{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:26:16Z","timestamp":1784395576018,"version":"3.55.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023674","name":"King Khalid University Deanship of Scientific Research","doi-asserted-by":"publisher","award":["RGP2\/405\/46"],"award-info":[{"award-number":["RGP2\/405\/46"]}],"id":[{"id":"10.13039\/501100023674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.drudis.2025.104373","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T18:29:56Z","timestamp":1746728996000},"page":"104373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic\u2013epigenetic targets for PCOS-associated diabesity"],"prefix":"10.1016","volume":"30","author":[{"given":"Arun K.","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monalisa","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Sayeed","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Orayj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadaf","family":"Farooqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abida","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2025.104373_b0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4239\/wjd.v13.i1.5","article-title":"Polycystic ovary syndrome and type 2 diabetes mellitus: a state-of-the-art review","volume":"13","author":"Livadas","year":"2022","journal-title":"World J Diabetes"},{"key":"10.1016\/j.drudis.2025.104373_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-14-0253","article-title":"The polycystic ovary syndrome: a position statement from the European Society of Endocrinology","volume":"171","author":"Conway","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0015","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s00125-019-4939-5","article-title":"Sex differences in the burden of type 2 diabetes and cardiovascular risk across the life course","volume":"62","author":"Huebschmann","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.drudis.2025.104373_b0020","doi-asserted-by":"crossref","DOI":"10.1002\/ajhb.23867","article-title":"Cardiovascular diseases display etiological and seasonal trend in human population: evidence from seasonal cardiovascular comorbid diseases (SCCD) index","author":"Patel","year":"2023","journal-title":"Am J Hum Biol"},{"key":"10.1016\/j.drudis.2025.104373_b0025","article-title":"Insulin resistance in polycystic ovarian syndrome","volume":"14","author":"Purwar","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.drudis.2025.104373_b0030","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.drudis.2021.03.022","article-title":"Targeting the endocannabinoid system in diabesity: fact or fiction?","volume":"26","author":"Deeba","year":"2021","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.drudis.2025.104373_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103558","article-title":"Dysbiosis versus diabesity: pathological signaling and promising therapeutic strategies","volume":"28","author":"Sharma","year":"2023","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.drudis.2025.104373_b0040","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1210\/js.2019-00078","article-title":"Polycystic ovary syndrome: pathophysiology, presentation, and treatment with emphasis on adolescent girls","volume":"3","author":"Witchel","year":"2019","journal-title":"J Endocr Soc"},{"key":"10.1016\/j.drudis.2025.104373_b0045","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11061567","article-title":"Immunological and metabolic causes of infertility in polycystic ovary syndrome","volume":"11","author":"Kici\u0144ska","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.drudis.2025.104373_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/genes13020302","article-title":"A review on CYP11A1, CYP17A1, and CYP19A1 polymorphism studies: candidate susceptibility genes for polycystic ovary syndrome (PCOS) and infertility","volume":"13","author":"Heidarzadehpilehrood","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.drudis.2025.104373_b0055","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/GRF.0000000000000581","article-title":"Polycystic ovarian syndrome genetics and epigenetics","volume":"64","author":"Combs","year":"2021","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.drudis.2025.104373_b0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.reprotox.2022.04.010","article-title":"DNA methylation in polycystic ovary syndrome: emerging evidence and challenges","volume":"111","author":"Liu","year":"2022","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.drudis.2025.104373_b0065","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1530\/JOE-20-0578","article-title":"Androgen-induced epigenetic modulations in the ovary","volume":"249","author":"Salinas","year":"2021","journal-title":"J Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13048-022-01091-0","article-title":"Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment","volume":"16","author":"Zhao","year":"2023","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.drudis.2025.104373_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1091147","article-title":"Insulin resistance, autophagy and apoptosis in patients with polycystic ovary syndrome: association with PI3K signaling pathway","volume":"13","author":"Tong","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020583","article-title":"Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing","volume":"23","author":"Sadeghi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2025.104373_b0085","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S2213-8587(19)30345-6","article-title":"Diabetes: a metabolic and reproductive disorder in women","volume":"8","author":"Thong","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0090","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1210\/me.2013-1413","article-title":"Minireview: metabolism of female reproduction: regulatory mechanisms and clinical implications","volume":"28","author":"Seli","year":"2014","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0095","doi-asserted-by":"crossref","DOI":"10.1093\/eep\/dvaa019","article-title":"Metabolic diseases affect male reproduction and induce signatures in gametes that may compromise the offspring health","volume":"6","author":"Pereira","year":"2020","journal-title":"Environ Epigenet"},{"key":"10.1016\/j.drudis.2025.104373_b0100","article-title":"Trends in insulin resistance: insights into mechanisms and therapeutic strategy","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.drudis.2025.104373_b0105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s13679-023-00531-2","article-title":"Hypothalamic-ovarian axis and adiposity relationship in polycystic ovary syndrome: physiopathology and therapeutic options for the management of metabolic and inflammatory aspects","volume":"13","author":"Lonardo","year":"2024","journal-title":"Curr Obes Rep"},{"key":"10.1016\/j.drudis.2025.104373_b0110","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.cellsig.2013.01.022","article-title":"Diabetes mellitus associated cardiovascular signalling alteration: a need for the revisit","volume":"25","author":"Sharma","year":"2013","journal-title":"Cell Signal"},{"key":"10.1016\/j.drudis.2025.104373_b0115","doi-asserted-by":"crossref","first-page":"36870","DOI":"10.1039\/C6RA03890E","article-title":"Synthesis and preliminary therapeutic evaluation of copper nanoparticles against diabetes mellitus and induced micro- (renal) and macro-vascular (vascular endothelial and cardiovascular) abnormalities in rats","volume":"6","author":"Sharma","year":"2016","journal-title":"RSC Adv"},{"key":"10.1016\/j.drudis.2025.104373_b0120","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.biopha.2015.12.015","article-title":"Albiglutide: is a better hope against diabetes mellitus?","volume":"77","author":"Sharma","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.drudis.2025.104373_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121322","article-title":"Preliminary investigation on impact of intergenerational treatment of resveratrol endorses the development of \u201csuper-pups.\u201d","volume":"314","author":"Sharma","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.drudis.2025.104373_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149756","article-title":"Amelioration of endothelial integrity by 3,5,4\u02b9-trihydroxy-trans-stilbene against high-fat-diet-induced obesity and -associated vasculopathy and myocardial infarction in rats, targeting TLR4\/MyD88\/NF-\u03baB\/iNOS signaling cascade","volume":"705","author":"Singh","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.drudis.2025.104373_b0135","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1042\/cs1020151","article-title":"Sex steroids and insulin resistance","volume":"102","author":"Livingstone","year":"2002","journal-title":"Clin Sci"},{"key":"10.1016\/j.drudis.2025.104373_b0140","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1007\/s10815-022-02625-7","article-title":"A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)","volume":"39","author":"Siddiqui","year":"2022","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.drudis.2025.104373_b0145","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jsbmb.2008.03.014","article-title":"Defects in insulin signaling pathways in ovarian steroidogenesis and other tissues in polycystic ovary syndrome (PCOS)","volume":"109","author":"Diamanti-Kandarakis","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.drudis.2025.104373_b0150","doi-asserted-by":"crossref","first-page":"18180","DOI":"10.18632\/oncotarget.24477","article-title":"Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat liver","volume":"9","author":"Zhang","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.drudis.2025.104373_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-023-04116-4","article-title":"The interplay between androgens and the immune response in polycystic ovary syndrome","volume":"21","author":"Shabbir","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.drudis.2025.104373_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.01.001","article-title":"Metabolic dysfunction in polycystic ovary syndrome: pathogenic role of androgen excess and potential therapeutic strategies","volume":"35","author":"Sanchez-Garrido","year":"2020","journal-title":"Mol Metab"},{"key":"10.1016\/j.drudis.2025.104373_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2021.105829","article-title":"Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like rats","volume":"208","author":"Cui","year":"2021","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.drudis.2025.104373_b0170","doi-asserted-by":"crossref","DOI":"10.1039\/C4RA90050B","article-title":"Erratum: prediabetes: grounds of pitfall signalling alteration for cardiovascular disease","volume":"5","author":"Goyal","year":"2015","journal-title":"RSC Adv"},{"key":"10.1016\/j.drudis.2025.104373_b0175","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1002\/jcp.26191","article-title":"Pulmonary hypertension: molecular aspects of current therapeutic intervention and future direction","volume":"233","author":"Arora","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.drudis.2025.104373_b0180","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.lfs.2019.01.011","article-title":"Insulin analogs: glimpse on contemporary facts and future prospective","volume":"219","author":"Sharma","year":"2019","journal-title":"Life