{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:58:03Z","timestamp":1792061883378,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024A1515013214"],"award-info":[{"award-number":["2024A1515013214"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M753780"],"award-info":[{"award-number":["2024M753780"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373307"],"award-info":[{"award-number":["82373307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241231"],"award-info":[{"award-number":["82241231"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Resistance Updates"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.drup.2025.101313","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T06:25:56Z","timestamp":1759299956000},"page":"101313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Dissection of immunotherapeutic predictive versus prognostic transcriptional programs identifies SLC22A5-centric carnitine metabolism-driven resistance to anti-PD-(L)1 treatment in non-small cell lung cancer"],"prefix":"10.1016","volume":"84","author":[{"given":"Yu-Ze","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanwen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Heng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichang","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanqi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuishen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-0328","authenticated-orcid":false,"given":"Si-Cong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3571-8154","authenticated-orcid":false,"given":"Chao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drup.2025.101313_bib1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.immuni.2020.08.005","article-title":"Endogenous glucocorticoid signaling regulates CD8(+) t cell differentiation and development of dysfunction in the tumor microenvironment","volume":"53","author":"Acharya","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.drup.2025.101313_bib2","article-title":"Porphyrin overdrive rewires cancer cell metabolism","volume":"7","author":"Adapa","year":"2024","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.drup.2025.101313_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.it.2024.05.006","article-title":"Targeting metabolic pathways to counter cancer immunotherapy resistance","volume":"45","author":"Agarwala","year":"2024","journal-title":"Trends Immunol."},{"key":"10.1016\/j.drup.2025.101313_bib4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccell.2023.01.009","article-title":"Metabolic programming and immune suppression in the tumor microenvironment","volume":"41","author":"Arner","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.drup.2025.101313_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2019-000381","article-title":"Development and validation of a genomic mutation signature to predict response to PD-1 inhibitors in non-squamous NSCLC: a multicohort study","volume":"8","author":"Bai","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.drup.2025.101313_bib6","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1200\/JCO.2015.63.3651","article-title":"Biomarker: predictive or prognostic?","volume":"33","author":"Ballman","year":"2015","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.drup.2025.101313_bib7","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature11935","article-title":"Replication stress links structural and numerical cancer chromosomal instability","volume":"494","author":"Burrell","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.drup.2025.101313_bib8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41577-020-0406-2","article-title":"Lactate modulation of immune responses in inflammatory versus tumour microenvironments","volume":"21","author":"Certo","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.drup.2025.101313_bib9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.annonc.2020.01.006","article-title":"Efficacy of chemotherapy and atezolizumab in patients with non-small-cell lung cancer receiving antibiotics and proton pump inhibitors: pooled post hoc analyses of the OAK and POPLAR trials","volume":"31","author":"Chalabi","year":"2020","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"10.1016\/j.drup.2025.101313_bib10","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.chembiol.2024.02.001","article-title":"Metabolic rewiring and communication in cancer immunity","volume":"31","author":"Chapman","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.drup.2025.101313_bib11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/path.6343","article-title":"Single-cell transcriptomic analysis reveals that the APP-CD74 axis promotes immunosuppression and progression of testicular tumors","volume":"264","author":"Chen","year":"2024","journal-title":"J. Pathol."},{"key":"10.1016\/j.drup.2025.101313_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.583850","article-title":"Carnitine traffic in cells. Link with cancer","volume":"8","author":"Console","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.drup.2025.101313_bib13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-3-030-02505-2_3","article-title":"Immunotherapy in lung cancer: a new age in cancer treatment","volume":"995","author":"Corrales","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.drup.2025.101313_bib14","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010928","article-title":"Society for immunotherapy of cancer (SITC) consensus statement on essential biomarkers for immunotherapy clinical protocols","volume":"13","author":"Cottrell","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.drup.2025.101313_bib15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1050-1738(02)00175-5","article-title":"Mildronate: cardioprotective action