{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:28:32Z","timestamp":1786987712856,"version":"build-2736575974"},"reference-count":126,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273998"],"award-info":[{"award-number":["82273998"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC3002203"],"award-info":[{"award-number":["2021YFC3002203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019062","name":"Tianjin Research Innovation Project for Postgraduate Students","doi-asserted-by":"publisher","award":["202410056380"],"award-info":[{"award-number":["202410056380"]}],"id":[{"id":"10.13039\/501100019062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.drudis.2025.104377","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T02:32:21Z","timestamp":1746757941000},"page":"104377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Peptide therapy: new promising therapeutics for acute kidney injury"],"prefix":"10.1016","volume":"30","author":[{"given":"Herui","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjiao","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2025.104377_b0005","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00134-023-07061-4","article-title":"Acute kidney injury","volume":"49","author":"Joannidis","year":"2023","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.drudis.2025.104377_b0010","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0140-6736(11)61454-2","article-title":"Acute kidney injury","volume":"380","author":"Bellomo","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.drudis.2025.104377_b0015","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.drudis.2025.104377_b0020","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1681\/ASN.2006070756","article-title":"Incidence and outcomes in acute kidney injury: a comprehensive population-based study","volume":"18","author":"Ali","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.drudis.2025.104377_b0025","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1186\/cc4915","article-title":"RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis","volume":"10","author":"Hoste","year":"2006","journal-title":"Crit Care"},{"key":"10.1016\/j.drudis.2025.104377_b0030","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/cc11454","article-title":"KDIGO AKI Guideline Work Group. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)","volume":"17","author":"Kellum","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.drudis.2025.104377_b0035","doi-asserted-by":"crossref","first-page":"431","DOI":"10.7861\/clinmedicine.15-5-431","article-title":"Recognition and management of acute kidney injury in hospitalised patients can be partially improved with the use of a care bundle","volume":"15","author":"Joslin","year":"2015","journal-title":"Clin Med (Lond)"},{"key":"10.1016\/j.drudis.2025.104377_b0040","doi-asserted-by":"crossref","first-page":"ITC66","DOI":"10.7326\/AITC201711070","article-title":"Acute kidney injury","volume":"167","author":"Levey","year":"2017","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.drudis.2025.104377_b0045","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-006497","article-title":"Long-term prognosis after acute kidney injury (AKI): what is the role of baseline kidney function and recovery? A systematic review","volume":"5","author":"Sawhney","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.drudis.2025.104377_b0050","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/ki.2011.379","article-title":"Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis","volume":"81","author":"Coca","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.drudis.2025.104377_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.semnephrol.2023.151439","article-title":"Acute kidney injury: gaps and opportunities for knowledge and growth","volume":"43","author":"Claure-Del Granado","year":"2023","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.drudis.2025.104377_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155194","article-title":"Transition of acute kidney injury to chronic kidney disease: role of metabolic reprogramming","volume":"131","author":"Zhu","year":"2022","journal-title":"Metabolism"},{"key":"10.1016\/j.drudis.2025.104377_b0065","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.2174\/1381612826666200213123029","article-title":"Inflammatory related cardiovascular diseases: from molecular mechanisms to therapeutic targets","volume":"26","author":"Sardu","year":"2020","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.drudis.2025.104377_b0070","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12933-022-01674-7","article-title":"The number of risk factors not at target is associated with cardiovascular risk in a type 2 diabetic population with albuminuria in primary cardiovascular prevention. Post-hoc analysis of the NID-2 trial","volume":"21","author":"Sasso","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.drudis.2025.104377_b0075","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12933-021-01343-1","article-title":"Efficacy and durability of multifactorial intervention on mortality and MACEs: a randomized clinical trial in type-2 diabetic kidney disease","volume":"20","author":"Sasso","year":"2021","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.drudis.2025.104377_b0080","article-title":"Engineered