{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:08:19Z","timestamp":1790096899718,"version":"4.0.1"},"reference-count":126,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.drudis.2026.104770","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:48:29Z","timestamp":1786492109000},"page":"104770","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastric retention for cardiovascular therapy: matching drug properties, dosage-form design, and translational evidence"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5637-8729","authenticated-orcid":false,"given":"Hossein","family":"Omidian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2026.104770_b0005","first-page":"267","article-title":"Effect of polymer concentration and viscosity grade on atenolol release from gastric floating drug delivery systems","volume":"44","author":"Bhosale","year":"2010","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.drudis.2026.104770_b0010","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1773-2247(12)50054-7","article-title":"Floating furosemide gel beads: in vitro and in vivo evaluation","volume":"22","author":"ElMeshad","year":"2012","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104770_b0015","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12247-019-09393-5","article-title":"Formulation optimization for gastroretentive drug delivery system of carvedilol cocrystals using design of experiment","volume":"15","author":"Fernandes","year":"2020","journal-title":"J Pharm Innov"},{"key":"10.1016\/j.drudis.2026.104770_b0020","first-page":"181","article-title":"Formulation and evaluation of buffered floating furosemide delivery systems","volume":"10","author":"Gabr","year":"2000","journal-title":"STP Pharma Sci"},{"key":"10.1016\/j.drudis.2026.104770_b0025","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1081\/DDC-100101274","article-title":"PVP solid dispersions for the controlled release of furosemide from a floating multiple-unit system","volume":"26","author":"Iannuccelli","year":"2000","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0030","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2174\/1567201811310050004","article-title":"Application of design of experiments to optimizing novel gastroretentive drug delivery of simvastatin","volume":"10","author":"Jagdale","year":"2013","journal-title":"Curr Drug Deliv"},{"key":"10.1016\/j.drudis.2026.104770_b0035","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1208\/s12249-009-9300-8","article-title":"Formulation and evaluation of gastroretentive drug delivery system of propranolol hydrochloride","volume":"10","author":"Jagdale","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0040","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jconrel.2021.08.026","article-title":"Development of a furosemide-containing expandable system for gastric retention","volume":"338","author":"Neumann","year":"2021","journal-title":"J Control Release"},{"key":"10.1016\/j.drudis.2026.104770_b0045","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/20415990.2025.2466418","article-title":"Gastroretentive microballoons of olmesartan medoxomil: formulation and in vitro-in vivo evaluation","volume":"16","author":"Patil","year":"2025","journal-title":"Ther Deliv"},{"key":"10.1016\/j.drudis.2026.104770_b0050","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.3390\/polym13203476","article-title":"Design and evaluation of losartan potassium effervescent floating matrix tablets: in vivo x-ray imaging and pharmacokinetic studies in albino rabbits","volume":"13","author":"Rahamathulla","year":"2021","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.drudis.2026.104770_b0055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5530\/ijper.48.3.10","article-title":"Gamascintigraphic in vivo-in vitro evaluation of floating matrix tablet","volume":"48","author":"Shinde","year":"2014","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.drudis.2026.104770_b0060","first-page":"367","article-title":"Oral sustained delivery of atenolol from floating matrix tablets - formulation and in vitro evaluation","volume":"31","author":"Srivastava","year":"2005","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0065","first-page":"325","article-title":"Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation","volume":"30","author":"Wadekar","year":"2011","journal-title":"Lat Am J Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0070","article-title":"HPMC\/Carbopol based extended release gastroretentive dosage form of losartan potassium: Formulation and in vivo pharmacokinetic evaluation in rabbits","volume":"60","author":"Wani","year":"2020","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104770_b0075","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1166\/jbt.2016.1413","article-title":"Gastroretentive floating microspheres of carvedilol: preparation, in vitro and in vivo characterization","volume":"6","author":"Zhang","year":"2016","journal-title":"J Biomater Tissue Eng"},{"key":"10.1016\/j.drudis.2026.104770_b0080","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.4314\/tjpr.v14i10.2","article-title":"Formulation