{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:02:03Z","timestamp":1789790523892,"version":"4.0.1"},"reference-count":192,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Resistance Updates"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.drup.2026.101465","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:32:20Z","timestamp":1786033940000},"page":"101465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Biomimetic delivery systems for overcoming drug resistance in gastrointestinal cancers"],"prefix":"10.1016","volume":"89","author":[{"given":"Gou","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Wei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Chen","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4871-1840","authenticated-orcid":false,"given":"Qing-Qing","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0444-957X","authenticated-orcid":false,"given":"Ji-Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drup.2026.101465_bib1","article-title":"Targeted nanoparticle delivery of lapatinib for cancer therapy: progress, challenges, and future directions","volume":"108","author":"Abbas Abad","year":"2025","journal-title":"J. Drug. Deliv. Sci. Technol."},{"key":"10.1016\/j.drup.2026.101465_bib2","doi-asserted-by":"crossref","first-page":"S171","DOI":"10.1016\/j.jhep.2015.02.042","article-title":"From immunosuppression to tolerance","volume":"62","author":"Adams","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.drup.2026.101465_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.30","article-title":"Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological trojan horse approach to eradicate multidrug-resistant cancers","volume":"3","author":"Adar","year":"2012","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.drup.2026.101465_bib4","article-title":"Long-term proliferation and delayed senescence of bone marrow-derived human mesenchymal stem cells on metformin co-embedded HA\/Gel electrospun composite nanofibers","volume":"80","author":"Ahmadi","year":"2023","journal-title":"J. Drug. Deliv. Sci. Technol."},{"key":"10.1016\/j.drup.2026.101465_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-071811-150124","article-title":"The effect of nanoparticle size, shape, and surface chemistry on biological systems","volume":"14","author":"Albanese","year":"2012","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.drup.2026.101465_bib6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12935-015-0221-1","article-title":"Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp","volume":"15","author":"Alfarouk","year":"2015","journal-title":"Cancer Cell. Int."},{"key":"10.1016\/j.drup.2026.101465_bib7","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1126\/science.aaa4024","article-title":"Malicious exosomes","volume":"346","author":"Anastasiadou","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.drup.2026.101465_bib8","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41573-022-00476-6","article-title":"Engineering the next generation of cell-based therapeutics","volume":"21","author":"Bashor","year":"2022","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.drup.2026.101465_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1158\/2326-6066.CIR-19-0293","article-title":"Glypican-3-specific CAR T cells co-expressing IL15 and IL21 have superior expansion and antitumor activity against hepatocellular carcinoma","volume":"8","author":"Batra","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.drup.2026.101465_bib10","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1158\/0008-5472.CAN-18-0124","article-title":"Transfer of miRNA in macrophage-derived exosomes induces drug resistance in pancreatic adenocarcinoma","volume":"78","author":"Binenbaum","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.drup.2026.101465_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114580","article-title":"Portrayal of the complex molecular landscape of multidrug resistance in gastric cancer: unveiling the potential targets","volume":"449","author":"Biswas","year":"2025","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.drup.2026.101465_bib12","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1200\/JCO.1998.16.11.3674","article-title":"Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance","volume":"16","author":"Bradshaw","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib13","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"Ca. Cancer J. Clin."},{"key":"10.1016\/j.drup.2026.101465_bib14","first-page":"3890","article-title":"Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer","volume":"17","author":"Buck","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.drup.2026.101465_bib15","doi-asserted-by":"crossref","first-page":"747","DOI":"10.4161\/cbt.4.7.1826","article-title":"Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps","volume":"4","author":"Burger","year":"2005","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.drup.2026.101465_bib16","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.2147\/IJN.S440881","article-title":"LGR5 as a Therapeutic Target of Antibody-Functionalized Biomimetic Magnetoliposomes for Colon Cancer Therapy","volume":"19","author":"Cepero","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.drup.2026.101465_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.canlet.2018.06.028","article-title":"The multifaceted role of glutathione S-transferases in cancer","volume":"433","author":"Chatterjee","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.drup.2026.101465_bib18","article-title":"HIF-1\u03b1 inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1\/P-glycoprotein","volume":"9","author":"Chen","year":"2014","journal-title":"PLOS One"},{"key":"10.1016\/j.drup.2026.101465_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tcb.2017.11.007","article-title":"Fighting resilient cancers with iron","volume":"28","author":"Chen","year":"2018","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.drup.2026.101465_bib20","doi-asserted-by":"crossref","first-page":"10049","DOI":"10.1021\/acsnano.6b04695","article-title":"Cancer cell membrane\u2013biomimetic nanoparticles for homologous-targeting dual-modal imaging and photothermal therapy","volume":"10","author":"Chen","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.drup.2026.101465_bib21","first-page":"2041","article-title":"Inhibition of wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells","volume":"30","author":"Chikazawa","year":"2010","journal-title":"Anticancer. Res."