{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:08:27Z","timestamp":1790096907541,"version":"4.0.1"},"reference-count":130,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"India Ministry of Science & Technology Department of Science and Technology","doi-asserted-by":"publisher","award":["DST\/TDT\/TC\/KSM\/2022\/05(G)"],"award-info":[{"award-number":["DST\/TDT\/TC\/KSM\/2022\/05(G)"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005116","name":"JNCASR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024591","name":"National Institute of Pharmaceutical Education and Research, Kolkata","doi-asserted-by":"publisher","award":["DoP-NIPERK\/2023\/CMT\/01\/30 March 2023"],"award-info":[{"award-number":["DoP-NIPERK\/2023\/CMT\/01\/30 March 2023"]}],"id":[{"id":"10.13039\/501100024591","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.drudis.2026.104778","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:07:53Z","timestamp":1787267273000},"page":"104778","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological targeting of GCN5\/PCAF (KAT2A\/B): current drug discovery strategies and translational potential"],"prefix":"10.1016","volume":"31","author":[{"given":"Priyanka","family":"Pandey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajjval","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritam","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourav","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapas K.","family":"Kundu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2026.104778_b0005","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/35073047","article-title":"Protein modules that manipulate histone tails for chromatin regulation","volume":"2","author":"Marmorstein","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0010","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd4360","article-title":"Histone deacetylases and their inhibitors in cancer, neurological diseases, and immune disorders","volume":"13","author":"Falkenberg","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.drudis.2026.104778_b0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13148-021-01069-7","article-title":"Advances in epigenetic therapeutics with focus on solid tumors","volume":"13","author":"Jin","year":"2021","journal-title":"Clin Epigenetics"},{"issue":"3","key":"10.1016\/j.drudis.2026.104778_b0020","first-page":"e173","article-title":"Targeting epigenetic regulators for inflammation: mechanisms and intervention therapy","volume":"2022","author":"Zhang","year":"2020","journal-title":"MedComm"},{"key":"10.1016\/j.drudis.2026.104778_b0025","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3389\/fphar.2020.01243","article-title":"Lysine acetyltransferase inhibitors from natural sources","volume":"11","author":"Fiorentino","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.drudis.2026.104778_b0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gene.2005.09.010","article-title":"Acetylation and deacetylation of non-histone proteins","volume":"363","author":"Glozak","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.drudis.2026.104778_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2022.102255","article-title":"KATs off: biomedical insights from lysine acetyltransferase inhibitors","volume":"72","author":"Whedon","year":"2023","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0040","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41573-024-01080-6","article-title":"Targeting lysine acetylation readers and writers","volume":"24","author":"Zhou","year":"2025","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.drudis.2026.104778_b0045","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1128\/MCB.19.2.1202","article-title":"p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage","volume":"19","author":"Liu","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0050","doi-asserted-by":"crossref","first-page":"26562","DOI":"10.1074\/jbc.M605391200","article-title":"PCAF modulates PTEN activity","volume":"281","author":"Okumura","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0055","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/20974","article-title":"Structure and ligand of a histone acetyltransferase bromodomain","volume":"399","author":"Dhalluin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2026.104778_b0060","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1002\/j.1460-2075.1992.tb05507.x","article-title":"Two distinct yeast transcriptional activators require the function of GCN5 protein to promote normal levels of transcription","volume":"11","author":"Georgakopoulos","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/j.drudis.2026.104778_b0065","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0092-8674(00)81063-6","article-title":"Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation","volume":"84","author":"Brownell","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2026.104778_b0070","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/382319a0","article-title":"A p300\/CBP-associated factor that competes with the adenoviral oncoprotein E1A","volume":"382","author":"Yang","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2026.104778_b0075","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/emboj.2010.318","article-title":"Distinct roles of GCN5\/PCAF-mediated H3K9ac and CBP\/p300-mediated H3K18\/27ac in nuclear receptor transactivation","volume":"30","author":"Jin","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.drudis.2026.104778_b0080","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/CS20200986","article-title":"The