optimization and in-vitro evaluation of oral floating captopril matrix tablets using factorial design","volume":"14","author":"Ahsan","year":"2015","journal-title":"Trop J Pharm Res"},{"key":"10.1016\/j.drudis.2026.104770_b0085","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1208\/s12249-017-0805-2","article-title":"Development of novel high density gastroretentive multiparticulate pulsatile tablet of clopidogrel bisulfate using quality by design approach","volume":"18","author":"Desai","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0090","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1208\/s12249-017-0731-3","article-title":"Design and development of clopidogrel bisulfate gastroretentive osmotic formulation using quality by design tools","volume":"18","author":"Desai","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0095","doi-asserted-by":"crossref","first-page":"18023","DOI":"10.1007\/s00210-025-04330-5","article-title":"Quality by design approach for nifedipine-adsorbed fluorite-loaded calcium-low methoxy pectin beads to impart chronotherapy: in vitro and in vivo assessment","volume":"398","author":"Jagtap","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.drudis.2026.104770_b0100","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.5530\/ijper.56.4.183","article-title":"Dual-pulse release system of atenolol: preparation and in-vitro characterization","volume":"56","author":"Kunjekar","year":"2022","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.drudis.2026.104770_b0105","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/10837450.2024.2352491","article-title":"Design and fabrication of 3D-printed gastric floating tablets of captopril: effect of geometry and thermal crosslinking of polymer on floating behavior and drug release","volume":"29","author":"Mohammed","year":"2024","journal-title":"Pharm Dev Technol"},{"key":"10.1016\/j.drudis.2026.104770_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2025.104340","article-title":"Gastroretentive drug delivery systems: a holy grail in oral delivery","volume":"30","author":"Omidian","year":"2025","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.drudis.2026.104770_b0115","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4314\/tjpr.v9i2.53707","article-title":"Formulation and evaluation of gastro-retentive floating multi-particulate system of metoprolol tartarate","volume":"9","author":"Baskar","year":"2010","journal-title":"Trop J Pharm Res"},{"key":"10.1016\/j.drudis.2026.104770_b0120","first-page":"975","article-title":"Losartan potassium-loaded linseed polysaccharide-alginate-calcium silicate biomucoadhesive-floating beads for gastroretentive delivery","volume":"63","author":"Behera","year":"2024","journal-title":"Polym Plast Technol Mater"},{"key":"10.1016\/j.drudis.2026.104770_b0125","doi-asserted-by":"crossref","first-page":"S254","DOI":"10.5530\/ijper.50.3.36","article-title":"Formulation and evaluation of controlled release gastro-retentive in situ gel for diltiazem hydrochloride","volume":"50","author":"Bobade","year":"2016","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.drudis.2026.104770_b0130","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1208\/s12249-019-1521-x","article-title":"Preparation and in vitro evaluation of FDM 3D-printed ellipsoid-shaped gastric floating tablets with low infill percentages","volume":"21","author":"Chen","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0135","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejps.2009.10.015","article-title":"Development of swelling\/floating gastroretentive drug delivery system based on a combination of hydroxyethyl cellulose and sodium carboxymethyl cellulose for Losartan and its clinical relevance in healthy volunteers with CYP2C9 polymorphism","volume":"39","author":"Chen","year":"2010","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.drudis.2026.104770_b0140","doi-asserted-by":"crossref","first-page":"935","DOI":"10.4314\/tjpr.v14i6.1","article-title":"Floating microparticulate oral diltiazem hydrochloride delivery system for improved delivery to heart","volume":"14","author":"Cheng","year":"2015","journal-title":"Trop J Pharm Res"},{"key":"10.1016\/j.drudis.2026.104770_b0145","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/396106","article-title":"Formulation and evaluation of fixed-dose combination of bilayer gastroretentive matrix tablet containing atorvastatin as fast-release and atenolol as sustained-release","volume":"2014","author":"Dey","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.drudis.2026.104770_b0150","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/22297928.2022.2132876","article-title":"Formulation and characterization of carvedilol in situ gels for oral delivery-in vitro and in vivo pharmacokinetic studies","volume":"12","author":"Harika","year":"2022","journal-title":"Anal Chem Lett"},{"key":"10.1016\/j.drudis.2026.104770_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3897\/pharmacia.71.e133399","article-title":"Novel propranolol-loaded