{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:52:04Z","timestamp":1784922724973,"version":"3.55.0"},"reference-count":200,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"am","delay-in-days":422,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Resistance Updates"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.drup.2021.100790","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T11:49:56Z","timestamp":1638964196000},"page":"100790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Why may citrate sodium significantly increase the effectiveness of transarterial chemoembolization in hepatocellular carcinoma?"],"prefix":"10.1016","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5613-0934","authenticated-orcid":false,"given":"Philippe","family":"Icard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-1810","authenticated-orcid":false,"given":"Luca","family":"Simula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zherui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Berzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Sogni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Dohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Dautry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Coquerel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Lincet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Loi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fuks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drup.2021.100790_bib0005","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1186\/s12885-019-5891-y","article-title":"Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo","volume":"19","author":"Abe","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0010","doi-asserted-by":"crossref","first-page":"777","DOI":"10.18632\/oncoscience.109","article-title":"Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question","volume":"1","author":"Alfarouk","year":"2014","journal-title":"Oncoscience"},{"key":"10.1016\/j.drup.2021.100790_bib0015","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.2353\/ajpath.2009.080596","article-title":"GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis","volume":"174","author":"Amann","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drup.2021.100790_bib0020","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1248\/bpb.b20-00825","article-title":"Neutralization of acidic tumor microenvironment (TME) with daily oral dosing of sodium potassium citrate (K\/Na citrate) increases therapeutic effect of anti-cancer agent in pancreatic cancer xenograft mice model","volume":"44","author":"Ando","year":"2021","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.drup.2021.100790_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2019.100645","article-title":"The multi-factorial nature of clinical multidrug resistance in cancer","volume":"46","author":"Assaraf","year":"2019","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0030","series-title":"Biochemistry","author":"Berg","year":"2019"},{"key":"10.1016\/j.drup.2021.100790_bib0035","doi-asserted-by":"crossref","first-page":"33895","DOI":"10.1074\/jbc.M204681200","article-title":"The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes","volume":"277","author":"Berwick","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2021.100790_bib0040","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1158\/0008-5472.CAN-20-3044","article-title":"HDAC11 regulates glycolysis through the LKB1\/AMPK signaling pathway to maintain hepatocellular carcinoma stemness","volume":"81","author":"Bi","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0045","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.drup.2021.100790_bib0050","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1124\/mol.106.028167","article-title":"The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models","volume":"71","author":"Breedveld","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.drup.2021.100790_bib0055","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/PPO.0000000000000106","article-title":"Drivers of the warburg phenotype","volume":"21","author":"Cairns","year":"2015","journal-title":"Cancer J."},{"key":"10.1016\/j.drup.2021.100790_bib0060","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1053\/j.gastro.2010.12.006","article-title":"Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma","volume":"140","author":"Calvisi","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.drup.2021.100790_bib0065","doi-asserted-by":"crossref","DOI":"10.1038\/nrc1713","article-title":"The role of disturbed pH dynamics and the NA+\/H+ exchanger in metastasis","author":"Cardone","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0070","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ccell.2016.07.004","article-title":"Mitochondrial akt regulation of hypoxic tumor reprogramming","volume":"30","author":"Chae","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.drup.2021.100790_bib0075","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/lt.24117","article-title":"Combinations of biomarkers and Milan criteria for predicting hepatocellular carcinoma recurrence after liver transplantation","volume":"21","author":"Chaiteerakij","year":"2015","journal-title":"Liver Transplant."},{"issue":"6","key":"10.1016\/j.drup.2021.100790_bib0080","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic competition in the tumor microenvironment is a driver of cancer progression","volume":"162","author":"Chang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.drup.2021.100790_bib0085","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.15691","article-title":"A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis","volume":"5","author":"Chao","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.drup.2021.100790_bib0090","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bbcan.2012.06.004","article-title":"Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells","volume":"1826","author":"Chen","year":"2012","journal-title":"Biochim. Biophys. Acta - Rev. Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0095","first-page":"493","article-title":"Effect of food additive citric acid on the growth of human esophageal carcinoma cell line EC109","volume":"18","author":"Chen","year":"2016","journal-title":"Cell J."