nanodrug targeting oxidative stress for treatment of acute kidney injury","volume":"3","author":"Li","year":"2023","journal-title":"Exploration (Beijing)"},{"key":"10.1016\/j.drudis.2025.104377_b0085","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.2174\/156802662032201118092318","article-title":"Peptide therapeutics: scientific approaches, current development trends, and future directions","volume":"20","author":"Qvit","year":"2020","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.drudis.2025.104377_b0090","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/molecules26020430","article-title":"A global review on short peptides: frontiers and perspectives","volume":"26","author":"Apostolopoulos","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2025.104377_b0095","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbae275","article-title":"Peptide-based drug discovery through artificial intelligence: towards an autonomous design of therapeutic peptides","volume":"25","author":"Goles","year":"2024","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.drudis.2025.104377_b0100","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jsps.2014.06.004","article-title":"A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives","volume":"24","author":"Muheem","year":"2016","journal-title":"Saudi Pharm J"},{"key":"10.1016\/j.drudis.2025.104377_b0105","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4155\/tde.14.111","article-title":"Challenges in the delivery of peptide drugs: an industry perspective","volume":"6","author":"Lewis","year":"2015","journal-title":"Ther Deliv"},{"key":"10.1016\/j.drudis.2025.104377_b0110","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41573-020-00135-8","article-title":"Trends in peptide drug discovery","volume":"20","author":"Muttenthaler","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.drudis.2025.104377_b0115","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1152\/physrev.00031.2017","article-title":"The oxytocin receptor: from intracellular signaling to behavior","volume":"98","author":"Jurek","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.drudis.2025.104377_b0120","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1124\/pr.120.019398","article-title":"Is oxytocin \u201cNature\u2019s medicine\u201d?","volume":"72","author":"Carter","year":"2020","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.drudis.2025.104377_b0125","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/9780470122778.ch6","article-title":"Solid-phase peptide synthesis","volume":"32","author":"Merrifield","year":"1969","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"key":"10.1016\/j.drudis.2025.104377_b0130","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.drudis.2014.10.003","article-title":"Peptide therapeutics: current status and future directions","volume":"20","author":"Fosgerau","year":"2015","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.drudis.2025.104377_b0135","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1016\/j.bmc.2017.06.052","article-title":"Therapeutic peptides: historical perspectives, current development trends, and future directions","volume":"26","author":"Lau","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2025.104377_b0140","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41591-022-01771-w","article-title":"Author correction: A phase 1\/2 trial of an immune-modulatory vaccine against IDO\/PD-L1 in combination with nivolumab in metastatic melanoma","volume":"28","author":"Kjeldsen","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.drudis.2025.104377_b0145","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/ijc.30510","article-title":"Phase II clinical trial using novel peptide cocktail vaccine as a postoperative adjuvant treatment for surgically resected pancreatic cancer patients","volume":"140","author":"Miyazawa","year":"2017","journal-title":"Int J Cancer"},{"key":"10.1016\/j.drudis.2025.104377_b0150","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1093\/annonc\/mdu211","article-title":"Final report of the phase I\/II clinical trial of the E75 (nelipepimut-S) vaccine with booster inoculations to prevent disease recurrence in high-risk breast cancer patients","volume":"25","author":"Mittendorf","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.drudis.2025.104377_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101762","article-title":"Discovery of ecnoglutide\u2014a novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog","volume":"75","author":"Guo","year":"2023","journal-title":"Mol Metab"},{"key":"10.1016\/j.drudis.2025.104377_b0160","doi-asserted-by":"crossref","first-page":"8289","DOI":"10.1038\/s41467-023-44067-4","article-title":"A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity","volume":"14","author":"Ji","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.drudis.2025.104377_b0165","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/S0140-6736(10)61485-7","article-title":"Exenatide in type 2 diabetes","volume":"376","author":"Verzegnassi","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.drudis.2025.104377_b0170","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1128\/AAC.04773-14","article-title":"In vitro spectrum of pexiganan activity when tested against pathogens from diabetic