{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:53:10Z","timestamp":1792079590622,"version":"4.4.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902396"],"award-info":[{"award-number":["81902396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2021GGB03"],"award-info":[{"award-number":["2021GGB03"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23S31900400"],"award-info":[{"award-number":["23S31900400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Resistance Updates"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.drup.2025.101339","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T08:05:43Z","timestamp":1764835543000},"page":"101339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["RCN2 facilitates esophageal squamous cellular carcinoma metastasis and cisplatin resistance through UBR5-mediated PPP2CA ubiquitination and degradation"],"prefix":"10.1016","volume":"85","author":[{"given":"Mengyuan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zitao","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3137-199X","authenticated-orcid":false,"given":"Lijie","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drup.2025.101339_bib1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.semcancer.2019.07.009","article-title":"PI3K\/Akt\/mTOR inhibitors in cancer: At the bench and bedside","volume":"59","author":"Alzahrani","year":"2019","journal-title":"Semin Cancer Biol."},{"key":"10.1016\/j.drup.2025.101339_bib2","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1053\/j.gastro.2011.07.038","article-title":"Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors","volume":"141","author":"Bakirtzi","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.drup.2025.101339_bib3","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1093\/jnci\/91.14.1211","article-title":"Potential drugs against cervical cancer: zinc-ejecting inhibitors of the human papillomavirus type 16 E6 oncoprotein","volume":"91","author":"Beerheide","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.drup.2025.101339_bib4","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.drup.2025.101339_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/v13040675","article-title":"Jr., Epstein-Barr Virus LMP1 Modulates the CD63 Interactome","volume":"13","author":"Cheerathodi","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.drup.2025.101339_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101055","article-title":"Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase \u03b1 (DGK\u03b1)\/NOX4 axis","volume":"73","author":"Chen","year":"2024","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.drup.2025.101339_bib7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1126\/science.7624774","article-title":"Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein","volume":"269","author":"Chen","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.drup.2025.101339_bib8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41388-020-01527-1","article-title":"E3 ubiquitin ligase UBR5 promotes pancreatic cancer growth and aerobic glycolysis by downregulating FBP1 via destabilization of C\/EBP\u03b1","volume":"40","author":"Chen","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2025.101339_bib9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41420-024-02008-0","article-title":"IL-1\u03b2 promotes esophageal squamous cell carcinoma growth and metastasis through FOXO3A by activating the PI3K\/AKT pathway","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.drup.2025.101339_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-074962","article-title":"Advances in diagnosis and management of cancer of the esophagus","volume":"385","author":"Deboever","year":"2024","journal-title":"Bmj"},{"key":"10.1016\/j.drup.2025.101339_bib11","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1038\/onc.2017.230","article-title":"Reticulocalbin-2 enhances hepatocellular carcinoma proliferation via modulating the EGFR-ERK pathway","volume":"36","author":"Ding","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2025.101339_bib12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1186\/s12967-022-03720-0","article-title":"Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K\/AKT\/FOXO3A signaling pathway in ESCC","volume":"20","author":"Du","year":"2022","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.drup.2025.101339_bib13","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1038\/s41388-023-02711-9","article-title":"Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix","volume":"42","author":"Duan","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2025.101339_bib14","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1158\/2159-8290.CD-23-0601","article-title":"p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression","volume":"13","author":"Efe","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.drup.2025.101339_bib15","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.ccell.2019.03.007","article-title":"Combination of hypoglycemia and metformin impairs tumor metabolic plasticity and growth by modulating the PP2A-GSK3\u03b2-MCL-1 Axis","volume":"35","author":"Elgendy","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.drup.2025.101339_bib16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev-pathmechdis-051222-122423","article-title":"Update on epithelial-mesenchymal plasticity in cancer progression","volume":"19","author":"Fontana","year":"2024","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.drup.2025.101339_bib17","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.oooo.2024.12.004","article-title":"Upregulation of RCN2 accelerates tumor progression and indicates poor prognosis in OSCC, Oral Surg Oral","volume":"139","author":"Guo","year":"2025","journal-title":"Med Oral. Pathol. Oral. Radio."