GCN5: its biological functions and therapeutic potentials","volume":"135","author":"Haque","year":"2021","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.drudis.2026.104778_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/b2bf9c2e-90a9-4228-9b38-2f1bc977a437","article-title":"Quantitating the specificity and selectivity of Gcn5-mediated acetylation of histone H3","volume":"8","author":"Kuo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.drudis.2026.104778_b0090","doi-asserted-by":"crossref","first-page":"9411","DOI":"10.1074\/jbc.M809617200","article-title":"The Gcn5 bromodomain of the SAGA complex facilitates cooperative and cross-tail acetylation of nucleosomes","volume":"284","author":"Li","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0095","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1002\/j.1460-2075.1994.tb06806.x","article-title":"Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors","volume":"13","author":"Marcus","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.drudis.2026.104778_b0100","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1006\/jmbi.2001.4859","article-title":"Structure of histone acetyltransferases","volume":"311","author":"Marmorstein","year":"2001","journal-title":"J Mol Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0105","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1093\/emboj\/18.13.3521","article-title":"Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A","volume":"18","author":"Clements","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.drudis.2026.104778_b0110","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1101\/gad.11.13.1640","article-title":"Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt\/Ada) complex","volume":"11","author":"Grant","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.drudis.2026.104778_b0115","doi-asserted-by":"crossref","first-page":"10010","DOI":"10.1073\/pnas.1805343115","article-title":"Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2","volume":"115","author":"Sun","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.drudis.2026.104778_b0120","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1038\/sj.onc.1210604","article-title":"Distinct GCN5\/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation","volume":"26","author":"Nagy","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.drudis.2026.104778_b0125","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/s12276-020-0463-4","article-title":"Dynamic modules of the coactivator SAGA in eukaryotic transcription","volume":"52","author":"Cheon","year":"2020","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.drudis.2026.104778_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114835","article-title":"Emerging role of GCN5 in human diseases and its therapeutic potential","volume":"165","author":"Xiao","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.drudis.2026.104778_b0135","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1073\/pnas.95.7.3561","article-title":"ESA1 is a histone acetyltransferase that is essential for growth in yeast","volume":"95","author":"Smith","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.drudis.2026.104778_b0140","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1093\/nar\/26.12.2948","article-title":"Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members","volume":"26","author":"Smith","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.drudis.2026.104778_b0145","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1128\/MCB.18.10.5659","article-title":"Mammalian GCN5 and P\/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates","volume":"18","author":"Xu","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0150","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/21922","article-title":"Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A","volume":"400","author":"Lin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2026.104778_b0155","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/43487","article-title":"Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide","volume":"401","author":"Rojas","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2026.104778_bib646","doi-asserted-by":"crossref","first-page":"8931","DOI":"10.1073\/pnas.96.16.8931","volume":"96","author":"Trievel","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.drudis.2026.104778_b0160","doi-asserted-by":"crossref","first-page":"14065","DOI":"10.1073\/pnas.222373899","article-title":"Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor","volume":"99","author":"Poux","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.drudis.2026.104778_b0165","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/prot.21407","article-title":"Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A","volume":"68","author":"Schuetz","year":"2007","journal-title":"Proteins"},{"key":"10.1016\/j.drudis.2026.104778_b0170","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1472-6807-14-2","article-title":"Dimeric structure of p300\/CBP associated factor","volume":"14","author":"Shi","year":"2014","journal-title":"BMC Struct Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0175","doi-asserted-by":"crossref","first-page":"14366","DOI":"10.1021\/bi035632n","article-title":"Molecular basis for