{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T20:46:30Z","timestamp":1791751590077,"version":"4.3.4"},"reference-count":119,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"publisher","award":["503\/1-156-04\/503-11-001"],"award-info":[{"award-number":["503\/1-156-04\/503-11-001"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.drudis.2026.104811","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:48:17Z","timestamp":1790232497000},"page":"104811","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["5-HT7 receptor as a potential therapeutic target in irritable bowel syndrome: Current insights and future perspectives"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5832-5579","authenticated-orcid":false,"given":"Zuzanna","family":"Kasprzak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Jaczynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Jarzabek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Salaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2026.104811_b0005","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12916-025-03930-5","article-title":"Risk factors for developing irritable bowel syndrome: systematic umbrella review of reviews","volume":"23","author":"Sulaimi","year":"2025","journal-title":"BMC Med"},{"key":"10.1016\/j.drudis.2026.104811_b0010","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0140-6736(20)31548-8","article-title":"Irritable bowel syndrome","volume":"396","author":"Ford","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.drudis.2026.104811_b0015","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1007\/s10620-025-08965-5","article-title":"It\u2019s a women\u2019s world: a new look at sex differences in patients with the irritable bowel syndrome","volume":"70","author":"Heath","year":"2025","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.drudis.2026.104811_b0020","doi-asserted-by":"crossref","first-page":"709","DOI":"10.20452\/pamw.16067","article-title":"Recent advances in the treatment of irritable bowel syndrome","volume":"131","author":"Bonetto","year":"2021","journal-title":"Pol Arch Intern Med"},{"key":"10.1016\/j.drudis.2026.104811_b0025","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.2174\/1389450119666171227225408","article-title":"Efficacy and safety of serotonin receptor ligands in the treatment of irritable bowel syndrome: a review","volume":"19","author":"Binienda","year":"2018","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.drudis.2026.104811_b0030","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fnpit.2017.00400","article-title":"The role of serotonin beyond the central nervous system during embryogenesis","volume":"11","author":"Lv","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.drudis.2026.104811_b0035","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.drudis.2026.104811_b0040","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s00018-007-7377-3","article-title":"Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectives","volume":"65","author":"Lesurtel","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.drudis.2026.104811_b0045","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1389296","article-title":"The role of descending pain modulation in chronic primary pain: potential application of drugs targeting serotonergic system","volume":"2019","author":"Tao","year":"2019","journal-title":"Neural Plast"},{"key":"10.1016\/j.drudis.2026.104811_b0050","doi-asserted-by":"crossref","first-page":"23422","DOI":"10.1016\/S0021-9258(19)49479-9","article-title":"Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase","volume":"268","author":"Bard","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.drudis.2026.104811_b0055","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1124\/jpet.104.081919","article-title":"Differential agonist-mediated internalization of the human 5-hydroxytryptamine 7 receptor isoforms","volume":"313","author":"Guthrie","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.drudis.2026.104811_b0060","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1021\/jm030030n","article-title":"Higher-end serotonin receptors: 5-HT5, 5-HT6, and 5-HT7","volume":"46","author":"Glennon","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2026.104811_b0065","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.pharmthera.2010.08.013","article-title":"Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders","volume":"129","author":"Leopoldo","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.drudis.2026.104811_b0070","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1177\/02698811231211228","article-title":"The 5-HT7 receptor system as a treatment target for mood and anxiety disorders: a systematic review","volume":"37","author":"Gottlieb","year":"2023","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0075","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00221-013-3694-y","article-title":"The serotonin 5-HT7 receptors: two decades of research","volume":"230","author":"Gellynck","year":"2013","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.drudis.2026.104811_b0080","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1182\/blood-2006-10-052787","article-title":"Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor","volume":"109","author":"Le\u00f3n-Ponte","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.drudis.2026.104811_b0085","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nrn1256","article-title":"The developmental role of serotonin: news from mouse molecular genetics","volume":"4","author":"Gaspar","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.drudis.2026.104811_b0090","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0306-4522(00)00460-7","article-title":"5-HT7 receptors activate the mitogen activated protein kinase extracellular signal related kinase in cultured rat hippocampal