive deficit and anxiety in Alzheimer's disease model","volume":"105","author":"Pinz","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.drudis.2024.104062_b0525","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pbb.2012.03.016","article-title":"In vitro antioxidant activity and in vivo antidepressant-like effect of alpha-(phenylselanyl) acetophenone in mice","volume":"102","author":"Gerzson","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.drudis.2024.104062_b0530","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuint.2017.02.014","article-title":"Selol, an organic selenium donor, prevents lipopolysaccharide-induced oxidative stress and inflammatory reaction in the rat brain","volume":"108","author":"Dominiak","year":"2017","journal-title":"Neurochem Int"},{"key":"10.1016\/j.drudis.2024.104062_b0535","doi-asserted-by":"crossref","first-page":"12104","DOI":"10.1021\/ja028030k","article-title":"Remarkable activity of a novel cyclic seleninate ester as a glutathione peroxidase mimetic and its facile in situ generation from allyl 3-hydroxypropyl selenide","volume":"124","author":"Back","year":"2002","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.drudis.2024.104062_b0540","doi-asserted-by":"crossref","first-page":"10369","DOI":"10.1021\/jo401757m","article-title":"Fluxional cyclic seleninate ester: NMR and computational studies, glutathione peroxidase-like behavior, and unexpected rearrangement","volume":"78","author":"McNeil","year":"2013","journal-title":"J Org Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0545","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bmc.2016.10.018","article-title":"New glutathione peroxidase mimetics-Insights into antioxidant and cytotoxic activity","volume":"25","author":"Pacula","year":"2017","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0550","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1021\/acschemneuro.0c00328","article-title":"Neuroprotective and anti-neuroinflammatory properties of ebselen derivatives and their potential to inhibit neurodegeneration","volume":"11","author":"Landgraf","year":"2020","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.drudis.2024.104062_b0555","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3390\/biom9060239","article-title":"Synthesis and biological evaluation of novel selenyl and sulfur-l-Dopa derivatives as potential anti-Parkinson's disease agents","volume":"9","author":"Di Stefano","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.drudis.2024.104062_b0560","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/1673-5374.375299","article-title":"Type-B monoamine oxidase inhibitors in neurological diseases: clinical applications based on preclinical findings","volume":"19","author":"Alborghetti","year":"2024","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.drudis.2024.104062_b0565","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s12031-016-0743-6","article-title":"4-Organoseleno-isoquinolines selectively and reversibly inhibit the cerebral monoamine oxidase B activity","volume":"59","author":"Sampaio","year":"2016","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.drudis.2024.104062_b0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112602","article-title":"Dopaminergic system contribution to the antidepressant-like effect of 3-phenyl-4-(phenylseleno) isoquinoline in mice","volume":"386","author":"Sampaio","year":"2020","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.drudis.2024.104062_b0575","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3109\/14756366.2012.670805","article-title":"2,2'-Dithienyl diselenide, an organoselenium compound, elicits antioxidant action and inhibits monoamine oxidase activity in vitro","volume":"28","author":"Bortolatto","year":"2013","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0580","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-022-01257-8","article-title":"The sirtuin family in health and disease","volume":"7","author":"Wu","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.drudis.2024.104062_b0585","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1478-811X-9-11","article-title":"Mammalian Sirt1: insights on its biological functions","volume":"9","author":"Rahman","year":"2011","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.drudis.2024.104062_b0590","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fnagi.2019.00372","article-title":"Emerging role of sirtuin 2 in Parkinson's disease","volume":"11","author":"Liu","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.drudis.2024.104062_b0595","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1016\/j.bmc.2010.06.035","article-title":"N\u03b5-Modified lysine containing inhibitors for SIRT1 and SIRT2","volume":"18","author":"Huhtiniemi","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2024.104062_b0600","article-title":"Selenomethionine improves mitochondrial function by upregulating mitochondrial selenoprotein in a model of Alzheimer's disease","volume":"13","author":"Chen","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.drudis.2024.104062_b0605","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.toxlet.2013.11.016","article-title":"Selenium neurotoxicity in humans: bridging laboratory and epidemiologic studies","volume":"230","author":"Vinceti","year":"2014","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.drudis.2024.104062_b0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144329","article-title":"A comprehensive review on the neuropathophysiology of selenium","volume":"767","author":"Naderi","year":"2021","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.drudis.2024.104062_b0615","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13195-017-0323-1","article-title":"A selenium species in cerebrospinal fluid predicts conversion to Alzheimer's dementia in persons with mild cognitive impairment","volume":"9","author":"Vinceti","year":"2017","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.drudis.2024.104062_b0620","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000502357","article-title":"Selenium and other trace elements in the etiology of Parkinson's disease: a systematic review and meta-analysis of case-control studies","volume":"54","author":"Adani","year":"2020","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.drudis.2024.104062_b0625","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3390\/pharmaceutics15010104","article-title":"Selenium-containing agents acting on cancer\u2014a new hope?","volume":"15","author":"Garbo","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.drudis.2024.104062_b0630","article-title":"Scientific opinion on the tolerable upper intake level for selenium","volume":"21","author":"EFSA Panel on Nutrition","year":"2023","journal-title":"EFSA J"},{"key":"10.1016\/j.drudis.2024.104062_b0635","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.nutres.2024.01.001","article-title":"Evidence-based proposal for lowering Chinese tolerable upper intake level for selenium","volume":"123","author":"Bai","year":"2024","journal-title":"Nutr Res"},{"key":"10.1016\/j.drudis.2024.104062_b0640","doi-asserted-by":"crossref","first-page":"46406","DOI":"10.1021\/acsami.1c14818","article-title":"Oral administration of resveratrol-selenium-peptide nanocomposites alleviates Alzheimer's disease-like pathogenesis by inhibiting A\u03b2 aggregation and regulating gut microbiota","volume":"13","author":"Li","year":"2021","journal-title":"ACS Appl Mater Interfaces"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644624001879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644624001879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T13:12:30Z","timestamp":1722604350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644624001879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":128,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S1359644624001879"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2024.104062","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selenium-containing compounds: a new hope for innovative treatments in Alzheimer\u2019s disease and Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2024.104062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104062"}}