Gcn5\/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates","volume":"42","author":"Poux","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.drudis.2026.104778_b0180","doi-asserted-by":"crossref","first-page":"18157","DOI":"10.1074\/jbc.274.26.18157","article-title":"Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator","volume":"274","author":"Tanner","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0185","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41576-018-0072-4","article-title":"The many lives of KATs \u2013 detectors, integrators and modulators of the cellular environment","volume":"20","author":"Sheikh","year":"2019","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.drudis.2026.104778_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagrm.2020.194609","article-title":"Complex functions of Gcn5 and Pcaf in development and disease","volume":"1864","author":"Koutelou","year":"2021","journal-title":"Biochim Biophys Acta, Gene Regul Mech"},{"key":"10.1016\/j.drudis.2026.104778_b0195","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1158\/0008-5472.CAN-20-2379","article-title":"Transcriptional activation of MYC-induced genes by GCN5 promotes B-cell lymphomagenesis","volume":"80","author":"Farria","year":"2020","journal-title":"Cancer Res"},{"key":"10.1016\/j.drudis.2026.104778_b0200","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.3390\/ijms18071449","article-title":"Differential effects of histone acetyltransferase GCN5 or PCAF knockdown on urothelial carcinoma cells","volume":"18","author":"Koutsogiannouli","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2026.104778_b0205","first-page":"3955","article-title":"Function of GCN5 in TGF-\u03b21-induced epithelial-to-mesenchymal transition in breast cancer","volume":"16","author":"Zhao","year":"2018","journal-title":"Oncol Lett"},{"key":"10.1016\/j.drudis.2026.104778_b0210","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.bbrc.2015.02.036","article-title":"The oncoprotein HBXIP promotes migration of breast cancer cells via GCN5-mediated microtubule acetylation","volume":"458","author":"Li","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.drudis.2026.104778_b0215","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ncb1545","article-title":"Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2","volume":"9","author":"Linares","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0220","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.1158\/0008-5472.CAN-12-4660","article-title":"Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation","volume":"73","author":"Malatesta","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.drudis.2026.104778_b0225","first-page":"2772","article-title":"PCAF acts as a gastric cancer suppressor through a novel PCAF-p16-CDK4 axis","volume":"6","author":"Fei","year":"2016","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.drudis.2026.104778_b0230","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1038\/onc.2009.137","article-title":"Characterization of tumor suppressive function of P300\/CBP-associated factor at frequently deleted region 3p24 in esophageal squamous cell carcinoma","volume":"28","author":"Zhu","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.drudis.2026.104778_b0235","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.247","article-title":"P300\/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy","volume":"7","author":"Jia","year":"2016","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.drudis.2026.104778_b0240","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.canlet.2020.09.017","article-title":"Elevated GCN5 expression confers tamoxifen resistance by upregulating AIB1 expression in ER-positive breast cancer","volume":"495","author":"Oh","year":"2020","journal-title":"Cancer Lett"},{"key":"10.1016\/j.drudis.2026.104778_b0245","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1158\/1541-7786.MCR-09-0458","article-title":"Enhanced expression of PCAF confers apoptosis resistance in cisplatin-resistant cells","volume":"8","author":"Hirano","year":"2010","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.drudis.2026.104778_b0250","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1349-7006.2012.02215.x","article-title":"Elevated levels of lysine 9-acetylated histone H3 at MDR1 promoter in multidrug-resistant cells","volume":"103","author":"Toth","year":"2012","journal-title":"Cancer Sci"},{"key":"10.1016\/j.drudis.2026.104778_b0255","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1038\/s41467-025-57598-9","article-title":"GCN5-targeted dual-modal probe across the blood-brain barrier for borders display in invasive glioblastoma","volume":"16","author":"Zheng","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.drudis.2026.104778_b0260","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/0022034510378683","article-title":"Epigenetic mechanisms in inflammation","volume":"90","author":"Bayarsaihan","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.drudis.2026.104778_b0265","doi-asserted-by":"crossref","first-page":"6337","DOI":"10.3892\/mmr.2015.4143","article-title":"Helicobacter pylori cytotoxin\u2011associated gene A activates tumor necrosis factor\u2011\u03b1 and interleukin\u20116 in gastric epithelial cells through P300\/CBP\u2011associated factor\u2011mediated nuclear factor\u2011\u03baB p65 acetylation","volume":"12","author":"Lin","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.drudis.2026.104778_b0270","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/imcb.12455","article-title":"P300\/CBP-associated factor (PCAF) attenuated M1 macrophage inflammatory responses possibly through KLF2 and KLF4","volume":"99","author":"Wang","year":"2021","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0275","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4161\/15592294.2014.990780","article-title":"Histone