{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:41:54Z","timestamp":1789530114431,"version":"build-2803163510"},"reference-count":86,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000288","name":"The Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.drudis.2026.104628","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T16:20:46Z","timestamp":1771431646000},"page":"104628","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Progress in allergen immunotherapy via advanced transdermal delivery routes"],"prefix":"10.1016","volume":"31","author":[{"given":"Ambreen","family":"Akhtar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neenu","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Sohail","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2026.104628_b0005","first-page":"376","article-title":"Clemens von Pirquet: a remarkable life and career","volume":"6","author":"Shulman","year":"2017","journal-title":"J Pediatric Infect Dis Soc"},{"key":"10.1016\/j.drudis.2026.104628_b0010","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41392-023-01344-4","article-title":"Pathogenesis of allergic diseases and implications for therapeutic interventions","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.drudis.2026.104628_b0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ymeth.2013.07.024","article-title":"Structure of allergens and structure based epitope predictions","volume":"66","author":"Dall\u2019Antonia","year":"2014","journal-title":"Methods"},{"key":"10.1016\/j.drudis.2026.104628_b0020","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.jaci.2021.10.018","article-title":"Food allergy across the globe","volume":"148","author":"Sampath","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0025","doi-asserted-by":"crossref","unstructured":"University of Manchester et al. Patterns and Prevalence of Adult Food Allergy (PAFA). https:\/\/science.food.gov.uk\/article\/126077-patterns-and-prevalence-of-adult-food-allergy. Published 16 May, 2024. Accessed 14 October, 2025. https:\/\/doi.org\/10.46756\/sci.fsa.ehu454.","DOI":"10.46756\/sci.fsa.ehu454"},{"key":"10.1016\/j.drudis.2026.104628_b0030","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/all.14666","article-title":"The global burden of illness of peanut allergy: a comprehensive literature review","volume":"76","author":"Lieberman","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.drudis.2026.104628_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2020.100491","article-title":"Recent advances in the management of nut allergy","volume":"14","author":"Midun","year":"2021","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.drudis.2026.104628_b0040","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.molimm.2018.04.005","article-title":"Peanut allergens","volume":"100","author":"Palladino","year":"2018","journal-title":"Mol Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0045","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2147\/JAA.S141636","article-title":"Current perspectives on tree nut allergy: a review","volume":"11","author":"Weinberger","year":"2018","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.drudis.2026.104628_b0050","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.tifs.2019.02.014","article-title":"Cashew nut allergy; immune health challenge","volume":"86","author":"Tufail","year":"2019","journal-title":"Trends Food Sci Technol"},{"key":"10.1016\/j.drudis.2026.104628_b0055","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ymeth.2013.07.033","article-title":"Production and analysis of recombinant tree nut allergens","volume":"66","author":"Willison","year":"2014","journal-title":"Methods"},{"key":"10.1016\/j.drudis.2026.104628_b0060","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jaip.2020.08.051","article-title":"Walnut allergy across Europe: distribution of allergen sensitization patterns and prediction of severity","volume":"9","author":"Lyons","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.drudis.2026.104628_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2022.100641","article-title":"Recent advances in diagnosing and managing nut allergies with focus on hazelnuts, walnuts, and cashew nuts","volume":"15","author":"Borres","year":"2022","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.drudis.2026.104628_bib416","unstructured":"Allergen Nomenclature Sub-Committee, 2025. Accessed 16 September 2025. https:\/\/www.allergen.org\/search.php?allergensource=hazelnut&searchsource=Search."},{"key":"10.1016\/j.drudis.2026.104628_bib415","unstructured":"Allergen Nomenclature Sub-Committee, 2022. Accessed 19 June 2025. https:\/\/allergen.org\/search.php?allergenname=&allergensource=walnut&TaxSource=&TaxOrder=&foodallerg=all&bioname=."},{"key":"10.1016\/j.drudis.2026.104628_bib414","unstructured":"Allergen Nomenclature Sub-Committee, 2021. Accessed 19 June 2025. https:\/\/www.allergen.org\/search.php?allergenname=&allergensource=pistachio&TaxSource=&TaxOrder=&foodallerg=all&bioname=."},{"key":"10.1016\/j.drudis.2026.104628_bib413","unstructured":"Allergen Nomenclature Sub-Committee, 2024. Accessed 19 June 2025. https:\/\/allergen.org\/search.php?allergenname=&allergensource=Arachis+hypogaea&TaxSource=&TaxOrder=&foodallerg=all&bioname=."