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(Basel)"},{"key":"10.1016\/j.drup.2024.101147_bib141","unstructured":"Roberts, M.Ch Nomenclature for Tetracycline Genes. \u3008http:\/\/faculty.washington.edu\/marilynr\/\u3009 (accessed July 16, 2023)."},{"issue":"11","key":"10.1016\/j.drup.2024.101147_bib142","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41579-020-0386-z","article-title":"Target protection as a key antibiotic resistance mechanism","volume":"18","author":"Wilson","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.drup.2024.101147_bib143","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22105356","article-title":"Ribosome protection proteins\u2014\u201cNew\u201d players in the global arms race with antibiotic-resistant pathogens","volume":"22","author":"Ero","year":"2021","journal-title":"Int. J. Mol. 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