{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:18:25Z","timestamp":1790673505335,"version":"4.1.0"},"reference-count":141,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Resistance Updates"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.drup.2008.08.005","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T11:49:53Z","timestamp":1224071393000},"page":"231-246","source":"Crossref","is-referenced-by-count":205,"title":["SPARC in cancer biology: Its role in cancer progression and potential for therapy"],"prefix":"10.1016","volume":"11","author":[{"given":"Isabella T.","family":"Tai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drup.2008.08.005_bib1","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/0277-5379(87)90060-5","article-title":"The EORTC early clinical trials cooperative group experience with 5-aza-2\u2032-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas","volume":"23","author":"Abele","year":"1987","journal-title":"Eur. J. Cancer Clin. Oncol."},{"key":"10.1016\/j.drup.2008.08.005_bib2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/path.1441","article-title":"Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid","volume":"201","author":"Ahmed","year":"2003","journal-title":"J. Pathol."},{"key":"10.1016\/j.drup.2008.08.005_bib3","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1158\/0008-5472.CAN-06-3481","article-title":"A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis","volume":"67","author":"Alonso","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00043426-200005000-00003","article-title":"Natural history and biology of stage A neuroblastoma: a Pediatric Oncology Group Study","volume":"22","author":"Alvarado","year":"2000","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.drup.2008.08.005_bib5","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1158\/0008-5472.CAN-04-1102","article-title":"Secreted protein acidic and rich in cysteine produced by human melanoma cells modulates polymorphonuclear leukocyte recruitment and antitumor cytotoxic capacity","volume":"65","author":"Alvarez","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib6","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1056\/NEJM199606063342304","article-title":"Role of ploidy, chromosome 1p, and Schwann cells in the maturation of neuroblastoma","volume":"334","author":"Ambros","year":"1996","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.drup.2008.08.005_bib7","doi-asserted-by":"crossref","first-page":"860","DOI":"10.3181\/0801-RM-12","article-title":"Forced expression of MMP9 rescues the loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC","volume":"233","author":"Arnold","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.drup.2008.08.005_bib8","doi-asserted-by":"crossref","first-page":"30479","DOI":"10.1074\/jbc.270.51.30479","article-title":"Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes","volume":"270","author":"Atkinson","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2008.08.005_bib9","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1091\/mbc.E03-05-0308","article-title":"Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN","volume":"14","author":"Attwell","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.drup.2008.08.005_bib10","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1083\/jcb.200404018","article-title":"Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen","volume":"167","author":"Bao","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.drup.2008.08.005_bib11","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s00428-005-1256-9","article-title":"Stromal remodeling and SPARC (secreted protein acid rich in cysteine) expression in invasive ductal carcinomas of the breast","volume":"446","author":"Barth","year":"2005","journal-title":"Virchows Arch."},{"key":"10.1016\/j.drup.2008.08.005_bib12","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/labinvest.2008.31","article-title":"The fibromatosis signature defines a robust stromal response in breast carcinoma","volume":"88","author":"Beck","year":"2008","journal-title":"Lab. Invest."},{"key":"10.1016\/j.drup.2008.08.005_bib13","first-page":"95","article-title":"Increased expression of osteonectin and osteopontin, two bone matrix proteins, in human breast cancer","volume":"146","author":"Bellahcene","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drup.2008.08.005_bib14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/path.2278","article-title":"Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome","volume":"214","author":"Bergamaschi","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.drup.2008.08.005_bib15","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0955-0674(02)00361-7","article-title":"Matricellular proteins: extracellular modulators of cell function","volume":"14","author":"Bornstein","year":"2002","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.drup.2008.08.005_bib16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.drup.2007.03.001","article-title":"Targeting tumor stroma and exploiting mature tumor vasculature to improve anticancer drug delivery","volume":"10","author":"Bouzin","year":"2007","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.drup.2008.08.005_bib17","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1172\/JCI12939","article-title":"SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury","volume":"107","author":"Bradshaw","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drup.2008.08.005_bib18","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0945-053X(00)00105-0","article-title":"SPARC, a matricellular protein: at the crossroads of cell\u2013matrix","volume":"19","author":"Brekken","year":"2000","journal-title":"Matrix Biol."