gastro-floating 3D-printed devices with zero-order release kinetics","volume":"71","author":"Jaiseri","year":"2024","journal-title":"Pharmacia"},{"key":"10.1016\/j.drudis.2026.104770_b0160","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1208\/s12249-018-1265-z","article-title":"Development of valsartan floating matrix tablets using low density polypropylene foam powder: in vitro and in vivo evaluation","volume":"20","author":"Rahamathulla","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119185","article-title":"Preparation and evaluation of captopril loaded gastro-retentive zein based porous floating tablets","volume":"579","author":"Raza","year":"2020","journal-title":"Int J Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0170","doi-asserted-by":"crossref","first-page":"442","DOI":"10.9734\/jpri\/2021\/v33i44B32696","article-title":"Preparation and evaluation of captopril oral floating controlled release formulations","volume":"33","author":"Vydana","year":"2021","journal-title":"J Pharm Res Int"},{"key":"10.1016\/j.drudis.2026.104770_b0175","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3109\/10717544.2013.834414","article-title":"Floating microspheres of carvedilol as gastro retentive drug delivery system: 32 full factorial design and in vitro evaluation","volume":"21","author":"Nila","year":"2014","journal-title":"Drug Deliv"},{"key":"10.1016\/j.drudis.2026.104770_b0180","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.ijbiomac.2017.04.067","article-title":"In vitro and in vivo evaluation of gastro-retentive carvedilol loaded chitosan beads using Gastroplus\u2122","volume":"102","author":"Praveen","year":"2017","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.drudis.2026.104770_b0185","doi-asserted-by":"crossref","first-page":"S316","DOI":"10.5530\/ijper.58.1s.34","article-title":"Preparation, in vitro and in vivo characteristics of floating in situ gel of carvedilol using semi synthetic and natural polymers to enhance the oral bioavailability","volume":"58","author":"Ramalingam","year":"2024","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.drudis.2026.104770_b0190","doi-asserted-by":"crossref","first-page":"620","DOI":"10.2174\/1567201811310050013","article-title":"Formulation and evaluation of non-effervescent floating tablets of losartan potassium","volume":"10","author":"Getyala","year":"2013","journal-title":"Curr Drug Deliv"},{"key":"10.1016\/j.drudis.2026.104770_b0195","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1773-2247(13)50093-1","article-title":"Development of floating matrix tablets of losartan potassium: in vitro and in vivo evaluation","volume":"23","author":"Saisivam","year":"2013","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104770_b0200","first-page":"4915","article-title":"Formulation and evaluation of floating tablets of diltiazem employing hydroxy propyl methyl cellulose and carbopol","volume":"23","author":"Chowdary","year":"2011","journal-title":"Asian J Chem"},{"key":"10.1016\/j.drudis.2026.104770_b0205","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3109\/03639045.2012.763138","article-title":"Formulation, in vitro evaluation and study of variables on tri-layered gastro-retentive delivery system of diltiazem HCl","volume":"40","author":"Desai","year":"2014","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0210","first-page":"1364","article-title":"In vitro and in vivo evaluation of floating controlled release dosage forms of verapamil hydrochloride","volume":"66","author":"Elkheshen","year":"2004","journal-title":"Pharm Ind"},{"key":"10.1016\/j.drudis.2026.104770_b0215","doi-asserted-by":"crossref","first-page":"E166","DOI":"10.1208\/pt0803073","article-title":"Development and in vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride","volume":"8","author":"Gambhire","year":"2007","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0220","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ijbiomac.2021.01.199","article-title":"Gellan gum based gastroretentive tablets for bioavailability enhancement of cilnidipine in human volunteers","volume":"174","author":"Karemore","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.drudis.2026.104770_b0225","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1208\/s12249-009-9210-9","article-title":"Development and in vivo floating behavior of verapamil HCl intragastric floating tablets","volume":"10","author":"Patel","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0230","doi-asserted-by":"crossref","first-page":"60","DOI":"10.5530\/ijper.48.3.8","article-title":"Optimization of diltiazem hydrochloride loaded mucoadhesive floating microspheres using calcium carbonate as gas generating agent as floatation aid","volume":"48","author":"Patel","year":"2014","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.drudis.2026.104770_b0235","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/02652048.2012.655330","article-title":"Development of photostable gastro retentive formulation for nifedipine using low-density polypropylene microporous particles","volume":"29","author":"Pawar","year":"2012","journal-title":"J