},{"key":"10.1016\/j.drudis.2026.104628_bib412","unstructured":"Allergen Nomenclature Sub-Committee, 2019. Accessed 19 June 2025. https:\/\/www.allergen.org\/search.php?allergenname=&allergensource=cashew&TaxSource=&TaxOrder=&foodallerg=all&bioname=."},{"key":"10.1016\/j.drudis.2026.104628_b0070","series-title":"Handbook of food allergen detection and control","first-page":"379","article-title":"Detection and control of fish, shellfish and molluscs as food allergens","author":"Wong","year":"2015"},{"key":"10.1016\/j.drudis.2026.104628_b0075","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molimm.2018.04.008","article-title":"Seafood allergy: a comprehensive review of fish and shellfish allergens","volume":"100","author":"Ruethers","year":"2018","journal-title":"Mol Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0080","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1111\/all.15801","article-title":"Prevalence estimates of eight big food allergies in Europe: updated systematic review and meta\u2010analysis","volume":"78","author":"Spolidoro","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.drudis.2026.104628_b0085","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.smallrumres.2006.09.016","article-title":"The challenge of cow milk protein allergy","volume":"68","author":"El-Agamy","year":"2007","journal-title":"Small Rumin Res"},{"key":"10.1016\/j.drudis.2026.104628_b0090","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.aller.2019.10.002","article-title":"The frequency of cross-reactivity with various avian eggs among children with hen\u2019s egg allergy using skin prick test results: fewer sensitizations with pigeon and goose egg","volume":"48","author":"Moghtaderi","year":"2020","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"Suppl 1","key":"10.1016\/j.drudis.2026.104628_b0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2249.2008.03714.x","article-title":"Allergy and the cardiovascular system","volume":"153","author":"Triggiani","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0100","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.foodres.2019.03.008","article-title":"Food allergen knowledge, attitude and practices among UK consumers: a structural modelling approach","volume":"120","author":"Soon","year":"2019","journal-title":"Food Res Int"},{"key":"10.1016\/j.drudis.2026.104628_b0105","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jaci.2003.10.039","article-title":"Development and validation of challenge materials for double-blind, placebo-controlled food challenges in children","volume":"113","author":"Vlieg-Boerstra","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2045-7022-3-3","article-title":"The skin prick test\u2014European standards","volume":"3","author":"Heinzerling","year":"2013","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.drudis.2026.104628_b0115","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jaip.2016.12.003","article-title":"Making the most of invitro tests to diagnose food allergy","volume":"5","author":"Santos","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.drudis.2026.104628_b0120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.foodchem.2014.02.025","article-title":"Allergenic properties and differential response of walnut subjected to processing treatments","volume":"157","author":"Cabanillas","year":"2014","journal-title":"Food Chem"},{"key":"10.1016\/j.drudis.2026.104628_b0125","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/cea.12267","article-title":"Walnut allergens: molecular characterization, detection and clinical relevance","volume":"44","author":"Costa","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.drudis.2026.104628_b0130","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3390\/biom13071151","article-title":"The history and science of the major birch pollen allergen Bet v 1","volume":"13","author":"Breiteneder","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.drudis.2026.104628_b0135","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1067\/mai.2002.120558","article-title":"Linear IgE epitope mapping of the English walnut (Juglans regia) major food allergen, Jug r 1","volume":"109","author":"Robotham","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0140","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ifset.2016.12.001","article-title":"The allergenic potential of walnuts treated with high pressure and heat in a mouse model of allergy","volume":"39","author":"Yang","year":"2017","journal-title":"Innov Food Sci Emerg Technol"},{"key":"10.1016\/j.drudis.2026.104628_b0145","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1111\/all.14632","article-title":"Advances and novel developments in mechanisms of allergic inflammation","volume":"75","author":"Han","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.drudis.2026.104628_b0150","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2017.07.004","article-title":"Immunology of food