},{"key":"10.1016\/j.drup.2008.08.005_bib19","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0945-053X(00)00133-5","article-title":"SPARC, a matricellular protein: at the crossroads of cell\u2013matrix communication","volume":"19","author":"Brekken","year":"2001","journal-title":"Matrix Biol."},{"key":"10.1016\/j.drup.2008.08.005_bib20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1172\/JCI16804","article-title":"Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM","volume":"111","author":"Brekken","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drup.2008.08.005_bib21","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.1038\/sj.onc.1205857","article-title":"Transcriptional upregulation of SPARC, in response to c-Jun overexpression, contributes to increased motility and invasion of MCF7 breast cancer cells","volume":"21","author":"Briggs","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2008.08.005_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/gyno.1999.5552","article-title":"Activation of SPARC expression in reactive stroma associated with human epithelial ovarian cancer","volume":"75","author":"Brown","year":"1999","journal-title":"Gyn. Oncol."},{"key":"10.1016\/j.drup.2008.08.005_bib23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/excr.1999.4765","article-title":"Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein","volume":"254","author":"Byzova","year":"2000","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.drup.2008.08.005_bib24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1158\/1055-9965.EPI-07-2615","article-title":"Meta-analysis of colorectal cancer gene expression profiling studies identifies consistently reported candidate biomarkers","volume":"17","author":"Chan","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.drup.2008.08.005_bib25","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1038\/sj.bjc.6604377","article-title":"SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2\u2032deoxycytidine to increase SPARC expression and improve therapy response","volume":"98","author":"Cheetham","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.drup.2008.08.005_bib26","first-page":"7357","article-title":"SPARC is a key Schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis","volume":"62","author":"Chlenski","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib27","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.1158\/0008-5472.CAN-04-2141","article-title":"Neuroblastoma angiogenesis is inhibited with a folded synthetic molecule corresponding to the epidermal growth factor-like module of the follistatin domain of SPARC","volume":"64","author":"Chlenski","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib28","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ijc.21357","article-title":"SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix","volume":"118","author":"Chlenski","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.drup.2008.08.005_bib29","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1093\/jnci\/81.24.1893","article-title":"Model predicting survival in stage I melanoma based on tumor progression","volume":"81","author":"Clark","year":"1989","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.drup.2008.08.005_bib30","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1038\/sj.onc.1206347","article-title":"alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells","volume":"22","author":"Cruet-Hennequart","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2008.08.005_bib31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1177\/002215549704500502","article-title":"Ectopic expression of SPARC in Xenopus embryos interferes with tissue morphogenesis: identification of a bioactive sequence in the C-terminal EF hand","volume":"45","author":"Damjanovski","year":"1997","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.drup.2008.08.005_bib32","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/35090585","article-title":"Delineation of prognostic biomarkers in prostate cancer","volume":"412","author":"Dhanasekaran","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.drup.2008.08.005_bib33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1023\/A:1016536725958","article-title":"Doxycycline-inducible expression of SPARC\/Osteonectin\/BM40 in MDA-MB-231 human breast cancer cells results in growth inhibition","volume":"75","author":"Dhanesuan","year":"2002","journal-title":"Breast Cancer Res. Treatm."},{"key":"10.1016\/j.drup.2008.08.005_bib34","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/sj.leu.2404102","article-title":"Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein","volume":"20","author":"DiMartino","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.drup.2008.08.005_bib35","doi-asserted-by":"crossref","first-page":"538D","DOI":"10.1136\/jnnp.68.4.538d","article-title":"Russell and Rubinstein\u2019s pathology of tumors of the nervous system","volume":"68","author":"Esiri","year":"2000","journal-title":"J. Neurol, Neurosurg. Psych."