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Sci."},{"key":"10.1016\/j.drup.2025.101310_bib110","first-page":"424","article-title":"Teaching an old dog new tricks: reactivated developmental signaling pathways regulate ABCB1 and chemoresistance in cancer","volume":"4","author":"Lee","year":"2021","journal-title":"Cancer Drug Resist."},{"key":"10.1016\/j.drup.2025.101310_bib111","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/mco2.106","article-title":"Overcoming multidrug resistance by knockout of ABCB1 gene using CRISPR\/Cas9 system in SW620\/Ad300 colorectal cancer cells","volume":"2","author":"Lei","year":"2021","journal-title":"MedComm"},{"key":"10.1016\/j.drup.2025.101310_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2020.100704","article-title":"Nanomedicine to target multidrug resistant tumors","volume":"52","author":"Lepeltier","year":"2020","journal-title":"Drug Resist. 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