},{"key":"10.1016\/j.drup.2026.101465_bib22","doi-asserted-by":"crossref","first-page":"17080","DOI":"10.1021\/acsnano.1c03800","article-title":"Cell membrane-coated mimics: a methodological approach for fabrication, characterization for therapeutic applications, and challenges for clinical translation","volume":"15","author":"Chugh","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.drup.2026.101465_bib23","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/s41573-021-00285-3","article-title":"Engineering living therapeutics with synthetic biology","volume":"20","author":"Cubillos-Ruiz","year":"2021","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.drup.2026.101465_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.113926","article-title":"Preparation and in vitro evaluation of cell adhesion and long-term proliferation of stem cells cultured on silibinin co-embedded PLGA\/Collagen electrospun composite nanofibers","volume":"435","author":"Dadashpour","year":"2024","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.drup.2026.101465_bib25","article-title":"Sustained in vitro delivery of metformin-loaded mesoporous silica nanoparticles for delayed senescence and stemness preservation of adipose-derived stem cells","volume":"87","author":"Dadashpour","year":"2023","journal-title":"J. Drug. Deliv. Sci. Technol."},{"key":"10.1016\/j.drup.2026.101465_bib26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrclinonc.2017.166","article-title":"Tumour heterogeneity and resistance to cancer therapies","volume":"15","author":"Dagogo-Jack","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41419-024-06531-x","article-title":"Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer","volume":"15","author":"Dash","year":"2024","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.drup.2026.101465_bib28","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ncb0905-847","article-title":"The lysosome turns fifty","volume":"7","author":"de Duve","year":"2005","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.drup.2026.101465_bib29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1081\/DDC-120030428","article-title":"Safety and efficacy: the role of chemistry, manufacturing, and controls in pharmaceutical drug development","volume":"30","author":"DiFeo","year":"2004","journal-title":"Drug. Dev. Ind. Pharm."},{"key":"10.1016\/j.drup.2026.101465_bib30","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00432-010-0828-5","article-title":"Expression and significance of hypoxia-inducible factor-1 alpha and MDR1\/P-glycoprotein in human colon carcinoma tissue and cells","volume":"136","author":"Ding","year":"2010","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101125","article-title":"Cellular and molecular mechanisms of gastrointestinal cancer liver metastases and drug resistance","volume":"77","author":"Dong","year":"2024","journal-title":"Drug. Resist. Updat."},{"key":"10.1016\/j.drup.2026.101465_bib32","article-title":"Overcoming cancer multi-drug resistance (MDR): reasons, mechanisms, nanotherapeutic solutions, and challenges","volume":"162","author":"Duan","year":"2023","journal-title":"Biomed. Pharmacother. Biomedecine Pharmacother."},{"key":"10.1016\/j.drup.2026.101465_bib33","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1124\/dmd.115.064824","article-title":"Potent and selective inhibition of plasma membrane monoamine transporter by HIV protease inhibitors","volume":"43","author":"Duan","year":"2015","journal-title":"Drug. Metab. Dispos."},{"key":"10.1016\/j.drup.2026.101465_bib34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.addr.2010.04.009","article-title":"The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect","volume":"63","author":"Fang","year":"2011","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.drup.2026.101465_bib35","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1021\/nl500618u","article-title":"Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery","volume":"14","author":"Fang","year":"2014","journal-title":"Nano Lett."},{"key":"10.1016\/j.drup.2026.101465_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12896-023-00825-2","article-title":"Fabrication and characterization of metformin-loaded PLGA\/Collagen nanofibers for modulation of macrophage polarization for tissue engineering and regenerative medicine","volume":"23","author":"Firouzi Amandi","year":"2023","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.drup.2026.101465_bib37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1073\/pnas.84.1.265","article-title":"Expression of a multidrug-resistance gene in human tumors and tissues","volume":"84","author":"Fojo","year":"1987","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.drup.2026.101465_bib38","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41568-019-0149-1","article-title":"Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion","volume":"19","author":"Friedmann Angeli","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.biocel.2011.12.009","article-title":"Intracellular trafficking of P-glycoprotein","volume":"44","author":"Fu","year":"2012","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.drup.2026.101465_bib40","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41467-025-67254-x","article-title":"\u03b1PD-1-conjugated acid-cleavable nanodrugs overcomes cellular immunotherapy barriers in pancreatic tumors","volume":"17","author":"Gan","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2026.101465_bib41","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s12015-023-10593-3","article-title":"Cancer stem cells and the tumor microenvironment in tumor drug resistance","volume":"19","author":"Gao","year":"2023","journal-title":"Stem Cell. Rev. Rep."