},{"key":"10.1016\/j.drup.2021.100790_bib0100","first-page":"708","article-title":"Epidermal growth factor upregulates the expression of A20 in hepatic cells via the MEK1\/MSK1\/p-p65 (Ser276) signaling pathway","volume":"13","author":"Chen","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.drup.2021.100790_bib0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.drup.2017.07.001","article-title":"A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer","volume":"31","author":"Coppola","year":"2017","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0110","doi-asserted-by":"crossref","DOI":"10.1038\/nrc.2017.77","article-title":"Tumour acidosis: from the passenger to the driver\u2019s seat","author":"Corbet","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0115","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s11033-015-3858-x","article-title":"Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K","volume":"42","author":"Courtnay","year":"2015","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.drup.2021.100790_bib0120","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/02640419408732197","article-title":"The physiological and ventilatory responses to repeated 60 s sprints following sodium citrate ingestion","volume":"12","author":"Cox","year":"1994","journal-title":"J Sport. Sci"},{"key":"10.1016\/j.drup.2021.100790_bib0125","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1016\/j.cub.2014.08.007","article-title":"The mTORC1\/S6K1 pathway regulates glutamine metabolism through the eif4b-dependent control of c-Myc translation","volume":"24","author":"Csibi","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.drup.2021.100790_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2020.100702","article-title":"New insights into the pharmacological, immunological, and CAR-T-cell approaches in the treatment of hepatocellular carcinoma","volume":"51","author":"Dal Bo","year":"2020","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0135","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014217","article-title":"MYC, metabolism, cell growth, and tumorigenesis","volume":"3","author":"Dang","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.drup.2021.100790_bib0140","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/mc.10103","article-title":"Hepatocyte growth factor, transforming growth factor \u03b1, and their receptors as combined markers of prognosis in hepatocellular carcinoma","volume":"36","author":"Daveau","year":"2003","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.drup.2021.100790_bib0145","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1053\/j.seminoncol.2012.05.002","article-title":"Surveillance for hepatocellular carcinoma, in: seminars in oncology","author":"Della Corte","year":"2012","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.drup.2021.100790_bib0150","article-title":"Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin","volume":"9","author":"DeWaal","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2021.100790_bib0155","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.2174\/138161212799504902","article-title":"Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis","volume":"18","author":"Dhup","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.drup.2021.100790_bib0160","doi-asserted-by":"crossref","first-page":"26948","DOI":"10.1074\/jbc.M800408200","article-title":"Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-Bisphosphate","volume":"283","author":"D\u00edaz-Ruiz","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2021.100790_bib0165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.drup.2017.02.001","article-title":"Novel immune check point inhibiting antibodies in cancer therapy\u2014opportunities and challenges","volume":"30","author":"Diesendruck","year":"2017","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0170","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/nsb730","article-title":"A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer","volume":"9","author":"DiGiammarino","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.drup.2021.100790_bib0175","article-title":"Hepatocellular carcinoma, novel therapies on the horizon","author":"Dika","year":"2020","journal-title":"Chin. Clin. Oncol."},{"key":"10.1016\/j.drup.2021.100790_bib0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2021.100307","article-title":"Ras related GTP binding D promotes aerobic glycolysis of hepatocellular carcinoma","volume":"23","author":"Ding","year":"2021","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.drup.2021.100790_bib0185","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-020-01520-4","article-title":"NONO promotes hepatocellular carcinoma progression by enhancing fatty acids biosynthesis through interacting with ACLY mRNA","volume":"20","author":"Ding","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.drup.2021.100790_bib0190","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.drup.2016.06.005","article-title":"The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: insights from knockout and humanized mice","volume":"27","author":"Durmus","year":"2016","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0195","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0887-7963(88)70035-8","article-title":"Citrate Toxicity During Massive Blood Transfusion","volume":"2","author":"Dzik","year":"1988","journal-title":"Transfus. Med. Rev."},{"key":"10.1016\/j.drup.2021.100790_bib0200","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10863-012-9455-y","article-title":"D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects","volume":"44","author":"El Sayed","year":"2012","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.drup.2021.100790_bib0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2020.100715","article-title":"Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance","volume":"53","author":"Erin","year":"2020","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0210","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12943-016-0562-y","article-title":"Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors","volume":"15","author":"Faes","year":"2016","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0215","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.2217\/nnm-2020-0313","article-title":"Radiosensitizing effects of citrate-coated cobalt and nickel ferrite nanoparticles on breast cancer cells","volume":"15","author":"Fagundes","year":"2020","journal-title":"Nanomedicine"},{"key":"10.1016\/j.drup.2021.100790_bib0220","first-page":"1641","article-title":"LOXL2 upregulates hypoxia\u2013inducible factor\u20131\u03b1 signaling through Snail\u2013FBP1 axis in hepatocellular carcinoma cells","volume":"43","author":"Fan","year":"2020","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.drup.2021.100790_bib0225","doi-asserted-by":"crossref","DOI":"10.3390\/nu13041314","article-title":"The role of fructose in non-alcoholic steatohepatitis: old relationship and new insights","author":"Federico","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.drup.2021.100790_bib0230","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-020-01629-4","article-title":"Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma","author":"Feng","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0235","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0240","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","author":"Forner","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.drup.2021.100790_bib0245","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/hep.24680","article-title":"Benefit of initial resection of hepatocellular carcinoma followed by transplantation in case of recurrence: an intention-to-treat