{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T08:37:23Z","timestamp":1794299843384,"version":"4.9.0"},"reference-count":108,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.drudis.2024.104187","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T21:14:57Z","timestamp":1726780497000},"page":"104187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Unveiling the macrophage dynamics in osteoarthritic joints: From inflammation to therapeutic strategies"],"prefix":"10.1016","volume":"29","author":[{"given":"Nicolas","family":"Gaigeard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Cardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Le Goff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Guicheux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Astrid","family":"Boutet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 120","key":"10.1016\/j.drudis.2024.104187_b0005","first-page":"64","article-title":"Phenotypes of osteoarthritis: current state and future implications","volume":"37","author":"Deveza","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.drudis.2024.104187_b0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.joca.2023.10.009","article-title":"Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features","volume":"32","author":"Boutet","year":"2024","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.drudis.2024.104187_b0015","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","article-title":"Osteoarthritis in 2020 and beyond: a Lancet Commission","volume":"396","author":"Hunter","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.drudis.2024.104187_b0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13075-017-1229-9","article-title":"Synovitis in osteoarthritis: current understanding with therapeutic implications","volume":"19","author":"Mathiessen","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.drudis.2024.104187_b0025","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.joca.2020.01.007","article-title":"Macrophages regulate the progression of osteoarthritis","volume":"28","author":"Zhang","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.drudis.2024.104187_b0030","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13075-017-1303-3","article-title":"Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis","volume":"19","author":"Bustamante","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.drudis.2024.104187_b0035","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.drudis.2024.104187_b0040","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jbspin.2018.04.004","article-title":"IMSYC immunologic synovitis score: a new score for synovial membrane characterization in inflammatory and non-inflammatory arthritis","volume":"86","author":"Najm","year":"2019","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.drudis.2024.104187_b0045","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/annrheumdis-2018-214539","article-title":"Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients","volume":"78","author":"Humby","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.drudis.2024.104187_b0050","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1136\/annrheumdis-2019-215751","volume":"78","author":"Lliso-Ribera","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.drudis.2024.104187_b0055","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.celrep.2019.07.091","article-title":"Molecular portraits of early rheumatoid arthritis identify clinical and treatment response phenotypes","volume":"28","author":"Lewis","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.drudis.2024.104187_b0060","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3899\/jrheum.151068","article-title":"Inflammatory cells in patients with endstage knee osteoarthritis: a comparison between the synovium and the infrapatellar fat pad","volume":"43","author":"Klein-Wieringa","year":"2016","journal-title":"J Rheumatol"},{"key":"10.1016\/j.drudis.2024.104187_b0065","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cytogfr.2019.03.004","article-title":"Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee","volume":"46","author":"Xie","year":"2019","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.drudis.2024.104187_b0070","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s13075-016-1057-3","article-title":"Inhomogeneity of immune cell composition in the synovial sublining: linear mixed modelling indicates differences in distribution and spatial decline of CD68+ macrophages in osteoarthritis and rheumatoid arthritis","volume":"18","author":"Mucke","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.drudis.2024.104187_b0075","article-title":"Spatial mapping of rheumatoid arthritis synovial niches reveals specific macrophage networks associated with response to therapy","author":"De Lima","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.drudis.2024.104187_b0080","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","article-title":"Tissue-resident macrophage ontogeny and homeostasis","volume":"44","author":"Ginhoux","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.drudis.2024.104187_b0085","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ni.3341","article-title":"The development and maintenance of resident macrophages","volume":"17","author":"Perdiguero","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102758","article-title":"Novel insights into macrophage diversity in rheumatoid arthritis synovium","volume":"20","author":"Boutet","year":"2021","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.drudis.2024.104187_b0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, mechanisms, and significance of macrophage plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.drudis.2024.104187_b0100","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41586-019-1471-1","article-title":"Locally renewing resident synovial macrophages provide a protective barrier for the joint","volume":"572","author":"Culemann","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2024.104187_b0105","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.3389\/fimmu.2019.02035","article-title":"Human monocyte subsets and phenotypes