},{"key":"10.1016\/j.drup.2008.08.005_bib36","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1073\/pnas.88.7.2648","article-title":"The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells","volume":"88","author":"Funk","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drup.2008.08.005_bib37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/jcp.1041540108","article-title":"Differential effects of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts","volume":"154","author":"Funk","year":"1993","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.drup.2008.08.005_bib38","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1200\/JCO.2003.05.063","article-title":"Cost of migration: invasion of malignant gliomas and implications for treatment","volume":"21","author":"Giese","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.drup.2008.08.005_bib39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/(SICI)1097-0215(19960117)65:2<209::AID-IJC14>3.0.CO;2-8","article-title":"High level of MT-MMP expression is associated with invasiveness of cervical cancer cells","volume":"65","author":"Gilles","year":"1996","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.drup.2008.08.005_bib40","first-page":"651","article-title":"Implication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma","volume":"76","author":"Gilles","year":"1997","journal-title":"Lab. Invest."},{"key":"10.1016\/j.drup.2008.08.005_bib41","first-page":"5529","article-title":"SPARC\/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines","volume":"58","author":"Gilles","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib42","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/glia.20679","article-title":"HSP27 mediates SPARC-induced changes in glioma morphology, migration and invasion","volume":"56","author":"Golembieski","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.drup.2008.08.005_bib43","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.1200\/JCO.2005.04.937","article-title":"Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer","volume":"23","author":"Gradishar","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.drup.2008.08.005_bib44","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/ijc.23216","article-title":"SPARC modulates the proliferation of stromal but not melanoma cells unless endogenous SPARC expression is downregulated","volume":"122","author":"Haber","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.drup.2008.08.005_bib45","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/jcb.240490310","article-title":"SPARC antagonizes the effect of basic fibroblast growth factor on the migration of bovine aortic endothelial cells","volume":"49","author":"Hasselaar","year":"1992","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.drup.2008.08.005_bib46","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1093\/emboj\/16.13.3778","article-title":"Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40","volume":"16","author":"Hohenester","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.drup.2008.08.005_bib47","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.105.1.473","article-title":"In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization","volume":"105","author":"Holland","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.drup.2008.08.005_bib48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1044-579X(02)00026-3","article-title":"Matrix-directed regulation of pericellular proteolysis and tumor progression","volume":"12","author":"Hornebeck","year":"2002","journal-title":"Sem. Cancer Biol."},{"key":"10.1016\/j.drup.2008.08.005_bib49","first-page":"5966","article-title":"Schwann cell-conditioned medium inhibits angiogenesis","volume":"60","author":"Huang","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib50","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1091\/mbc.6.3.327","article-title":"Expression of SPARC during development of the chicken chorioallantoic membrane: evidence for regulated proteolysis in vivo","volume":"6","author":"Iruela-Arispe","year":"1995","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.drup.2008.08.005_bib51","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1158\/0008-5472.CAN-03-2028","article-title":"Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer","volume":"64","author":"Jones","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib52","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1182\/blood.V80.12.3112.3112","article-title":"Characterization of human osteoblast and megakaryocyte-derived osteonectin (SPARC)","volume":"80","author":"Kelm","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.drup.2008.08.005_bib53","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/glia.440150303","article-title":"Histopathology, classification and grading of gliomas","volume":"15","author":"Kleihues","year":"1995","journal-title":"Glia"},{"key":"10.1016\/j.drup.2008.08.005_bib54","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1158\/0008-5472.CAN-05-0807","article-title":"Endogenous osteonectin\/SPARC\/BM-40 expression inhibits MDA-MB-231 breast cancer cell metastasis","volume":"65","author":"Koblinski","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib55","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0090-8258(02)00152-X","article-title":"Invasion of interstitial matrix by a novel cell line from primary peritoneal carcinosarcoma, and by established ovarian carcinoma cell lines: role of cell\u2013matrix adhesion molecules, proteinases, and E-cadherin expression","volume":"89","author":"Kokenyesi","year":"2003","journal-title":"Gyn. Oncol."