neurons","volume":"102","author":"Errico","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.drudis.2026.104811_b0095","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1046\/j.1471-4159.2003.02076.x","article-title":"Coupling of neuronal 5-HT7 receptors to activation of extracellular-regulated kinase through a protein kinase A-independent pathway that can utilize Epac","volume":"87","author":"Lin","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.drudis.2026.104811_b0100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1471-4159.2004.02832.x","article-title":"Enhanced activation of Akt and extracellular-regulated kinase pathways by simultaneous occupancy of Gq-coupled 5-HT2A receptors and Gs-coupled 5-HT7A receptors in PC12 cells","volume":"92","author":"Johnson-Farley","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.drudis.2026.104811_b0105","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1523\/JNEUROSCI.1790-05.2005","article-title":"5-HT7 receptor is coupled to G\u03b1 subunits of heterotrimeric G12-protein to regulate gene transcription and neuronal morphology","volume":"25","author":"Kvachnina","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.drudis.2026.104811_b0110","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1471-4159.2005.03079.x","article-title":"Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C \u03b5 resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells","volume":"93","author":"Lieb","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.drudis.2026.104811_b0115","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201352RR","article-title":"Serotonin\/5\u2010HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP\u2010PKA\u2010MAPK, Rab27a\/RhoA, and PI3K\/AKT signaling pathways","volume":"37","author":"Tang","year":"2023","journal-title":"FASEB J"},{"key":"10.1016\/j.drudis.2026.104811_b0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41388-025-03645-0","article-title":"Serotonin receptor type 7 (5-HT7) promotes colorectal cancer progression by activating Wnt\/\u03b2-catenin signaling via interacting with CK1\u03b5","volume":"45","author":"Lv","year":"2026","journal-title":"Oncogene"},{"key":"10.1016\/j.drudis.2026.104811_b0125","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1021\/acsptsci.3c00142","article-title":"In vitro and in vivo evaluation of pellotine: a hypnotic Lophophora alkaloid","volume":"6","author":"Poulie","year":"2023","journal-title":"ACS Pharmacol Transl Sci"},{"key":"10.1016\/j.drudis.2026.104811_b0130","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1021\/acschemneuro.4c00667","article-title":"Synthesis, pharmacological characterization, and binding mode analysis of 8-hydroxy-tetrahydroisoquinolines as 5-HT7 receptor inverse agonists","volume":"16","author":"Chan","year":"2025","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.drudis.2026.104811_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116867","article-title":"Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation","volume":"177","author":"Arias","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.drudis.2026.104811_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118742","article-title":"Ibogalogs improve spatial and recognition memory in rodents through a mechanism involving 5-HT2A receptor activation-enhanced NMDA receptor activity in hippocampal pyramidal CA1 neurons","volume":"193","author":"Chagraoui","year":"2025","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.drudis.2026.104811_b0145","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11064-026-04727-5","article-title":"Ibogalogs activate the 5-HT2A receptor through a mechanism involving outward and inward movements of the respective transmembrane segment TM6 and TM7","volume":"51","author":"Rudin","year":"2026","journal-title":"Neurochem Res"},{"key":"10.1016\/j.drudis.2026.104811_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176329","article-title":"The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation","volume":"966","author":"Arias","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0155","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-2999(91)90463-Z","article-title":"Single-dose 8-OH-DPAT pretreatment does not Induce tachyphylaxis to the 5-HT release-reducing effect of 5-HT1A autoreceptor agonists","volume":"199","author":"Hjorth","year":"1991","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0160","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejphar.2008.08.026","article-title":"5-HT7 receptor stimulation by 8-OH-DPAT counteracts the impairing effect of 5-HT1A receptor stimulation on contextual learning in mice","volume":"596","author":"Eriksson","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0165","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1471-4159.1986.tb04532.x","article-title":"Pharmacological differentiation and characterization of 5-HT1A, 5-HT1B, and 5-HT1C binding sites in rat frontal cortex","volume":"47","author":"Peroutka","year":"1986","journal-title":"J Neurochem"},{"key":"10.1016\/j.drudis.2026.104811_b0170","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/sj.bjp.0701336","article-title":"Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b)","volume":"122","author":"Jasper","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0175","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/sj.bjp.0701946","article-title":"Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719","volume":"124","author":"Thomas","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0180","series-title":"5-Carboxamidotryptamine","first-page":"1","author":"DuPre","year":"2007"},{"key":"10.1016\/j.drudis.2026.104811_b0185","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/sj.bjp.0703357","article-title":"Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist","volume":"130","author":"Hagan","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0190","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1211\/0022357044346","article-title":"Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation","volume":"56","author":"Sharif","year":"2004","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0195","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41421-022-00412-3","article-title":"Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A","volume":"8","author":"Tan","year":"2022","journal-title":"Cell