in major chronic inflammatory diseases","volume":"10","author":"Kapellos","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0110","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-immunol-042617-053119","article-title":"Nonclassical monocytes in health and disease","volume":"37","author":"Narasimhan","year":"2019","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0115","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.celrep.2014.09.032","article-title":"Nonclassical Ly6C\u2212 monocytes drive the development of inflammatory arthritis in mice","volume":"9","author":"Misharin","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.drudis.2024.104187_b0120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s13075-017-1426-6","article-title":"S100A8\/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis","volume":"19","author":"Cremers","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.drudis.2024.104187_b0125","article-title":"Typical response of CD14++CD16\u2013 monocyte to knee synovial derived mediators as a key target to overcome the onset and progression of osteoarthritis","volume":"9","author":"Saffery","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.drudis.2024.104187_b0130","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J Pathol"},{"key":"10.1016\/j.drudis.2024.104187_b0135","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.drudis.2024.104187_b0140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13075-018-1631-y","article-title":"Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue","volume":"20","author":"Donlin","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.drudis.2024.104187_b0145","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/annrheumdis-2013-204603","article-title":"Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients","volume":"74","author":"Kelly","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.drudis.2024.104187_b0150","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0155","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/s41591-020-0939-8","article-title":"Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis","volume":"26","author":"Alivernini","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.drudis.2024.104187_b0160","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41584-022-00790-8","article-title":"Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission","volume":"18","author":"Kurowska-Stolarska","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.drudis.2024.104187_b0165","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125325","article-title":"Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients","volume":"4","author":"Wood","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.drudis.2024.104187_b0170","doi-asserted-by":"crossref","first-page":"10868","DOI":"10.1038\/s41598-020-67730-y","article-title":"Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis","volume":"10","author":"Chou","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2024.104187_b0175","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41586-023-06708-y","article-title":"Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes","volume":"623","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2024.104187_b0180","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.938075","article-title":"Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis","volume":"13","author":"Sebastian","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0185","doi-asserted-by":"crossref","first-page":"6495","DOI":"10.1002\/jcp.26497","article-title":"Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses","volume":"233","author":"Daskalaki","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.drudis.2024.104187_b0190","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41590-020-00849-2","article-title":"Does tissue imprinting restrict macrophage plasticity?","volume":"22","author":"Guilliams","year":"2021","journal-title":"Nat Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0195","article-title":"Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis","author":"Knights","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.drudis.2024.104187_b0200","doi-asserted-by":"crossref","unstructured":"Human and mouse peritoneal macrophages and dendritic cells compared. Nat Immunol 2024;25:17\u20138. https:\/\/doi.org\/10.1038\/s41590-023-01709-5.","DOI":"10.1038\/s41590-023-01709-5"},{"key":"10.1016\/j.drudis.2024.104187_b0205","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41423-020-00541-3","article-title":"Macrophages and the maintenance of homeostasis","volume":"18","author":"Mosser","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0210","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3899\/jrheum.140382","article-title":"The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive","volume":"42","author":"Orlowsky","year":"2015","journal-title":"J Rheumatol"},{"key":"10.1016\/j.drudis.2024.104187_b0215","doi-asserted-by":"crossref","first-page":"8381","DOI":"10.3390\/ijms23158381","article-title":"Phenotype diversity of macrophages in osteoarthritis: implications for development of macrophage modulating therapies","volume":"23","author":"Mushenkova","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2024.104187_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.715894","article-title":"Critical role of synovial tissue\u2013resident macrophage and fibroblast subsets in the persistence of joint inflammation","volume":"12","author":"Kemble","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0225","doi-asserted-by":"crossref","first-page":"1021413","DOI":"10.3389\/fimmu.2022.1021413","article-title":"Resolution therapy: harnessing efferocytic macrophages to trigger the resolution of inflammation","volume":"13","author":"Saas","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0230","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s11914-023-00817-3","article-title":"From inflammation to resolution: specialized pro-resolving mediators in posttraumatic