allergy","volume":"47","author":"Tordesillas","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.drudis.2026.104628_b0155","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/S0140-6736(00)78276-6","article-title":"Prophylactic inoculation against hay fever","volume":"177","author":"Noon","year":"1911","journal-title":"Lancet"},{"key":"10.1016\/j.drudis.2026.104628_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106525","article-title":"Immune responses modulation by curcumin and allergen encapsulated into PLGA nanoparticles in mice model of rhinitis allergic through sublingual immunotherapy","volume":"84","author":"Shahgordi","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.drudis.2026.104628_b0165","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jaci.2022.01.007","article-title":"Allergen immunotherapy for long-term tolerance and prevention","volume":"149","author":"Penagos","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0170","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41577-022-00786-1","article-title":"Allergen immunotherapy: past, present and future","volume":"23","author":"Durham","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0175","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.iac.2015.08.007","article-title":"Oral immunotherapy for food allergy","volume":"36","author":"Burbank","year":"2016","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.drudis.2026.104628_b0180","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jaci.2013.12.1040","article-title":"State of the art on food allergen immunotherapy: oral,sublingual, and epicutaneous","volume":"133","author":"Jones","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0185","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3390\/ph18030437","article-title":"Omalizumab and oral immunotherapy in IgE-mediated food allergy in children: a systematic review and a meta-analysis","volume":"18","author":"Buono","year":"2025","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.drudis.2026.104628_b0190","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.jaip.2021.12.022","article-title":"Real-world adoption of FDA-approved peanut oral immunotherapy with palforzia","volume":"10","author":"Patrawala","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.drudis.2026.104628_b0195","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jaci.2013.11.007","article-title":"Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy","volume":"133","author":"Vickery","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0200","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jaci.2016.03.057","article-title":"Epicutaneous immunotherapy induces gastrointestinal LAP+ regulatory Tcells and prevents food-induced anaphylaxis","volume":"139","author":"Tordesillas","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0205","unstructured":"Creticos PS. Sublingual immunotherapy for allergic rhinitis and conjunctivitis. www.uptodate.com\/contents\/sublingual-immunotherapy-for-allergic-rhinitis-and-conjunctivitis?search=sublingual%20immunotherapy%20for%20allergic%20rhinitis%20and%20conjunctivitis.%20uptodate.com&source=search_result&selectedTitle=1\u223c150&usage_type=default&display_rank=1. Updated 12 August, 2025. Accessed February 10, 2026."},{"key":"10.1016\/j.drudis.2026.104628_b0210","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2217\/imt-2020-0123","article-title":"Sublingual immunotherapy for food allergy and its future directions","volume":"12","author":"Schworer","year":"2020","journal-title":"Immunotherapy"},{"key":"10.1016\/j.drudis.2026.104628_b0215","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.actbio.2021.04.024","article-title":"Sublingual protein delivery by a mucoadhesive patch made of natural polymers","volume":"128","author":"Paris","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.drudis.2026.104628_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2020.106039","article-title":"Compliance in subcutaneous and sublingual allergen immunotherapy: a nationwide study","volume":"170","author":"Borg","year":"2020","journal-title":"Respir Med"},{"key":"10.1016\/j.drudis.2026.104628_b0225","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.anai.2016.06.027","article-title":"Basic science for the clinician: mechanisms of sublingual and subcutaneous immunotherapy","volume":"117","author":"Lawrence","year":"2016","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0230","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.imlet.2009.12.001","article-title":"IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB","volume":"130","author":"Cady","year":"2010","journal-title":"Immunol Lett"},{"key":"10.1016\/j.drudis.2026.104628_b0235","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1600-065X.2011.01028.x","article-title":"Anaphylaxis: a history with emphasis on food allergy","volume":"242","author":"Boden","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.drudis.2026.104628_b0240","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jaci.2019.11.022","article-title":"Delivery of allergen powder for safe and effective epicutaneous