Discov"},{"key":"10.1016\/j.drudis.2026.104811_b0200","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0028-3908(97)00019-1","article-title":"Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells","volume":"36","author":"Boess","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.drudis.2026.104811_b0205","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.pain.2008.11.009","article-title":"5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice","volume":"141","author":"Brenchat","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.drudis.2026.104811_b0210","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.pain.2010.03.007","article-title":"Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity","volume":"149","author":"Brenchat","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.drudis.2026.104811_b0215","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbr.2007.11.023","article-title":"The effects of the 5-HT6 receptor agonist EMD and the 5-HT7 receptor agonist AS19 on memory formation","volume":"195","author":"Meneses","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.drudis.2026.104811_b0220","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.bbr.2005.04.014","article-title":"Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task","volume":"163","author":"Perez-Garc\u00eda","year":"2005","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.drudis.2026.104811_b0225","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1515\/revneuro-2014-0009","article-title":"Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview","volume":"25","author":"Di Pilato","year":"2014","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.drudis.2026.104811_b0230","doi-asserted-by":"crossref","first-page":"8475","DOI":"10.1021\/acs.jmedchem.7b01898","article-title":"Structure-activity relationships and therapeutic potentials of 5-HT7 receptor ligands: an update","volume":"61","author":"Modica","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2026.104811_b0235","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1021\/jm800615e","article-title":"Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity","volume":"51","author":"Leopoldo","year":"2008","journal-title":"Part III J Med Chem"},{"key":"10.1016\/j.drudis.2026.104811_b0240","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.neuropharm.2011.08.022","article-title":"On the role of brain 5-HT7 receptor in the mechanism of hypothermia: comparison with hypothermia mediated via 5-HT1A and 5-HT3 receptor","volume":"61","author":"Naumenko","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.drudis.2026.104811_b0245","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbr.2008.03.025","article-title":"The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat","volume":"191","author":"Monti","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.drudis.2026.104811_b0250","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2010.06.036","article-title":"LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor","volume":"481","author":"Hedlund","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.drudis.2026.104811_b0255","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.biopsych.2012.06.008","article-title":"Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and fmr1 knockout mice, a model of fragile X syndrome","volume":"72","author":"Costa","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.drudis.2026.104811_b0260","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/jnc.12157","article-title":"5-hydroxytryptamine type 7 receptor neuroprotection against NMDA-induced excitotoxicity is PDGF\u03b2 receptor dependent","volume":"125","author":"Vasefi","year":"2013","journal-title":"J Neurochem"},{"key":"10.1016\/j.drudis.2026.104811_b0265","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/s41374-022-00800-z","article-title":"5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome","volume":"102","author":"Chang","year":"2022","journal-title":"Lab Invest"},{"key":"10.1016\/j.drudis.2026.104811_b0270","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ejphar.2004.05.033","article-title":"Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors","volume":"495","author":"Mah\u00e9","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0275","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.neuroscience.2005.05.006","article-title":"Slow excitatory post-synaptic potentials in myenteric AH neurons of the guinea-pig ileum are reduced by the 5-hydroxytrytamine7 receptor antagonist SB 269970","volume":"134","author":"Monro","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.drudis.2026.104811_b0280","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/sj.bjp.0705290","article-title":"SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats","volume":"139","author":"Thomas","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0285","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ejmech.2015.11.040","article-title":"Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: multiobjective based design, synthesis, and antidepressant and anxiolytic properties","volume":"108","author":"Canale","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2026.104811_b0290","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1113\/JP286444","article-title":"5\u2010HT7 antagonists confer analgesia via suppression of neurotrophin overproduction in submucosal nerves of mouse models with visceral hypersensitivity","volume":"603","author":"Lee","year":"2025","journal-title":"J Physiol"},{"key":"10.1016\/j.drudis.2026.104811_b0295","unstructured":"Yu LC-H, Hsin L-W, Lee T-C. 8-phenyl-isoquinolines and pharmaceutical composition thereof used in the treatment of irritable bowel syndrome. World Intellectual Property Organization (WO2018157233A1). Published online 7 September 2018. https:\/\/patents.google.com\/patent\/WO2018157233A1\/zh."