},{"key":"10.1016\/j.drup.2026.101465_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.688070","article-title":"Surface PEGylated cancer cell membrane-coated nanoparticles for codelivery of curcumin and doxorubicin for the treatment of multidrug resistant esophageal carcinoma","volume":"9","author":"Gao","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.drup.2026.101465_bib43","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41571-025-01059-1","article-title":"Understanding and overcoming multidrug resistance in cancer","volume":"22","author":"Ge","year":"2025","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib44","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.aah5043","article-title":"Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine","volume":"357","author":"Geller","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.drup.2026.101465_bib45","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib46","doi-asserted-by":"crossref","first-page":"7337","DOI":"10.1158\/1078-0432.CCR-11-1667","article-title":"Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance","volume":"17","author":"Gotink","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.drup.2026.101465_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.158843","article-title":"A tetrahedral DNA nanoplatform with ultrasound-triggered biomimetic nanocarriers for targeted siMCM2 delivery and reversal of imatinib resistance in gastrointestinal stromal tumors","volume":"504","author":"Han","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.drup.2026.101465_bib48","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/s41575-024-00931-2","article-title":"Mitochondrial function and gastrointestinal diseases","volume":"21","author":"Haque","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.drup.2026.101465_bib49","article-title":"Multifunctional Pluronic nanomedicine: Bridging the gap between chemoresistance and effective cancer therapy","volume":"120","author":"Hasannia","year":"2026","journal-title":"J. Drug. Deliv. Sci. Technol."},{"key":"10.1016\/j.drup.2026.101465_bib50","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12943-024-02208-3","article-title":"Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy","volume":"24","author":"He","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib51","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jconrel.2016.03.001","article-title":"Co-delivery of erlotinib and doxorubicin by pH-sensitive charge conversion nanocarrier for synergistic therapy","volume":"229","author":"He","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.drup.2026.101465_bib52","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Hoff","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.drup.2026.101465_bib53","doi-asserted-by":"crossref","DOI":"10.1142\/S179398442630013X","article-title":"Bioinspired and biomimetic systems: cell-derived vesicles as drug carriers for targeted delivery in neurodegenerative disorders","author":"Holghoomi","year":"2026","journal-title":"Nano LIFE"},{"key":"10.1016\/j.drup.2026.101465_bib54","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","article-title":"Cancer drug resistance: an evolving paradigm","volume":"13","author":"Holohan","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib55","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrd.2016.175","article-title":"Screening out irrelevant cell-based models of disease","volume":"15","author":"Horvath","year":"2016","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.drup.2026.101465_bib56","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12668-025-02265-y","article-title":"Multifunctional nanocarriers for prednisolone delivery: a new frontier in cancer and inflammation therapy","volume":"16","author":"Hoseini","year":"2026","journal-title":"BioNanoScience"},{"key":"10.1016\/j.drup.2026.101465_bib57","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.3748\/wjg.v22.i30.6876","article-title":"Mechanisms of drug resistance in colon cancer and its therapeutic strategies","volume":"22","author":"Hu","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.drup.2026.101465_bib58","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/s41388-018-0557-9","article-title":"Exosomal wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance","volume":"38","author":"Hu","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.drup.2026.101465_bib59","article-title":"Synergistic Induction of Ferroptosis by GPX4 Inhibitor and GSH-Depleted Nanoparticles Effectively Reverses Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma PDX Model","author":"Huang","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.drup.2026.101465_bib60","doi-asserted-by":"crossref","first-page":"12385","DOI":"10.2147\/CMAR.S274599","article-title":"Multidrug resistance of gastric cancer: the mechanisms and chinese medicine reversal agents","volume":"12","author":"Huang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.drup.2026.101465_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123147","article-title":"High-density lipoprotein-based nanoplatform reprograms tumor microenvironment and enhances chemotherapy against pancreatic ductal adenocarcinoma","volume":"318","author":"Huang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.drup.2026.101465_bib62","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/1097-4652(200011)185:2<293::AID-JCP14>3.0.CO;2-C","article-title":"Induction of MRP1 and \u03b3-glutamylcysteine synthetase gene expression by interleukin 1\u03b2 is mediated by nitric oxide-related signalings in human colorectal cancer cells","volume":"185","author":"Ikegami","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.drup.2026.101465_bib63","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrd3028","article-title":"Membrane