analysis","volume":"55","author":"Fuks","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.drup.2021.100790_bib0250","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL clinical practice guidelines: management of hepatocellular carcinoma","volume":"69","author":"Galle","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.drup.2021.100790_bib0255","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1158\/0008-5472.CAN-18-3726","article-title":"The tumor metabolic microenvironment: lessons from lactate","volume":"79","author":"Garc\u00eda-Ca\u00f1averas","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0260","series-title":"Advances in Cancer Research","first-page":"63","article-title":"Signaling pathways in hepatocellular carcinoma","author":"Garcia-Lezana","year":"2021"},{"key":"10.1016\/j.drup.2021.100790_bib0265","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124414","article-title":"Immuno-metabolism and microenvironment in cancer: key players for immunotherapy","author":"Giannone","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.drup.2021.100790_bib0270","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.bcp.2012.01.033","article-title":"Inhibition of the PI3K-Akt signaling pathway disrupts ABCG2-rich extracellular vesicles and overcomes multidrug resistance in breast cancer cells","volume":"83","author":"Goler-Baron","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.drup.2021.100790_bib0275","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jhep.2016.10.015","article-title":"Geographical variations in incidence, management and survival of hepatocellular carcinoma in a Western country","volume":"66","author":"Goutt\u00e9","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.drup.2021.100790_bib0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181230","article-title":"Potassium citrate prevents increased osteoclastogenesis resulting from acidic conditions: implication for the treatment of postmenopausal bone loss","volume":"12","author":"Granchi","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.drup.2021.100790_bib0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2019.05.006","article-title":"Gluconeogenesis in cancer cells \u2013 repurposing of a starvation-induced metabolic pathway?","author":"Grasmann","year":"2019","journal-title":"Biochim. Biophys. Acta - Rev. Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0290","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbrc.2016.04.151","article-title":"3-Bromopyruvate and sodium citrate induce apoptosis in human gastric cancer cell line MGC-803 by inhibiting glycolysis and promoting mitochondria-regulated apoptosis pathway","volume":"475","author":"Guo","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.drup.2021.100790_bib0295","doi-asserted-by":"crossref","DOI":"10.1080\/14728214.2021.1916468","article-title":"Emerging drugs for the treatment of triple-negative breast cancer: a focus on phase II immunotherapy trials","author":"Hall","year":"2021","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.drup.2021.100790_bib0300","first-page":"725","article-title":"Glycolysis module activated by hypoxia-inducible factor 1\u03b1 is related to the aggressive phenotype of hepatocellular carcinoma","volume":"33","author":"Hamaguchi","year":"2008","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.drup.2021.100790_bib0305","article-title":"ATP-citrate lyase regulates stemness and metastasis in hepatocellular carcinoma via the Wnt\/\u03b2-catenin signaling pathway","author":"Han","year":"2020","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.drup.2021.100790_bib0310","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/jcp.22895","article-title":"Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)\/AKT pathways","volume":"227","author":"Hanai","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.drup.2021.100790_bib0315","doi-asserted-by":"crossref","first-page":"e696","DOI":"10.1038\/cddis.2013.215","article-title":"ATP citrate lyase knockdown impacts cancer stem cells in vitro","volume":"4","author":"Hanai","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.drup.2021.100790_bib0320","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ccr.2005.09.008","article-title":"ATP citrate lyase inhibition can suppress tumor cell growth","volume":"8","author":"Hatzivassiliou","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.drup.2021.100790_bib0325","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.drup.2019.04.001","article-title":"YY1 regulates cancer cell immune resistance by modulating PD-L1 expression","volume":"43","author":"Hays","year":"2019","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0330","article-title":"Understanding the warburg effect: the metabolic requirements of cell proliferation","author":"Heiden","year":"2009","journal-title":"Science (80-.)"},{"key":"10.1016\/j.drup.2021.100790_bib0335","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1158\/0008-5472.CAN-15-2601","article-title":"Decreased expression of fructose-1,6-bisphosphatase associates with glucose metabolism and tumor progression in hepatocellular carcinoma","volume":"76","author":"Hirata","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0340","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1158\/0008-5472.CAN-09-1089","article-title":"Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma","volume":"69","author":"Hoshida","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2008.08.021","article-title":"Cancer cell metabolism: warburg and beyond","author":"Hsu","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.drup.2021.100790_bib0350","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12772","article-title":"Aberrant lipid metabolism in hepatocellular carcinoma cells as well as immune microenvironment: a review","author":"Hu","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.drup.2021.100790_bib0355","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1080\/15548627.2019.1580105","article-title":"The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance","volume":"15","author":"Huang","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.drup.2021.100790_bib0360","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1172\/JCI37156","article-title":"Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation","volume":"118","author":"Hui","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drup.2021.100790_bib0365","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.3390\/ijms20092105","article-title":"Citrate-induced p85\u03b1\u2013PTEN complex formation causes G2\/M phase arrest in human pharyngeal squamous carcinoma cell lines","volume":"20","author":"Hung","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.drup.2021.100790_bib0370","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.4049\/jimmunol.1202702","article-title":"Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells","volume":"191","author":"Husain","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.drup.2021.100790_bib0375","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8882","article-title":"PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation","volume":"6","author":"Iansante","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2021.100790_bib0380","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.drup.2016.09.003","article-title":"The reduced concentration of citrate in cancer cells: an indicator of cancer aggressiveness and a possible therapeutic target","volume":"29","author":"Icard","year":"2016","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0385","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbcan.2014.06.002","article-title":"The metabolic cooperation between cells in solid cancer tumors","volume":"1846","author":"Icard","year":"2014","journal-title":"Biochim. Biophys. Acta - Rev. Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2018.03.001","article-title":"How the Warburg effect supports aggressiveness and drug resistance of cancer cells?","volume":"38","author":"Icard","year":"2018","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0395","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.3390\/ijms22126587","article-title":"Understanding the central role of citrate in the metabolism of cancer cells and tumors: an update","volume":"22","author":"Icard","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.drup.2021.100790_bib0400","doi-asserted-by":"crossref","DOI":"10.1093\/advances\/nmaa174","article-title":"Metabolic strategies for inhibiting cancer development","author":"Icard","year":"2021","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.drup.2021.100790_bib0405","doi-asserted-by":"crossref","DOI":"10.1634\/theoncologist.2018-0337","article-title":"Radiofrequency ablation and microwave ablation in liver tumors: an update","volume":"24","author":"Izzo","year":"2019","journal-title":"Oncologist"},{"key":"10.1016\/j.drup.2021.100790_bib0410","first-page":"42","article-title":"Effect of sodium citrate ingestion on oxygen debt & exercise endurance during supramaximal exercise","volume":"118","author":"Jain","year":"2003","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.drup.2021.100790_bib0415","first-page":"829","article-title":"Enhanced effects of citrate on UVB-induced apoptosis of B16 melanoma cells","volume":"64","author":"Jeong","year":"2009","journal-title":"Pharmazie"},{"key":"10.1016\/j.drup.2021.100790_bib0420","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ebiom.2019.03.068","article-title":"Increased glycolysis correlates with elevated immune activity in tumor immune microenvironment","volume":"42","author":"Jiang","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.drup.2021.100790_bib0425","first-page":"461","article-title":"Activation of PI3 kinase\/Akt\/HIF-1\u03b1 pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma","volume":"40","author":"Jiao","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.drup.2021.100790_bib0430","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0969-2126(98)00021-5","article-title":"The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate","volume":"6","author":"Jurica","year":"1998","journal-title":"Structure"},{"key":"10.1016\/j.drup.2021.100790_bib0435","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.drup.2018.09.001","article-title":"Precision medicine in head and neck cancer","volume":"40","author":"Kaidar-Person","year":"2018","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0440","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","article-title":"HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia","volume":"3","author":"Kim","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.drup.2021.100790_bib0445","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ccell.2018.12.012","article-title":"Wild-type p53 promotes cancer metabolic switch by inducing PUMA-Dependent suppression of oxidative phosphorylation","volume":"35","author":"Kim","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.drup.2021.100790_bib0450","article-title":"Metabolic spectrum of liver failure in type 2 diabetes and obesity: From nafld to nash to hcc","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.drup.2021.100790_bib0455","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.drup.2019.07.004","article-title":"Immune checkpoint inhibitor combinations: current efforts and important aspects for success","volume":"45","author":"Kon","year":"2019","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0460","article-title":"Comparative efficacy of interventional therapies for early-stage hepatocellular carcinoma","volume":"95","author":"Lan","year":"2016","journal-title":"Med. (United States)"},{"key":"10.1016\/j.drup.2021.100790_bib0465","article-title":"How and why are cancers acidic? Carbonic anhydrase ix and the homeostatic control of tumour extracellular ph","author":"Lee","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.drup.2021.100790_bib0470","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2049-3002-2-1","article-title":"TIGAR, TIGAR, burning bright","volume":"2","author":"Lee","year":"2014","journal-title":"Cancer Metab."},{"key":"10.1016\/j.drup.2021.100790_bib0475","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1158\/1078-0432.CCR-14-1979","article-title":"Gain of HIF-1\u03b1 under normoxia in cancer mediates immune adaptation through the AKT\/ERK and VEGFA axes","volume":"21","author":"Lee","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0480","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cmet.2020.12.002","article-title":"Tumor reliance on cytosolic versus mitochondrial one-carbon flux depends on folate availability","volume":"33","author":"Lee","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.drup.2021.100790_bib0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2019.100644","article-title":"Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer","volume":"46","author":"Leonetti","year":"2019","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0490","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.clinimag.2021.05.007","article-title":"Lipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial","volume":"78","author":"Letzen","year":"2021","journal-title":"Clin. Imaging"},{"key":"10.1016\/j.drup.2021.100790_bib0495","doi-asserted-by":"crossref","DOI":"10.1126\/science.1193494","article-title":"The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes","author":"Levine","year":"2010","journal-title":"Science (80-.)"