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A."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0435","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nsmb.2197","article-title":"Experimental conditions can obscure the second high-affinity site in LeuT","volume":"19","author":"Quick","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0440","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1124\/jpet.103.053504","article-title":"Evaluation of the blood\u2013brain barrier transport, population pharmacokinetics, and brain distribution of benztropine analogs and cocaine using in vitro and in vivo techniques","volume":"307","author":"Raje","year":"2003","journal-title":"J. Pharmacol. Exp. 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A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists","volume":"53","author":"Rothman","year":"1993","journal-title":"Life Sci."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0490","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1124\/jpet.104.082503","article-title":"Development of a rationally designed, low abuse potential, biogenic amine releaser that suppresses cocaine self-administration","volume":"313","author":"Rothman","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0495","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1749-6632.1998.tb08222.x","article-title":"Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction","volume":"844","author":"Rothman","year":"1998","journal-title":"Ann. N. Y. Acad. 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Pharmacol. Exp. Ther."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0530","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/minf.201300013","article-title":"Probing the selectivity of monoamine transporter substrates by means of molecular modeling","volume":"32","author":"Seddik","year":"2013","journal-title":"Mol. Inform."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0535","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1021\/cn300040f","article-title":"Binding of the amphetamine-like 1-phenyl-piperazine to monoamine transporters","volume":"3","author":"Severinsen","year":"2012","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0540","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2008.05.008","article-title":"The mechanism of a neurotransmitter:sodium symporter \u2013 inward release of Na+ and substrate is triggered by substrate in a second binding site","volume":"30","author":"Shi","year":"2008","journal-title":"Mol. 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Neurochem."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0560","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1046\/j.1471-4159.1998.71031289.x","article-title":"Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter","volume":"71","author":"Sitte","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0565","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1523\/JNEUROSCI.17-03-00960.1997","article-title":"Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants","volume":"17","author":"Sonders","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0570","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neuron.2011.02.010","article-title":"How addictive drugs disrupt presynaptic dopamine neurotransmission","volume":"69","author":"Sulzer","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0575","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.pneurobio.2005.04.003","article-title":"Mechanisms of neurotransmitter release by amphetamines: a review","volume":"75","author":"Sulzer","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0580","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.phrs.2007.09.001","article-title":"Modulation of the endocannabinoid system: therapeutic potential against cocaine dependence","volume":"56","author":"Tanda","year":"2007","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0585","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1124\/jpet.104.080465","article-title":"Effects of 4\u2032-chloro-3 alpha-(diphenylmethoxy)-tropane on mesostriatal, mesocortical, and mesolimbic dopamine transmission: comparison with effects of cocaine","volume":"313","author":"Tanda","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0590","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1124\/jpet.106.118067","article-title":"Effects of muscarinic M1 receptor blockade on cocaine-induced elevations of brain dopamine levels and locomotor behavior in rats","volume":"321","author":"Tanda","year":"2007","journal-title":"J. Pharmacol. Exp. 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Neurochem."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0600","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00213-013-3109-6","article-title":"Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change","volume":"229","author":"Tanda","year":"2013","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0605","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1054-3589(08)57007-4","article-title":"Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors","volume":"57","author":"Tanda","year":"2009","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0610","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1126\/science.276.5321.2048","article-title":"Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism","volume":"276","author":"Tanda","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0615","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1046\/j.1471-4159.1998.71010258.x","article-title":"Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine","volume":"71","author":"Teng","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0620","first-page":"33","article-title":"Effects of histamine and histamine antagonists on the uptake and release of catecholamines and 5-HT in brain synaptosomes","volume":"58","author":"Tuomisto","year":"1980","journal-title":"Med. Biol."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0625","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1124\/jpet.105.085829","article-title":"Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue","volume":"314","author":"Ukairo","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0630","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1471-4159.1993.tb03174.x","article-title":"Comparison of [3H]WIN 35,428 binding, a marker for dopamine transporter, in embryonic mesencephalic neuronal cultures with striatal membranes of adult rats","volume":"60","author":"Valchar","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0635","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.drugalcdep.2009.09.002","article-title":"Modafinil does not serve as a reinforcer in cocaine abusers","volume":"106","author":"Vosburg","year":"2010","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0640","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nature12648","article-title":"Structural basis for action by diverse antidepressants on biogenic amine transporters","volume":"503","author":"Wang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0645","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neuroscience.2005.07.041","article-title":"Contribution of vesicular and cytosolic dopamine to the increased striatal dopamine efflux elicited by intrastriatal injection of dexamphetamine","volume":"136","author":"Watanabe","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.drugalcdep.2014.12.005_bib0650","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1124\/jpet.104.080101","article-title":"Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs","volume":"313","author":"Wee","year":"2005","journal-title":"J. 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