osteoarthritis","volume":"21","author":"Leite","year":"2023","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.drudis.2024.104187_b0235","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1136\/annrheumdis-2019-215325","article-title":"Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the osteoarthritis initiative","volume":"78","author":"Camacho-Encina","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.drudis.2024.104187_b0240","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.joca.2021.03.008","article-title":"Auto-antibodies to post-translationally modified proteins in osteoarthritis","volume":"29","author":"Xie","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.drudis.2024.104187_b0245","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.it.2023.10.004","article-title":"Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis","volume":"44","author":"Rodr\u00edguez-Morales","year":"2023","journal-title":"Trends Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0250","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.83069","article-title":"Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis","volume":"12","author":"Yao","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.drudis.2024.104187_b0255","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41598-018-36909-9","article-title":"Pro-resolving lipid mediator ameliorates obesity induced osteoarthritis by regulating synovial macrophage polarisation","volume":"9","author":"Sun","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2024.104187_b0260","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.joca.2022.09.003","article-title":"Osteoarthritis year in review 2022: biology","volume":"30","author":"Han","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.drudis.2024.104187_b0265","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.3390\/ijms23116003","article-title":"The extracellular matrix of articular cartilage controls the bioavailability of pericellular matrix-bound growth factors to drive tissue homeostasis and repair","volume":"23","author":"Vincent","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.drudis.2024.104187_b0270","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1038\/s41598-020-64515-1","article-title":"Transcriptional profiling of murine macrophages stimulated with cartilage fragments revealed a strategy for treatment of progressive osteoarthritis","volume":"10","author":"Hamasaki","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2024.104187_b0275","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/ten.tea.2016.0007","article-title":"A three-dimensional chondrocyte-macrophage coculture system to probe inflammation in experimental osteoarthritis","volume":"23","author":"Samavedi","year":"2017","journal-title":"Tissue Eng Part a"},{"key":"10.1016\/j.drudis.2024.104187_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102643","article-title":"Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis","volume":"24","author":"Ebata","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.drudis.2024.104187_b0285","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000442876","article-title":"The infrapatellar adipose body: a histotopographic study","volume":"201","author":"Macchi","year":"2016","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.drudis.2024.104187_b0290","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.3390\/biomedicines10051071","article-title":"The corpus adiposum infrapatellare (Hoffa\u2019s fat pad)\u2014the role of the infrapatellar fat pad in osteoarthritis pathogenesis","volume":"10","author":"Braun","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.drudis.2024.104187_b0295","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41514-024-00159-z","article-title":"The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis","volume":"10","author":"Wang","year":"2024","journal-title":"NPJ Aging"},{"key":"10.1016\/j.drudis.2024.104187_b0300","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/jor.21125","article-title":"Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI","volume":"28","author":"Chuckpaiwong","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1016\/j.drudis.2024.104187_b0305","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/joa.12820","article-title":"The infrapatellar fat pad and the synovial membrane: an anatomo-functional unit","volume":"233","author":"Macchi","year":"2018","journal-title":"J Anat"},{"key":"10.1016\/j.drudis.2024.104187_b0310","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/ard.2010.140046","article-title":"The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype","volume":"70","author":"Klein-Wieringa","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.drudis.2024.104187_b0315","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/ard.2011.153858","article-title":"Infrapatellar fat pad of patients with end-stage osteoarthritis inhibits catabolic mediators in cartilage","volume":"71","author":"Bastiaansen-Jenniskens","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.drudis.2024.104187_b0320","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf4590","article-title":"Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology","volume":"16","author":"Tang","year":"2024","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.drudis.2024.104187_b0325","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/art.1780110513","article-title":"Synovial fluid as a lubricant","volume":"11","author":"Radin","year":"1968","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.drudis.2024.104187_b0330","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/10739689509146768","article-title":"Microvascular architecture and exchange in synovial joints","volume":"2","author":"Levick","year":"1995","journal-title":"Microcirculation"},{"key":"10.1016\/j.drudis.2024.104187_b0335","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/art.41486","article-title":"Synergistic roles of macrophages and neutrophils in osteoarthritis progression","volume":"73","author":"Hsueh","year":"2021","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.drudis.2024.104187_b0340","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13075-018-1798-2","article-title":"Synovial fluid monocyte\/macrophage subsets and their