transporters in drug development","volume":"9","author":"International Transporter Consortium","year":"2010","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.drup.2026.101465_bib64","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41586-022-04437-2","article-title":"Effective drug combinations in breast, colon and pancreatic cancer cells","volume":"603","author":"Jaaks","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.drup.2026.101465_bib65","article-title":"Lysosome-targeting bacterial outer membrane vesicles for tumor specific degradation of PD-L1","volume":"20","author":"Ji","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.drup.2026.101465_bib66","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1186\/s12885-021-09020-y","article-title":"Exosomal microRNA-107 reverses chemotherapeutic drug resistance of gastric cancer cells through HMGA2\/mTOR\/P-gp pathway","volume":"21","author":"Jiang","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib67","doi-asserted-by":"crossref","first-page":"31497","DOI":"10.1021\/acsami.7b09458","article-title":"Tumor microenvironment modulation by cyclopamine improved photothermal therapy of biomimetic gold nanorods for pancreatic ductal adenocarcinomas","volume":"9","author":"Jiang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.drup.2026.101465_bib68","first-page":"264","article-title":"Current treatment and recent progress in gastric cancer","volume":"71","author":"Joshi","year":"2021","journal-title":"Ca. Cancer J. Clin."},{"key":"10.1016\/j.drup.2026.101465_bib69","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1124\/mol.114.096065","article-title":"The c-MET\/PI3K signaling is associated with cancer resistance to doxorubicin and photodynamic therapy by elevating BCRP\/ABCG2 expression","volume":"87","author":"Jung","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.drup.2026.101465_bib70","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrc.2017.32","article-title":"Common pitfalls in preclinical cancer target validation","volume":"17","author":"Kaelin","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib71","doi-asserted-by":"crossref","first-page":"8696","DOI":"10.1038\/s41467-025-63718-2","article-title":"Engineered exosomes with KrasG12D specific siRNA in pancreatic cancer: a phase I study with immunological correlates","volume":"16","author":"Kalluri","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2026.101465_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123880","article-title":"Diabetic wound healing function of PCL\/cellulose acetate nanofiber engineered with chitosan\/cerium oxide nanoparticles","volume":"653","author":"Kamalipooya","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.drup.2026.101465_bib73","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature22341","article-title":"Exosomes Facilitate Therapeutic Targeting of Oncogenic Kras in Pancreatic Cancer","volume":"546","author":"Kamerkar","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.drup.2026.101465_bib74","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1124\/dmd.112.050054","article-title":"Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells)","volume":"41","author":"Kazmi","year":"2013","journal-title":"Drug. Metab. Dispos."},{"key":"10.1016\/j.drup.2026.101465_bib75","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10876-026-03004-3","article-title":"pH-triggered curcumin delivery via a hybrid starch\u2013GQD\u2013\u03b3-Al\u2082O\u2083 nanocarrier: a machine learning study","volume":"37","author":"Khajeh","year":"2026","journal-title":"J. Clust. Sci."},{"key":"10.1016\/j.drup.2026.101465_bib76","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.nano.2015.10.012","article-title":"Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells","volume":"12","author":"Kim","year":"2016","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.drup.2026.101465_bib77","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/ijc.20140","article-title":"MRP1 and glucosylceramide are coordinately over expressed and enriched in rafts during multidrug resistance acquisition in colon cancer cells","volume":"110","author":"Klappe","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib78","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.3390\/vaccines10101727","article-title":"Advances in nanotechnology for cancer immunoprevention and immunotherapy: a review","volume":"10","author":"Koyande","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.drup.2026.101465_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/IJN.S579622","article-title":"Biomimetic nanoparticles for targeted and efficient cancer therapy: progress, challenges and perspectives","volume":"21","author":"Kumar","year":"2026","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.drup.2026.101465_bib80","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41571-023-00846-y","article-title":"Myeloid-derived suppressor cells in cancer and cancer therapy","volume":"21","author":"Lasser","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib81","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00253-011-3695-3","article-title":"Engineering bacteria toward tumor targeting for cancer treatment: current state and perspectives","volume":"93","author":"Lee","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.drup.2026.101465_bib82","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/cas.13894","article-title":"Upregulated microRNA-193a-3p is responsible for cisplatin resistance in CD44(+) gastric cancer cells","volume":"110","author":"Lee","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.drup.2026.101465_bib83","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.30087","article-title":"Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper","volume":"4","author":"Lener","year":"2015","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.drup.2026.101465_bib84","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ccell.2021.12.004","article-title":"Functional precision oncology: testing tumors with drugs to identify vulnerabilities and novel combinations","volume":"40","author":"Letai","year":"2022","journal-title":"Cancer Cell."