},{"key":"10.1016\/j.drup.2025.101339_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102656","article-title":"Biased holoenzyme assembly of protein phosphatase 2A (PP2A): From cancer to small molecules","volume":"298","author":"Haanen","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2025.101339_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110847","article-title":"gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC\/PPP2CA ubiquitination","volume":"27","author":"Han","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.drup.2025.101339_bib20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","article-title":"Targeting PI3K\/Akt signal transduction for cancer therapy","volume":"6","author":"He","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.drup.2025.101339_bib21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13045-022-01347-8","article-title":"The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis","volume":"15","author":"Huang","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.drup.2025.101339_bib22","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1593\/neo.12768","article-title":"Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner","volume":"14","author":"Jackson","year":"2012","journal-title":"Neoplasia"},{"key":"10.1016\/j.drup.2025.101339_bib23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/bj3530417","article-title":"Protein phosphatase 2A: a highly regulated family of serine\/threonine phosphatases implicated in cell growth and signalling","volume":"353","author":"Janssens","year":"2001","journal-title":"Biochem J."},{"key":"10.1016\/j.drup.2025.101339_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaq1093","article-title":"PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells","volume":"10","author":"Kauko","year":"2018","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.drup.2025.101339_bib25","article-title":"Reticulocalbin 2 as a Potential Biomarker and Therapeutic Target for Atherosclerosis","volume":"11","author":"Li","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.drup.2025.101339_bib26","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1073\/pnas.0905657107","article-title":"Stk40 links the pluripotency factor Oct4 to the Erk\/MAPK pathway and controls extraembryonic endoderm differentiation","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.drup.2025.101339_bib27","article-title":"SAMD9 Promotes Postoperative Recurrence of Esophageal Squamous Cell Carcinoma by Stimulating MYH9-Mediated GSK3\u03b2\/\u03b2-Catenin Signaling","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.drup.2025.101339_bib28","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2307914120","article-title":"Targeting MFGE8 secreted by cancer-associated fibroblasts blocks angiogenesis and metastasis in esophageal squamous cell carcinoma","volume":"120","author":"Liu","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.drup.2025.101339_bib29","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12943-024-02046-3","article-title":"Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches","volume":"23","author":"Liu","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.drup.2025.101339_bib30","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1200\/JCO.23.01284","article-title":"Effectiveness of Endoscopic Screening on Esophageal Cancer Incidence and Mortality: A 9-Year Report of the Endoscopic Screening for Esophageal Cancer in China (ESECC) Randomized Trial","volume":"42","author":"Liu","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.drup.2025.101339_bib31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2016.12.040","article-title":"The depletion of ATM inhibits colon cancer proliferation and migration via B56\u03b32-mediated Chk1\/p53\/CD44 cascades","volume":"390","author":"Liu","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.drup.2025.101339_bib32","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1182\/bloodadvances.2017013615","article-title":"CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML","volume":"2","author":"Lucas","year":"2018","journal-title":"Blood Adv."},{"key":"10.1016\/j.drup.2025.101339_bib33","article-title":"PI3K\/Akt\/mTOR Signaling Pathway: Role in Esophageal Squamous Cell Carcinoma, Regulatory Mechanisms and Opportunities for Targeted Therapy","volume":"12","author":"Luo","year":"2022","journal-title":"Front Oncol."},{"key":"10.1016\/j.drup.2025.101339_bib34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13045-024-01534-9","article-title":"Proteomic characterization of esophageal squamous cell carcinoma response to immunotherapy reveals potential therapeutic strategy and predictive biomarkers","volume":"17","author":"Ma","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.drup.2025.101339_bib35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12964-023-01225-x","article-title":"PI3K\/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells","volume":"21","author":"Maharati","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.drup.2025.101339_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113168","article-title":"Drug-resistant exosome miR-99b-3p induces macrophage polarization and confers chemoresistance on sensitive cells by targeting PPP2CA","volume":"142","author":"Mao","year":"2024","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.drup.2025.101339_bib37","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.mce.2013.09.033","article-title":"Progestin-inducible