{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:18:32Z","timestamp":1778768312864,"version":"3.51.4"},"reference-count":67,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Operational Program for Competitiveness Factors \u2013 COMPETE"},{"name":"Portuguese Foundation for Science and Technology"}],"content-domain":{"domain":["drupjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Resistance Updates"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.drup.2014.08.001","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T14:48:13Z","timestamp":1407854893000},"page":"51-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["What should be considered in the treatment of bacterial infections by multi-drug therapies: A mathematical perspective?"],"prefix":"10.1016","volume":"17","author":[{"given":"Francisco","family":"Pimenta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia Chaves","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.drup.2014.08.001_bib0005","first-page":"85","article-title":"Innate and induced resistance mechanisms of bacterial biofilms","volume":"322","author":"Anderson","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.drup.2014.08.001_bib0010","doi-asserted-by":"crossref","first-page":"e1003300","DOI":"10.1371\/journal.ppat.1003300","article-title":"The pharmaco, population and evolutionary dynamics of multi-drug therapy: experiments with S. aureus and E. coli and computer simulations","volume":"9","author":"Ankomah","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.drup.2014.08.001_bib0015","doi-asserted-by":"crossref","first-page":"e1002487","DOI":"10.1371\/journal.ppat.1002487","article-title":"Two-drug antimicrobial chemotherapy: a mathematical model and experiments with Mycobacterium marinum","volume":"8","author":"Ankomah","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.drup.2014.08.001_bib0020","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/978-1-60327-853-9_23","article-title":"What antimicrobial resistance has taught us about horizontal gene transfer?","volume":"532","author":"Barlow","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.drup.2014.08.001_bib0025","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1093\/cid\/cit070","article-title":"Seven ways to preserve the miracle of antibiotics","volume":"56","author":"Bartlett","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.drup.2014.08.001_bib0030","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3934\/mbe.2010.7.527","article-title":"Rotating antibiotics selects optimally against antibiotic resistance, in theory","volume":"7","author":"Beardmore","year":"2010","journal-title":"Math. Biosci. Eng."},{"key":"10.1016\/j.drup.2014.08.001_bib0035","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1128\/AAC.06113-11","article-title":"Novel modeling framework to guide design of optimal dosing strategies for \u03b2-lactamase inhibitors","volume":"56","author":"Bhagunde","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.drup.2014.08.001_bib0040","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/ppul.21011","article-title":"Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients","volume":"44","author":"Bjarnsholt","year":"2009","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.drup.2014.08.001_bib0045","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1744-7348.1939.tb06990.x","article-title":"The toxicity of poisons applied jointly","volume":"26","author":"Bliss","year":"1939","journal-title":"Ann. Appl. Biol."},{"key":"10.1016\/j.drup.2014.08.001_bib0050","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/cid\/cit152","article-title":"10\u00d7\u201920 Progress-development of new drugs active against Gram-negative bacilli: an update from the Infectious Diseases Society of America","volume":"56","author":"Boucher","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.drup.2014.08.001_bib0055","series-title":"Empirical Model-Building and Response Surfaces","first-page":"424","author":"Box","year":"1987"},{"key":"10.1016\/j.drup.2014.08.001_bib0060","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/jac\/dkh482","article-title":"Antibiotic cycling or rotation: a systematic review of the evidence of efficacy","volume":"55","author":"Brown","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.drup.2014.08.001_bib0065","doi-asserted-by":"crossref","first-page":"e349","DOI":"10.1371\/journal.pbio.0040349","article-title":"Intracellular demography and the dynamics of Salmonella enterica infections","volume":"4","author":"Brown","year":"2006","journal-title":"PLoS Biol."