},{"key":"10.1016\/j.drup.2008.08.005_bib56","first-page":"1349","article-title":"SPARC-induced migration of glioblastoma cell lines via uPA-uPAR signaling and activation of small GTPase RhoA","volume":"29","author":"Kunigal","year":"2006","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.drup.2008.08.005_bib57","doi-asserted-by":"crossref","first-page":"29635","DOI":"10.1074\/jbc.273.45.29635","article-title":"SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells","volume":"273","author":"Kupprion","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2008.08.005_bib58","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1083\/jcb.111.6.3065","article-title":"Functional mapping of SPARC: peptides from two distinct Ca+(+)-binding sites modulate cell shape","volume":"111","author":"Lane","year":"1990","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.drup.2008.08.005_bib59","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1083\/jcb.125.4.929","article-title":"SPARC is a source of copper-binding peptides that stimulate angiogenesis","volume":"125","author":"Lane","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.drup.2008.08.005_bib60","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1073\/pnas.0304146101","article-title":"Gene expression profiling identifies clinically relevant subtypes of prostate cancer","volume":"101","author":"Lapointe","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drup.2008.08.005_bib61","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/1523-1747.ep12334263","article-title":"The expression of the secreted protein acidic and rich in cysteine (SPARC) is associated with the neoplastic progression of human melanoma","volume":"108","author":"Ledda","year":"1997","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.drup.2008.08.005_bib62","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nm0297-171","article-title":"Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells","volume":"3","author":"Ledda","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.drup.2008.08.005_bib63","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/labinvest.3700108","article-title":"Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia","volume":"84","author":"Lee","year":"2004","journal-title":"Lab. Invest."},{"key":"10.1016\/j.drup.2008.08.005_bib64","doi-asserted-by":"crossref","first-page":"7859","DOI":"10.1038\/sj.onc.1210593","article-title":"Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition","volume":"26","author":"Lien","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2008.08.005_bib65","doi-asserted-by":"crossref","first-page":"17602","DOI":"10.1074\/jbc.270.29.17602","article-title":"Calcium ionophores decrease pericellular gelatinolytic activity via inhibition of 92-kDa gelatinase expression and decrease of 72-kDa gelatinase activation","volume":"270","author":"Lohi","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2008.08.005_bib66","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/1097-4644(20010601)81:3<463::AID-JCB1060>3.0.CO;2-L","article-title":"Expression of SPARC\/osteonectin\/BM4O in the human gut: predominance in the stroma of the remodeling distal intestine","volume":"81","author":"Lussier","year":"2001","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.drup.2008.08.005_bib67","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s00427-002-0220-9","article-title":"Evolutionary conservation and association of SPARC with the basal lamina in Drosophila","volume":"212","author":"Martinek","year":"2002","journal-title":"Dev. Genes Evol."},{"key":"10.1016\/j.drup.2008.08.005_bib68","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/j.1460-2075.1986.tb04434.x","article-title":"Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11","volume":"5","author":"Mason","year":"1986","journal-title":"EMBO J."},{"key":"10.1016\/j.drup.2008.08.005_bib69","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/j.1460-2075.1986.tb04383.x","article-title":"Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell \u2018culture shock\u2019 glycoprotein of Mr 43.000","volume":"5","author":"Mason","year":"1986","journal-title":"EMBO J."