{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:11:22Z","timestamp":1789506682488,"version":"build-2803163510"},"reference-count":101,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.drudis.2026.104731","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:06:40Z","timestamp":1783091200000},"page":"104731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inorganic nanoparticles for diagnostics, drug delivery and therapy for solid tumors"],"prefix":"10.1016","volume":"31","author":[{"given":"Lakshmi Ganapati","family":"Peetani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapna Priya","family":"Ganji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganji Purnachandra","family":"Nagaraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2026.104731_b0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12964-025-02632-y","article-title":"Immune cell-based therapies for solid tumors, current challenges and therapeutic advances","volume":"24","author":"Torabi","year":"2025","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.drudis.2026.104731_b0010","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22900","article-title":"The current knowledge concerning solid cancer and therapy","volume":"35","author":"Najafi","year":"2021","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1016\/j.drudis.2026.104731_b0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s44371-025-00237-5","article-title":"Nanoscale frontiers in cancer diagnosis and therapy","volume":"2","author":"Addissouky","year":"2025","journal-title":"Discov Chem"},{"key":"10.1016\/j.drudis.2026.104731_b0020","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.3390\/app15063189","article-title":"Enhancement of EPR effect for passive tumor targeting: current status and future perspectives","volume":"15","author":"Vagena","year":"2025","journal-title":"Appl Sci"},{"key":"10.1016\/j.drudis.2026.104731_b0025","article-title":"Pericytes regulate vascular basement membrane remodeling and govern neutrophil extravasation during inflammation","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.drudis.2026.104731_b0030","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3390\/cancers11050640","article-title":"Active targeting strategies using biological ligands for nanoparticle drug delivery systems","volume":"11","author":"Yoo","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.drudis.2026.104731_b0035","doi-asserted-by":"crossref","first-page":"13735","DOI":"10.1039\/D3RA01421E","article-title":"Organic and inorganic nanomaterials: fabrication, properties and applications","volume":"13","author":"Alshammari","year":"2023","journal-title":"RSC Adv"},{"key":"10.1016\/j.drudis.2026.104731_b0040","first-page":"270","article-title":"Nanoparticles in cancer therapy: strategies to penetrate and modulate the tumor microenvironment \u2013 a review","volume":"6","author":"Minh Hoang","year":"2025","journal-title":"Smart Mater Med"},{"key":"10.1016\/j.drudis.2026.104731_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.nxnano.2023.100013","article-title":"Current updated review on preparation of polymeric nanoparticles for drug delivery and biomedical applications","volume":"2","author":"Bhardwaj","year":"2023","journal-title":"Next Nanotechnol"},{"key":"10.1016\/j.drudis.2026.104731_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e09394","article-title":"Liposomes: structure, composition, types, and clinical applications","volume":"8","author":"Nsairat","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.drudis.2026.104731_b0055","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.3390\/pharmaceutics14081636","article-title":"Progress in polymeric micelles for drug delivery applications","volume":"14","author":"Kotta","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.drudis.2026.104731_b0060","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.3390\/nano13182566","article-title":"Recent breakthroughs in using quantum dots for cancer imaging and drug delivery purposes","volume":"13","author":"Hamidu","year":"2023","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.drudis.2026.104731_b0065","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.7150\/ijbs.72534","article-title":"Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance","volume":"18","author":"Zhang","year":"2022","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.drudis.2026.104731_b0070","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41392-023-01332-8","article-title":"Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.drudis.2026.104731_b0075","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3390\/cells14090673","article-title":"The distinct role of HIF-1\u03b1 and HIF-2\u03b1 in hypoxia and angiogenesis","volume":"14","author":"Bakleh","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.drudis.2026.104731_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188792","article-title":"Interstitial fluid pressure as an emerging biomarker in solid tumors","volume":"1877","author":"Salavati","year":"2022","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.drudis.2026.104731_b0085","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1089068","article-title":"Cancer-associated