correlation to patient-reported outcomes in osteoarthritic patients: a cohort study","volume":"21","author":"G\u00f3mez-Aristiz\u00e1bal","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.drudis.2024.104187_b0345","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.joca.2022.08.019","article-title":"Knee osteoarthritis phenotypes based on synovial fluid immune cells correlate with clinical outcome trajectories","volume":"30","author":"Trajerova","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.drudis.2024.104187_b0350","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13075-019-1923-x","article-title":"Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation","volume":"21","author":"Haraden","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.drudis.2024.104187_b0355","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1097\/j.pain.0000000000001466","article-title":"Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors","volume":"160","author":"Sakurai","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.drudis.2024.104187_b0360","doi-asserted-by":"crossref","first-page":"e0118203","DOI":"10.1371\/journal.pone.0118203","article-title":"Consistent inhibition of cyclooxygenase drives macrophages towards the inflammatory phenotype","volume":"10","author":"Na","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.drudis.2024.104187_b0365","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.1038\/s41598-017-06253-5","article-title":"Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the ApcMin\/+ mouse model of intestinal tumorigenesis","volume":"7","author":"Hull","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2024.104187_b0370","doi-asserted-by":"crossref","first-page":"e30354","DOI":"10.1097\/MD.0000000000030354","article-title":"Relative safety and efficacy of topical and oral NSAIDs in the treatment of osteoarthritis: a systematic review and meta-analysis","volume":"101","author":"Wang","year":"2022","journal-title":"Medicine"},{"key":"10.1016\/j.drudis.2024.104187_b0375","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.drudis.2024.104187_b0380","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/1529-0131(200102)44:2<343::AID-ANR52>3.0.CO;2-Q","article-title":"Effects of intraarticular glucocorticoids on macrophage infiltration and mediators of joint damage in osteoarthritis synovial membranes: findings in a double-blind, placebo-controlled study","volume":"44","author":"Young","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.drudis.2024.104187_b0385","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.joca.2016.04.013","article-title":"Guiding synovial inflammation by macrophage phenotype modulation: an in vitro study towards a therapy for osteoarthritis","volume":"24","author":"Utomo","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.drudis.2024.104187_b0390","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mce.2018.11.001","article-title":"Glucocorticoid signaling and osteoarthritis","volume":"480","author":"Savvidou","year":"2019","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.drudis.2024.104187_b0395","article-title":"Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis","volume":"378","author":"Pereira","year":"2022","journal-title":"Br Med J"},{"key":"10.1016\/j.drudis.2024.104187_b0400","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1039\/C9BM00298G","article-title":"Shear-thinning hyaluronan-based fluid hydrogels to modulate viscoelastic properties of osteoarthritis synovial fluids","volume":"7","author":"Cai","year":"2019","journal-title":"Biomater Sci"},{"key":"10.1016\/j.drudis.2024.104187_b0405","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40824-021-00228-4","article-title":"The effects of the molecular weights of hyaluronic acid on the immune responses","volume":"25","author":"Lee","year":"2021","journal-title":"Biomater Res"},{"key":"10.1016\/j.drudis.2024.104187_b0410","doi-asserted-by":"crossref","first-page":"758","DOI":"10.4049\/jimmunol.1700713","article-title":"Role of CD44 in regulating TLR2 activation of human macrophages and downstream expression of proinflammatory cytokines","volume":"200","author":"Qadri","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0415","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1186\/s12891-022-05767-y","article-title":"Effect of hyaluronic acid on cytokines and immune cells change in patients of knee osteoarthritis","volume":"23","author":"Jin","year":"2022","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.drudis.2024.104187_b0420","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2174\/1874325001307010378","article-title":"Hyaluronic acid (HA) viscosupplementation on synovial fluid inflammation in knee osteoarthritis: a pilot study","volume":"7","author":"Vincent","year":"2013","journal-title":"Open Orthop J"},{"key":"10.1016\/j.drudis.2024.104187_b0425","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40169-017-0180-3","article-title":"Recent advances in hyaluronic acid based therapy for osteoarthritis","volume":"7","author":"Bowman","year":"2018","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.drudis.2024.104187_b0430","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1128856","article-title":"An update on the effect of intra-articular intervention strategies using nanomaterials in osteoarthritis: possible clinical application","volume":"11","author":"Amirsaadat","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.drudis.2024.104187_b0435","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.678757","article-title":"Synovial macrophages in osteoarthritis: the key to understanding pathogenesis?","volume":"12","author":"Thomson","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0440","doi-asserted-by":"crossref","first-page":"R125","DOI":"10.1186\/ar3430","article-title":"A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee","volume":"13","author":"Cohen","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.drudis.2024.104187_b0445","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/art.40840","article-title":"A phase II trial of lutikizumab, an anti-interleukin-1\u03b1\/\u03b2 dual variable domain immunoglobulin, in