{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:17:10Z","timestamp":1793297830502,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372795"],"award-info":[{"award-number":["82372795"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360519"],"award-info":[{"award-number":["82360519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960433"],"award-info":[{"award-number":["81960433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303084"],"award-info":[{"award-number":["82303084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303903"],"award-info":[{"award-number":["82303903"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010265","name":"Guizhou Medical University","doi-asserted-by":"publisher","award":["gyfyxkyc-2023-03"],"award-info":[{"award-number":["gyfyxkyc-2023-03"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","award":["080"],"award-info":[{"award-number":["080"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","award":["GCC [2023] 082"],"award-info":[{"award-number":["GCC [2023] 082"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Resistance Updates"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.drup.2024.101171","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T16:54:29Z","timestamp":1731084869000},"page":"101171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4"],"prefix":"10.1016","volume":"78","author":[{"given":"Zhiwei","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dijie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.drup.2024.101171_bib1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10555-021-09990-2","article-title":"Targeting KRAS in pancreatic cancer: new drugs on the horizon","volume":"40","author":"Bannoura","year":"2021","journal-title":"Cancer Metastas-.-. Rev."},{"key":"10.1016\/j.drup.2024.101171_bib2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.ccell.2020.08.004","article-title":"Challenges and opportunities for pancreatic cancer immunotherapy","volume":"38","author":"Bear","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.drup.2024.101171_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1119369","article-title":"Ferroptosis and tumor immunotherapy: a promising combination therapy for tumors","volume":"13","author":"Cai","year":"2023","journal-title":"Front Oncol."},{"issue":"5","key":"10.1016\/j.drup.2024.101171_bib4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.drup.2024.101171_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s13046-022-02411-4","article-title":"Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1\/RhoA signaling","volume":"41","author":"Chen","year":"2022","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"3-4","key":"10.1016\/j.drup.2024.101171_bib6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10974-013-9349-6","article-title":"Tropomodulins and tropomyosins: working as a team","volume":"34","author":"Colpan","year":"2013","journal-title":"J. Muscle Res Cell Motil."},{"issue":"8","key":"10.1016\/j.drup.2024.101171_bib7","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","article-title":"Autophagy and autophagy-related pathways in cancer","volume":"24","author":"Debnath","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.drup.2024.101171_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2217\/fca-2019-0095","article-title":"Cangrelor in clinical use","volume":"16","author":"Feng","year":"2020","journal-title":"Future Cardiol."},{"key":"10.1016\/j.drup.2024.101171_bib9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41568-019-0149-1","article-title":"Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion","volume":"19","author":"Friedmann Angeli","year":"2019","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.drup.2024.101171_bib10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.drup.2024.101171_bib11","doi-asserted-by":"crossref","DOI":"10.1080\/08941939.2022.2129884","article-title":"Pancreatic cancer: a review of current treatment and novel therapies","volume":"36","author":"Kolbeinsson","year":"2023","journal-title":"J. Invest Surg."},{"issue":"9","key":"10.1016\/j.drup.2024.101171_bib12","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrc.2017.53","article-title":"Targeting autophagy in cancer","volume":"17","author":"Levy","year":"2017","journal-title":"Nat. Rev. Cancer"},{"issue":"12","key":"10.1016\/j.drup.2024.101171_bib13","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.drup.2024.101171_bib14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ccell.2022.02.003","article-title":"CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4","volume":"40","author":"Liao","year":"2022","journal-title":"Cancer Cell"},{"issue":"19","key":"10.1016\/j.drup.2024.101171_bib15","doi-asserted-by":"crossref","first-page":"9433","DOI":"10.1073\/pnas.1821323116","article-title":"Cystine\/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance","volume":"116","author":"Lim","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.drup.2024.101171_bib16","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2020.02.005","article-title":"Autophagy-dependent ferroptosis: machinery and regulation","volume":"27","author":"Liu","year":"2020","journal-title":"Cell Chem. Biol."},{"issue":"3","key":"10.1016\/j.drup.2024.101171_bib17","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1080\/15548627.2022.2111635","article-title":"TMEM164 is a new determinant of autophagy-dependent ferroptosis","volume":"19","author":"Liu","year":"2023","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.drup.2024.101171_bib18","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.apsb.2019.03.002","article-title":"Targeting the untargetable KRAS in cancer therapy","volume":"9","author":"Liu","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.drup.2024.101171_bib19","doi-asserted-by":"crossref","first-page":"7799","DOI":"10.1038\/s41467-022-35557-y","article-title":"USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"issue":"13","key":"10.1016\/j.drup.2024.101171_bib20","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.022125","article-title":"Cangrelor: clinical data, contemporary use, and future perspectives","volume":"10","author":"De Luca","year":"2021","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.drup.2024.101171_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.seminoncol.2021.02.003","article-title":"KRAS mutation in pancreatic cancer","volume":"48","author":"Luo","year":"2021","journal-title":"Semin Oncol."},{"issue":"8","key":"10.1016\/j.drup.2024.101171_bib22","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/s41423-022-00883-0","article-title":"Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis","volume":"19","author":"Luoqian","year":"2022","journal-title":"Cell Mol. Immunol."