},{"key":"10.1016\/j.drup.2021.100790_bib0500","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.molcel.2016.02.009","article-title":"Mitochondria-translocated PGK1 functions as a protein kinase to coordinate glycolysis and the TCA cycle in Tumorigenesis","volume":"61","author":"Li","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.drup.2021.100790_bib0505","doi-asserted-by":"crossref","first-page":"24777","DOI":"10.18632\/oncotarget.15801","article-title":"STAT3 regulates glycolysis via targeting hexokinase 2 in hepatocellular carcinoma cells","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.drup.2021.100790_bib0510","doi-asserted-by":"crossref","DOI":"10.1007\/s00432-021-03604-8","article-title":"A review: hippo signaling pathway promotes tumor invasion and metastasis by regulating target gene expression","author":"Li","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.drup.2021.100790_bib0515","article-title":"Locoregional combined with systemic therapies for advanced hepatocellular carcinoma: an inevitable trend of rapid development","author":"Li","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.drup.2021.100790_bib0520","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41416-020-0912-9","article-title":"Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds","volume":"123","author":"Li Petri","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0525","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.12659\/MSM.906528","article-title":"Butein inhibited in vitro hexokinase-2-mediated tumor glycolysis in hepatocellular carcinoma by blocking epidermal growth factor receptor (EGFR)","volume":"24","author":"Liao","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.drup.2021.100790_bib0530","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1158\/0008-5472.CAN-19-2060","article-title":"A feedback circuitry between polycomb signaling and fructose-1, 6-bisphosphatase enables hepatic and renal tumorigenesis","volume":"80","author":"Liao","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0535","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.drup.2016.02.001","article-title":"Could drugs inhibiting the mevalonate pathway also target cancer stem cells?","volume":"25","author":"Likus","year":"2016","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0540","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1757-2215-6-72","article-title":"Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells","volume":"6","author":"Lincet","year":"2013","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.drup.2021.100790_bib0545","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/JHC.S278517","article-title":"Targeting de novo lipogenesis and cholesterol biosynthesis simultaneously is a novel therapeutic option for hepatocellular carcinoma","volume":"8","author":"Liu","year":"2021","journal-title":"J. Hepatocell. Carcinoma"},{"key":"10.1016\/j.drup.2021.100790_bib0550","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-018-1165-x","article-title":"Restoration of FBP1 suppressed Snail-induced epithelial to mesenchymal transition in hepatocellular carcinoma","volume":"9","author":"Liu","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.drup.2021.100790_bib0555","article-title":"Targeting FBPase is an emerging novel approach for cancer therapy","author":"Liu","year":"2018","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.drup.2021.100790_bib0560","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1053\/jhep.2003.50047","article-title":"Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival","volume":"37","author":"Llovet","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.drup.2021.100790_bib0565","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1111\/cas.14412","article-title":"Activator of thyroid and retinoid receptor increases sorafenib resistance in hepatocellular carcinoma by facilitating the Warburg effect","volume":"111","author":"Ma","year":"2020","journal-title":"Cancer Sci."},{"key":"10.1016\/j.drup.2021.100790_bib0570","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrclinonc.2016.60","article-title":"Cancer metabolism: a therapeutic perspective","volume":"14","author":"Martinez-Outschoorn","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.drup.2021.100790_bib0575","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/BF00376437","article-title":"Sodium citrate ingestion and its effects on maximal anaerobic exercise of different durations","volume":"64","author":"Mc Naughton","year":"1992","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"10.1016\/j.drup.2021.100790_bib0580","doi-asserted-by":"crossref","DOI":"10.1038\/s12276-018-0159-1","article-title":"Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors","author":"M\u00e9ndez-Blanco","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.drup.2021.100790_bib0585","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1158\/0008-5472.CAN-17-0498","article-title":"Glucose catabolism in liver tumors induced by c-MYC can be sustained by various PKM1\/PKM2 ratios and pyruvate kinase activities","volume":"77","author":"Mendez-Lucas","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0590","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2019.07.003","article-title":"Exosomes and their role in tumorigenesis and anticancer drug resistance","volume":"45","author":"Milman","year":"2019","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0595","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12061668","article-title":"Glucose metabolism and oxidative stress in hepatocellular carcinoma: Role and possible implications in novel therapeutic strategies","author":"Mossenta","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.drup.2021.100790_bib0600","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13601-8","article-title":"O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth","volume":"11","author":"Nie","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2021.100790_bib0605","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/BF01213320","article-title":"Fructose 2,6-bisphosphate metabolism in Ehrlich ascites tumour cells","volume":"121","author":"Nissler","year":"1995","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.drup.2021.100790_bib0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2017.10.002","article-title":"New insights into sorafenib resistance in hepatocellular carcinoma: responsible mechanisms and promising strategies","author":"Niu","year":"2017","journal-title":"Biochim. Biophys. Acta - Rev. Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102699","article-title":"Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance","volume":"54","author":"Nwosu","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.drup.2021.100790_bib0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcancer.2017.01.002","article-title":"Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer","author":"Omran","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.drup.2021.100790_bib0625","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.drup.2017.10.001","article-title":"Cancer immunotherapy getting brainy: visualizing the distinctive CNS metastatic niche to illuminate therapeutic resistance","volume":"33\u201335","author":"Owyong","year":"2017","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0630","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.22400","article-title":"pH control mechanisms of tumor survival and growth","author":"Parks","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.drup.2021.100790_bib0635","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/s41467-017-01019-z","article-title":"Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras","volume":"8","author":"Peeters","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2021.100790_bib0640","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.aaf6284","article-title":"Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism","volume":"354","author":"Peng","year":"2016","journal-title":"Science (80-.)"