},{"key":"10.1016\/j.drup.2026.101465_bib85","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1039\/C8BM00343B","article-title":"Cancer cell membrane-coated magnetic nanoparticles for MR\/NIR fluorescence dual-modal imaging and photodynamic therapy","volume":"6","author":"Li","year":"2018","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.drup.2026.101465_bib86","doi-asserted-by":"crossref","first-page":"24593","DOI":"10.1021\/acsnano.3c10212","article-title":"Advanced generation therapeutics: biomimetic nanodelivery system for tumor immunotherapy","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.drup.2026.101465_bib87","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/cac2.70017","article-title":"Global trends and epidemiological shifts in gastrointestinal cancers: insights from the past four decades","volume":"45","author":"Li","year":"2025","journal-title":"Cancer Commun."},{"key":"10.1016\/j.drup.2026.101465_bib88","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s13287-024-04061-z","article-title":"Exosome crosstalk between cancer stem cells and tumor microenvironment: cancer progression and therapeutic strategies","volume":"15","author":"Li","year":"2024","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.drup.2026.101465_bib89","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.biomaterials.2017.07.026","article-title":"Cancer cell membrane-coated biomimetic platform for tumor targeted photodynamic therapy and hypoxia-amplified bioreductive therapy","volume":"142","author":"Li","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.drup.2026.101465_bib90","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12964-020-00627-5","article-title":"Drug resistance and cancer stem cells","volume":"19","author":"Li","year":"2021","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.drup.2026.101465_bib91","article-title":"Biomimetic exosome-camouflaged pH-responsive dendrimer nanogels as a therapeutic vaccine against pancreatic cancer through reprogramming of multiple cell types","author":"Li","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.drup.2026.101465_bib92","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40880-017-0219-2","article-title":"Autophagy and multidrug resistance in cancer","volume":"36","author":"Li","year":"2017","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib93","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12951-019-0563-2","article-title":"Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer","volume":"18","author":"Liang","year":"2020","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.drup.2026.101465_bib94","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1002\/1878-0261.13052","article-title":"iRGD-modified exosomes effectively deliver CPT1A siRNA to colon cancer cells, reversing oxaliplatin resistance by regulating fatty acid oxidation","volume":"15","author":"Lin","year":"2021","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib95","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41467-024-55568-1","article-title":"Nucleus-translocated GCLM promotes chemoresistance in colorectal cancer through a moonlighting function","volume":"16","author":"Lin","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2026.101465_bib96","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3892\/ijo.2024.5684","article-title":"Drug resistance and tumor immune microenvironment: an overview of current understandings (review)","volume":"65","author":"Liu","year":"2024","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib97","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.2147\/OTT.S82835","article-title":"Hypoxia-inducible factor-1\u03b1 induces multidrug resistance protein in colon cancer","volume":"8","author":"Lv","year":"2015","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.drup.2026.101465_bib98","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.mucimm.2024.03.007","article-title":"Interaction of microbiota, mucosal malignancies, and immunotherapy\u2014Mechanistic insights","volume":"17","author":"Mager","year":"2024","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.drup.2026.101465_bib99","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1517\/17425247.2014.889679","article-title":"Approaches to erythrocyte-mediated drug delivery","volume":"11","author":"Magnani","year":"2014","journal-title":"Expert. Opin. Drug. Deliv."},{"key":"10.1016\/j.drup.2026.101465_bib100","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s44222-024-00255-5","article-title":"The physico-chemical landscape of extracellular vesicles","volume":"3","author":"Manno","year":"2025","journal-title":"Nat. Rev. Bioeng."},{"key":"10.1016\/j.drup.2026.101465_bib101","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.addr.2013.09.019","article-title":"Nanomedicine therapeutic approaches to overcome cancer drug resistance","volume":"65","author":"Markman","year":"2013","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.drup.2026.101465_bib102","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pharmthera.2016.01.009","article-title":"The role of glucuronidation in drug resistance","volume":"159","author":"Mazerska","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.drup.2026.101465_bib103","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1136\/jcp.52.6.450","article-title":"Increased expression of multidrug resistance related proteins pgp, MRP1, and LRP\/MVP occurs early in colorectal carcinogenesis","volume":"52","author":"Meijer","year":"1999","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.drup.2026.101465_bib104","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12225","article-title":"A salmonella nanoparticle mimic overcomes multidrug resistance in tumours","volume":"7","author":"Mercado-Lubo","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2026.101465_bib105","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/1097-0215(20000901)87:5<615::AID-IJC1>3.0.CO;2-4","article-title":"Intracellular