fibroblasts: the chief architect in the tumor microenvironment","volume":"11","author":"Sarkar","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.drudis.2026.104731_b0090","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3390\/cimb47060460","article-title":"Targeting cancer cell fate: apoptosis, autophagy, and gold nanoparticles in treatment strategies","volume":"47","author":"Kouri","year":"2025","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.drudis.2026.104731_b0095","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3390\/pharmaceutics16101332","article-title":"Review of gold nanoparticles: synthesis, properties, shapes, cellular uptake, targeting, release mechanisms and applications in drug delivery and therapy","volume":"16","author":"Georgeous","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.drudis.2026.104731_b0100","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12668-025-02384-6","article-title":"Functionalization strategies for the delivery of anticancer agents: advancing tumor-targeted liposomal systems for cancer therapy","volume":"16","author":"Lee","year":"2026","journal-title":"BioNanoScience"},{"key":"10.1016\/j.drudis.2026.104731_b0105","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12943-025-02431-6","article-title":"Multifunctional gold nanoparticles: bridging detection, diagnosis, and targeted therapy in cancer","volume":"24","author":"Zhuang","year":"2025","journal-title":"Mol Cancer"},{"key":"10.1016\/j.drudis.2026.104731_b0110","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3390\/pharmaceutics15010236","article-title":"Superparamagnetic iron oxide nanoparticles (SPION): from fundamentals to state-of-the-art innovative applications for cancer therapy","volume":"15","author":"Vangijzegem","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.drudis.2026.104731_b0115","doi-asserted-by":"crossref","unstructured":"Kumar HP, Sharmila P, Yashika SB, Sree TD, Mukesh VR, Karthikeyan E. Recent advances in iron oxide nanoparticles for cancer theranostics: emerging strategies and applications. Biomed Mater Devices. Published online 22 October 2025. https:\/\/doi.org\/10.1007\/s44174-025-00540-w.","DOI":"10.1007\/s44174-025-00540-w"},{"key":"10.1016\/j.drudis.2026.104731_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.106054","article-title":"Superparamagnetic iron oxide nanoparticles in clinical applications: current status and future perspectives","volume":"122","author":"Guo","year":"2025","journal-title":"eBioMedicine"},{"key":"10.1016\/j.drudis.2026.104731_b0125","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.3390\/pharmaceutics14081579","article-title":"Application of mesoporous silica nanoparticles in cancer therapy and delivery of repurposed anthelmintics for cancer therapy","volume":"14","author":"Koohi Moftakhari Esfahani","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.drudis.2026.104731_b0130","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.3390\/molecules29204854","article-title":"Enhancing drug solubility, bioavailability, and targeted therapeutic applications through magnetic nanoparticles","volume":"29","author":"Zhuo","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2026.104731_b0135","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2147\/IJN.S504629","article-title":"Design of pH-responsive nanomaterials based on the tumor microenvironment","volume":"20","author":"Liu","year":"2025","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.drudis.2026.104731_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117459","article-title":"Chondroitin sulfate-based nanoparticles for enhanced chemo-photodynamic therapy overcoming multidrug resistance and lung metastasis of breast cancer","volume":"254","author":"Shi","year":"2021","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.drudis.2026.104731_b0145","doi-asserted-by":"crossref","first-page":"24624","DOI":"10.1039\/D0RA04778C","article-title":"Curcumin-loaded PEGylated mesoporous silica nanoparticles for effective photodynamic therapy","volume":"10","author":"Kuang","year":"2020","journal-title":"RSC Adv"},{"key":"10.1016\/j.drudis.2026.104731_b0150","article-title":"Engineering mesoporous silica nanoparticles for cancer immunotherapy: mechanistic insights, therapeutic synergies, and translational roadmap","volume":"262","author":"Gharehbaba","year":"2026","journal-title":"Mater Des"},{"key":"10.1016\/j.drudis.2026.104731_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.nanoen.2025.111316","article-title":"Highly efficient large-area quantum dot near-infrared light-emitting device for advanced non-invasive bioimaging","volume":"143","author":"Din","year":"2025","journal-title":"Nano Energy"},{"key":"10.1016\/j.drudis.2026.104731_b0160","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3390\/cancers17050878","article-title":"Advancing cancer therapy with quantum dots and other nanostructures: a review of drug delivery innovations, applications, and challenges","volume":"17","author":"Pareek","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.drudis.2026.104731_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.onano.2021.100031","article-title":"Advances in pH-responsive drug delivery