acetyltransferase PCAF regulates inflammatory molecules in the development of renal injury","volume":"10","author":"Huang","year":"2015","journal-title":"Epigenetics"},{"key":"10.1016\/j.drudis.2026.104778_b0280","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.adp8973","article-title":"The acetyltransferase GCN5 contributes to neuroinflammation in mice by acetylating and activating the NF-\u03baB subunit p65 in microglia","volume":"18","author":"Cho","year":"2025","journal-title":"Sci Signal"},{"key":"10.1016\/j.drudis.2026.104778_b0285","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1093\/nar\/gkt156","article-title":"IL-1\u03b2\u2013specific recruitment of GCN5 histone acetyltransferase induces the release of PAF1 from chromatin for the de-repression of inflammatory response genes","volume":"41","author":"Kim","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.drudis.2026.104778_b0290","doi-asserted-by":"crossref","first-page":"26542","DOI":"10.1038\/srep26542","article-title":"GCN5 modulates osteogenic differentiation of periodontal ligament stem cells through DKK1 acetylation in inflammatory microenvironment","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2026.104778_b0295","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nm.2691","article-title":"CITED2 links hormonal signaling to PGC-1\u03b1 acetylation in the regulation of gluconeogenesis","volume":"18","author":"Sakai","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.drudis.2026.104778_b0300","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1038\/sj.emboj.7601633","article-title":"Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1\/PGC\u20101alpha","volume":"26","author":"Gerhart-hines","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.drudis.2026.104778_b0305","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/tpj.13300","article-title":"Histone acetyltransferase general control non-repressed protein 5 (GCN5) affects the fatty acid composition of Arabidopsis thaliana seeds by acetylating fatty acid desaturase3 (FAD3)","volume":"88","author":"Wang","year":"2016","journal-title":"Plant J"},{"key":"10.1016\/j.drudis.2026.104778_b0310","doi-asserted-by":"crossref","first-page":"H265","DOI":"10.1152\/ajpheart.00752.2016","article-title":"Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart","volume":"313","author":"Thapa","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.drudis.2026.104778_b0315","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1016\/j.celrep.2014.11.029","article-title":"PCAF improves glucose homeostasis by suppressing the gluconeogenic activity of PGC-1\u03b1","volume":"9","author":"Sun","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.drudis.2026.104778_b0320","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/10799890903517947","article-title":"PCAF represses transactivation function of FOXO1 in an acetyltransferase-independent manner","volume":"30","author":"Yoshimochi","year":"2010","journal-title":"J Recept Signal Transduct Res"},{"key":"10.1016\/j.drudis.2026.104778_b0325","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1128\/MCB.00622-14","article-title":"Gcn5 and PCAF regulate PPAR\u03b3 and Prdm16 expression to facilitate brown adipogenesis","volume":"34","author":"Jin","year":"2014","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0330","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1523\/JNEUROSCI.2121-16.2017","article-title":"Diencephalic size is restricted by a novel interplay between GCN5 acetyltransferase activity and retinoic acid signaling","volume":"37","author":"Wilde","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.drudis.2026.104778_b0335","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948335","article-title":"Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB","volume":"21","author":"Wang","year":"2020","journal-title":"EMBO Rep"},{"key":"10.1016\/j.drudis.2026.104778_b0340","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbrc.2014.03.118","article-title":"Acetylation of cyclin-dependent kinase 5 is mediated by GCN5","volume":"447","author":"Lee","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.drudis.2026.104778_b0345","doi-asserted-by":"crossref","first-page":"e2570","DOI":"10.1038\/cddis.2016.465","article-title":"Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein Bim","volume":"8","author":"Wu","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.drudis.2026.104778_b0350","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1101\/lm.053536.121","article-title":"Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300\/CBP-associated factor (PCAF) in 3xTG Alzheimer\u2019s disease mice","volume":"29","author":"Creighton","year":"2022","journal-title":"Learn Mem"},{"key":"10.1016\/j.drudis.2026.104778_b0355","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1038\/ncomms4527","article-title":"PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system","volume":"5","author":"Puttagunta","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.drudis.2026.104778_b0360","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/sj.npp.1301551","article-title":"Altered memory capacities and response to stress in p300\/CBP-associated factor (PCAF) histone acetylase knockout mice","volume":"33","author":"Maurice","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.drudis.2026.104778_b0365","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2443.2004.00706.x","article-title":"Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5","volume":"9","author":"Kahata","year":"2004","journal-title":"Genes