foot infections and with selected resistance mechanisms","volume":"59","author":"Flamm","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2025.104377_b0175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/SLA.0000000000005508","article-title":"Efficacy and safety of PL-5 (Peceleganan) spray for wound infections: a Phase IIb randomized clinical trial","volume":"277","author":"Wei","year":"2023","journal-title":"Ann Surg"},{"key":"10.1016\/j.drudis.2025.104377_b0180","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.canlet.2014.05.002","article-title":"Peptide-based cancer therapy: opportunity and challenge","volume":"351","author":"Wu","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1016\/j.drudis.2025.104377_b0185","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.2165\/0003495-200868180-00012","article-title":"Teriparatide: a review of its use in osteoporosis","volume":"68","author":"Blick","year":"2008","journal-title":"Drugs"},{"key":"10.1016\/j.drudis.2025.104377_b0190","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J Nat Prod"},{"key":"10.1016\/j.drudis.2025.104377_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108169","article-title":"Small molecules as a source for acute kidney injury therapy","volume":"237","author":"Feng","year":"2022","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.drudis.2025.104377_b0200","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrd989","article-title":"The further evolution of biotech","volume":"2","author":"Nagle","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.drudis.2025.104377_b0205","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.apsb.2014.01.002","article-title":"Research and development in drug innovation: reflections from the 2013 bioeconomy conference in China, lessons learned and future perspectives","volume":"4","author":"Liu","year":"2014","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.drudis.2025.104377_b0210","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1089\/sur.2017.278","article-title":"Sepsis 2018: definitions and guideline changes","volume":"19","author":"Napolitano","year":"2018","journal-title":"Surg Infect (larchmt)"},{"key":"10.1016\/j.drudis.2025.104377_b0215","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3390\/cells13050439","article-title":"Advances and challenges in sepsis management: modern tools and future directions","volume":"13","author":"Santacroce","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.drudis.2025.104377_b0220","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.3390\/jcm12093188","article-title":"2023 Update on sepsis and septic shock in adult patients: management in the emergency department","volume":"12","author":"Guarino","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.drudis.2025.104377_b0225","doi-asserted-by":"crossref","first-page":"E1058","DOI":"10.1503\/cmaj.170149","article-title":"Clinical implications of the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"190","author":"Fernando","year":"2018","journal-title":"CMAJ"},{"key":"10.1016\/j.drudis.2025.104377_b0230","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s00134-018-5203-z","article-title":"Sepsis-related mortality in China: a descriptive analysis","volume":"44","author":"Weng","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.drudis.2025.104377_b0235","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00134-018-5134-8","article-title":"Unexplained mortality differences between septic shock trials: a systematic analysis of population characteristics and control-group mortality rates","volume":"44","author":"de Grooth","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.drudis.2025.104377_b0240","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1001\/jama.2016.6389","article-title":"Definitions for sepsis and septic shock\u2014reply","volume":"316","author":"Deutschman","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.drudis.2025.104377_b0245","first-page":"211","article-title":"Advances in the management of renal dysfunction in patients with cirrhosis","volume":"17","author":"Pena Polanco","year":"2021","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"10.1016\/j.drudis.2025.104377_b0250","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1194\/jlr.M008086","article-title":"The apolipoprotein A-I mimetic peptide 4F prevents defects in vascular function in endotoxemic rats","volume":"51","author":"Dai","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1016\/j.drudis.2025.104377_b0255","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/01.mol.0000226114.89812.75","article-title":"Synthetic peptides: managing lipid disorders","volume":"17","author":"Anantharamaiah","year":"2006","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.drudis.2025.104377_b0260","doi-asserted-by":"crossref","first-page":"H866","DOI":"10.1152\/ajpheart.01232.2008","article-title":"Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats","volume":"297","author":"Zhang","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.drudis.2025.104377_b0265","doi-asserted-by":"crossref","first-page":"R514","DOI":"10.1152\/ajpregu.00445.2013","article-title":"Apolipoprotein A-I mimetic peptide 4F attenuates kidney injury, heart injury, and endothelial dysfunction in