},{"key":"10.1016\/j.drup.2008.08.005_bib70","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0046-8177(99)90014-X","article-title":"Osteonectin expression correlates with clinical outcome in thin cutaneous malignant melanomas","volume":"30","author":"Massi","year":"1999","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.drup.2008.08.005_bib71","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neulet.2007.04.037","article-title":"SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells","volume":"419","author":"McClung","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.drup.2008.08.005_bib72","doi-asserted-by":"crossref","first-page":"11111","DOI":"10.1016\/S0021-9258(18)37929-8","article-title":"Characterization of the mouse SPARC\/osteonectin gene. Intron\/exon organization and an unusual promoter region","volume":"263","author":"McVey","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2008.08.005_bib73","first-page":"683","article-title":"A study of SPARC and vitronectin localization and expression in pediatric and adult gliomas: high SPARC secretion correlates with decreased migration on vitronectin","volume":"17","author":"Menon","year":"2000","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.drup.2008.08.005_bib74","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/S0002-9440(10)65669-6","article-title":"Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization","volume":"153","author":"Mesiano","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drup.2008.08.005_bib75","doi-asserted-by":"crossref","first-page":"5668","DOI":"10.1002\/j.1460-2075.1994.tb06905.x","article-title":"SPARC and thrombospondin genes are repressed by the c-jun oncogene in rat embryo fibroblasts","volume":"13","author":"Mettouchi","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.drup.2008.08.005_bib76","first-page":"1895","article-title":"SPARC, an extracellular matrix protein with tumor-suppressing activity in human ovarian epithelial cells","volume":"12","author":"Mok","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2008.08.005_bib77","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/ki.1997.189","article-title":"Regulation of vascular morphogenesis by the matricellular protein SPARC","volume":"51","author":"Motamed","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.drup.2008.08.005_bib78","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/(SICI)1097-4644(19980915)70:4<543::AID-JCB10>3.0.CO;2-I","article-title":"SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway","volume":"70","author":"Motamed","year":"1998","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.drup.2008.08.005_bib79","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jcb.240570218","article-title":"SPARC mediates focal adhesion disassembly in endothelial cells through a follistatin-like region and the Ca(2+)-binding EF-hand","volume":"57","author":"Murphy-Ullrich","year":"1995","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.drup.2008.08.005_bib80","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/BF02556062","article-title":"Developmental expression of genes in chick growth cartilage detected by in situ hybridization","volume":"45","author":"Oshima","year":"1989","journal-title":"Calc. Tissue Int."},{"key":"10.1016\/j.drup.2008.08.005_bib81","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/gyno.2000.5894","article-title":"Alterations in SPARC and VEGF immunoreactivity in epithelial ovarian cancer","volume":"78","author":"Paley","year":"2000","journal-title":"Gyn. Oncol."},{"key":"10.1016\/j.drup.2008.08.005_bib82","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.critrevonc.2003.10.008","article-title":"Tumour invasion and matrix metalloproteinases","volume":"49","author":"Polette","year":"2004","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.drup.2008.08.005_bib83","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1177\/43.8.7622842","article-title":"Distribution of SPARC in normal and neoplastic human tissue","volume":"43","author":"Porter","year":"1995","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.drup.2008.08.005_bib84","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1038\/sj.jid.5700962","article-title":"SPARC endogenous level, rather than fibroblast-produced SPARC or stroma reorganization induced by SPARC, is responsible for melanoma cell growth","volume":"127","author":"Prada","year":"2007","journal-title":"J. Invent. Dermatol."},{"key":"10.1016\/j.drup.2008.08.005_bib85","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1158\/1541-7786.215.2.4","article-title":"Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis","volume":"2","author":"Puolakkainen","year":"2004","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib86","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1073\/pnas.89.4.1281","article-title":"The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors","volume":"89","author":"Raines","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drup.2008.08.005_bib87","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1177\/41.10.8245406","article-title":"Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization","volume":"41","author":"Reed","year":"1993","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.drup.2008.08.005_bib88","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1097\/00005072-199812000-00002","article-title":"SPARC: a signal of astrocytic neoplastic transformation and reactive response in human primary and xenograft gliomas","volume":"57","author":"Rempel","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.drup.2008.08.005_bib89","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1012201300188","article-title":"SPARC modulates cell growth, attachment and migration of U87 glioma cells on brain extracellular matrix proteins","volume":"53","author":"Rempel","year":"2001","journal-title":"J. Neuro-oncol."