through carnitine-lowering effect","volume":"12","author":"Dambrova","year":"2002","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.drup.2025.101313_bib16","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.phrs.2016.01.019","article-title":"Pharmacological effects of meldonium: biochemical mechanisms and biomarkers of cardiometabolic activity","volume":"113","author":"Dambrova","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.drup.2025.101313_bib17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.6004\/jnccn.2023.0020","article-title":"NCCN Guidelines\u00ae insights: Non-Small cell lung cancer, version 2.2023","volume":"21","author":"Ettinger","year":"2023","journal-title":"Journal National Comprehensive Cancer Network JNCCN"},{"key":"10.1016\/j.drup.2025.101313_bib18","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/S0140-6736(16)00587-0","article-title":"Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial","volume":"387","author":"Fehrenbacher","year":"2016","journal-title":"Lancet (Lond. Engl. )"},{"key":"10.1016\/j.drup.2025.101313_bib19","first-page":"2874","article-title":"L-Carnitine-Mediated tumor cell protection and poor patient survival associated with OCTN2 overexpression in glioblastoma multiforme, clinical cancer research: an official journal of the","volume":"25","author":"Fink","year":"2019","journal-title":"Am. Assoc. Cancer Res."},{"key":"10.1016\/j.drup.2025.101313_bib20","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1161\/CIRCULATIONAHA.105.586107","article-title":"Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5)","volume":"113","author":"Grube","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.drup.2025.101313_bib21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12916-022-02713-6","article-title":"Interstitial pneumonitis associated with combined regimen of immunotherapy and conventional therapies-pharmacovigilance database analysis with real-world data validation","volume":"21","author":"Guo","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.drup.2025.101313_bib22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-024-01891-4","article-title":"Drug tolerant persister cell plasticity in cancer: a revolutionary strategy for more effective anticancer therapies","volume":"9","author":"He","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.drup.2025.101313_bib23","article-title":"TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4","volume":"78","author":"He","year":"2025","journal-title":"Drug Resist. Update. Rev. Comment. Antimicrob. Anticancer Chemother."},{"key":"10.1016\/j.drup.2025.101313_bib24","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2025.101313_bib25","article-title":"SLC22A5 (OCTN2) carnitine Transporter-Indispensable for cell metabolism, a jekyll and hyde of human cancer","volume":"25","author":"Juraszek","year":"2019","journal-title":"Mol. (Basel Switz. )"},{"key":"10.1016\/j.drup.2025.101313_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.devcel.2020.06.018","article-title":"Cancer cells Don't live alone: metabolic communication within tumor microenvironments","volume":"54","author":"Li","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.drup.2025.101313_bib27","article-title":"Sciatic nerve stimulation enhances NK cell cytotoxicity through dopamine signaling and synergizes immunotherapy in triple-negative breast cancer","volume":"79","author":"Li","year":"2025","journal-title":"Drug Resist. Update. Rev. Comment. Antimicrob. Anticancer Chemother."},{"key":"10.1016\/j.drup.2025.101313_bib28","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1158\/0008-5472.CAN-23-2941","article-title":"Regular use of aspirin and statins reduces the risk of cancer in individuals with systemic inflammatory diseases","volume":"84","author":"Lin","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2025.101313_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167449","article-title":"Therapeutic modulation of APP-CD74 axis can activate phagocytosis of TAMs in GBM","volume":"1870","author":"Ma","year":"2024","journal-title":"Biochim. Et. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.drup.2025.101313_bib30","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41392-024-01772-w","article-title":"Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer","volume":"9","author":"Ma","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.drup.2025.101313_bib31","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12916-022-02315-2","article-title":"Organ-specific metastatic landscape dissects PD-(L)1 blockade efficacy in advanced non-small cell lung cancer: applicability from clinical trials to real-world practice","volume":"20","author":"Ma","year":"2022","journal-title":"BMC Med."},{"key":"10.1016\/j.drup.2025.101313_bib32","doi-asserted-by":"crossref","first-page":"1909296","DOI":"10.1080\/2162402X.2021.1909296","article-title":"Integrative evaluation of primary and metastatic lesion spectrum to guide anti-PD-L1 therapy of non-small cell lung cancer: results from two randomized studies","volume":"10","author":"Ma","year":"2021","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.drup.2025.101313_bib33","doi-asserted-by":"crossref","first-page":"638","DOI":"10.2353\/ajpath.2009.080463","article-title":"Expression of CD74, the receptor for macrophage migration inhibitory factor, in non-small cell lung cancer","volume":"174","author":"McClelland","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drup.2025.101313_bib34","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0140-6736(24)01029-8","article-title":"New promises and challenges in the treatment of advanced non-small-cell lung cancer","volume":"404","author":"Meyer","year":"2024","journal-title":"Lancet (Lond. Engl. )"},{"key":"10.1016\/j.drup.2025.101313_bib35","article-title":"Research progress of therapeutic effects and drug resistance of immunotherapy based on PD-1\/PD-L1 blockade","volume":"66","author":"Pang","year":"2023","journal-title":"Drug Resist. Update. Rev. Comment. Antimicrob. Anticancer Chemother."