},{"key":"10.1016\/j.drudis.2026.104811_b0300","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0091-3057(01)00744-4","article-title":"Effects of the 5-HT7 receptor antagonist SB-258741 in animal models for schizophrenia","volume":"71","author":"Pouzet","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.drudis.2026.104811_b0305","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1527-3458.2002.tb00217.x","article-title":"SB-258741: a 5-HT7 receptor antagonist of potential clinical interest","volume":"8","author":"Pouzet","year":"2002","journal-title":"CNS Drug Rev"},{"key":"10.1016\/j.drudis.2026.104811_b0310","doi-asserted-by":"crossref","first-page":"30307","DOI":"10.1038\/s41598-024-76329-6","article-title":"Targeting serotonin receptors with phytochemicals \u2013 an in-silico study","volume":"14","author":"Elalouf","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2026.104811_b0315","unstructured":"PubChem. (+)-Pellotine. C13H19NO3 | CID 12314029. Accessed 30 August 2026. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/12314029."},{"key":"10.1016\/j.drudis.2026.104811_b0320","unstructured":"DM506 | C13H16N2 | CSID:22605. Retrieved 2 September 2026. https:\/\/www.chemspider.com\/Chemical-Structure.22605.html."},{"key":"10.1016\/j.drudis.2026.104811_b0325","unstructured":"PubChem. 8-OH-Dpat. C16H25NO | CID 1220. Accessed 2 September 2026. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/1220."},{"key":"10.1016\/j.drudis.2026.104811_b0330","unstructured":"PubChem. 5-Carboxamidotryptamine. C11H13N3O | CID 1809. Accessed 30 August 2026. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/1809."},{"key":"10.1016\/j.drudis.2026.104811_b0335","unstructured":"PubChem. AS-19. C18H25N3 | CID 23642275. Accessed 30 August 2026. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/23642275."},{"key":"10.1016\/j.drudis.2026.104811_b0340","unstructured":"PubChem. 1-Piperazinehexanamide, 4-(2-(methylthio)phenyl)-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1) C27H38ClN3OS | CID 11225543. Accessed 30 August 2026. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/11225543."},{"key":"10.1016\/j.drudis.2026.104811_b0345","unstructured":"PubChem. SB269970. C18H28N2O3S | CID 6604889. Accessed 30 August 2026. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/6604889."},{"key":"10.1016\/j.drudis.2026.104811_b0350","unstructured":"PubChem. Jnj-18038683. C26H28ClN3O7 | CID 11249539. Accessed 30 August 2026. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/11249539."},{"key":"10.1016\/j.drudis.2026.104811_b0355","doi-asserted-by":"crossref","first-page":"6750","DOI":"10.1016\/j.bmc.2011.09.044","article-title":"Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands","volume":"19","author":"Zajdel","year":"2011","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.drudis.2026.104811_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.118369","article-title":"Fine-tuning 5-HT7 receptor selectivity, inverse agonism, and metabolic stability of new (aryloxy)ethyl-piperidines toward antidepressant and pro-cognitive properties","volume":"302","author":"Canale","year":"2026","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.drudis.2026.104811_b0365","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1021\/jm070279v","article-title":"(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists","volume":"51","author":"Volk","year":"2008","journal-title":"J Med Chem"},{"key":"10.1016\/j.drudis.2026.104811_b0370","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.lfs.2006.12.025","article-title":"Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon","volume":"80","author":"Irving","year":"2007","journal-title":"Life Sci"},{"key":"10.1016\/j.drudis.2026.104811_b0375","doi-asserted-by":"crossref","first-page":"361","DOI":"10.5056\/jnm14157","article-title":"Distribution of 5-HT3, 5-HT4, and 5-HT7 receptors along the human colon","volume":"21","author":"Yaakob","year":"2015","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.drudis.2026.104811_b0380","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/sj.bjp.0702762","article-title":"Evidence for 5-HT7 receptors mediating relaxation of human colonic circular smooth muscle","volume":"128","author":"Prins","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0385","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/sj.bjp.0703615","article-title":"5-HT4 receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle","volume":"131","author":"Prins","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0390","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3389\/fnbeh.2014.00396","article-title":"5-HT7 receptor signaling: improved therapeutic strategy in GUT disorders","volume":"8","author":"Kim","year":"2014","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.drudis.2026.104811_b0395","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1016\/S0024-3205(01)01318-2","article-title":"Expression patterns of 5-HT7 receptor isoforms in the rat digestive tract","volume":"69","author":"Liu","year":"2001","journal-title":"Life Sci"},{"key":"10.1016\/j.drudis.2026.104811_b0400","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1053\/j.gastro.2005.08.005","article-title":"5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum","volume":"129","author":"Tonini","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.drudis.2026.104811_b0405","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/sj.bjp.0705184","article-title":"5-HT7 receptors mediate the inhibitory effect of 5-HT on peristalsis in the isolated guinea-pig