Microencapsul"},{"key":"10.1016\/j.drudis.2026.104770_b0240","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0939-6411(01)00189-8","article-title":"Pharmacokinetics of verapamil and norverapamil from controlled release floating pellets in humans","volume":"53","author":"Sawicki","year":"2002","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.drudis.2026.104770_b0245","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejpb.2004.11.003","article-title":"Compressibility of floating pellets with verapamil hydrochloride coated with dispersion Kollicoat SR 30 D","volume":"60","author":"Sawicki","year":"2005","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.drudis.2026.104770_b0250","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1080\/15363830903132875","article-title":"Carbon nanotube as adsorbent for floating microspheres of diltiazem hydrochloride","volume":"17","author":"Shah","year":"2009","journal-title":"Fullerenes Nanotubes Carbon Nanostruct"},{"key":"10.1016\/j.drudis.2026.104770_b0255","doi-asserted-by":"crossref","first-page":"861","DOI":"10.4314\/tjpr.v12i6.1","article-title":"Formulation and optimization of gastric bioadhesive tablets of diltiazem hydrochloride using central composite design","volume":"12","author":"Sharma","year":"2013","journal-title":"Trop J Pharm Res"},{"key":"10.1016\/j.drudis.2026.104770_b0260","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1208\/pt050343","article-title":"Preparation and evaluation of diltiazem hydrochloride-Gelucire 43\/01 floating granules prepared by melt granulation","volume":"5","author":"Shimpi","year":"2004","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0265","first-page":"1841","article-title":"Formulation and evaluation of floating matrix tablet for controlled drug release","volume":"6","author":"Shivhare","year":"2011","journal-title":"Dig J Nanomater Biostruct"},{"key":"10.1016\/j.drudis.2026.104770_b0270","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/app.23192","article-title":"Effect of coexcipients on drug release and floating property of nifedipine hollow microspheres: a novel gastro retentive drug delivery system","volume":"100","author":"Soppimath","year":"2006","journal-title":"J Appl Polym Sci"},{"key":"10.1016\/j.drudis.2026.104770_b0275","first-page":"667","article-title":"Nifedipine gastro retentive drug delivery system: formulation, characterization and evaluation","volume":"85","author":"Ughade","year":"2023","journal-title":"Indian J Pharm Sci"},{"key":"10.1016\/j.drudis.2026.104770_b0280","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.5897\/AJPP11.525","article-title":"Formulation development and characterization of propranolol hydrochloride microballoons for gastroretentive floating drug delivery","volume":"5","author":"Yadav","year":"2011","journal-title":"Afr J Pharm Pharmacol"},{"key":"10.1016\/j.drudis.2026.104770_b0285","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s12272-010-0314-2","article-title":"Polymer blends used to prepare nifedipine loaded hollow microspheres for a floating-type oral drug delivery system: in vitro evaluation","volume":"33","author":"Zhao","year":"2010","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.drudis.2026.104770_b0290","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2008-2231-20-21","article-title":"Statistical optimization of a novel excipient (CMEC) based gastro retentive floating tablets of propranolol HCl and it's in vivo buoyancy characterization in healthy human volunteers","volume":"20","author":"Meka","year":"2012","journal-title":"Daru"},{"key":"10.1016\/j.drudis.2026.104770_b0295","first-page":"60","article-title":"Design and in vitro evaluation of effervescent gastric floating drug delivery systems of propanolol HCl","volume":"53","author":"Meka","year":"2012","journal-title":"Invest Clin"},{"key":"10.1016\/j.drudis.2026.104770_b0300","first-page":"1373","article-title":"Formulation and optimization of gastric floating drug delivery system using Central composite design and its biopharmaceutical evaluation","volume":"28","author":"Meka","year":"2015","journal-title":"Pak J Pharm Sci"},{"key":"10.1016\/j.drudis.2026.104770_b0305","doi-asserted-by":"crossref","first-page":"971","DOI":"10.2174\/1567201812666151009115756","article-title":"formulation of gastric floating system using bio-sourced Terminalia catappa gum and in vivo evaluation","volume":"13","author":"Meka","year":"2016","journal-title":"Curr Drug Deliv"},{"key":"10.1016\/j.drudis.2026.104770_b0310","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/03639045.2012.744416","article-title":"Thermal sintering: a novel technique used in the design, optimization and biopharmaceutical evaluation of propranolol HCl gastric floating tablets","volume":"40","author":"Srikanth","year":"2014","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0315","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1208\/s12249-010-9468-y","article-title":"Floating tablet of trimetazidine dihydrochloride: an approach for extended release with zero-order