P-glycoprotein expression is associated with the intrinsic multidrug resistance phenotype in human colon adenocarcinoma cells","volume":"87","author":"Meschini","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib106","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.drup.2026.101465_bib107","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jconrel.2022.03.026","article-title":"Combined nano cancer immunotherapy based on immune status in a tumor microenvironment","volume":"345","author":"Nakamura","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.drup.2026.101465_bib108","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1111\/cas.70167","article-title":"Potential of platelet-based drug delivery system for treating peritoneal metastasis of gastric cancer","volume":"116","author":"Nakayama","year":"2025","journal-title":"Cancer Sci."},{"key":"10.1016\/j.drup.2026.101465_bib109","doi-asserted-by":"crossref","unstructured":"Neesse, A., Alg\u00fcl, H., Tuveson, D.A., Gress, T.M., 2015. Stromal biology and therapy in pancreatic cancer: a changing paradigm. https:\/\/doi.org\/10.1136\/gutjnl-2015-309304.","DOI":"10.1136\/gutjnl-2015-309304"},{"key":"10.1016\/j.drup.2026.101465_bib110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","article-title":"Cell death","volume":"187","author":"Newton","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.drup.2026.101465_bib111","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202504188","article-title":"Neutrophil-Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer","volume":"12","author":"Niu","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.drup.2026.101465_bib112","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrclinonc.2009.111","article-title":"Implications for KRAS status and EGFR-targeted therapies in metastatic CRC","volume":"6","author":"Normanno","year":"2009","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib113","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1582-4934.2007.00013.x","article-title":"bcl-2-specific siRNAs restore Gemcitabine sensitivity in human pancreatic cancer cells","volume":"11","author":"Okamoto","year":"2007","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.drup.2026.101465_bib114","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3390\/cancers3011467","article-title":"Overexpression of CYP3A4 in a COLO 205 colon cancer stem cell model in vitro","volume":"3","author":"Olszewski","year":"2011","journal-title":"Cancers"},{"key":"10.1016\/j.drup.2026.101465_bib115","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/cncr.31335","article-title":"Targeting autophagy in cancer","volume":"124","author":"Onorati","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib116","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay2574","article-title":"Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients","volume":"11","author":"Ooft","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.drup.2026.101465_bib117","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.7150\/thno.26758","article-title":"Combination of NIR therapy and regulatory T cell modulation using layer-by-layer hybrid nanoparticles for effective cancer photoimmunotherapy","volume":"8","author":"Ou","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.drup.2026.101465_bib118","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1200\/JCO.22.01423","article-title":"Resistance mechanisms to anti\u2013epidermal growth factor receptor therapy in RAS\/RAF wild-type colorectal cancer vary by regimen and line of therapy","volume":"41","author":"Parseghian","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib119","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13045-022-01305-4","article-title":"Emerging role of exosomes in cancer progression and tumor microenvironment remodeling","volume":"15","author":"Paskeh","year":"2022","journal-title":"J. Hematol. Oncol. J. Hematol. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib120","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/s41423-024-01207-0","article-title":"CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors","volume":"21","author":"Peng","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.drup.2026.101465_bib121","series-title":"Intelligent Nanocarriers","first-page":"381","article-title":"AI-guided radiotherapy and nanocarrier synergy to treat cancers","author":"Pourmadadi","year":"2026"},{"key":"10.1016\/j.drup.2026.101465_bib122","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18122574","article-title":"Drug resistance driven by cancer stem cells and their niche","volume":"18","author":"Prieto-Vila","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.drup.2026.101465_bib123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.2012.569","article-title":"Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer","volume":"108","author":"Provenzano","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib124","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s41591-022-01800-8","article-title":"Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results","volume":"28","author":"Qi","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.drup.2026.101465_bib125","article-title":"Macrophage membrane-coated SN-38-encapsulated liposomes for efficient treatment of colorectal cancer","volume":"91","author":"Qi","year":"2024","journal-title":"J. Drug. Deliv. Sci. Technol."