},{"key":"10.1016\/j.drup.2008.08.005_bib90","first-page":"1301","article-title":"Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinoma","volume":"17","author":"Rodriguez-Jimenez","year":"2007","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.drup.2008.08.005_bib91","doi-asserted-by":"crossref","first-page":"14831","DOI":"10.1016\/S0021-9258(18)98545-5","article-title":"Extracellular proteins that modulate cell\u2013matrix interactions. SPARC, tenascin, and thrombospondi","volume":"266","author":"Sage","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2008.08.005_bib92","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1016\/S0021-9258(17)43194-2","article-title":"Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture","volume":"259","author":"Sage","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2008.08.005_bib93","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jcb.240570113","article-title":"Inhibition of endothelial cell proliferation by SPARC is mediated through a Ca(2+)-binding EF-hand sequence","volume":"57","author":"Sage","year":"1995","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.drup.2008.08.005_bib94","doi-asserted-by":"crossref","first-page":"37849","DOI":"10.1074\/jbc.M302946200","article-title":"Cleavage of the matricellular protein SPARC by matrix metalloproteinase 3 produces polypeptides that influence angiogenesis","volume":"278","author":"Sage","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2008.08.005_bib95","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0002-9440(10)61255-2","article-title":"Absence of host-secreted protein acidic and rich in cysteine (SPARC) augments peritoneal ovarian carcinomatosis","volume":"167","author":"Said","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drup.2008.08.005_bib96","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.2353\/ajpath.2007.060903","article-title":"Secreted protein acidic and rich in cysteine (SPARC) inhibits integrin-mediated adhesion and growth factor-dependent survival signaling in ovarian cancer","volume":"170","author":"Said","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drup.2008.08.005_bib97","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1158\/1541-7786.MCR-07-0001","article-title":"Normalization of the ovarian cancer microenvironment by SPARC","volume":"5","author":"Said","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib98","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1593\/neo.06658","article-title":"SPARC inhibits LPA-mediated mesothelial-ovarian cancer cell crosstalk","volume":"9","author":"Said","year":"2007","journal-title":"Neoplasia"},{"key":"10.1016\/j.drup.2008.08.005_bib99","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0003-9969(90)90180-I","article-title":"Immunohistochemical localization of SPARC (osteonectin) and denatured collagen and their relationship to remodelling in rat dental tissues","volume":"35","author":"Salonen","year":"1990","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.drup.2008.08.005_bib100","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1084\/jem.20030202","article-title":"Leukocyte, rather than tumor-produced SPARC, determines stroma and collagen type IV deposition in mammary carcinoma","volume":"198","author":"Sangaletti","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.drup.2008.08.005_bib101","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1136\/gut.2006.116921","article-title":"Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin\/+ mice","volume":"56","author":"Sansom","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.drup.2008.08.005_bib102","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/oxfordjournals.jbchem.a021223","article-title":"Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis","volume":"119","author":"Sato","year":"1996","journal-title":"J. Biochem."},{"key":"10.1016\/j.drup.2008.08.005_bib103","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/370061a0","article-title":"A matrix metalloproteinase expressed on the surface of invasive tumour cells","volume":"370","author":"Sato","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.drup.2008.08.005_bib104","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1038\/sj.onc.1206807","article-title":"SPARC\/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions","volume":"22","author":"Sato","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2008.08.005_bib105","first-page":"6270","article-title":"Secreted protein acidic and rich in cysteine promotes glioma invasion and delays tumor growth in vivo","volume":"62","author":"Schultz","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib106","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1091\/mbc.4.9.941","article-title":"The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC\/osteonectin affects nematode body morphology and mobility","volume":"4","author":"Schwarzbauer","year":"1993","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.drup.2008.08.005_bib107","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/(SICI)1097-4652(199712)173:3<327::AID-JCP4>3.0.CO;2-P","article-title":"Regulation