immunotherapy","volume":"145","author":"Yu","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0245","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2500\/jfa.2020.2.200016","article-title":"Food allergy: epicutaneous immunotherapy","volume":"2","author":"Chow","year":"2020","journal-title":"J Food Allergy"},{"key":"10.1016\/j.drudis.2026.104628_b0250","doi-asserted-by":"crossref","DOI":"10.1111\/pai.70096","article-title":"Epicutaneous immunotherapy: a review of safety and efficacy","volume":"36","author":"Anagnostou","year":"2025","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0255","doi-asserted-by":"crossref","DOI":"10.1002\/clt2.70045","article-title":"Epicutaneous immunotherapy for food allergy: a systematic review and meta-analysis","volume":"15","author":"Csonka","year":"2025","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.drudis.2026.104628_b0260","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.jaci.2016.08.017","article-title":"Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults","volume":"139","author":"Jones","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.drudis.2026.104628_b0265","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.jaip.2025.02.004","article-title":"Efficacy and safety of epicutaneous immunotherapy in peanut-allergic toddlers: open-label extension to EPITOPE","volume":"13","author":"Greenhawt","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.drudis.2026.104628_b0270","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1056\/NEJMoa2212895","article-title":"Phase 3 trial of epicutaneous immunotherapy in toddlers with peanut allergy","volume":"388","author":"Greenhawt","year":"2023","journal-title":"N Eng J Med"},{"key":"10.1016\/j.drudis.2026.104628_b0275","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.jaip.2025.02.024","article-title":"Long-term safety of epicutaneous immunotherapy in peanut-allergic children: an open-label active treatment (REALISE Study)","volume":"13","author":"Pongracic","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.drudis.2026.104628_b0280","article-title":"Current progressions in transdermal drug delivery systems for management of rheumatoid and osteoarthritis: a comprehensive review","volume":"73","author":"Chakraborty","year":"2022","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104628_b0285","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejpb.2019.05.001","article-title":"Expanding the applications of microneedles in dermatology","volume":"140","author":"Sabri","year":"2019","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.drudis.2026.104628_b0290","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.matpr.2021.10.320","article-title":"A review on polymer hydrogel and polymer microneedle based transdermal drug delivery system","volume":"61","author":"Swain","year":"2022","journal-title":"Mater Today Proc"},{"key":"10.1016\/j.drudis.2026.104628_b0295","article-title":"Flow field analysis and structure optimization of high-dose multi-hole needle-free jet injector","volume":"72","author":"Liu","year":"2022","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104628_b0300","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jddst.2017.08.014","article-title":"Experimental studies on shock wave and particle dynamics in a needle-free drug delivery device","volume":"41","author":"Zhang","year":"2017","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104628_b0305","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1111\/all.13926","article-title":"Allergy\u2026No more fear of needles!","volume":"74","author":"Traina","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.drudis.2026.104628_b0310","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ultras.2013.07.007","article-title":"Sonophoresis in transdermal drug deliverys","volume":"54","author":"Park","year":"2014","journal-title":"Ultrasonics"},{"key":"10.1016\/j.drudis.2026.104628_b0315","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jddst.2016.09.009","article-title":"Enhancing percutaneous permeability of sinomenine hydrochloride using dual-frequency sonophoresis","volume":"36","author":"Yin","year":"2016","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104628_b0320","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/cea.14307","article-title":"Intralymphatic immunotherapy with birch and grass pollen extracts. A randomized double\u2010blind placebo\u2010controlled clinical trial","volume":"53","author":"Ahlbeck","year":"2023","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.drudis.2026.104628_b0325","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jconrel.2016.07.016","article-title":"Exploitation of sub-micron cavitation nuclei to enhance ultrasound-mediated transdermal transport and penetration of vaccines","volume":"238","author":"Bhatnagar","year":"2016","journal-title":"J Control Release"},{"key":"10.1016\/j.drudis.2026.104628_b0330","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijpharm.2017.02.002","article-title":"Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen","volume":"521","author":"Manikkath","year":"2017","journal-title":"Int J