},{"key":"10.1016\/j.drup.2021.100790_bib0645","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2020.100718","article-title":"Cancer immunotherapy resistance based on immune checkpoints inhibitors: targets, biomarkers, and remedies","volume":"53","author":"P\u00e9rez-Ruiz","year":"2020","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0650","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2020.593866","article-title":"Extracellular citrate is a trojan horse for cancer cells","volume":"7","author":"Petillo","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.drup.2021.100790_bib0655","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.bi.64.070195.004055","article-title":"6-Phosphofructo-2-kinase\/fructose-2,6-bisphosphatase: a metabolic signaling enzyme","author":"Pilkis","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.drup.2021.100790_bib0660","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1158\/0008-5472.CAN-15-1743","article-title":"Neutralization of tumor acidity improves antitumor responses to immunotherapy","volume":"76","author":"Pilon-Thomas","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0665","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1093\/hmg\/ddi227","article-title":"Accumulation of Krebs cycle intermediates and over-expression of HIF1\u03b1 in tumours which result from germline FH and SDH mutations","volume":"14","author":"Pollard","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.drup.2021.100790_bib0670","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/14728222.2019.1615883","article-title":"Aberrant lipid metabolism as a therapeutic target in liver cancer","volume":"23","author":"Pope","year":"2019","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.drup.2021.100790_bib0675","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2011.00049","article-title":"Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review","author":"Porporato","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.drup.2021.100790_bib0680","first-page":"1169","article-title":"Phosphorylation of Recombinant Human ATP:Citrate Lyase by cAMP-Dependent Protein Kinase Abolishes Homotropic Allosteric Regulation of the Enzyme by Citrate and Increases the Enzyme Activity","volume":"39","author":"Potapova","year":"2000","journal-title":"Allosteric Activation of ATP: Citrate Lyase by Phosphorylated Sug. Biochemistry"},{"key":"10.1016\/j.drup.2021.100790_bib0685","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/sj.bjc.6690455","article-title":"Enhancement of chemotherapy by manipulation of tumour pH","volume":"80","author":"Raghunand","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0690","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2018.11.002","article-title":"Updated use of TACE for hepatocellular carcinoma treatment: how and when to use it based on clinical evidence","author":"Raoul","year":"2019","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.drup.2021.100790_bib0695","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2147\/JHC.S224938","article-title":"Combination antiangiogenic and immunotherapy for advanced hepatocellular carcinoma: evidence to date","volume":"7","author":"Raybould","year":"2020","journal-title":"J. Hepatocell. Carcinoma"},{"key":"10.1016\/j.drup.2021.100790_bib0700","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/ki.1972.46","article-title":"Metabolic consequences of acid-base disorders","volume":"1","author":"Relman","year":"1972","journal-title":"Kidney Int."},{"key":"10.1016\/j.drup.2021.100790_bib0705","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1038\/s41598-017-04626-4","article-title":"Citrate suppresses tumor growth in multiple models through inhibition of glycolysis, the tricarboxylic acid cycle and the IGF-1R pathway","volume":"7","author":"Ren","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drup.2021.100790_bib0710","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/annonc\/mdx645","article-title":"The Warburg effect: persistence of stem-cell metabolism in cancers as a failure of differentiation","volume":"29","author":"Riester","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.drup.2021.100790_bib0715","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-11-235","article-title":"Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer","volume":"11","author":"Robey","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0720","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1158\/0008-5472.CAN-07-5575","article-title":"Bicarbonate increases tumor pH and inhibits spontaneous metastases","volume":"69","author":"Robey","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0725","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.drup.2011.03.001","article-title":"Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways","volume":"14","author":"Rohwer","year":"2011","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0730","doi-asserted-by":"crossref","DOI":"10.1172\/JCI67230","article-title":"HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations","author":"Semenza","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drup.2021.100790_bib0735","doi-asserted-by":"crossref","first-page":"6585","DOI":"10.2147\/CMAR.S241383","article-title":"LncRNA HEIH confers cell sorafenib resistance in hepatocellular carcinoma by regulating miR-98-5p\/PI3K\/AKT pathway","volume":"12","author":"Shen","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.drup.2021.100790_bib0740","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2019.08.025","article-title":"Epidemiology and surveillance for hepatocellular carcinoma: new trends","author":"Singal","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.drup.2021.100790_bib0745","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2174\/138920006775541552","article-title":"Preclinical pharmacokinetics: an approach towards safer and efficacious drugs","volume":"7","author":"Singh","year":"2006","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.drup.2021.100790_bib0750","doi-asserted-by":"crossref","DOI":"10.1038\/onc.2010.215","article-title":"EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer","author":"Singh","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2021.100790_bib0755","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.3390\/cancers13092164","article-title":"Immunotherapy updates in advanced hepatocellular carcinoma","volume":"13","author":"Singh","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.drup.2021.100790_bib0760","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1002\/1878-0261.12780","article-title":"Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer","volume":"14","author":"Smolle","year":"2020","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.drup.2021.100790_bib0765","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3390\/cells9051082","article-title":"The