kinetics","volume":"11","author":"Abdelbary","year":"2010","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0320","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1080\/03639045.2017.1413111","article-title":"Development of sustained release gastro-retentive tablet formulation of nicardipine hydrochloride using quality by design (QbD) approach","volume":"44","author":"Chudiwal","year":"2018","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0325","first-page":"2019","article-title":"Formulation and in-vitro evaluation of floating bilayer tablet of lisinopril maleate and metoprolol tartrate","volume":"28","author":"Ijaz","year":"2015","journal-title":"Pak J Pharm Sci"},{"key":"10.1016\/j.drudis.2026.104770_b0330","first-page":"38","article-title":"Formulation and evaluation of sustained release floating capsules of nicardipine hydrochloride","volume":"58","author":"Moursy","year":"2003","journal-title":"Pharmazie"},{"key":"10.1016\/j.drudis.2026.104770_b0335","doi-asserted-by":"crossref","first-page":"E23","DOI":"10.1208\/pt070234","article-title":"Optimization of bilayer floating tablet containing metoprolol tartrate as a model drug for gastric retention","volume":"7","author":"Narendra","year":"2006","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0340","first-page":"259","article-title":"Formulation and evaluation of bilayer floating tablets of trimetazidine hydrochloride and metoprolol succinate","volume":"46","author":"Santhanalakshmi","year":"2012","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.drudis.2026.104770_b0345","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2174\/15672018113106660065","article-title":"A gastroretentive drug delivery system of lisinopril imbibed on isabgol-husk","volume":"11","author":"Semwal","year":"2014","journal-title":"Curr Drug Deliv"},{"key":"10.1016\/j.drudis.2026.104770_b0350","doi-asserted-by":"crossref","first-page":"34","DOI":"10.14227\/DT170310P34","article-title":"Formulation and characterization of floating gelucire matrices of metoprolol succinate","volume":"17","author":"Siripuram","year":"2010","journal-title":"Dissolution Technol"},{"key":"10.1016\/j.drudis.2026.104770_b0355","doi-asserted-by":"crossref","first-page":"260","DOI":"10.5530\/ijper.49.4.7","article-title":"Effect of sodium alginate in combination with HPMC K 100 M in extending the release of metoprolol succinate from its gastro-retentive floating tablets","volume":"49","author":"Thulluru","year":"2015","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.drudis.2026.104770_b0360","doi-asserted-by":"crossref","first-page":"140","DOI":"10.26650\/IstanbulJPharm.2023.1061291","article-title":"Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery","volume":"53","author":"Sabale","year":"2023","journal-title":"Istanbul J Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0365","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s13318-014-0194-9","article-title":"Development of hollow\/porous floating beads of metoprolol for pulsatile drug delivery","volume":"40","author":"Taranalli","year":"2015","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1016\/j.drudis.2026.104770_b0370","first-page":"527","article-title":"Pharmacokinetics and pharmacodynamics of diltiazem floating tablets","volume":"13","author":"Gu","year":"1992","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.drudis.2026.104770_b0375","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3390\/pharmaceutics14020350","article-title":"In vitro and in vivo studies of a verapamil-containing gastroretentive solid foam capsule","volume":"14","author":"Haimhoffer","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.drudis.2026.104770_b0380","article-title":"Multistage release matrices for potential antiplatelet therapy: assessing the impact of polymers and Sorb-Cel M\u00ae on floating, swelling, and release behavior","volume":"55","author":"Hammad","year":"2020","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104770_b0385","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.22377\/ajp.v18i04.5856","article-title":"Development and evaluation of gastroretentive floating bilayer tablets containing ivabradine hydrochloride and trimetazidine dihydrochloride","volume":"18","author":"Jadhav","year":"2024","journal-title":"Asian J Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0390","doi-asserted-by":"crossref","first-page":"S890","DOI":"10.5530\/ijper.20252275","article-title":"Quality by design based formulation and development of a novel bi-compound pharmaceutical capsule: an innovative approach for the treatment of hypertension","volume":"59","author":"Rabiya","year":"2025","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.drudis.2026.104770_b0395","doi-asserted-by":"crossref","first-page":"458","DOI":"10.4172\/pharmaceutical-sciences.1000140","article-title":"Formulation and evaluation of gastro-bilayer floating tablets of simvastatin as immediate release layer and atenolol as sustained release layer","volume":"78","author":"Swain","year":"2016","journal-title":"Indian J Pharm