knee osteoarthritis patients with synovitis","volume":"71","author":"Fleischmann","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.drudis.2024.104187_b0450","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13018-023-03590-2","article-title":"Efficacy and safety of anti-interleukin-1 therapeutics in the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials","volume":"18","author":"Yu","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.drudis.2024.104187_b0455","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/annrheumdis-2020-218547","article-title":"Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial","volume":"80","author":"Richette","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.drudis.2024.104187_b0460","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Sanchez-Lopez","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.drudis.2024.104187_b0465","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.joca.2018.02.899","article-title":"A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis \u2013 the HUMOR trial","volume":"26","author":"Aitken","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.drudis.2024.104187_b0470","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1136\/annrheumdis-2018-213202","article-title":"Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"77","author":"Kloppenburg","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.drudis.2024.104187_b0475","article-title":"Nanomaterials manipulate macrophages for rheumatoid arthritis treatment","volume":"12","author":"Li","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.drudis.2024.104187_b0480","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.actbio.2016.05.005","article-title":"Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis","volume":"39","author":"Kang","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.drudis.2024.104187_b0485","first-page":"14","article-title":"Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis","volume":"7","author":"Seo","year":"2022","journal-title":"Bioact Mater"},{"key":"10.1016\/j.drudis.2024.104187_b0490","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s40265-019-01083-3","article-title":"Triamcinolone acetonide extended-release: a review in osteoarthritis pain of the knee","volume":"79","author":"Paik","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.drudis.2024.104187_b0495","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.4049\/jimmunol.1501701","article-title":"Resolvin D1 Polarizes primary human macrophages toward a proresolution phenotype through GPR32","volume":"196","author":"Schmid","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.drudis.2024.104187_b0500","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10281","article-title":"Resolvin D1-loaded nanoliposomes promote M2 macrophage polarization and are effective in the treatment of osteoarthritis","volume":"7","author":"Dravid","year":"2022","journal-title":"Bioeng Transl Med"},{"key":"10.1016\/j.drudis.2024.104187_b0505","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1021\/acsami.9b16327","article-title":"Modified ZIF-8 nanoparticles attenuate osteoarthritis by reprogramming the metabolic pathway of synovial macrophages","volume":"12","author":"Zhou","year":"2020","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.drudis.2024.104187_b0510","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jconrel.2022.04.037","article-title":"Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: a trapping strategy","volume":"347","author":"Kou","year":"2022","journal-title":"J Control Release"},{"key":"10.1016\/j.drudis.2024.104187_b0515","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.7150\/thno.29313","article-title":"Delivery of miR-146a to Ly6Chigh monocytes inhibits pathogenic bone erosion in inflammatory arthritis","volume":"8","author":"Ammari","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.drudis.2024.104187_b0520","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1136\/annrheumdis-2012-202403","article-title":"Nicotinamide phosphoribosyltransferase\/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis","volume":"72","author":"Pr\u00e9sumey","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.drudis.2024.104187_b0525","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.joca.2016.04.010","article-title":"Direct in vivo evidence of activated macrophages in human osteoarthritis","volume":"24","author":"Kraus","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.drudis.2024.104187_b0530","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/art.30363","article-title":"Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon\u2013emission computed tomography\/computed tomography","volume":"63","author":"Piscaer","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.drudis.2024.104187_b0535","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/annrheumdis-2018-213450","article-title":"Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2","volume":"77","author":"Zhang","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.drudis.2024.104187_b0540","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1002\/ejp.2036","article-title":"Interplay between cellular changes in the knee joint, circulating lipids and pain behaviours in a slowly progressing murine model of osteoarthritis","volume":"26","author":"Gowler","year":"2022","journal-title":"Eur J Pain"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135964462400312X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135964462400312X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T13:14:41Z","timestamp":1731503681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S135964462400312X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":108,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S135964462400312X"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2024.104187","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the macrophage dynamics in osteoarthritic joints: From inflammation to therapeutic strategies","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2024.104187","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104187"}}