of human monocyte matrix metalloproteinases by SPARC","volume":"173","author":"Shankavaram","year":"1997","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.drup.2008.08.005_bib108","doi-asserted-by":"crossref","first-page":"52200","DOI":"10.1074\/jbc.M409630200","article-title":"Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation","volume":"279","author":"Shi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2008.08.005_bib109","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1038\/sj.onc.1210181","article-title":"Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases","volume":"26","author":"Shi","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2008.08.005_bib110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/jnci\/73.2.405","article-title":"Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas","volume":"73","author":"Shimada","year":"1984","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.drup.2008.08.005_bib111","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1093\/bioinformatics\/btg282","article-title":"Venn Mapping: clustering of heterologous microarray data based on the number of co-occurring differentially expressed genes","volume":"19","author":"Smid","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.drup.2008.08.005_bib112","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1158\/1055-9965.EPI-05-0323","article-title":"Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis","volume":"15","author":"Sova","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.drup.2008.08.005_bib113","first-page":"259","article-title":"Progelatinase A activation during tumor cell invasion","volume":"14","author":"Stetler-Stevenson","year":"1994","journal-title":"Invas. Metast."},{"key":"10.1016\/j.drup.2008.08.005_bib114","doi-asserted-by":"crossref","first-page":"14033","DOI":"10.1016\/S0021-9258(19)85205-5","article-title":"Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2","volume":"268","author":"Strongin","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2008.08.005_bib115","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/sj.bjc.6602376","article-title":"Aberrant methylation of SPARC in human lung cancers","volume":"92","author":"Suzuki","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.drup.2008.08.005_bib116","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0888-7543(88)90107-3","article-title":"Molecular analysis of the cDNA for human SPARC\/osteonectin\/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33","volume":"2","author":"Swaroop","year":"1988","journal-title":"Genomics"},{"key":"10.1016\/j.drup.2008.08.005_bib117","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1158\/1535-7163.MCT-06-0517","article-title":"Synergism between vitamin D and secreted protein acidic and rich in cysteine-induced apoptosis and growth inhibition results in increased susceptibility of therapy-resistant colorectal cancer cells to chemotherapy","volume":"6","author":"Taghizadeh","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.drup.2008.08.005_bib118","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1172\/JCI23002","article-title":"Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy","volume":"115","author":"Tai","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drup.2008.08.005_bib119","doi-asserted-by":"crossref","first-page":"34457","DOI":"10.1074\/jbc.M704459200","article-title":"A novel interaction between procaspase 8 and SPARC enhances apoptosis and potentiates chemotherapy sensitivity in colorectal cancers","volume":"282","author":"Tang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2008.08.005_bib120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0092-8674(81)90037-4","article-title":"Osteonectin, a bone-specific protein linking mineral to collagen","volume":"26","author":"Termine","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.drup.2008.08.005_bib121","doi-asserted-by":"crossref","first-page":"R157","DOI":"10.1186\/gb-2007-8-8-r157","article-title":"An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer","volume":"8","author":"Teschendorff","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.drup.2008.08.005_bib122","first-page":"1140","article-title":"Differential expression of osteonectin\/SPARC during human prostate cancer progression","volume":"6","author":"Thomas","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib123","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1073\/pnas.96.15.8681","article-title":"CpG island methylator phenotype in colorectal cancer","volume":"96","author":"Toyota","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drup.2008.08.005_bib124","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1083\/jcb.121.6.1433","article-title":"SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway","volume":"121","author":"Tremble","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.drup.2008.08.005_bib125","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/1097-0215(20000715)87:2<261::AID-IJC18>3.0.CO;2-6","article-title":"Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC","volume":"87","author":"Vajkoczy","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.drup.2008.08.005_bib126","first-page":"3747","article-title":"Soluble