Cells"},{"key":"10.1016\/j.drudis.2026.104778_b0370","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1534\/g3.116.031310","article-title":"Transcriptome profiling identifies multiplexin as a target of SAGA deubiquitinase activity in glia required for precise axon guidance during Drosophila visual development","volume":"6","author":"Ma","year":"2016","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.drudis.2026.104778_b0375","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1038\/s12276-025-01533-x","article-title":"Loss of PCAF in proximal tubular cells exacerbates renal fibrosis by promoting partial epithelial-to-mesenchymal transition","volume":"57","author":"Kim","year":"2025","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.drudis.2026.104778_b0380","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ebiom.2019.10.054","article-title":"Pharmacological blockade of PCAF ameliorates osteoarthritis development via dual inhibition of TNF-\u03b1-driven inflammation and ER stress","volume":"50","author":"Chen","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.drudis.2026.104778_b0385","doi-asserted-by":"crossref","first-page":"11303","DOI":"10.1073\/pnas.97.21.11303","article-title":"Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B\/GCN5 in mouse embryogenesis","volume":"97","author":"Yamauchi","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.drudis.2026.104778_b0390","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3390\/cancers11040554","article-title":"Complementary roles of GCN5 and PCAF in Foxp3+ T-regulatory cells","volume":"11","author":"Liu","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.drudis.2026.104778_b0395","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S1097-2765(00)80452-9","article-title":"HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF","volume":"5","author":"Lau","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.drudis.2026.104778_b0400","doi-asserted-by":"crossref","first-page":"19134","DOI":"10.1074\/jbc.M301580200","article-title":"Small molecule modulators of histone acetyltransferase p300","volume":"278","author":"Balasubramanyam","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0405","doi-asserted-by":"crossref","first-page":"13116","DOI":"10.3390\/molecules171113116","article-title":"Inhibition of PCAF histone acetyltransferase, cytotoxicity and cell permeability of 2-acylamino-1-(3- or 4-carboxy-phenyl)benzamides","volume":"17","author":"Park","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.drudis.2026.104778_b0410","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.chembiol.2010.06.014","article-title":"Nitric oxide-mediated histone hyperacetylation in oral cancer: target for a water-soluble HAT inhibitor, CTK7A","volume":"17","author":"Arif","year":"2010","journal-title":"Chem Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0415","doi-asserted-by":"crossref","first-page":"33716","DOI":"10.1074\/jbc.M402839200","article-title":"Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression","volume":"279","author":"Balasubramanyam","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0420","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1002\/anie.200453879","article-title":"Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5","volume":"43","author":"Biel","year":"2004","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.drudis.2026.104778_b0425","doi-asserted-by":"crossref","first-page":"22623","DOI":"10.18632\/oncotarget.8033","article-title":"Oridonin, a novel lysine acetyltransferase inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms","volume":"7","author":"Shi","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.drudis.2026.104778_b0430","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1021\/cb4000597","article-title":"Probing p300\/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor","volume":"8","author":"Modak","year":"2013","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0435","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1021\/jm800885d","article-title":"A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4\u2032-chlorophenyl)thiazol-2-yl)hydrazone","volume":"52","author":"Chimenti","year":"2009","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0440","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1158\/1078-0432.CCR-11-0579","article-title":"CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells","volume":"18","author":"Trisciuoglio","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.drudis.2026.104778_b0445","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.bmc.2014.01.022","article-title":"Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors","volume":"22","author":"Secci","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0450","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1158\/1535-7163.MCT-05-0135","article-title":"Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity","volume":"4","author":"Stimson","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.drudis.2026.104778_b0455","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1016\/j.bmc.2011.01.063","article-title":"Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors","volume":"19","author":"Furdas","year":"2011","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0460","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1038\/oncsis.2014.51","article-title":"Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo","volume":"4","author":"Gajer","year":"2015","journal-title":"Oncogenesis"},{"key":"10.1016\/j.drudis.2026.104778_b0465","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1158\/1535-7163.MCT-12-0930","article-title":"Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents","volume":"12","author":"Yang","year":"2013","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.drudis.2026.104778_b0470","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ejmech.2018.02.005","article-title":"Discovery