ileum","volume":"138","author":"Tuladhar","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0410","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/sj.bjp.0705264","article-title":"5-HT decreases contractile and electrical activities in lymphatic vessels of the guinea-pig mesentery: role of 5-HT7-receptors","volume":"139","author":"Chan","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0415","doi-asserted-by":"crossref","first-page":"G144","DOI":"10.1152\/ajpgi.00496.2009","article-title":"Critical role of 5-HT1A, 5-HT3, and 5-HT7 receptor subtypes in the initiation, generation, and propagation of the murine colonic migrating motor complex","volume":"299","author":"Dickson","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.drudis.2026.104811_b0420","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2249.2007.03531.x","article-title":"Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease","volume":"151","author":"Szebeni","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.drudis.2026.104811_b0425","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/ajg.2010.438","article-title":"Differential expression of toll-like receptors in patients with irritable bowel syndrome","volume":"106","author":"Brint","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.drudis.2026.104811_b0430","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/cei.12381","article-title":"Toll-like receptor expression in crypt epithelial cells, putative stem cells and intestinal myofibroblasts isolated from controls and patients with inflammatory bowel disease","volume":"178","author":"Brown","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.drudis.2026.104811_b0435","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000339057","article-title":"Toll-like receptor 3 activation affects serotonin transporter activity and expression in human enterocyte-like Caco-2 cells","volume":"30","author":"Mendoza","year":"2012","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.drudis.2026.104811_b0440","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/nmo.12619","article-title":"Toll-like receptors 2 and 4 modulate the contractile response induced by serotonin in mouse ileum: analysis of the serotonin receptors involved","volume":"27","author":"Forc\u00e9n","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.drudis.2026.104811_b0445","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.bjp.0705922","article-title":"5-HT7 receptor efficacy distribution throughout the canine stomach","volume":"143","author":"Janssen","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0450","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00535-005-1766-x","article-title":"Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome","volume":"41","author":"Zuo","year":"2006","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.drudis.2026.104811_b0455","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/cne.20667","article-title":"Pre- and postsynaptic localization of the 5-HT7 receptor in rat dorsal spinal cord: immunocytochemical evidence","volume":"490","author":"Doly","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.drudis.2026.104811_b0460","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.brainres.2009.05.001","article-title":"Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors","volume":"1280","author":"Dogrul","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.drudis.2026.104811_b0465","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pbb.2014.10.007","article-title":"Antihyperalgesic effect of 5-HT7 receptor activation on the midbrain periaqueductal gray in a rat model of neuropathic pain","volume":"127","author":"Li","year":"2014","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.drudis.2026.104811_b0470","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1097\/00029330-200712010-00002","article-title":"Expression and role of 5-HT7 receptor in brain and intestine in rats with irritable bowel syndrome","volume":"120","author":"Zou","year":"2007","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.drudis.2026.104811_b0475","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.bbrc.2019.02.126","article-title":"MiRNA-29a modulates visceral hyperalgesia in irritable bowel syndrome by targeting HTR7","volume":"511","author":"Zhu","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.drudis.2026.104811_b0480","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1097\/MEG.0000000000000921","article-title":"The prevalence of irritable bowel syndrome-type symptoms in inflammatory bowel disease patients in remission","volume":"29","author":"Hoekman","year":"2017","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.drudis.2026.104811_b0485","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/ajg.2015.120","article-title":"C-reactive protein, fecal calprotectin, and stool lactoferrin for detection of endoscopic activity in symptomatic inflammatory bowel disease patients: a systematic review and meta-analysis","volume":"110","author":"Mosli","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.drudis.2026.104811_b0490","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.coph.2011.02.004","article-title":"5-HT and the immune system","volume":"11","author":"Ahern","year":"2011","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.drudis.2026.104811_b0495","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.4049\/jimmunol.1201887","article-title":"Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation","volume":"190","author":"Kim","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.drudis.2026.104811_b0500","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.4049\/jimmunol.1201133","article-title":"Serotonin skews human macrophage polarization through HTR2B and HTR7","volume":"190","author":"de