},{"key":"10.1016\/j.drup.2026.101465_bib126","doi-asserted-by":"crossref","first-page":"62759","DOI":"10.18632\/oncotarget.18663","article-title":"Interplay between apoptosis and autophagy in colorectal cancer","volume":"8","author":"Qian","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.drup.2026.101465_bib127","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.985363","article-title":"The role of BCL-2 family proteins in regulating apoptosis and cancer therapy","volume":"12","author":"Qian","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib128","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10495-020-01601-9","article-title":"BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy","volume":"25","author":"Ramesh","year":"2020","journal-title":"Apoptosis"},{"key":"10.1016\/j.drup.2026.101465_bib129","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/s41565-024-01753-8","article-title":"Designing nanotheranostics with machine learning","volume":"19","author":"Rao","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.drup.2026.101465_bib130","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202002081","article-title":"Recent advances in cell membrane-derived biomimetic nanotechnology for cancer immunotherapy","volume":"10","author":"Raza","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.drup.2026.101465_bib131","unstructured":"Research, C. for D.E. and, 2024. FDA approves irinotecan liposome for first-line treatment of metastatic pancreatic adenocarcinoma. Fda."},{"key":"10.1016\/j.drup.2026.101465_bib132","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/s41467-018-03705-y","article-title":"Progress and challenges towards targeted delivery of cancer therapeutics","volume":"9","author":"Rosenblum","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2026.101465_bib133","doi-asserted-by":"crossref","DOI":"10.3390\/cells14221750","article-title":"Exosome-mediated crosstalk between cancer cells and tumor microenvironment","volume":"14","author":"Saad","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.drup.2026.101465_bib134","doi-asserted-by":"crossref","first-page":"6345","DOI":"10.3748\/wjg.v22.i28.6345","article-title":"Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer","volume":"22","author":"Sforza","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.drup.2026.101465_bib135","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1172\/JCI36049","article-title":"Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family","volume":"118","author":"Shepard","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drup.2026.101465_bib136","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrc.2016.108","article-title":"Cancer nanomedicine: progress, challenges and opportunities","volume":"17","author":"Shi","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib137","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41419-025-07443-0","article-title":"Engineered mesenchymal stem\/stromal cells against cancer","volume":"16","author":"Shi","year":"2025","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.drup.2026.101465_bib138","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s13046-025-03505-5","article-title":"A new era in cancer therapy: targeting the proteasome-bcl-2 axis","volume":"44","author":"Soni","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.drup.2026.101465_bib139","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0006-2952(91)90531-9","article-title":"P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines: evidence for a saturation of active daunorubicin transport","volume":"41","author":"Spoelstra","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.drup.2026.101465_bib140","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0140-6736(25)00261-2","article-title":"Pancreatic cancer","volume":"405","author":"Stoop","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.drup.2026.101465_bib141","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41392-024-02035-4","article-title":"Nucleic acid drugs: recent progress and future perspectives","volume":"9","author":"Sun","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.drup.2026.101465_bib142","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-65056-9","article-title":"Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma","volume":"16","author":"Tang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.drup.2026.101465_bib143","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/j.apsb.2022.02.007","article-title":"Membrane-camouflaged supramolecular nanoparticles for co-delivery of chemotherapeutic and molecular-targeted drugs with siRNA against patient-derived pancreatic carcinoma","volume":"12","author":"Tang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.drup.2026.101465_bib144","doi-asserted-by":"crossref","DOI":"10.26599\/NR.2025.94907701","article-title":"CD11b activated nanovesicles synergizing external defense against MDSCs and internal attack on tumor cells for enhanced chemo-immunotherapy of pancreatic cancer","volume":"18","author":"Tang","year":"2025","journal-title":"Nano Res."},{"key":"10.1016\/j.drup.2026.101465_bib145","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ccell.2023.02.014","article-title":"Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy","volume":"41","author":"Tay","year":"2023","journal-title":"Cancer Cell."},{"key":"10.1016\/j.drup.2026.101465_bib146","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jconrel.2023.02.025","article-title":"RSPO3 furin domain-conjugated liposomes for selective drug delivery to LGR5-high cells","volume":"356","author":"van Kerkhof","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.drup.2026.101465_bib147","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","article-title":"A view on drug resistance in cancer","volume":"575","author":"Vasan","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.drup.2026.101465_bib148","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.addr.2016.02.007","article-title":"Red blood cells: supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems","volume":"106","author":"Villa","year":"2016","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.drup.2026.101465_bib149","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2217\/nnm.12.22","article-title":"Cancer Stem Cells and Drug Resistance: The Potential of Nanomedicine","volume":"7","author":"Vinogradov","year":"2012","journal-title":"Nanomed"},{"key":"10.1016\/j.drup.2026.101465_bib150","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrc2499","article-title":"Cancer