},{"issue":"5","key":"10.1016\/j.drup.2024.101171_bib23","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","article-title":"CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability","volume":"33","author":"Ma","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.drup.2024.101171_bib24","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.trecan.2018.04.001","article-title":"Immunotherapy and prevention of pancreatic cancer","volume":"4","author":"Morrison","year":"2018","journal-title":"Trends Cancer"},{"issue":"1","key":"10.1016\/j.drup.2024.101171_bib25","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13045-022-01375-4","article-title":"Drugging KRAS: current perspectives and state-of-art review","volume":"15","author":"Parikh","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"6","key":"10.1016\/j.drup.2024.101171_bib26","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1007\/s12551-018-0481-9","article-title":"Multifunctional roles of tropomodulin-3 in regulating actin dynamics","volume":"10","author":"Parreno","year":"2018","journal-title":"Biophys. Rev."},{"issue":"12","key":"10.1016\/j.drup.2024.101171_bib27","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.tcb.2023.05.003","article-title":"Regulation of ferroptosis by lipid metabolism","volume":"33","author":"Pope","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.drup.2024.101171_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102324","article-title":"Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells","volume":"53","author":"Rademaker","year":"2022","journal-title":"Redox Biol."},{"issue":"6166","key":"10.1016\/j.drup.2024.101171_bib29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1247005","article-title":"Genome-scale CRISPR-Cas9 knockout screening in human cells","volume":"343","author":"Shalem","year":"2014","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.drup.2024.101171_bib30","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1093\/hmg\/ddab291","article-title":"Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia","volume":"31","author":"Stobdan","year":"2022","journal-title":"Hum. Mol. Genet"},{"issue":"11","key":"10.1016\/j.drup.2024.101171_bib31","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/s41419-021-04306-2","article-title":"Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells","volume":"12","author":"Sun","year":"2021","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.drup.2024.101171_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res"},{"issue":"4","key":"10.1016\/j.drup.2024.101171_bib33","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s10555-020-09915-5","article-title":"Molecular epidemiology and diagnostics of KRAS mutations in human cancer","volume":"39","author":"Timar","year":"2020","journal-title":"Cancer Metastas-.-. Rev."},{"issue":"1","key":"10.1016\/j.drup.2024.101171_bib34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12859-023-05142-1","article-title":"ShrinkCRISPR: a flexible method for differential fitness analysis of CRISPR-Cas9 screen data","volume":"24","author":"Tissier","year":"2023","journal-title":"BMC Bioinforma."},{"issue":"Pt 20","key":"10.1016\/j.drup.2024.101171_bib35","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1242\/jcs.011445","article-title":"Tmod3 regulates polarized epithelial cell morphology","volume":"120","author":"Weber","year":"2007","journal-title":"J. Cell Sci."},{"issue":"19","key":"10.1016\/j.drup.2024.101171_bib36","doi-asserted-by":"crossref","first-page":"14614","DOI":"10.3390\/ijms241914614","article-title":"Regulation of Ferroptosis in Lung Adenocarcinoma","volume":"24","author":"Wei","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.drup.2024.101171_bib37","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1053\/j.gastro.2022.03.056","article-title":"Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment","volume":"163","author":"Wood","year":"2022","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.drup.2024.101171_bib38","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.molmed.2021.06.014","article-title":"Ferroptosis in the tumor microenvironment: perspectives for immunotherapy","volume":"27","author":"Xu","year":"2021","journal-title":"Trends Mol. Med"},{"issue":"11","key":"10.1016\/j.drup.2024.101171_bib39","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41419-021-04367-3","article-title":"Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2\/HO-1 signalling pathway in KRAS mutant colorectal cancer","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.drup.2024.101171_bib40","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"issue":"8","key":"10.1016\/j.drup.2024.101171_bib41","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/s41416-023-02149-6","article-title":"Ferroptosis in colorectal cancer: a future target?","volume":"128","author":"Yan","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.drup.2024.101171_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102699","article-title":"Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations","volume":"62","author":"Yan","year":"2023","journal-title":"Redox Biol."},{"issue":"15","key":"10.1016\/j.drup.2024.101171_bib43","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1158\/0008-5472.CAN-20-3792","article-title":"Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition","volume":"81","author":"Yan","year":"2021","journal-title":"Cancer Res"},{"issue":"35","key":"10.1016\/j.drup.2024.101171_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202300379","article-title":"Ferroptosis Detection: From Approaches to Applications","volume":"62","author":"Zeng","year":"2023","journal-title":"Angew. Chem. Int Ed. Engl."},{"key":"10.1016\/j.drup.2024.101171_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216152","article-title":"Ferroptosis: Promising approach for cancer and cancer immunotherapy","volume":"561","author":"Zheng","year":"2023","journal-title":"Cancer Lett."},{"issue":"10","key":"10.1016\/j.drup.2024.101171_bib46","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/mc.23083","article-title":"Tropomodulin 3 modulates EGFR-PI3K-AKT signaling to drive hepatocellular carcinoma metastasis","volume":"58","author":"Zheng","year":"2019","journal-title":"Mol. Carcinog."}],"container-title":["Drug Resistance Updates"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764624001298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764624001298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:28:39Z","timestamp":1778520519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1368764624001298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":46,"alternative-id":["S1368764624001298"],"URL":"https:\/\/doi.org\/10.1016\/j.drup.2024.101171","relation":{},"ISSN":["1368-7646"],"issn-type":[{"value":"1368-7646","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4","name":"articletitle","label":"Article Title"},{"value":"Drug Resistance Updates","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drup.2024.101171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101171"}}