aminopeptidase N\/CD13 in malignant and nomalignant effusions and intratumoral fluid","volume":"8","author":"Van Hensbergen","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib127","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/415530a","article-title":"Gene expression profiling predicts clinical outcome of breast cancer","volume":"415","author":"Van\u2019t Veer","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.drup.2008.08.005_bib128","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1038\/sj.onc.1203493","article-title":"Down-regulation of the extracellular matrix protein SPARC in vSrc- and vJun-transformed chick embryo fibroblasts contributes to tumor formation in vivo","volume":"19","author":"Vial","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2008.08.005_bib129","doi-asserted-by":"crossref","unstructured":"Von Hoff, D.D., Borad, M., Ramanathan, R.K., Smith, L.S., Drengler, R.L., Wood, T.E., Laheru, D., Hedalgo, M., 2008. Promising clinical activity of a NAB pacitaxel plus gemcitabine combination in a disease-specific phase I trial in patients with advanced pancreatic cancer (Abstracts 4179). In: Proceedings of the 99th Annual Meeting, April 12\u201316, 2008. Am. Assoc. Cancer Res, San Diego, CA.","DOI":"10.1158\/1538-7445.AM2008-4179"},{"key":"10.1016\/j.drup.2008.08.005_bib130","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1593\/neo.05289","article-title":"Survey of differentially methylated promoters in prostate cancer cell lines","volume":"7","author":"Wang","year":"2005","journal-title":"Neoplasia"},{"key":"10.1016\/j.drup.2008.08.005_bib131","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.plefa.2004.12.003","article-title":"Increased levels of SPARC (osteonectin) in human breast cancer tissues and its association with clinical outcomes","volume":"72","author":"Watkins","year":"2005","journal-title":"Prostaglan. Leukotr. Essent. Fatty Acids"},{"key":"10.1016\/j.drup.2008.08.005_bib132","first-page":"5974","article-title":"Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer","volume":"61","author":"Welsh","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2008.08.005_bib133","first-page":"345","article-title":"Osteonectin\/ SPARC\/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane","volume":"132","author":"Wewer","year":"1988","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drup.2008.08.005_bib134","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.cdp.2007.07.003","article-title":"Identification of gene signatures for invasive colorectal tumor cells","volume":"31","author":"Wiese","year":"2007","journal-title":"Cancer Detect. Prevent."},{"key":"10.1016\/j.drup.2008.08.005_bib135","doi-asserted-by":"crossref","first-page":"12784","DOI":"10.1073\/pnas.0705499104","article-title":"Protein 4.1B suppresses prostate cancer progression and metastasis","volume":"104","author":"Wong","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drup.2008.08.005_bib136","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10585-007-9126-2","article-title":"Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer","volume":"25","author":"Wong","year":"2008","journal-title":"Clin. Exp. Metast."},{"key":"10.1016\/j.drup.2008.08.005_bib137","first-page":"89","article-title":"Vascular endothelial growth factor activating matrix metalloproteinase in ascitic fluid during peritoneal dissemination of ovarian cancer","volume":"10","author":"Yabushita","year":"2003","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.drup.2008.08.005_bib138","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1177\/002215549904701201","article-title":"SPARC, a matricellular glycoprotein with important biological functions","volume":"47","author":"Yan","year":"1999","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.drup.2008.08.005_bib139","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/ijc.22706","article-title":"Frequent inactivation of SPARC by promoter hypermethylation in colon cancers","volume":"121","author":"Yang","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.drup.2008.08.005_bib140","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0002-9440(10)61732-4","article-title":"SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells","volume":"159","author":"Yiu","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drup.2008.08.005_bib141","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1093\/nar\/14.11.4483","article-title":"Osteonectin mRNA: distribution in normal and transformed cells","volume":"14","author":"Young","year":"1986","journal-title":"Nucleic Acids Res."}],"container-title":["Drug Resistance Updates"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764608000484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764608000484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T09:50:35Z","timestamp":1684576235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1368764608000484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":141,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S1368764608000484"],"URL":"https:\/\/doi.org\/10.1016\/j.drup.2008.08.005","relation":{},"ISSN":["1368-7646"],"issn-type":[{"value":"1368-7646","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}