sepsis","volume":"307","author":"Moreira","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.drudis.2025.104377_b0270","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/HYPERTENSIONAHA.114.03726","article-title":"Ghrelin as a treatment for cardiovascular diseases","volume":"64","author":"Mao","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.drudis.2025.104377_b0275","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.peptides.2017.12.015","article-title":"Ghrelin regulation of glucose metabolism","volume":"100","author":"Poher","year":"2018","journal-title":"Peptides"},{"key":"10.1016\/j.drudis.2025.104377_b0280","doi-asserted-by":"crossref","first-page":"11695","DOI":"10.3390\/ijms222111695","article-title":"Involvement of ghrelin dynamics in stress-induced eating disorder: effects of sex and aging","volume":"22","author":"Yamada","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2025.104377_b0285","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2025.104377_b0290","doi-asserted-by":"crossref","first-page":"17254","DOI":"10.3390\/ijms242417254","article-title":"Emerging relevance of ghrelin in programmed cell death and its application in diseases","volume":"24","author":"Zhang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2025.104377_b0295","doi-asserted-by":"crossref","first-page":"F1032","DOI":"10.1152\/ajprenal.00044.2009","article-title":"Ghrelin protects mice against endotoxemia-induced acute kidney injury","volume":"297","author":"Wang","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.drudis.2025.104377_b0300","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2119\/molmed.2015.00255","article-title":"Combined administration of human ghrelin and human growth hormone attenuates organ injury and improves survival in aged septic rats","volume":"22","author":"Yang","year":"2016","journal-title":"Mol Med"},{"key":"10.1016\/j.drudis.2025.104377_b0305","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10157-014-1006-x","article-title":"Effects of ghrelin on sepsis-induced acute kidney injury: one step forward","volume":"19","author":"Khowailed","year":"2015","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.drudis.2025.104377_b0310","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/14728222.2023.2206954","article-title":"Emerging therapeutic targets for anorexia nervosa","volume":"27","author":"Stengel","year":"2023","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.drudis.2025.104377_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2023.104565","article-title":"Myocardial ischemia-reperfusion injury; molecular mechanisms and prevention","volume":"149","author":"Liu","year":"2023","journal-title":"Microvasc Res"},{"key":"10.1016\/j.drudis.2025.104377_b0320","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbabio.2017.01.004","article-title":"Mitochondrial dysfunction and mitochondrial dynamics\u2014the cancer connection","volume":"1858","author":"Srinivasan","year":"2017","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"10.1016\/j.drudis.2025.104377_b0325","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41581-020-00369-0","article-title":"Mitochondrial quality control in kidney injury and repair","volume":"17","author":"Tang","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.drudis.2025.104377_b0330","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000313754","article-title":"The changing pattern of acute kidney injury: from one to multiple organ failure","volume":"165","author":"Okusa","year":"2010","journal-title":"Contrib Nephrol"},{"key":"10.1016\/j.drudis.2025.104377_b0335","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000280099","article-title":"Modern classification of acute kidney injury","volume":"29","author":"Srisawat","year":"2010","journal-title":"Blood Purif"},{"key":"10.1016\/j.drudis.2025.104377_b0340","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1111\/bph.14998","article-title":"Cathelicidin-related antimicrobial peptide protects against ischaemia reperfusion-induced acute kidney injury in mice","volume":"177","author":"Pan","year":"2020","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2025.104377_b0345","doi-asserted-by":"crossref","first-page":"6993","DOI":"10.1007\/s12010-024-04893-8","article-title":"Understanding the dynamics of human defensin antimicrobial peptides: pathogen resistance and commensal induction","volume":"196","author":"Kumaresan","year":"2024","journal-title":"Appl Biochem Biotechnol"},{"key":"10.1016\/j.drudis.2025.104377_b0350","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri.2016.29","article-title":"The immunology of host defence peptides: beyond antimicrobial activity","volume":"16","author":"Hancock","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.drudis.2025.104377_b0355","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nchembio.1393","article-title":"Immune modulation by multifaceted cationic host defense (antimicrobial) peptides","volume":"9","author":"Hilchie","year":"2013","journal-title":"Nat Chem Biol"},{"issue":"1","key":"10.1016\/j.drudis.2025.104377_bib626","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12916-019-1268-y","article-title":"Cathelicidin-related antimicrobial peptide protects against myocardial ischemia\/reperfusion injury","volume":"17","author":"Bei","year":"2019","journal-title":"BMC