lysosomotropic activity of hydrophobic weak base drugs is mediated via their intercalation into the lysosomal membrane","volume":"9","author":"Stark","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.drup.2021.100790_bib0770","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.2215\/CJN.01100112","article-title":"Correction of metabolic acidosis with potassium citrate in renal transplant patients and its effect on bone quality","volume":"7","author":"Starke","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.drup.2021.100790_bib0775","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/s10620-020-06229-y","article-title":"Androgen receptor stimulates hexokinase 2 and induces glycolysis by PKA\/CREB signaling in hepatocellular carcinoma","volume":"66","author":"Sun","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.drup.2021.100790_bib0780","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0099","article-title":"The chemistry, physiology and pathology of pH in cancer","author":"Swietach","year":"2014","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.drup.2021.100790_bib0785","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.drup.2015.08.004","article-title":"Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach","volume":"23","author":"Taylor","year":"2015","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0790","doi-asserted-by":"crossref","DOI":"10.1093\/gastro\/goaa066","article-title":"Metabolic alterations and vulnerabilities in hepatocellular carcinoma","author":"Tenen","year":"2021","journal-title":"Gastroenterol. Rep."},{"key":"10.1016\/j.drup.2021.100790_bib0795","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1593\/neo.05697","article-title":"Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs","volume":"8","author":"Thews","year":"2006","journal-title":"Neoplasia"},{"key":"10.1016\/j.drup.2021.100790_bib0800","doi-asserted-by":"crossref","DOI":"10.2147\/CMAR.S258196","article-title":"Glucometabolic reprogramming in the hepatocellular carcinoma microenvironment: cause and effect","author":"Tian","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.drup.2021.100790_bib0805","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1089\/ars.2013.5215","article-title":"MicroRNA-126 suppresses mesothelioma malignancy by targeting IRS1 and interfering with the mitochondrial function","volume":"21","author":"Tomasetti","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.drup.2021.100790_bib0810","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jhep.2010.01.015","article-title":"IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage","volume":"52","author":"Tovar","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.drup.2021.100790_bib0815","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/gutjnl-2015-309501","article-title":"Tumour initiating cells and IGF\/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma","volume":"66","author":"Tovar","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.drup.2021.100790_bib0820","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1016\/S0021-9258(18)99819-4","article-title":"Effect of pH on the kinetics of frog muscle phosphofructokinase","volume":"241","author":"Trivedi","year":"1966","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2021.100790_bib0825","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-21361-6","article-title":"Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect","volume":"8","author":"Tseng","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drup.2021.100790_bib0830","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14216","article-title":"Sodium citrate ingestion protocol impacts induced alkalosis, gastrointestinal symptoms, and palatability","volume":"7","author":"Urwin","year":"2019","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.drup.2021.100790_bib0835","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1096\/fasebj.9.11.7649406","article-title":"Evidence from transgenic mice that myc regulates hepatic glycolysis","volume":"9","author":"Valera","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/j.drup.2021.100790_bib0840","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2019.100647","article-title":"Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance","volume":"47","author":"Vasconcelos","year":"2019","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0845","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2012.05.019","article-title":"Availability, not respiratory capacity governs oxygen consumption of solid tumors","author":"Vaupel","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.drup.2021.100790_bib0850","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMra1713263","article-title":"Hepatocellular carcinoma","volume":"380","author":"Villanueva","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.drup.2021.100790_bib0855","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2008.08.008","article-title":"Pivotal role of mTOR signaling in hepatocellular carcinoma","volume":"135","author":"Villanueva","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.drup.2021.100790_bib0860","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.drup.2016.10.001","article-title":"Heparanase: from basic research to therapeutic applications in cancer and inflammation","volume":"29","author":"Vlodavsky","year":"2016","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0865","doi-asserted-by":"crossref","DOI":"10.1016\/j.annonc.2021.02.014","article-title":"Updated treatment recommendations for hepatocellular carcinoma (HCC) from the ESMO Clinical Practice Guidelines","author":"Vogel","year":"2021","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.drup.2021.100790_bib0870","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.trecan.2018.11.003","article-title":"Gluconeogenesis in cancer: function and regulation of PEPCK, FBPase, and G6Pase","volume":"5","author":"Wang","year":"2019","journal-title":"Trends Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0875","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1478-3231.2010.02221.x","article-title":"Transarterial chemoembolization in combination with percutaneous ablation therapy in unresectable hepatocellular carcinoma: a meta-analysis","volume":"30","author":"Wang","year":"2010","journal-title":"Liver Int."},{"key":"10.1016\/j.drup.2021.100790_bib0880","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.3892\/or.2015.4511","article-title":"3-Bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial-mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth","volume":"35","author":"Wang","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.drup.2021.100790_bib0885","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science (80-.)"