Sci"},{"key":"10.1016\/j.drudis.2026.104770_b0400","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.5530\/ijper.53.2s.53","article-title":"Formulation and evaluation of gastro-bilayer floating tablets of ezetimibe as immediate release layer and atenolol as sustained release layer","volume":"53","author":"Swain","year":"2019","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.drudis.2026.104770_b0405","first-page":"P1","article-title":"Design and development of captopril gastro-retentive tablet using natural polymers of maize and jowar plant","volume":"13","author":"Gayakwad","year":"2023","journal-title":"Int J Life Sci Pharma Res"},{"key":"10.1016\/j.drudis.2026.104770_b0410","first-page":"1001","article-title":"Development and in vitro evaluation of swellable floating formulation of captopril","volume":"33","author":"Hafiz","year":"2014","journal-title":"Lat Am J Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0415","doi-asserted-by":"crossref","first-page":"731","DOI":"10.31083\/ph.2008.8096","article-title":"Influence of the components of Kollicoat SR film on mechanical properties of floating pellets from the point of view of tableting","volume":"63","author":"Luni","year":"2008","journal-title":"Pharmazie"},{"key":"10.1016\/j.drudis.2026.104770_b0420","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271442","article-title":"Influence of Prunus domestica gum on the release profiles of propranolol HCl floating tablets","volume":"17","author":"Mehmood","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.drudis.2026.104770_b0425","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1208\/s12249-012-9873-5","article-title":"Characterization and In vitro drug release studies of a natural polysaccharide Terminalia catappa gum (Badam gum)","volume":"13","author":"Meka","year":"2012","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0430","first-page":"223","article-title":"Thermal sintering: a novel technique in the design of gastroretentive floating tablets of propranolol HCl and its evaluation","volume":"53","author":"Meka","year":"2012","journal-title":"Invest Clin"},{"key":"10.1016\/j.drudis.2026.104770_b0435","first-page":"572","article-title":"Development of gastroretentive floating tablets of diltiazem hydrochloride and its statistical optimization","volume":"64","author":"Meka","year":"2016","journal-title":"Farmacia"},{"key":"10.1016\/j.drudis.2026.104770_b0440","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s13346-016-0315-x","article-title":"Risk-based approach for systematic development of gastroretentive drug delivery system","volume":"6","author":"Mirani","year":"2016","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.drudis.2026.104770_b0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124215","article-title":"Amorphous solid dispersion of a binary formulation with felodipine and HPMC for 3D printed floating tablets","volume":"658","author":"Mora-Casta\u00f1o","year":"2024","journal-title":"Int J Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0450","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3390\/pharmaceutics14020281","article-title":"FDM 3D-printed sustained-release gastric-floating verapamil hydrochloride formulations with cylinder, capsule and hemisphere shapes, and low infill percentage","volume":"14","author":"Qian","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.drudis.2026.104770_b0455","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s12247-020-09440-6","article-title":"Fibroin-alginate scaffold for design of floating microspheres containing felodipine","volume":"16","author":"Rathod","year":"2021","journal-title":"J Pharm Innov"},{"key":"10.1016\/j.drudis.2026.104770_b0460","first-page":"2004","article-title":"Effect of drug properties on formulation properties of eudragit non effervescent floating microparticulates","volume":"30","author":"Singh","year":"2011","journal-title":"Lat Am J Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0465","doi-asserted-by":"crossref","first-page":"16704","DOI":"10.1038\/s41598-025-95732-1","article-title":"Formulation optimization of furosemide floating-bioadhesive matrix tablets using waste-derived Citrus aurantifolia peel pectin as a polymer","volume":"15","author":"Siraj","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2026.104770_b0470","first-page":"411","article-title":"Thermal sintering: a novel technique used in the design of gastroretentive floating tablets of propranolol HCl and its statistical optimization using Box-Behnken design","volume":"60","author":"Srikanth","year":"2012","journal-title":"Farmacia"},{"key":"10.1016\/j.drudis.2026.104770_b0475","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ejpb.2007.12.009","article-title":"New insights on poly(vinyl acetate)-based coated floating tablets: characterisation of hydration and CO2 generation by benchtop MRI and its relation to drug release and floating strength","volume":"69","author":"Str\u00fcbing","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.drudis.2026.104770_b0480","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jconrel.2007.11.013","article-title":"Characterization of poly(vinyl acetate) based