systems","volume":"5","author":"Mu","year":"2021","journal-title":"OpenNano"},{"key":"10.1016\/j.drudis.2026.104731_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.216542","article-title":"Copper-based nanoplatforms and their role in cancer therapy","volume":"534","author":"Garcia-Peiro","year":"2025","journal-title":"Coord Chem Rev"},{"key":"10.1016\/j.drudis.2026.104731_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123523","article-title":"Disrupting intracellular redox homeostasis through copper-driven dual cell death to induce anti-tumor immunotherapy","volume":"324","author":"Wang","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.drudis.2026.104731_b0180","article-title":"Nanosystems for chemodynamic based combination therapy: strategies and recent advances","volume":"13","author":"Li","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.drudis.2026.104731_b0185","article-title":"Cuproptosis-driven nanostrategies: synergistic nanoplatforms for tumor microenvironment reprogramming and enhanced anticancer efficacy","volume":"32","author":"Cheng","year":"2025","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.drudis.2026.104731_b0190","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1039\/D5CS00083A","article-title":"Cuproptosis: mechanisms and nanotherapeutic strategies in cancer and beyond","volume":"54","author":"Mao","year":"2025","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.drudis.2026.104731_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2026.114775","article-title":"Bioorthogonal Cu-MOF nanocatalyst enables GSH-triggered in situ drug synthesis for xCT-driven ferroptosis in colorectal cancer","volume":"393","author":"Chahal","year":"2026","journal-title":"J Control Release"},{"key":"10.1016\/j.drudis.2026.104731_b0200","doi-asserted-by":"crossref","first-page":"13541","DOI":"10.1074\/jbc.R111.312181","article-title":"Battles with iron: manganese in oxidative stress protection","volume":"287","author":"Aguirre","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.drudis.2026.104731_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217385","article-title":"Tumor microenvironment: nurturing cancer cells for immunoevasion and druggable vulnerabilities for cancer immunotherapy","volume":"611","author":"Yu","year":"2025","journal-title":"Cancer Lett"},{"key":"10.1016\/j.drudis.2026.104731_b0210","article-title":"MnO2 nanoflowers induce immunogenic cell death under nutrient deprivation: enabling an orchestrated cancer starvation-immunotherapy","volume":"8","author":"Yang","year":"2021","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.drudis.2026.104731_b0215","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/07357907.2024.2445528","article-title":"A comprehensive insight into apoptosis: molecular mechanisms, signaling pathways, and modulating therapeutics","volume":"43","author":"Mosadegh","year":"2025","journal-title":"Cancer Invest"},{"key":"10.1016\/j.drudis.2026.104731_b0220","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12645-025-00344-z","article-title":"Potential applications of metal-based nanomaterials in tumor radiotherapy: from x-ray to particle therapies","volume":"16","author":"Liu","year":"2025","journal-title":"Cancer Nanotechnol"},{"key":"10.1016\/j.drudis.2026.104731_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114100","article-title":"Recent developments in the use of carbon-based nanomaterials in cancer therapy","volume":"386","author":"Algarra","year":"2025","journal-title":"J Control Release"},{"key":"10.1016\/j.drudis.2026.104731_b0230","article-title":"Revolutionizing cancer care: advances in carbon-based materials for diagnosis and treatment","volume":"16","author":"Khan","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.drudis.2026.104731_b0235","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3390\/biomedicines9030305","article-title":"Advances in nanomaterial-mediated photothermal cancer therapies: toward clinical applications","volume":"9","author":"Han","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.drudis.2026.104731_b0240","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jcis.2024.08.037","article-title":"Rational construction of CQDs-based targeted multifunctional nanoplatform for synergistic chemo-photothermal tumor therapy","volume":"677","author":"Liu","year":"2025","journal-title":"J Colloid Interface Sci"},{"key":"10.1016\/j.drudis.2026.104731_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.216848","article-title":"Inorganic nanoparticle-based cancer immunotheranostics","volume":"542","author":"Lee","year":"2025","journal-title":"Coord Chem Rev"},{"key":"10.1016\/j.drudis.2026.104731_b0250","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1016\/j.sjbs.2020.08.029","article-title":"Anti-cancer activity of biosynthesized silver nanoparticles using Avicennia marina against A549 lung cancer cells through ROS\/mitochondrial damages","volume":"27","author":"Tian","year":"2020","journal-title":"Saudi J Biol Sci"},{"key":"10.1016\/j.drudis.2026.104731_b0255","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1080\/1061186X.2018.1527338","article-title":"Application of titanium dioxide (TiO2) nanoparticles in cancer