EDD E3 ubiquitin ligase binds to \u03b14 phosphoprotein to regulate ubiquitination and degradation of protein phosphatase PP2Ac","volume":"382","author":"McDonald","year":"2014","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.drup.2025.101339_bib38","first-page":"2238","article-title":"YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling","volume":"11","author":"Mei","year":"2021","journal-title":"Am. J. Cancer Res"},{"key":"10.1016\/j.drup.2025.101339_bib39","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41419-023-06288-9","article-title":"Targeting protein methylation in pancreatic cancer cells results in KRAS signaling imbalance and inhibition of autophagy","volume":"14","author":"Montenegro","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.drup.2025.101339_bib40","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s42003-025-07869-4","article-title":"An organoid library of human esophageal squamous cell carcinomas (ESCCs) uncovers the chemotherapy-resistant ESCC features","volume":"8","author":"Nakagawa","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.drup.2025.101339_bib41","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1073\/pnas.1521018113","article-title":"PP2A methylation controls sensitivity and resistance to \u03b2-amyloid-induced cognitive and electrophysiological impairments","volume":"113","author":"Nicholls","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.drup.2025.101339_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101114","article-title":"Cancer plasticity in therapy resistance: Mechanisms and novel strategies","volume":"76","author":"Niu","year":"2024","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.drup.2025.101339_bib43","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1038\/emboj.2013.183","article-title":"Toll-like receptor-mediated IRE1\u03b1 activation as a therapeutic target for inflammatory arthritis","volume":"32","author":"Qiu","year":"2013","journal-title":"Embo J."},{"key":"10.1016\/j.drup.2025.101339_bib44","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.drup.2025.101339_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217110","article-title":"PP2A B55\u03b1 inhibits epithelial-mesenchymal transition via regulation of Slug expression in non-small cell lung cancer","volume":"598","author":"Singh","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.drup.2025.101339_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103349","article-title":"UBR5 mediates colorectal cancer chemoresistance by attenuating ferroptosis via Lys 11 ubiquitin-dependent stabilization of Smad3-SLC7A11 signaling","volume":"76","author":"Song","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.drup.2025.101339_bib47","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1038\/s41467-020-20140-0","article-title":"Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages","volume":"11","author":"Song","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2025.101339_bib48","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI123049","article-title":"RABL6A inhibits tumor-suppressive PP2A\/AKT signaling to drive pancreatic neuroendocrine tumor growth","volume":"129","author":"Umesalma","year":"2019","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.drup.2025.101339_bib49","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.cell.2021.04.022","article-title":"The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer","volume":"184","author":"Vervoort","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.drup.2025.101339_bib50","first-page":"2169","article-title":"Reticulocalbin 2 correlates with recurrence and prognosis in colorectal cancer","volume":"7","author":"Wang","year":"2017","journal-title":"Am. J. Cancer Res"},{"key":"10.1016\/j.drup.2025.101339_bib51","first-page":"4475","article-title":"Downregulation of microRNA\u2011183\u20115p inhibits the proliferation and invasion of colorectal cancer cells by inactivating the reticulocalbin\u20112\/Wnt\/\u03b2\u2011catenin signaling pathway","author":"Wang","year":"2019","journal-title":"Mol. Med Rep. 19"},{"key":"10.1016\/j.drup.2025.101339_bib52","doi-asserted-by":"crossref","first-page":"12500","DOI":"10.1073\/pnas.1820131116","article-title":"UBE3A-mediated PTPA ubiquitination and degradation regulate PP2A activity and dendritic spine morphology","volume":"116","author":"Wang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.drup.2025.101339_bib53","doi-asserted-by":"crossref","first-page":"11535","DOI":"10.7150\/thno.45261","article-title":"FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.drup.2025.101339_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215884","article-title":"NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A\/MEK\/ERK\/c-Jun\/ABCA1 pathway mediated membrane fluidity","volume":"547","author":"Wang","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.drup.2025.101339_bib55","first-page":"993","article-title":"Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells","volume":"9","author":"Wang","year":"2015","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.drup.2025.101339_bib56","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.1038\/s41388-019-0790-x","article-title":"AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation","volume":"38","author":"Wang","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2025.101339_bib57","doi-asserted-by":"crossref","first-page":"19142","DOI":"10.1016\/S0021-9258(17)32286-X","article-title":"The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif","volume":"269","author":"Weis","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2025.101339_bib58","article-title":"Identification