Pharm"},{"key":"10.1016\/j.drudis.2026.104628_b0335","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s13346-021-00909-6","article-title":"Enhancement strategies for transdermal drug delivery systems: current trends and applications","volume":"12","author":"Ramadon","year":"2022","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.drudis.2026.104628_b0340","article-title":"Iontophoresis of basal insulin controlled delivery based on thermoplastic polyurethane","volume":"76","author":"Morarad","year":"2022","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104628_b0345","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/j.nano.2016.07.001","article-title":"Effective transcutaneous immunization using a combination of iontophoresis and nanoparticles","volume":"12","author":"Bernardi","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.drudis.2026.104628_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2020.125607","article-title":"Iontophoretic transdermal delivery using chitosan-coated PLGA nanoparticles for transcutaneous immunization","volume":"608","author":"Takeuchi","year":"2021","journal-title":"Colloids Surf A Physicochem Eng Asp"},{"key":"10.1016\/j.drudis.2026.104628_b0355","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3109\/10717544.2014.935985","article-title":"Lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel delivery by combined microneedle and ultrasound","volume":"23","author":"Nayak","year":"2016","journal-title":"Drug Deliv"},{"key":"10.1016\/j.drudis.2026.104628_b0360","article-title":"Advances in porous microneedle systems for drug delivery and biomarker detection: a mini review","volume":"74","author":"He","year":"2022","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104628_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106203","article-title":"Polymer coated polymeric (PCP) microneedles for sampling of drugs and biomarkers from tissues","volume":"175","author":"Jakka","year":"2022","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.drudis.2026.104628_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125722","article-title":"Development and characterisation of co-axial electrosprayed curcumin-loaded mesoporous silica and polymer composite coated microneedles","volume":"678","author":"Ali","year":"2025","journal-title":"Int J Pharm"},{"key":"10.1016\/j.drudis.2026.104628_b0375","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1124\/jpet.119.258707","article-title":"Microneedle coating methods: a review with a perspective","volume":"370","author":"Ingrole","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.drudis.2026.104628_b0380","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jconrel.2022.05.045","article-title":"Dissolving microneedles: applications and growing therapeutic potential","volume":"348","author":"Sartawi","year":"2022","journal-title":"J Control Release"},{"key":"10.1016\/j.drudis.2026.104628_b0385","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ijbiomac.2021.09.161","article-title":"Systematic comparisons of dissolving and swelling hyaluronic acid microneedles in transdermal drug delivery","volume":"191","author":"Yu","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.drudis.2026.104628_b0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120455","article-title":"Hollow microneedles: a perspective in biomedical applications","volume":"599","author":"C\u00e1rcamo-Mart\u00ednez","year":"2021","journal-title":"Int J Pharm"},{"key":"10.1016\/j.drudis.2026.104628_b0395","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jconrel.2019.09.022","article-title":"Microneedles coated with peanut allergen enable desensitization of peanut sensitized mice","volume":"314","author":"Shakya","year":"2019","journal-title":"J Control Release"},{"key":"10.1016\/j.drudis.2026.104628_b0400","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2217\/imt-2021-0206","article-title":"Targeted allergen-specific immunotherapy within the skin improves allergen delivery to induce desensitization to peanut","volume":"14","author":"Landers","year":"2022","journal-title":"Immunotherapy"},{"key":"10.1016\/j.drudis.2026.104628_b0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.124398","article-title":"Dissolving microneedle-based epicutaneous immunotherapy for peanut allergy using hyaluronic acid via a film-gluing method","volume":"370","author":"Kim","year":"2025","journal-title":"Carbohydr Polym"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644626000334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644626000334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:04:29Z","timestamp":1773421469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644626000334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":86,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1359644626000334"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2026.104628","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progress in allergen immunotherapy via advanced transdermal delivery routes","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2026.104628","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104628"}}