Sci"},{"key":"10.1016\/j.drudis.2025.104373_b0185","doi-asserted-by":"crossref","first-page":"57267","DOI":"10.1039\/C5RA07927F","article-title":"Reactive oxygen species: friend or foe?","volume":"5","author":"Sharma","year":"2015","journal-title":"RSC Adv"},{"key":"10.1016\/j.drudis.2025.104373_b0190","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-018-0762-4","article-title":"Association between insulin resistance and the development of cardiovascular disease","volume":"17","author":"Ormazabal","year":"2018","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.drudis.2025.104373_b0195","doi-asserted-by":"crossref","first-page":"R161","DOI":"10.1530\/JME-18-0079","article-title":"Ovarian and extra-ovarian mediators in the development of polycystic ovary syndrome","volume":"61","author":"Puttabyatappa","year":"2018","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0200","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/cen.13808","article-title":"Inter-related effects of insulin resistance, hyperandrogenism, sympathetic dysfunction and chronic inflammation in PCOS","volume":"89","author":"Shorakae","year":"2018","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043140","article-title":"Insulin metabolism in polycystic ovary syndrome: secretion, signaling, and clearance","volume":"24","author":"Herman","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2025.104373_b0210","first-page":"1","article-title":"Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth","volume":"2014","author":"Rojas","year":"2014","journal-title":"Int J Reprod Med"},{"key":"10.1016\/j.drudis.2025.104373_b0215","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.metabol.2018.11.002","article-title":"Characteristics of obesity in polycystic ovary syndrome: etiology, treatment, and genetics","volume":"92","author":"Glueck","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.drudis.2025.104373_b0220","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.2174\/1568026617666170307112837","article-title":"Therapeutic implications of superoxide dismutase and its importance in kinase drug discovery","volume":"17","author":"Kaur","year":"2017","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.drudis.2025.104373_b0225","first-page":"129","article-title":"Obesity and the polycystic ovary syndrome","volume":"32","author":"Mart\u00ednez-Bermejo","year":"2007","journal-title":"Minerva Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0230","doi-asserted-by":"crossref","DOI":"10.1186\/s12958-023-01094-6","article-title":"PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin","volume":"21","author":"Wilson","year":"2023","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0235","doi-asserted-by":"crossref","DOI":"10.1530\/JME-21-0285","article-title":"Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes","volume":"70","author":"M\u00e4kinen","year":"2023","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0240","doi-asserted-by":"crossref","first-page":"R305","DOI":"10.1530\/EC-21-0327","article-title":"CYP17 T\/C (rs74357) gene polymorphism contributes to polycystic ovary syndrome susceptibility: evidence from a meta-analysis","volume":"10","author":"Liu","year":"2021","journal-title":"Endocr Connect"},{"key":"10.1016\/j.drudis.2025.104373_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22052734","article-title":"The role of chronic inflammation in polycystic ovarian syndrome. A systematic review and meta-analysis","volume":"22","author":"Aboeldalyl","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2025.104373_b0250","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12082912","article-title":"The role of peroxisome proliferator-activated receptors in polycystic ovary syndrome","volume":"12","author":"Psilopatis","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.drudis.2025.104373_b0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005455","article-title":"Systems genetics reveals the functional context of PCOS loci and identifies genetic and molecular mechanisms of disease heterogeneity","volume":"11","author":"Jones","year":"2015","journal-title":"PLoS Genet"},{"key":"10.1016\/j.drudis.2025.104373_b0260","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9101363","article-title":"Genome profiling of H3k4me3 histone modification in human adipose tissue during obesity and insulin resistance","volume":"9","author":"Castellano-Castillo","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.drudis.2025.104373_b0265","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10815-020-02019-7","article-title":"The role of miRNAs in polycystic ovary syndrome with insulin resistance","volume":"38","author":"Luo","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.drudis.2025.104373_b0270","article-title":"Involvement of transcription factor FoxO1 in the pathogenesis of polycystic ovary syndrome","volume":"12","author":"Xu","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.drudis.2025.104373_b0275","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1677\/jme.0.0290265","article-title":"Role of Sp1 in insulin regulation of gene expression","volume":"29","author":"Samson","year":"2002","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0280","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23168942","article-title":"AMPK activation is important for the preservation of insulin sensitivity in visceral, but not in subcutaneous adipose tissue of postnatally overfed rat model of polycystic ovary syndrome","volume":"23","author":"Mi\u0107i\u0107","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2025.104373_b0285","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tjog.2021.11.009","article-title":"Polycystic ovarian syndrome-current pharmacotherapy and clinical