},{"key":"10.1016\/j.drup.2021.100790_bib0890","doi-asserted-by":"crossref","DOI":"10.1038\/nrc3110","article-title":"Dysregulated pH: a perfect storm for cancer progression","author":"Webb","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.drup.2021.100790_bib0895","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1126\/science.1164097","article-title":"ATP-citrate lyase links cellular metabolism to histone acetylation","volume":"324","author":"Wellen","year":"2009","journal-title":"Science (80-.)"},{"key":"10.1016\/j.drup.2021.100790_bib0900","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1242\/jcs.195297","article-title":"Cancer cell behaviors mediated by dysregulated pH dynamics at a glance","volume":"130","author":"White","year":"2017","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.drup.2021.100790_bib0905","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1073\/pnas.0810199105","article-title":"Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction","volume":"105","author":"Wise","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.drup.2021.100790_bib0910","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115036","article-title":"Switching of pyruvate kinase isoform l to M2 promotes metabolic reprogramming in hepatocarcinogenesis","volume":"9","author":"Wong","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.drup.2021.100790_bib0915","first-page":"6622","article-title":"Sodium citrate inhibits the proliferation of human gastric adenocarcinoma epithelia cells","volume":"15","author":"Xia","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.drup.2021.100790_bib0920","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3892\/mmr.2013.1702","article-title":"Citrate induces apoptosis of the acute monocytic leukemia U937 cell line through regulation of HIF-1\u03b1 signaling","volume":"8","author":"Xu","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.drup.2021.100790_bib0925","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8619096","article-title":"The combination strategy of transarterial chemoembolization and radiofrequency ablation or microwave ablation against hepatocellular carcinoma","author":"Xu","year":"2019","journal-title":"Anal. Cell. Pathol."},{"key":"10.1016\/j.drup.2021.100790_bib0930","doi-asserted-by":"crossref","first-page":"24223","DOI":"10.1074\/jbc.M109.016816","article-title":"Nuclear targeting of 6-Phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases","volume":"284","author":"Yalcin","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2021.100790_bib0935","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01399","article-title":"Lipid metabolic pathways confer the immunosuppressive function of myeloid-derived suppressor cells in tumor","author":"Yan","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.drup.2021.100790_bib0940","doi-asserted-by":"crossref","DOI":"10.1002\/ar.20668","article-title":"Vascular changes in hepatocellular carcinoma","author":"Yang","year":"2008","journal-title":"Anat. Rec."},{"key":"10.1016\/j.drup.2021.100790_bib0945","article-title":"Inhibiting histone deacetylases suppresses glucose metabolism and hepatocellular carcinoma growth by restoring FBP1 expression","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drup.2021.100790_bib0950","doi-asserted-by":"crossref","DOI":"10.1038\/s41575-019-0186-y","article-title":"A global view of hepatocellular carcinoma: trends, risk, prevention and management","author":"Yang","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.drup.2021.100790_bib0955","first-page":"1607","article-title":"HSF2 regulates aerobic glycolysis by suppression of FBP1 in hepatocellular carcinoma","volume":"9","author":"Yang","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0960","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo pathway activity influences liver cell fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.drup.2021.100790_bib0965","article-title":"Effect of citrate on malignant pleural mesothelioma cells: a synergistic effect with cisplatin","volume":"29","author":"Zhang","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib0970","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10047-012-0680-2","article-title":"Simplified regional citrate anticoagulation using a calcium-containing replacement solution for continuous venovenous hemofiltration","volume":"16","author":"Zhang","year":"2013","journal-title":"J. Artif. Organs"},{"key":"10.1016\/j.drup.2021.100790_bib0975","doi-asserted-by":"crossref","first-page":"8025","DOI":"10.2147\/OTT.S172084","article-title":"miR-517a promotes Warburg effect in HCC by directly targeting FBP1","volume":"11","author":"Zhang","year":"2018","journal-title":"Onco. Ther."},{"key":"10.1016\/j.drup.2021.100790_bib0980","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41419-019-2221-x","article-title":"SIK2 enhances synthesis of fatty acid and cholesterol in ovarian cancer cells and tumor growth through PI3K\/Akt signaling pathway","volume":"11","author":"Zhao","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.drup.2021.100790_bib0985","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.drup.2015.11.004","article-title":"Lysosomes as mediators of drug resistance in cancer","volume":"24","author":"Zhitomirsky","year":"2016","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.drup.2021.100790_bib0990","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.618050","article-title":"Random survival forests to predict disease control for hepatocellular carcinoma treated with transarterial chemoembolization combined with sorafenib","volume":"8","author":"Zhong","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.drup.2021.100790_bib0995","first-page":"793","article-title":"BMP4 augments the survival of hepatocellular carcinoma (HCC) cells under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway","volume":"11","author":"Zhong","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.drup.2021.100790_bib1000","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12943-015-0331-3","article-title":"Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation","volume":"14","author":"Zhou","year":"2015","journal-title":"Mol. Cancer"}],"container-title":["Drug Resistance Updates"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764621000480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764621000480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:01:16Z","timestamp":1761282076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1368764621000480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":200,"alternative-id":["S1368764621000480"],"URL":"https:\/\/doi.org\/10.1016\/j.drup.2021.100790","relation":{},"ISSN":["1368-7646"],"issn-type":[{"value":"1368-7646","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Why may citrate sodium significantly increase the effectiveness of transarterial chemoembolization in hepatocellular carcinoma?","name":"articletitle","label":"Article Title"},{"value":"Drug Resistance Updates","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drup.2021.100790","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100790"}}