floating matrix tablets","volume":"126","author":"Str\u00fcbing","year":"2008","journal-title":"J Control Release"},{"key":"10.1016\/j.drudis.2026.104770_b0485","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4103\/epj.epj_29_21","article-title":"Formulation and evaluation of mucoadhesive tablets of furosemide by design of experiment","volume":"20","author":"Thimmaraju","year":"2021","journal-title":"Egypt Pharm J"},{"key":"10.1016\/j.drudis.2026.104770_b0490","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/4322375","article-title":"Formulation and in vitro evaluation of furosemide floating matrix tablets using Boswellia papyrifera resin as matrix forming polymer","volume":"2023","author":"Yehualaw","year":"2023","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.drudis.2026.104770_b0495","article-title":"Prescription optimization of gastroretentive furosemide hollow-bioadhesive microspheres via Box-Behnken design: in vitro characterization and in vivo evaluation","volume":"70","author":"Meng","year":"2022","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104770_b0500","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1081\/DDC-100101323","article-title":"Captopril floating and\/or bioadhesive tablets: design and release kinetics","volume":"26","author":"Nur","year":"2000","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0505","first-page":"10906","article-title":"Formulation and evaluation of biphasic gastro floating tablets of nateglinide and atenolol","volume":"11","author":"Gupta","year":"2021","journal-title":"Biointerface Res Appl Chem"},{"key":"10.1016\/j.drudis.2026.104770_b0510","first-page":"15","article-title":"Development and evaluation of regioselective bilayer floating tablets of atenolol and lovastatin for biphasic release profile","volume":"8","author":"Kulkarni","year":"2009","journal-title":"Iran J Pharm Res"},{"key":"10.1016\/j.drudis.2026.104770_b0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e05459","article-title":"Formulation and evaluation of gastro-retentive floating bilayer tablet for the treatment of hypertension","volume":"6","author":"Maddiboyina","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.drudis.2026.104770_b0520","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3109\/03639045.2015.1096279","article-title":"Designing of the fixed-dose gastroretentive bilayer tablet for sustained release of metformin and immediate release of atorvastatin","volume":"42","author":"Oh","year":"2016","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0525","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijbiomac.2015.11.039","article-title":"Tapioca starch blended alginate mucoadhesive-floating beads for intragastric delivery of metoprolol tartrate","volume":"83","author":"Biswas","year":"2016","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.drudis.2026.104770_b0530","article-title":"Predicting pharmacokinetic parameters by convolution: an in vitro approach for investigating bifunctional capsulated dosage form","volume":"60","author":"Porwal","year":"2020","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104770_b0535","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2478\/v10007-010-0031-x","article-title":"Development and optimization of metoprolol succinate gastroretentive drug delivery system","volume":"60","author":"Boldhane","year":"2010","journal-title":"Acta Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0540","doi-asserted-by":"crossref","first-page":"322","DOI":"10.2174\/1574885516666210609123207","article-title":"Quality by design enabled anti-hypertensive floating drug delivery system by risk assessment and design of experiment (DoE)-in vitro-in vivo correlation studies","volume":"16","author":"Chidurala","year":"2021","journal-title":"Curr Drug Ther"},{"key":"10.1016\/j.drudis.2026.104770_b0545","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijbiomac.2014.01.049","article-title":"Polymers derived from Xanthomonas campesteris and Cyamopsis tetragonolobus used as retardant materials for the formulation of sustained release floating matrix tablet of atenolol","volume":"65","author":"Dey","year":"2014","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.drudis.2026.104770_b0550","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1208\/s12249-019-1391-2","article-title":"Formulation, optimization, and in vivo evaluation of gastroretentive drug delivery system of nifedipine for the treatment of preeclampsia","volume":"20","author":"Karemore","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0555","article-title":"QbD-based development of extended-release floating furosemide tablets: formulation and in vitro\/in vivo evaluation","volume":"113","author":"Rodriguez","year":"2025","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104770_b0560","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4103\/0250-474X.169036","article-title":"Design, development and optimization of S (-) atenolol floating sustained release matrix tablets using surface response methodology","volume":"77","author":"Gunjal","year":"2015","journal-title":"Indian