therapies","volume":"27","author":"\u00c7e\u015fmeli","year":"2019","journal-title":"J Drug Target"},{"key":"10.1016\/j.drudis.2026.104731_b0260","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1021\/acs.molpharmaceut.6b00311","article-title":"Zinc oxide nanoparticles as adjuvant to facilitate doxorubicin intracellular accumulation and visualize pH-responsive release for overcoming drug resistance","volume":"13","author":"Liu","year":"2016","journal-title":"Mol Pharm"},{"key":"10.1016\/j.drudis.2026.104731_b0265","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12645-026-00377-y","article-title":"Redox-responsive cisplatin-loaded cerium oxide nanozymes for oral squamous cell carcinoma: oxidative stress modulation, anti-inflammatory activity, and enhanced cytotoxicity","volume":"17","author":"Zhai","year":"2026","journal-title":"Cancer Nanotechnol"},{"key":"10.1016\/j.drudis.2026.104731_b0270","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1016\/j.msec.2013.07.012","article-title":"Contrast agents for MRI","volume":"33","author":"Shokrollahi","year":"2013","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"10.1016\/j.drudis.2026.104731_b0275","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1073\/pnas.1620145114","article-title":"Exceedingly small iron oxide nanoparticles as positive MRI contrast agents","volume":"114","author":"Wei","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.drudis.2026.104731_b0280","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s12274-014-0518-8","article-title":"Color tunable Gd-Zn-Cu-In-S\/ZnS quantum dots for dual modality magnetic resonance and fluorescence imaging","volume":"7","author":"Guo","year":"2014","journal-title":"Nano Res"},{"key":"10.1016\/j.drudis.2026.104731_b0285","doi-asserted-by":"crossref","first-page":"424","DOI":"10.7150\/ntno.86467","article-title":"Magnetic resonance imaging and iron-oxide nanoparticles in the era of personalized medicine","volume":"7","author":"Rahman","year":"2023","journal-title":"Nanotheranostics"},{"key":"10.1016\/j.drudis.2026.104731_b0290","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s42003-024-06043-6","article-title":"Hybridized quantum dot, silica, and gold nanoparticles for targeted chemo-radiotherapy in colorectal cancer theranostics","volume":"7","author":"Abrishami","year":"2024","journal-title":"Commun Biol"},{"key":"10.1016\/j.drudis.2026.104731_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlumin.2020.117541","article-title":"Synthesis, structural and fluorescence optimization of ternary Cu\u2013In\u2013S quantum dots passivated with ZnS","volume":"227","author":"Tsolekile","year":"2020","journal-title":"J Lumin"},{"key":"10.1016\/j.drudis.2026.104731_b0300","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s12951-021-01056-3","article-title":"Improving anti-cancer drug delivery performance of magnetic mesoporous silica nanocarriers for more efficient colorectal cancer therapy","volume":"19","author":"Iranpour","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.drudis.2026.104731_b0305","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.3332\/ecancer.2023.1529","article-title":"Role of CT in the detection and management of cancer related complications: a study of 599 patients","volume":"17","author":"Bansal","year":"2023","journal-title":"Ecancermedicalscience"},{"key":"10.1016\/j.drudis.2026.104731_b0310","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3390\/mi15081007","article-title":"Recent advances in photoacoustic imaging: current status and future perspectives","volume":"15","author":"Liu","year":"2024","journal-title":"Micromachines (Basel)"},{"key":"10.1016\/j.drudis.2026.104731_b0315","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40580-024-00428-3","article-title":"SERS biosensors for liquid biopsy towards cancer diagnosis by detection of various circulating biomarkers: current progress and perspectives","volume":"11","author":"Lyu","year":"2024","journal-title":"Nano Converg"},{"key":"10.1016\/j.drudis.2026.104731_b0320","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3390\/pharmaceutics14051113","article-title":"Functionalization of nanoparticulate drug delivery systems and its influence in cancer therapy","volume":"14","author":"Seidu","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.drudis.2026.104731_b0325","doi-asserted-by":"crossref","DOI":"10.3389\/fnano.2024.1456939","article-title":"Recent advances in surface decoration of nanoparticles in drug delivery","volume":"6","author":"Ly","year":"2024","journal-title":"Front Nanotechnol"},{"key":"10.1016\/j.drudis.2026.104731_b0330","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/ijms19010195","article-title":"Surface functionalization and targeting strategies of liposomes in solid tumor therapy: a review","volume":"19","author":"Riaz","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2026.104731_b0335","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3390\/polym14050936","article-title":"pH-responsive nanocarriers in cancer therapy","volume":"14","author":"AlSawaftah","year":"2022","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.drudis.2026.104731_b0340","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s42247-020-00109-x","article-title":"Recent