implications","volume":"61","author":"Rashid","year":"2022","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.drudis.2025.104373_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112563","article-title":"AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: a pre-clinical and clinical investigation","volume":"146","author":"Entezari","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.drudis.2025.104373_b0295","article-title":"Thiazolidinedione an auspicious scaffold as PPAR-\u03b3 agonist: its possible mechanism to manoeuvre against insulin resistant diabetes mellitus","volume":"11","author":"Basak","year":"2024","journal-title":"Eur J Med Chem Rep"},{"key":"10.1016\/j.drudis.2025.104373_b0300","doi-asserted-by":"crossref","first-page":"8974","DOI":"10.3390\/ijms22168974","article-title":"PPARs-orchestrated metabolic homeostasis in the adipose tissue","volume":"22","author":"Sun","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2025.104373_b0305","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1273542","article-title":"Androgen excess: a hallmark of polycystic ovary syndrome","volume":"14","author":"Wang","year":"2023","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.drudis.2025.104373_b0310","doi-asserted-by":"crossref","first-page":"15250","DOI":"10.3390\/ijms232315250","article-title":"The role of hormones in Hidradenitis suppurativa: a systematic review","volume":"23","author":"Abu Rached","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2025.104373_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2021.105808","article-title":"The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies","volume":"207","author":"Nikolaou","year":"2021","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.drudis.2025.104373_b0320","doi-asserted-by":"crossref","DOI":"10.1186\/s13048-022-01091-0","article-title":"Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment","volume":"16","author":"Zhao","year":"2023","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.drudis.2025.104373_b0325","first-page":"26","article-title":"The association between increment of interleukin-1 and interleukin-6 in women with polycystic ovary syndrome and body mass index","volume":"24","author":"Mazloomi","year":"2023","journal-title":"J Reprod Infertil"},{"key":"10.1016\/j.drudis.2025.104373_b0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-023-01690-3","article-title":"Targeting proprotein convertase subtilisin\/kexin type 9 (PCSK9): from bench to bedside","volume":"9","author":"Bao","year":"2024","journal-title":"Signal Transduct Target Therapy"},{"key":"10.1016\/j.drudis.2025.104373_b0335","article-title":"Effects of atorvastatin on the insulin resistance in women of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"100","author":"Chen","year":"2021","journal-title":"Medicine"},{"key":"10.1016\/j.drudis.2025.104373_b0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-023-01333-7","article-title":"Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct Target Therapy"},{"key":"10.1016\/j.drudis.2025.104373_b0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-024-01692-0","article-title":"Exploring histone deacetylases in type 2 diabetes mellitus: pathophysiological insights and therapeutic avenues","volume":"16","author":"Kumar","year":"2024","journal-title":"Clin Epigenet"},{"key":"10.1016\/j.drudis.2025.104373_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103695","article-title":"Investigating miRNA subfamilies: can they assist in the early diagnosis of acute myocardial infarction?","volume":"28","author":"Sharma","year":"2023","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.drudis.2025.104373_b0355","first-page":"85","article-title":"Polycystic ovaries and herbal remedies: a systematic review","volume":"27","author":"Manouchehri","year":"2023","journal-title":"JBRA Assist Reprod"},{"key":"10.1016\/j.drudis.2025.104373_b0360","doi-asserted-by":"crossref","DOI":"10.3390\/biotech12010004","article-title":"Herbs as a source for the treatment of polycystic ovarian syndrome: a systematic review","volume":"12","author":"Lakshmi","year":"2023","journal-title":"Biotech"},{"key":"10.1016\/j.drudis.2025.104373_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123508","article-title":"Integrated insights into gene expression dynamics and transcription factor roles in diabetic and diabetic-infectious wound healing using rat model","volume":"368","author":"Sharma","year":"2025","journal-title":"Life Sci"},{"key":"10.1016\/j.drudis.2025.104373_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176795","article-title":"Validating the temporal performance of genetic biomarkers in an animal model of recurrence\/ non-recurrence myocardial infarction persuades by bioinformatics tools","volume":"978","author":"Sharma","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.drudis.2025.104373_b0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103824","article-title":"Molecular basis of phytochemical-gut microbiota interactions","volume":"28","author":"Lal","year":"2023","journal-title":"Drug Discov Today"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644625000868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644625000868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T22:01:36Z","timestamp":1749679296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644625000868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":75,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1359644625000868"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2025.104373","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic\u2013epigenetic targets for PCOS-associated diabesity","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2025.104373","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104373"}}