J Pharm Sci"},{"key":"10.1016\/j.drudis.2026.104770_b0565","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12247-024-09831-z","article-title":"Enhancing the entrapment efficiency of alginate floating beads using double emulsion technique","volume":"19","author":"Alazzo","year":"2024","journal-title":"J Pharm Innov"},{"key":"10.1016\/j.drudis.2026.104770_b0570","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1208\/s12249-008-9090-4","article-title":"Preparation of a matrix type multiple-unit gastro retentive floating drug delivery system for captopril based on gas formation technique: in vitro evaluation","volume":"9","author":"Meka","year":"2008","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.drudis.2026.104770_b0575","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1002\/jps.21562","article-title":"Design and evaluation of polymeric coated minitablets as multiple unit gastroretentive floating drug delivery systems for furosemide","volume":"98","author":"Meka","year":"2009","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.drudis.2026.104770_b0580","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijbiomac.2015.02.026","article-title":"Alginate beads of Captopril using galactomannan containing Senna tora gum, guar gum and locust bean gum","volume":"76","author":"Pawar","year":"2015","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.drudis.2026.104770_b0585","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4314\/tjpr.v16i6.5","article-title":"Herbal carrier-based floating microparticles of diltiazem hydrochloride for improved cardiac activity","volume":"16","author":"Zhou","year":"2017","journal-title":"Trop J Pharm Res"},{"key":"10.1016\/j.drudis.2026.104770_b0590","first-page":"428","article-title":"Preparation and evaluation of mucoadhesive nanoparticles of rosuvastatin","volume":"80","author":"Sangave","year":"2018","journal-title":"Indian J Pharm Sci"},{"key":"10.1016\/j.drudis.2026.104770_b0595","doi-asserted-by":"crossref","first-page":"S848","DOI":"10.5530\/ijper.58.3s.86","article-title":"Development and evaluation of gastroretentive bioadhesive tablet of atenolol using a naturally occurring biodegradable polymer","volume":"58","author":"Soman","year":"2024","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.drudis.2026.104770_b0600","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jddst.2017.05.026","article-title":"Valsartan floating bioadhesive compression-coated mini-tablets: Formulation and pharmacokinetics","volume":"40","author":"Vemula","year":"2017","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.drudis.2026.104770_b0605","first-page":"5277","article-title":"Formulation and evaluation of floating tablets of diltiazem employing olibanum gum","volume":"22","author":"Chowdary","year":"2010","journal-title":"Asian J Chem"},{"key":"10.1016\/j.drudis.2026.104770_b0610","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1080\/14786419.2022.2140154","article-title":"Exploration of Cassia fistula L. seed mucilage into floating drug delivery system","volume":"37","author":"Gaikwad","year":"2023","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.drudis.2026.104770_b0615","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ijpharm.2008.05.040","article-title":"Sustained delivery of captopril from floating matrix tablets","volume":"362","author":"Jim\u00e9nez-Mart\u00ednez","year":"2008","journal-title":"Int J Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0620","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3109\/10837450903110737","article-title":"Effect of antioxidants on captopril floating matrices","volume":"15","author":"Jim\u00e9nez-Mart\u00ednez","year":"2010","journal-title":"Pharm Dev Technol"},{"key":"10.1016\/j.drudis.2026.104770_b0625","first-page":"1396","article-title":"Development and optimization of gastro retentive floating tablets of atorvastatin calcium using simplex lattice design","volume":"32","author":"Hosny","year":"2013","journal-title":"Lat Am J Pharm"},{"key":"10.1016\/j.drudis.2026.104770_b0630","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1179\/1753555714Y.0000000199","article-title":"Development of ranolazine loaded floating biomaterial gellan beads using Box-Behnken factorial design","volume":"30","author":"Pawar","year":"2015","journal-title":"Mater Technol"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644626001753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644626001753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:17:18Z","timestamp":1790093838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644626001753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":126,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1359644626001753"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2026.104770","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastric retention for cardiovascular therapy: matching drug properties, dosage-form design, and translational evidence","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2026.104770","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104770"}}