advances in stimuli-responsive drug release and targeting concepts using mesoporous silica nanoparticles","volume":"3","author":"Abdo","year":"2020","journal-title":"Emerg Mater"},{"key":"10.1016\/j.drudis.2026.104731_b0345","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1186\/s12951-024-02859-w","article-title":"Redox-manipulating nanocarriers for anticancer drug delivery: a systematic review","volume":"22","author":"Meng","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.drudis.2026.104731_b0350","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.3390\/cancers13092058","article-title":"Nanomedicine to overcome multidrug resistance mechanisms in colon and pancreatic cancer: recent progress","volume":"13","author":"Ort\u00edz","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.drudis.2026.104731_b0355","first-page":"159","article-title":"Nanodrug delivery in reversing multidrug resistance in cancer cells","volume":"5","author":"Kapse-Mistry","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.drudis.2026.104731_b0360","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s43586-022-00104-y","article-title":"Nanodelivery of nucleic acids","volume":"2","author":"Mendes","year":"2022","journal-title":"Nat Rev Methods Primers"},{"key":"10.1016\/j.drudis.2026.104731_b0365","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/s41551-017-0137-2","article-title":"Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair","volume":"1","author":"Lee","year":"2017","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.drudis.2026.104731_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111450","article-title":"Ex vivo photothermal treatment-induced immunogenic cell death for anticancer vaccine development","volume":"127","author":"Yu","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.drudis.2026.104731_b0375","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10103-007-0470-x","article-title":"Plasmonic photothermal therapy (PPTT) using gold nanoparticles","volume":"23","author":"Huang","year":"2008","journal-title":"Lasers Med Sci"},{"key":"10.1016\/j.drudis.2026.104731_b0380","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41392-025-02140-y","article-title":"Phototherapy in cancer treatment: strategies and challenges","volume":"10","author":"Cai","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.drudis.2026.104731_b0385","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41427-021-00303-1","article-title":"Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment","volume":"13","author":"Shen","year":"2021","journal-title":"NPG Asia Mater"},{"key":"10.1016\/j.drudis.2026.104731_b0390","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.apsb.2023.11.007","article-title":"Towards overcoming obstacles of type II photodynamic therapy: endogenous production of light, photosensitizer, and oxygen","volume":"14","author":"Yu","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.drudis.2026.104731_b0395","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.3390\/pharmaceutics15092337","article-title":"Advancements in the application of the Fenton reaction in the cancer microenvironment","volume":"15","author":"Ou","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.drudis.2026.104731_b0400","doi-asserted-by":"crossref","first-page":"54770","DOI":"10.1021\/acsami.1c16835","article-title":"Boosting chemodynamic therapy via a synergy of hypothermal ablation and oxidation resistance reduction","volume":"13","author":"Yao","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.drudis.2026.104731_b0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213724","article-title":"Synergistic effect of photothermal and magnetic hyperthermia for in situ activation of Fenton reaction in tumor microenvironment for chemodynamic therapy","volume":"157","author":"Thirumurugan","year":"2024","journal-title":"Biomater Adv"},{"key":"10.1016\/j.drudis.2026.104731_b0410","article-title":"Magnetic hyperthermia in oncology: nanomaterials-driven combinatorial strategies for synergistic therapeutic gains","volume":"33","author":"Xiong","year":"2025","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.drudis.2026.104731_b0415","doi-asserted-by":"crossref","DOI":"10.3389\/fnano.2025.1603334","article-title":"Radiobiological perspective on metrics for quantifying dose enhancement effects of high-Z nanoparticles","volume":"7","author":"Luo","year":"2025","journal-title":"Front Nanotechnol"},{"key":"10.1016\/j.drudis.2026.104731_b0420","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cpt.2022.09.001","article-title":"PI3K\/AKT\/mTOR pathway, hypoxia, and glucose metabolism: potential targets to overcome radioresistance in small cell lung cancer","volume":"1","author":"Deng","year":"2023","journal-title":"Cancer Pathog Ther"},{"key":"10.1016\/j.drudis.2026.104731_b0425","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12943-022-01708-4","article-title":"Advancements in nanoparticle-based treatment approaches for skin cancer therapy","volume":"22","author":"Zeng","year":"2023","journal-title":"Mol Cancer"},{"key":"10.1016\/j.drudis.2026.104731_b0430","article-title":"Smart organic-inorganic copolymer nanoparticles