},{"key":"10.1016\/j.drup.2025.101313_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.132","article-title":"Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer","volume":"7","author":"Qu","year":"2016","journal-title":"Cell death Dis."},{"key":"10.1016\/j.drup.2025.101313_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179451","article-title":"Battling chemoresistance in cancer: root causes and strategies to uproot them","volume":"22","author":"Ramos","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.drup.2025.101313_bib38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0140-6736(16)32517-X","article-title":"Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial","volume":"389","author":"Rittmeyer","year":"2017","journal-title":"Lancet (Lond. Engl. )"},{"key":"10.1016\/j.drup.2025.101313_bib39","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.aaa1348","article-title":"Mutational landscape determines sensitivity to PD-1 blockade in non\u2013small cell lung cancer","volume":"348","author":"Rizvi","year":"2015","journal-title":"Science (New York N. Y. )"},{"key":"10.1016\/j.drup.2025.101313_bib40","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1097\/JTO.0b013e318292bdcd","article-title":"Biostatistics primer: what a clinician ought to know--prognostic and predictive factors","volume":"8","author":"Simms","year":"2013","journal-title":"Journal thoracic oncology official publication International Association Study Lung Cancer"},{"key":"10.1016\/j.drup.2025.101313_bib41","doi-asserted-by":"crossref","first-page":"1.30.31","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinforma."},{"key":"10.1016\/j.drup.2025.101313_bib42","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.7150\/thno.45543","article-title":"Mass spectrometry imaging-based metabolomics to visualize the spatially resolved reprogramming of carnitine metabolism in breast cancer","volume":"10","author":"Sun","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.drup.2025.101313_bib43","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1126\/science.2554494","article-title":"p53: a frequent target for genetic abnormalities in lung cancer","volume":"246","author":"Takahashi","year":"1989","journal-title":"Science (New York N. Y. )"},{"key":"10.1016\/j.drup.2025.101313_bib44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12263-018-0609-3","article-title":"Exploring the cellular network of metabolic flexibility in the adipose tissue","volume":"13","author":"Tareen","year":"2018","journal-title":"Genes Nutr."},{"key":"10.1016\/j.drup.2025.101313_bib45","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science (New York N. Y. )"},{"key":"10.1016\/j.drup.2025.101313_bib46","article-title":"Navigating established and emerging biomarkers for immune checkpoint inhibitor therapy","author":"Wang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.drup.2025.101313_bib47","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009024","article-title":"Targeting tumor-associated macrophage-derived CD74 improves efficacy of neoadjuvant chemotherapy in combination with PD-1 blockade for cervical cancer","volume":"12","author":"Wang","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.drup.2025.101313_bib48","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s12967-025-06341-5","article-title":"Comprehensive review of the expanding roles of the carnitine pool in metabolic physiology: beyond fatty acid oxidation","volume":"23","author":"Xiang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.drup.2025.101313_bib49","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1158\/2767-9764.CRC-24-0082","article-title":"First-in-human phase I trial of TPST-1120, an inhibitor of PPAR\u03b1, as monotherapy or in combination with nivolumab, in patients with advanced solid tumors","volume":"4","author":"Yarchoan","year":"2024","journal-title":"Cancer Res. Commun."},{"key":"10.1016\/j.drup.2025.101313_bib50","doi-asserted-by":"crossref","first-page":"7726","DOI":"10.1111\/febs.16181","article-title":"PPAR\u03b1 at the crossroad of metabolic-immune regulation in cancer","volume":"289","author":"Zeng","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.drup.2025.101313_bib51","article-title":"crVDAC3 alleviates ferroptosis by impeding HSPB1 ubiquitination and confers trastuzumab deruxtecan resistance in HER2-low breast cancer","volume":"77","author":"Zou","year":"2024","journal-title":"Drug Resist. Update. Rev. Comment. Antimicrob. Anticancer Chemother."}],"container-title":["Drug Resistance Updates"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764625001165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764625001165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T11:06:18Z","timestamp":1773140778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1368764625001165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":51,"alternative-id":["S1368764625001165"],"URL":"https:\/\/doi.org\/10.1016\/j.drup.2025.101313","relation":{},"ISSN":["1368-7646"],"issn-type":[{"value":"1368-7646","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissection of immunotherapeutic predictive versus prognostic transcriptional programs identifies SLC22A5-centric carnitine metabolism-driven resistance to anti-PD-(L)1 treatment in non-small cell lung cancer","name":"articletitle","label":"Article Title"},{"value":"Drug Resistance Updates","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drup.2025.101313","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101313"}}