},{"key":"10.1016\/j.drup.2014.08.001_bib0070","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nature05685","article-title":"Antibiotic interactions that select against resistance","volume":"446","author":"Chait","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.drup.2014.08.001_bib0075","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.drup.2014.08.001_bib0080","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/sj.bjp.0707432","article-title":"Novel approaches to developing new antibiotics for bacterial infections","volume":"152","author":"Coates","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.drup.2014.08.001_bib0085","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1098\/rsif.2009.0400","article-title":"What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae?","volume":"7","author":"Colijn","year":"2010","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.drup.2014.08.001_bib0090","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s10928-007-9069-x","article-title":"Mechanism-based pharmacokinetic\u2013pharmacodynamic modeling of antimicrobial drug effects","volume":"34","author":"Czock","year":"2007","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.drup.2014.08.001_bib0095","doi-asserted-by":"crossref","first-page":"e4036","DOI":"10.1371\/journal.pone.0004036","article-title":"The impact of different antibiotic regimens on the emergence of antimicrobial-resistant bacteria","volume":"3","author":"D\u2019Agata","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.drup.2014.08.001_bib0100","first-page":"287","article-title":"Where have all the antibiotics gone?","volume":"17","author":"Davies","year":"2006","journal-title":"Can. J. Infect. Dis."},{"key":"10.1016\/j.drup.2014.08.001_bib0105","doi-asserted-by":"crossref","first-page":"e1002121","DOI":"10.1371\/journal.ppat.1002121","article-title":"\u201cPersisters\u201d: survival at the cellular level","volume":"7","author":"Dawson","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.drup.2014.08.001_bib0110","doi-asserted-by":"crossref","first-page":"e1000989","DOI":"10.1371\/journal.ppat.1000989","article-title":"Can bacteria evolve resistance to quorum sensing disruption?","volume":"6","author":"Defoirdt","year":"2010","journal-title":"PLoS Pathog."},{"issue":"Suppl. 3","key":"10.1016\/j.drup.2014.08.001_bib0115","doi-asserted-by":"crossref","first-page":"S177","DOI":"10.1086\/519472","article-title":"Principles of antibiotic therapy in severe infections: optimizing the therapeutic approach by use of laboratory and clinical data","volume":"45","author":"Deresinski","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.drup.2014.08.001_bib0120","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1371\/journal.pbio.0060280","article-title":"The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing","volume":"6","author":"Dethlefsen","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.drup.2014.08.001_bib0125","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0140-6736(01)38705-6","article-title":"Address in pathology on chemotherapeutics","volume":"182","author":"Ehrlich","year":"1913","journal-title":"Lancet"},{"key":"10.1016\/j.drup.2014.08.001_bib0135","doi-asserted-by":"crossref","first-page":"e5383","DOI":"10.1371\/journal.pone.0005383","article-title":"Location of pathogenic bacteria during persistent infections: insights from an analysis using game theory","volume":"4","author":"Eswarappa","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.drup.2014.08.001_bib0140","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1472-8206.2008.00633.x","article-title":"The Hill equation: a review of its capabilities in pharmacological modelling","volume":"22","author":"Goutelle","year":"2008","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.drup.2014.08.001_bib0145","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0031-6997(25)06847-4","article-title":"The search for synergy: a critical review from a response surface perspective","volume":"47","author":"Greco","year":"1995","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.drup.2014.08.001_bib0150","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.jim.7000256","article-title":"Role of dose concentration in biocide efficacy against Pseudomonas aeruginosa biofilms","volume":"29","author":"Grobe","year":"2002","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.drup.2014.08.001_bib0155","doi-asserted-by":"crossref","first-page":"10775","DOI":"10.1073\/pnas.1117716109","article-title":"On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient","volume":"109","author":"Hermsen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.drup.2014.08.001_bib0160","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ijantimicag.2009.12.011","article-title":"Antibiotic resistance of bacterial biofilms","volume":"35","author":"H\u00f8iby","year":"2010","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.drup.2014.08.001_bib0165","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/archinte.164.6.637","article-title":"Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia","volume":"164","author":"Houck","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.drup.2014.08.001_bib0170","doi-asserted-by":"crossref","first-page":"16008","DOI":"10.1073\/pnas.1110489108","article-title":"Tempo and mode of inhibitor\u2013mutagen antiviral therapies: a multidisciplinary approach","volume":"108","author":"Iranzo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.drup.2014.08.001_bib0175","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0031-6997(25)07327-2","article-title":"Antibiotic synergism and antagonism; an assessment of the