distinguish between microglia and cancer cells for synergistic immunotherapy in glioma","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.drudis.2026.104731_b0435","article-title":"Induction of ferroptosis using functionalized iron-based nanoparticles for anti-cancer therapy","volume":"17","author":"Bae","year":"2022","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.drudis.2026.104731_b0440","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2147\/NSA.S550828","article-title":"Nanoparticle-mediated ferroptosis for cancer therapy: mechanisms and therapeutic strategies","volume":"18","author":"Szwed","year":"2025","journal-title":"Nanotechnol Sci Appl"},{"key":"10.1016\/j.drudis.2026.104731_b0445","doi-asserted-by":"crossref","first-page":"29170","DOI":"10.1021\/acsami.5c01445","article-title":"Turning waste into treasure: radiation byproduct-induced Fe(III)\/Fe(II) conversion for efficient ferroptosis to improve iodine-131-based transarterial radioembolization for liver tumors","volume":"17","author":"Xu","year":"2025","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.drudis.2026.104731_b0450","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202403939","article-title":"Three-level nanoparticle rocket strategy for colorectal cancer therapeutics in photothermal therapy, inflammation modulation, and cuproptosis induction","volume":"14","author":"Shang","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.drudis.2026.104731_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123874","article-title":"Nano-purpurin-Cu delivery via TPGS-induced macropinocytosis enables cuproptosis\/metabolic synergy to ablate cancer stemness and boost immunotherapy in colorectal cancer","volume":"328","author":"Song","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.drudis.2026.104731_b0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2025.137337","article-title":"Copper\/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis","volume":"690","author":"Zheng","year":"2025","journal-title":"J Colloid Interface Sci"},{"key":"10.1016\/j.drudis.2026.104731_b0465","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12951-023-01878-3","article-title":"Cascade amplification of tumor chemodynamic therapy and starvation with re-educated TAMs via Fe-MOF based functional nanosystem","volume":"21","author":"Zheng","year":"2023","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.drudis.2026.104731_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.150141","article-title":"Construction of a cascade nanosystem to implement indirect and direct cell modulation for tumor microenvironment immunostimulation","volume":"485","author":"Wang","year":"2024","journal-title":"Chem Eng J"},{"key":"10.1016\/j.drudis.2026.104731_b0475","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.biomaterials.2019.04.004","article-title":"Carbon monoxide (CO)-strengthened cooperative bioreductive anti-tumor therapy via mitochondrial exhaustion and hypoxia induction","volume":"209","author":"Li","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.drudis.2026.104731_b0480","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jconrel.2016.12.026","article-title":"Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy","volume":"263","author":"Kim","year":"2017","journal-title":"J Control Release"},{"key":"10.1016\/j.drudis.2026.104731_b0485","article-title":"Recent advances in glucose oxidase-based nanocarriers for tumor targeting therapy","volume":"9","author":"Li","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.drudis.2026.104731_b0490","article-title":"Machine learning reshapes the paradigm of nanomedicine research","author":"Wei","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.drudis.2026.104731_b0495","article-title":"Pharmacokinetics and toxicity of inorganic nanoparticles and the physicochemical properties\/factors affecting them","volume":"99","author":"Saker","year":"2024","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104731_b0500","first-page":"1","article-title":"Nanoparticle-induced oxidative stress: mechanisms and implications for human health and environmental safety","volume":"37","author":"Neogi","year":"2025","journal-title":"Environ Earth Sci Proc"},{"key":"10.1016\/j.drudis.2026.104731_b0505","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1208\/s12248-015-9780-2","article-title":"A review of clinical translation of inorganic nanoparticles","volume":"17","author":"Anselmo","year":"2015","journal-title":"AAPS J"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644626001364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644626001364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:37:57Z","timestamp":1789504677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644626001364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":101,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1359644626001364"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2026.104731","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inorganic nanoparticles for diagnostics, drug delivery and therapy for solid tumors","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2026.104731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104731"}}