Med"},{"key":"10.1016\/j.drudis.2025.104377_b0360","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114059","article-title":"Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy","volume":"13","author":"Ren","year":"2021","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.drudis.2025.104377_b0365","doi-asserted-by":"crossref","first-page":"F768","DOI":"10.1152\/ajprenal.00189.2023","article-title":"Mitochondrial dysfunction in the pathophysiology of renal diseases","volume":"326","author":"Guo","year":"2024","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.drudis.2025.104377_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2024.101846","article-title":"Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction","volume":"75","author":"Du","year":"2024","journal-title":"Mitochondrion"},{"key":"10.1016\/j.drudis.2025.104377_b0375","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.drudis.2025.104377_b0380","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1295509","article-title":"SS-31, a mitochondria-targeting peptide, ameliorates kidney disease","volume":"2022","author":"Zhu","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.drudis.2025.104377_b0385","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1681\/ASN.2010080808","article-title":"Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury","volume":"22","author":"Szeto","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.drudis.2025.104377_b0390","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1080\/10715762.2021.2018426","article-title":"The mitochondrial antioxidant SS-31 attenuated lipopolysaccharide-induced apoptosis and pyroptosis of nucleus pulposus cells via scavenging mitochondrial ROS and maintaining the stability of mitochondrial dynamics","volume":"55","author":"Peng","year":"2021","journal-title":"Free Radic Res"},{"key":"10.1016\/j.drudis.2025.104377_b0395","doi-asserted-by":"crossref","first-page":"19847","DOI":"10.1038\/s41598-022-24231-4","article-title":"Beneficial effects of SS-31 peptide on cardiac mitochondrial dysfunction in tafazzin knockdown mice","volume":"12","author":"Russo","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2025.104377_b0400","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.2106\/JBJS.21.01449","article-title":"SS-31 as a mitochondrial protectant in the treatment of tendinopathy: evaluation in a murine supraspinatus tendinopathy model","volume":"104","author":"Zhang","year":"2022","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.drudis.2025.104377_b0405","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1126\/science.2821619","article-title":"New perspectives in cell adhesion: RGD and integrins","volume":"238","author":"Ruoslahti","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.drudis.2025.104377_b0410","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.cellbio.12.1.697","article-title":"RGD and other recognition sequences for integrins","volume":"12","author":"Ruoslahti","year":"1996","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.drudis.2025.104377_b0415","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s13346-022-01116-7","article-title":"Internalizing RGD, a great motif for targeted peptide and protein delivery: a review article","volume":"12","author":"Davoodi","year":"2022","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.drudis.2025.104377_b0420","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/309030a0","article-title":"Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule","volume":"309","author":"Pierschbacher","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2025.104377_b0425","doi-asserted-by":"crossref","first-page":"e6800","DOI":"10.1002\/cam4.6800","article-title":"RGD peptide in cancer targeting: benefits, challenges, solutions, and possible integrin-RGD interactions","volume":"13","author":"Javid","year":"2024","journal-title":"Cancer Med"},{"key":"10.1016\/j.drudis.2025.104377_b0430","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/ki.1997.204","article-title":"Therapeutic potential of RGD peptides in acute renal injury","volume":"51","author":"Goligorsky","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.drudis.2025.104377_b0435","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.surg.2022.02.003","article-title":"A novel eCIRP\/TREM-1 pathway inhibitor attenuates acute kidney injury","volume":"172","author":"Siskind","year":"2022","journal-title":"Surgery"},{"key":"10.1016\/j.drudis.2025.104377_b0440","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.surg.2018.06.048","article-title":"Cold-inducible RNA-binding protein-derived peptide C23 attenuates inflammation and tissue injury in a murine model of intestinal ischemia-reperfusion","volume":"164","author":"McGinn","year":"2018","journal-title":"Surgery"},{"key":"10.1016\/j.drudis.2025.104377_b0445","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3576892","article-title":"Change in oxidative stress and mitochondrial dynamics in response to elevated cold-inducible RNA-binding protein in cardiac surgery-associated acute kidney injury","volume":"2022","author":"Zheng","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.drudis.2025.104377_b0450","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s10020-025-01071-2","article-title":"An eCIRP inhibitor attenuates fibrosis and ferroptosis in ischemia and reperfusion