Las","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.drudis.2026.104811_b0505","doi-asserted-by":"crossref","first-page":"14761","DOI":"10.1038\/s41598-017-15348-y","article-title":"Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis","volume":"7","author":"Dom\u00ednguez-Soto","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.drudis.2026.104811_b0510","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1097\/MIB.0000000000000150","article-title":"Serotonin 5-HT7 receptor is critically involved in acute and chronic inflammation of the gastrointestinal tract","volume":"20","author":"Guseva","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.drudis.2026.104811_b0515","first-page":"2866","article-title":"The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells","volume":"128","author":"Holst","year":"2015","journal-title":"J Cell Sci"},{"key":"10.1016\/j.drudis.2026.104811_b0520","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2018.07.011","article-title":"Rome foundation working team report on post-infection irritable bowel syndrome","volume":"156","author":"Barbara","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.drudis.2026.104811_b0525","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/apt.15001","article-title":"Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome","volume":"48","author":"Ford","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.drudis.2026.104811_b0530","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2026.104811_b0535","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.chom.2018.05.004","article-title":"Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion","volume":"23","author":"Bhattarai","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.drudis.2026.104811_b0540","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.cell.2020.08.007","article-title":"Longitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome","volume":"182","author":"Mars","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2026.104811_b0545","first-page":"1085","article-title":"Gut microbiota-derived short-chain fatty acids: novel regulators of intestinal serotonin transporter","volume":"13","author":"Buey","year":"2023","journal-title":"Life (Basel)"},{"key":"10.1016\/j.drudis.2026.104811_b0550","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/cns.12247","article-title":"Interplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders","volume":"20","author":"Naumenko","year":"2014","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.drudis.2026.104811_b0555","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroscience.2025.11.035","article-title":"Impact of 5-HT7 receptor gene deletion on memory and affective behaviors in young and aged mice","volume":"592","author":"Rodriguez","year":"2026","journal-title":"Neuroscience"},{"key":"10.1016\/j.drudis.2026.104811_b0560","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.trsl.2008.10.002","article-title":"Changes in brain G proteins and colonic sympathetic neural signaling in chronic-acute combined stress rat model of irritable bowel syndrome (IBS)","volume":"152","author":"Zou","year":"2008","journal-title":"Transl Res"},{"key":"10.1016\/j.drudis.2026.104811_b0565","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3390\/ph18101485","article-title":"Novel dual 5-HT7 antagonists and sodium channel inhibitors as potential therapeutic agents with antidepressant and anxiolytic activities","volume":"18","author":"Czopek","year":"2025","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.drudis.2026.104811_b0570","doi-asserted-by":"crossref","first-page":"9103","DOI":"10.3390\/ijms23169103","article-title":"Dose-dependent biphasic action of quetiapine on AMPK signalling via 5-HT7 receptor: exploring pathophysiology of clinical and adverse effects of quetiapine","volume":"23","author":"Okada","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2026.104811_b0575","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.3390\/ijms24032070","article-title":"Therapeutic potential and limitation of serotonin type 7 receptor modulation","volume":"24","author":"Fukuyama","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.drudis.2026.104811_b0580","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1365-2982.2005.00716.x","article-title":"5-hydroxytryptamine effects in the gut: the 3, 4, and 7 receptors","volume":"17","author":"Tonini","year":"2005","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.drudis.2026.104811_b0585","article-title":"The effects of serotonin receptor type 7 modulation on bowel sensitivity and smooth muscle tone in patients with irritable bowel syndrome","volume":"15","author":"Osman","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.drudis.2026.104811_b0590","doi-asserted-by":"crossref","first-page":"G57","DOI":"10.1152\/ajpgi.00299.2023","article-title":"Novel 5-HT7 receptor antagonists modulate intestinal immune responses and reduce severity of colitis","volume":"327","author":"Kwon","year":"2024","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.drudis.2026.104811_b0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108233","article-title":"Targeting the 5-HT system: potential side effects","volume":"179","author":"Hoyer","year":"2020","journal-title":"Neuropharmacology"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644626002163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644626002163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T20:04:44Z","timestamp":1791749084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644626002163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":119,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S1359644626002163"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2026.104811","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"5-HT7 receptor as a potential therapeutic target in irritable bowel syndrome: Current insights and future perspectives","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2026.104811","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104811"}}