of 1,8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening","volume":"151","author":"Xiong","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0475","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1039\/C8RA10074H","article-title":"Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening","volume":"9","author":"Tao","year":"2019","journal-title":"RSC Adv"},{"key":"10.1016\/j.drudis.2026.104778_b0480","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.1016\/j.bmc.2010.06.089","article-title":"Improved inhibition of the histone acetyltransferase PCAF by anacardic acid derivative","volume":"18","author":"Ghizzoni","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0485","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1128\/AAC.03059-15","article-title":"Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii","volume":"60","author":"Jeffers","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.drudis.2026.104778_b0490","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/path.4773","article-title":"P\/CAF mediates PAX3-FOXO1-dependent oncogenesis in alveolar rhabdomyosarcoma","volume":"240","author":"Bharathy","year":"2016","journal-title":"J Pathol"},{"key":"10.1016\/j.drudis.2026.104778_b0495","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13148-018-0473-4","article-title":"KAT3B-p300 and H3AcK18\/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2","volume":"10","author":"Cocco","year":"2018","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.drudis.2026.104778_b0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105220","article-title":"Inhibition of mitochondrial fatty acid \u03b2-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish","volume":"299","author":"Zhou","year":"2023","journal-title":"J Biol Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0505","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1016\/j.ejmech.2009.07.025","article-title":"Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase","volume":"44","author":"Ghizzoni","year":"2009","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0510","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3892\/ijmm.2013.1407","article-title":"Selective inhibition of PCAF suppresses microglial-mediated \u03b2-amyloid neurotoxicity","volume":"32","author":"Park","year":"2013","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.drudis.2026.104778_b0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2023.102323","article-title":"Bromodomain inhibitors and therapeutic applications","volume":"75","author":"Gajjela","year":"2023","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0520","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.4155\/fmc-2016-0136","article-title":"Targeting the bromome: are we there yet?","volume":"8","author":"M\u00fcller","year":"2016","journal-title":"Future Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0525","doi-asserted-by":"crossref","first-page":"7346","DOI":"10.1021\/jm300346w","article-title":"Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites","volume":"55","author":"Vidler","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0530","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.str.2008.01.010","article-title":"Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP\/p300","volume":"16","author":"Zeng","year":"2008","journal-title":"Structure"},{"key":"10.1016\/j.drudis.2026.104778_b0535","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1093\/emboj\/19.22.6141","article-title":"The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p","volume":"19","author":"Owen","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.drudis.2026.104778_b0540","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1021\/ja044885g","article-title":"Selective small molecules blocking HIV-1 Tat and coactivator PCAF association","volume":"127","author":"Zeng","year":"2005","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.drudis.2026.104778_b0545","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1021\/acsmedchemlett.6b00154","article-title":"Discovery of new bromodomain scaffolds by biosensor fragment screening","volume":"7","author":"Navratilova","year":"2016","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.drudis.2026.104778_b0550","article-title":"Phthalazine derivatives of formula (i) as pcaf and gcn5 inhibitors for use in the treatment of cancer","author":"Albrecht","year":"2016","journal-title":"WO Patent"},{"key":"10.1016\/j.drudis.2026.104778_b0555","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1021\/acs.jmedchem.6b01566","article-title":"Discovery of a potent, cell-penetrant, and selective p300\/CBP-associated factor (PCAF)\/general control nonderepressible 5 (GCN5) bromodomain chemical probe","volume":"60","author":"Humphreys","year":"2017","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0560","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/anie.201610816","article-title":"Discovery of a PCAF bromodomain chemical probe","volume":"56","author":"Moustakim","year":"2017","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.drudis.2026.104778_b0565","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1021\/acs.jmedchem.9b00096","article-title":"Discovery