problem","volume":"5","author":"Jawetz","year":"1953","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.drup.2014.08.001_bib0180","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1128\/AAC.48.3.693-715.2004","article-title":"Combination antifungal therapy","volume":"48","author":"Johnson","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.drup.2014.08.001_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2004.10.014","article-title":"Towards a mechanism-based analysis of pharmacodynamic drug\u2013drug interactions in vivo","volume":"106","author":"Jonker","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.drup.2014.08.001_bib0190","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1172\/JCI200316814","article-title":"Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy","volume":"112","author":"Jumbe","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drup.2014.08.001_bib0195","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/jac\/dkf046","article-title":"Patient compliance with antibiotic treatment for respiratory tract infections","volume":"49","author":"Kardas","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.drup.2014.08.001_bib0200","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-1097(03)00856-5","article-title":"Persister cells and tolerance to antimicrobials","volume":"230","author":"Keren","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.drup.2014.08.001_bib0205","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/S0140-6736(12)60964-7","article-title":"Europe to boost development of new antimicrobial drugs","volume":"379","author":"Kirby","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.drup.2014.08.001_bib0210","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1046\/j.1365-2672.2003.01908.x","article-title":"Theory of antimicrobial combinations: biocide mixtures \u2013 synergy or addition?","volume":"94","author":"Lambert","year":"2003","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.drup.2014.08.001_bib0215","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1128\/AAC.00092-13","article-title":"Quantifying subpopulation synergy for antibiotic combinations via mechanism-based modeling and a sequential dosing design","volume":"57","author":"Landersdorfer","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.drup.2014.08.001_bib0220","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/10543400701199593","article-title":"Interaction index and different methods for determining drug interaction in combination therapy","volume":"17","author":"Lee","year":"2007","journal-title":"J. Biopharm. Stat."},{"key":"10.1016\/j.drup.2014.08.001_bib0225","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1128\/AAC.00381-10","article-title":"Population dynamics of antibiotic treatment: a mathematical model and hypotheses for time-kill and continuous-culture experiments","volume":"54","author":"Levin","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.drup.2014.08.001_bib0230","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.micro.112408.134306","article-title":"Persister cells","volume":"64","author":"Lewis","year":"2010","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.drup.2014.08.001_bib0235","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1128\/AAC.41.2.363","article-title":"The population dynamics of antimicrobial chemotherapy","volume":"41","author":"Lipsitch","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.drup.2014.08.001_bib0240","first-page":"285","article-title":"The problem of synergism and antagonism of combined drugs","volume":"3","author":"Loewe","year":"1953","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.drup.2014.08.001_bib0245","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1128\/AAC.00601-07","article-title":"Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms","volume":"51","author":"Lynch","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.drup.2014.08.001_bib0250","first-page":"112","article-title":"The evolution of antibiotic resistance: insight into the roles of molecular mechanisms of resistance and treatment context","volume":"10","author":"Maclean","year":"2010","journal-title":"Discov. Med."},{"key":"10.1016\/j.drup.2014.08.001_bib0255","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1128\/IAI.00995-06","article-title":"Cryptococcus neoformans cells in biofilms are less susceptible than planktonic cells to antimicrobial molecules produced by the innate immune system","volume":"74","author":"Martinez","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.drup.2014.08.001_bib0260","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1063\/1.166098","article-title":"A basic mathematical model of the immune response","volume":"5","author":"Mayer","year":"1995","journal-title":"Chaos"},{"key":"10.1016\/j.drup.2014.08.001_bib0265","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10096-004-1107-7","article-title":"Pharmacokinetic and pharmacodynamic issues in the treatment of bacterial infectious diseases","volume":"23","author":"McKinnon","year":"2004","journal-title":"Eur. J. Clin. Microbiol."