induced chronic kidney disease","volume":"31","author":"Zhang","year":"2025","journal-title":"Mol Med"},{"key":"10.1016\/j.drudis.2025.104377_b0455","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1038\/s41598-017-13139-z","article-title":"A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2025.104377_b0460","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.134172","article-title":"Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis","volume":"5","author":"Denning","year":"2020","journal-title":"JCI Insight"},{"issue":"63","key":"10.1016\/j.drudis.2025.104377_b0465","first-page":"418","article-title":"Blood collection and processing for measurement of catecholamines in exercising rats","volume":"1987","author":"Winder","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.drudis.2025.104377_b0470","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/toxsci\/kfy159","article-title":"Nephrotoxicity and renal pathophysiology: a contemporary perspective","volume":"164","author":"Barnett","year":"2018","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.drudis.2025.104377_b0475","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.drudis.2025.104377_b0480","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1055\/s-0039-1684048","article-title":"Mechanisms of Cisplatin-induced ototoxicity and prevention","volume":"40","author":"Rybak","year":"2019","journal-title":"Semin Hear"},{"key":"10.1016\/j.drudis.2025.104377_b0485","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41581-022-00631-7","article-title":"Cisplatin nephrotoxicity: new insights and therapeutic implications","volume":"19","author":"Tang","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.drudis.2025.104377_b0490","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrneph.2016.196","article-title":"Understanding and preventing contrast-induced acute kidney injury","volume":"13","author":"F\u00e4hling","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.drudis.2025.104377_b0495","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1007\/s10495-013-0876-9","article-title":"Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation","volume":"18","author":"Cannavo","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.drudis.2025.104377_b0500","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.4155\/fmc.11.72","article-title":"Intracellular and extracellular cytokine-like functions of prothymosin \u03b1: implications for the development of immunotherapies","volume":"3","author":"Mosoian","year":"2011","journal-title":"Future Med Chem"},{"key":"10.1016\/j.drudis.2025.104377_b0505","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/jnc.13356","article-title":"Prothymosin-alpha preconditioning activates TLR4-TRIF signaling to induce protection of ischemic retina","volume":"135","author":"Halder","year":"2015","journal-title":"J Neurochem"},{"key":"10.1016\/j.drudis.2025.104377_b0510","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10157-019-01843-1","article-title":"Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury","volume":"24","author":"Torigoe","year":"2020","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.drudis.2025.104377_b0515","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-3-030-45328-2_5","article-title":"Amino acid metabolism in the kidneys: nutritional and physiological significance","volume":"1265","author":"Li","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.drudis.2025.104377_b0520","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/s10517-015-3062-y","article-title":"Peptides restore functional state of the kidneys during Cisplatin-induced acute renal failure","volume":"159","author":"Zamorskii","year":"2015","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.drudis.2025.104377_b0525","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.phrs.2010.04.004","article-title":"Gentamicin-induced nephrotoxicity: do we have a promising therapeutic approach to blunt it?","volume":"62","author":"Balakumar","year":"2010","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.drudis.2025.104377_b0530","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.3390\/cancers13071572","article-title":"Mechanisms of cisplatin-induced acute kidney injury: pathological mechanisms, pharmacological interventions, and genetic mitigations","volume":"13","author":"McSweeney","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.drudis.2025.104377_b0535","doi-asserted-by":"crossref","DOI":"10.2174\/1573403X17666210202102210","article-title":"Atrial natriuretic peptide: structure, function, and physiological effects: a narrative review","volume":"17","author":"Rao","year":"2021","journal-title":"Curr Cardiol Rev"},{"key":"10.1016\/j.drudis.2025.104377_b0540","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/sj.cr.7290350","article-title":"The presence of ANP in rat peritoneal mast cells","volume":"15","author":"Martynova","year":"2005","journal-title":"Cell Res"},{"key":"10.1016\/j.drudis.2025.104377_b0545","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s10557-016-6683-0","article-title":"Prevention of contrast-induced acute kidney injury: an update","volume":"30","author":"Chalikias","year":"2016","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.drudis.2025.104377_b0550","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12882-020-1701-7","article-title":"Effect