of pyrrolo[3,2-d]pyrimidin-4-one derivatives as a new class of potent and cell-active inhibitors of P300\/CBP-associated factor bromodomain","volume":"62","author":"Huang","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103899","article-title":"Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies","volume":"100","author":"Abulkhair","year":"2020","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116266","article-title":"From triazolophthalazines to triazoloquinazolines: a bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity","volume":"42","author":"El-Shershaby","year":"2021","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0580","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1021\/acs.jmedchem.5b01719","article-title":"Structure-based identification of inhibitory fragments targeting the p300\/CBP-associated factor bromodomain","volume":"59","author":"Chaikuad","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0585","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1080\/07391102.2017.1415820","article-title":"Unravelling novel congeners from acetyllysine mimicking ligand targeting a lysine acetyltransferase PCAF bromodomain","volume":"36","author":"Suryanarayanan","year":"2018","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.drudis.2026.104778_b0590","article-title":"Pyridazinone derivatives and their use in the treatment of cancer","author":"Albrecht","year":"2016","journal-title":"WO Patent"},{"key":"10.1016\/j.drudis.2026.104778_b0595","doi-asserted-by":"crossref","first-page":"8554","DOI":"10.1073\/pnas.141230798","article-title":"Protacs: chimeric molecules that target proteins to the Skp1\u2013Cullin\u2013F box complex for ubiquitination and degradation","volume":"98","author":"Sakamoto","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.drudis.2026.104778_b0600","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s43556-022-00112-0","article-title":"An overview of PROTACs: a promising drug discovery paradigm","volume":"3","author":"Liu","year":"2022","journal-title":"Mol Biomed"},{"key":"10.1016\/j.drudis.2026.104778_b0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115765","article-title":"Targeted protein modification as a paradigm shift in drug discovery","volume":"260","author":"Amirian","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0610","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1021\/acschembio.8b00705","article-title":"Modulating PCAF\/GCN5 immune cell function through a PROTAC approach","volume":"13","author":"Bassi","year":"2018","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0615","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/bs.mie.2022.08.014","article-title":"A heterobifunctional molecule system for targeted protein acetylation in cells","volume":"681","author":"Chen","year":"2023","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.drudis.2026.104778_b0620","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1021\/acschembio.4c00438","article-title":"Functional investigations of p53 acetylation enabled by heterobifunctional molecules","volume":"19","author":"Chen","year":"2024","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0625","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejmech.2017.06.009","article-title":"Designing novel inhibitors against histone acetyltransferase (HAT: GCN5) of Plasmodium falciparum","volume":"138","author":"Kumar","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2026.104778_b0630","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1021\/acschembio.7b00114","article-title":"Profiling cellular substrates of lysine acetyltransferases GCN5 and p300 with orthogonal labeling and click chemistry","volume":"12","author":"Han","year":"2017","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.drudis.2026.104778_b0635","doi-asserted-by":"crossref","DOI":"10.1002\/minf.201700150","article-title":"Multiple machine learning based-chemoinformatics models for identification of histone acetyl transferase inhibitors","volume":"37","author":"Krishna","year":"2018","journal-title":"Mol Inform"},{"key":"10.1016\/j.drudis.2026.104778_b0640","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1002\/jcb.25153","article-title":"Gcn5 modulates the cellular response to oxidative stress and histone deacetylase inhibition","volume":"116","author":"Gaupel","year":"2015","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.drudis.2026.104778_b0645","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2174\/1871520611313050010","article-title":"Inhibition of PCAF by anacardic acid derivative leads to apoptosis and breaks resistance to DNA damage in BCR-ABL-expressing cells","volume":"13","author":"Kusio-kobialka","year":"2013","journal-title":"Anticancer Agents Med Chem"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644626001832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644626001832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:17:36Z","timestamp":1790093856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644626001832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":130,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1359644626001832"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2026.104778","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological targeting of GCN5\/PCAF (KAT2A\/B): current drug discovery strategies and translational potential","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2026.104778","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104778"}}