},{"key":"10.1016\/j.drup.2014.08.001_bib0270","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10955-009-9768-3","article-title":"A general Isserlis theorem for mixed-Gaussian random variables","volume":"136","author":"Michalowicz","year":"2011","journal-title":"J. Stat. Phys."},{"key":"10.1016\/j.drup.2014.08.001_bib0275","doi-asserted-by":"crossref","first-page":"14918","DOI":"10.1073\/pnas.0800944105","article-title":"Drug interactions modulate the potential for evolution of resistance","volume":"105","author":"Michel","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.drup.2014.08.001_bib0280","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1128\/AAC.00182-11","article-title":"Pharmacokinetic\/pharmacodynamic (PK\/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization","volume":"55","author":"Nielsen","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.drup.2014.08.001_bib0285","doi-asserted-by":"crossref","first-page":"e1001540","DOI":"10.1371\/journal.pbio.1001540","article-title":"When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transition","volume":"11","author":"Pena-Miller","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.drup.2014.08.001_bib0290","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1098\/rsif.2012.0279","article-title":"The optimal deployment of synergistic antibiotics: a control theoretic approach","volume":"9","author":"Pena-Miller","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.drup.2014.08.001_bib0295","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/aje\/kwt017","article-title":"A modeling framework for the evolution and spread of antibiotic resistance: literature review and model categorization","volume":"178","author":"Spicknall","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.drup.2014.08.001_bib0300","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1128\/JB.185.5.1485-1491.2003","article-title":"Diffusion in biofilms","volume":"185","author":"Stewart","year":"2003","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.drup.2014.08.001_bib0305","doi-asserted-by":"crossref","first-page":"e1000796","DOI":"10.1371\/journal.pcbi.1000796","article-title":"Optimal drug synergy in antimicrobial treatments","volume":"6","author":"Torella","year":"2010","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.drup.2014.08.001_bib0310","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/cid\/cir899","article-title":"Infection control in the multidrug-resistant era: tending the human microbiome","volume":"54","author":"Tosh","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.drup.2014.08.001_bib0315","doi-asserted-by":"crossref","first-page":"e3866","DOI":"10.1371\/journal.pone.0038866","article-title":"Staphylococcus aureus in continuous culture: a tool for the rational design of antibiotic treatment","volume":"7","author":"Udekwu","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.drup.2014.08.001_bib0320","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrd1032","article-title":"ADMET in silico modelling: towards prediction paradise?","volume":"2","author":"van de Waterbeemd","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.drup.2014.08.001_bib0325","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0924-8579(02)00348-5","article-title":"An approach for the evaluation of synergy between antimicrobials","volume":"21","author":"Wang","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.drup.2014.08.001_bib0330","doi-asserted-by":"crossref","first-page":"12254","DOI":"10.1073\/pnas.1201281109","article-title":"Mechanism-independent method for predicting response to multidrug combinations in bacteria","volume":"109","author":"Wood","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.drup.2014.08.001_bib0335","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nrmicro2133","article-title":"Drug interactions and the evolution of antibiotic resistance","volume":"7","author":"Yeh","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.drup.2014.08.001_bib0340","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1128\/JB.01655-07","article-title":"Involvement of a novel efflux system in biofilm-specific resistance to antibiotics","volume":"190","author":"Zhang","year":"2008","journal-title":"J. Bacteriol."}],"container-title":["Drug Resistance Updates"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764614000363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764614000363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T04:37:26Z","timestamp":1746333446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1368764614000363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1368764614000363"],"URL":"https:\/\/doi.org\/10.1016\/j.drup.2014.08.001","relation":{},"ISSN":["1368-7646"],"issn-type":[{"value":"1368-7646","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What should be considered in the treatment of bacterial infections by multi-drug therapies: A mathematical perspective?","name":"articletitle","label":"Article Title"},{"value":"Drug Resistance Updates","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drup.2014.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}