of low-dose atrial natriuretic peptide in critically ill patients with acute kidney injury: a retrospective, single-center study with propensity-score matching","volume":"21","author":"Saito","year":"2020","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.drudis.2025.104377_b0555","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13054-019-2330-z","article-title":"Low-dose atrial natriuretic peptide for prevention or treatment of acute kidney injury: a systematic review and meta-analysis","volume":"23","author":"Yamada","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.drudis.2025.104377_b0560","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/eurheartj\/eht466","article-title":"Natriuretic peptides in cardiovascular diseases: current use and perspectives","volume":"35","author":"Volpe","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.drudis.2025.104377_b0565","doi-asserted-by":"crossref","first-page":"20752","DOI":"10.1038\/s41598-023-48125-1","article-title":"Impact of recombinant human brain natriuretic peptide on emergency dialysis and prognosis in end-stage renal disease patients with type 4 cardiorenal syndrome","volume":"13","author":"Zhou","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2025.104377_b0570","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5847\/wjem.j.issn.1920-8642.2012.01.002","article-title":"Rhabdomyolosis and its pathogenesis","volume":"3","author":"Zhang","year":"2012","journal-title":"World J Emerg Med"},{"key":"10.1016\/j.drudis.2025.104377_b0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.disamonth.2020.101015","article-title":"Rhabdomyolysis","volume":"66","author":"Cabral","year":"2020","journal-title":"Dis Mon"},{"key":"10.1016\/j.drudis.2025.104377_b0580","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.semnephrol.2020.06.001","article-title":"Acute kidney injury in active wars and other man-made disasters","volume":"40","author":"Sever","year":"2020","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.drudis.2025.104377_b0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115933","article-title":"Synthesis and structure-activity optimization of hydroxypyridinones against rhabdomyolysis-induced acute kidney injury","volume":"263","author":"Cen","year":"2024","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2025.104377_b0590","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/bmj.298.6671.443","article-title":"Dialysis for acute renal failure due to crush injuries after the Armenian earthquake","volume":"298","author":"Richards","year":"1989","journal-title":"BMJ"},{"key":"10.1016\/j.drudis.2025.104377_b0595","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bbrc.2023.06.013","article-title":"Precision engineered peptide targeting leukocyte extracellular traps mitigate acute kidney injury in Crush syndrome","volume":"671","author":"Okubo","year":"2023","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.drudis.2025.104377_b0600","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ebiom.2016.07.012","article-title":"Lactoferrin suppresses neutrophil extracellular traps release in inflammation","volume":"10","author":"Okubo","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.drudis.2025.104377_b0605","first-page":"478","article-title":"Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging [in Russian]","volume":"25","author":"Lin\u2019kova NS, Kuznik BI, Khavinson VK.","year":"2012","journal-title":"Adv Gerontol"},{"key":"10.1016\/j.drudis.2025.104377_b0610","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3390\/molecules25030609","article-title":"AEDG peptide (Epitalon) stimulates gene expression and protein synthesis during neurogenesis: possible epigenetic mechanism","volume":"25","author":"Khavinson","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2025.104377_b0615","first-page":"429","article-title":"AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging","volume":"33","author":"Ivko","year":"2020","journal-title":"Adv Gerontol"},{"key":"10.1016\/j.drudis.2025.104377_b0620","first-page":"1023","article-title":"Main mechanisms of rhabdomyolysis-caused kidney injury and their correction by organospecific peptides","volume":"59","author":"Zamorski\u012d","year":"2014","journal-title":"Biofizika"},{"key":"10.1016\/j.drudis.2025.104377_b0625","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1743-7075-10-7","article-title":"Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2\/HO-1 pathway","volume":"10","author":"Kilic","year":"2013","journal-title":"Nutr Metab (Lond)"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135964462500090X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135964462500090X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T19:37:51Z","timestamp":1762371471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S135964462500090X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":126,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S135964462500090X"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2025.104377","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peptide therapy: new promising therapeutics for acute kidney injury","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2025.104377","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104377"}}