and Characterization of Metastasis-Initiating Cells in ESCC in a Multi-Timepoint Pulmonary Metastasis Mouse Model","volume":"11","author":"Wong","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.drup.2025.101339_bib59","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cytogfr.2023.08.010","article-title":"Exosome-mediated metabolic reprogramming: Implications in esophageal carcinoma progression and tumor microenvironment remodeling","volume":"73","author":"Xi","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.drup.2025.101339_bib60","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/JS9.0000000000000816","article-title":"Comparison of efficacy and safety between neoadjuvant chemotherapy and neoadjuvant immune checkpoint inhibitors combined with chemotherapy for locally advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis","volume":"110","author":"Xu","year":"2024","journal-title":"Int J. Surg."},{"key":"10.1016\/j.drup.2025.101339_bib61","doi-asserted-by":"crossref","first-page":"259","DOI":"10.7150\/ijbs.53795","article-title":"NETO2 promotes esophageal cancer progression by inducing proliferation and metastasis via PI3K\/AKT and ERK pathway","volume":"17","author":"Xu","year":"2021","journal-title":"Int J. Biol. Sci."},{"key":"10.1016\/j.drup.2025.101339_bib62","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1001\/jamasurg.2021.2373","article-title":"Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: The NEOCRTEC5010 Randomized Clinical Trial","volume":"156","author":"Yang","year":"2021","journal-title":"JAMA Surg."},{"key":"10.1016\/j.drup.2025.101339_bib63","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2024.5401","article-title":"Luteolin enhances drug chemosensitivity by downregulating the FAK\/PI3K\/AKT pathway in paclitaxel\u2011resistant esophageal squamous cell carcinoma","volume":"54","author":"Yang","year":"2024","journal-title":"Int J. Mol. Med"},{"key":"10.1016\/j.drup.2025.101339_bib64","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s13402-023-00796-8","article-title":"RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis","volume":"46","author":"Yao","year":"2023","journal-title":"Cell Oncol (Dordr)"},{"key":"10.1016\/j.drup.2025.101339_bib65","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ijsu.2018.09.020","article-title":"Association between PPP2CA expression and colorectal cancer prognosis tumor marker prognostic study","volume":"59","author":"Yong","year":"2018","journal-title":"Int J. Surg."},{"key":"10.1016\/j.drup.2025.101339_bib66","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.7150\/ijbs.107130","article-title":"E3 ligase MKRN2 destabilizes PPP2CA proteins to inactivate canonical Wnt pathway and mitigates tumorigenesis of clear cell renal cell carcinoma","volume":"21","author":"Yu","year":"2025","journal-title":"Int J. Biol. Sci."},{"key":"10.1016\/j.drup.2025.101339_bib67","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/carcin\/bgab124","article-title":"The miR-345-3p\/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells","volume":"43","author":"Zeng","year":"2022","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.drup.2025.101339_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101096","article-title":"KLF12 interacts with TRIM27 to affect cisplatin resistance and cancer metastasis in esophageal squamous cell carcinoma by regulating L1CAM expression","volume":"76","author":"Zhang","year":"2024","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.drup.2025.101339_bib69","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2174\/1574892817666220905114120","article-title":"Gliotoxin Induced Ferroptosis by Downregulating SUV39H1 Expression in Esophageal Cancer Cells","volume":"18","author":"Zhang","year":"2023","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"10.1016\/j.drup.2025.101339_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2025.101224","article-title":"DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal \u03b2-oxidation in hepatocellular carcinoma","volume":"81","author":"Zhang","year":"2025","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.drup.2025.101339_bib71","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/s13402-024-00976-0","article-title":"ZNF468-mediated epigenetic upregulation of VEGF-C facilitates lymphangiogenesis and lymphatic metastasis in ESCC via PI3K\/Akt and ERK1\/2 signaling pathways","volume":"47","author":"Zhu","year":"2024","journal-title":"Cell Oncol (Dordr)"}],"container-title":["Drug Resistance Updates"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764625001426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764625001426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:03:43Z","timestamp":1773907423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1368764625001426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":71,"alternative-id":["S1368764625001426"],"URL":"https:\/\/doi.org\/10.1016\/j.drup.2025.101339","relation":{},"ISSN":["1368-7646"],"issn-type":[{"value":"1368-7646","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RCN2 facilitates esophageal squamous cellular carcinoma metastasis and cisplatin resistance through UBR5-mediated PPP2CA ubiquitination and degradation","name":"articletitle","label":"Article Title"},{"value":"Drug Resistance Updates","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drup.2025.101339","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101339"}}