stem cells in solid tumours: accumulating evidence and unresolved questions","volume":"8","author":"Visvader","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib151","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.aao2774","article-title":"Patient-derived organoids model treatment response of metastatic gastrointestinal cancers","volume":"359","author":"Vlachogiannis","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.drup.2026.101465_bib152","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41392-025-02176-0","article-title":"The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy","volume":"10","author":"Vogler","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.drup.2026.101465_bib153","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.1021\/acsnano.5b02017","article-title":"The role of micelle size in tumor accumulation, penetration, and treatment","volume":"9","author":"Wang","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.drup.2026.101465_bib154","doi-asserted-by":"crossref","DOI":"10.1002\/sstr.202000018","article-title":"Drug targeting via platelet membrane-coated nanoparticles","volume":"1","author":"Wang","year":"2020","journal-title":"Small Struct."},{"key":"10.1016\/j.drup.2026.101465_bib155","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1074\/jbc.M114.590364","article-title":"Inhibition of transient receptor potential channel 5 reverses 5-fluorouracil resistance in human colorectal cancer cells","volume":"290","author":"Wang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drup.2026.101465_bib156","doi-asserted-by":"crossref","DOI":"10.4028\/b-XDTcg5","article-title":"A Mitochondria-Targeted Biomimetic Nanomedicine Capable of Reversing Drug Resistance in Colorectal Cancer Through Mitochondrial Dysfunction","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.drup.2026.101465_bib157","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejca.2018.12.007","article-title":"NAPOLI-1 phase 3 study of liposomal irinotecan in metastatic pancreatic cancer: Final overall survival analysis and characteristics of long-term survivors","volume":"108","author":"Wang-Gillam","year":"2019","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib158","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0140-6736(15)00986-1","article-title":"Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial","volume":"387","author":"Wang-Gillam","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.drup.2026.101465_bib159","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.drup.2026.101465_bib160","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/cdd.2014.170","article-title":"Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer","volume":"22","author":"Wu","year":"2015","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.drup.2026.101465_bib161","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1021\/acs.molpharmaceut.5c01556","article-title":"Ultrasmall iron oxide as an imaging nanoenzyme loaded autologous exosomes for targeted imaging and chemotherapy promotion of pancreatic cancer","volume":"23","author":"Wu","year":"2026","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.drup.2026.101465_bib162","doi-asserted-by":"crossref","first-page":"11838","DOI":"10.1021\/acsnano.3c03050","article-title":"Therapeutic m6A Eraser ALKBH5 mRNA-Loaded Exosome\u2013Liposome Hybrid Nanoparticles Inhibit Progression of Colorectal Cancer in Preclinical Tumor Models","volume":"17","author":"Wu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.drup.2026.101465_bib163","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celbio.2025.100092","article-title":"Biomimetic \u201cTrojan Horse\u201d nanoparticles with biotactic behavior toward tumor-associated bacteria for targeted therapy of colorectal cancer","volume":"1","author":"Wu","year":"2025","journal-title":"Cell. Biomater."},{"key":"10.1016\/j.drup.2026.101465_bib164","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.drup.2026.101465_bib165","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.apsb.2019.01.011","article-title":"Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application","volume":"9","author":"Xia","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.drup.2026.101465_bib166","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jconrel.2017.10.041","article-title":"Doxorubicin-conjugated Escherichia coli Nissle 1917 swimmers to achieve tumor targeting and responsive drug release","volume":"268","author":"Xie","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.drup.2026.101465_bib167","article-title":"Platelets membrane camouflaged irinotecan-loaded gelatin nanogels for in vivo colorectal carcinoma therapy","volume":"53","author":"Xu","year":"2019","journal-title":"J. Drug. Deliv. Sci. Technol."},{"key":"10.1016\/j.drup.2026.101465_bib168","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13046-023-02717-x","article-title":"Harnessing cancer stem cell-derived exosomes to improve cancer therapy","volume":"42","author":"Yang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.drup.2026.101465_bib169","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.2147\/IJN.S202910","article-title":"Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer","volume":"14","author":"Yang","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.drup.2026.101465_bib170","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202201609","article-title":"Extracellular vesicles in cancer drug resistance: roles, mechanisms, and implications","volume":"9","author":"Yang","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.drup.2026.101465_bib171","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41392-022-01168-8","article-title":"Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective","volume":"7","author":"Yang","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.drup.2026.101465_bib172","article-title":"Empowering pancreatic tumor homing with augmented anti-tumor potency of CXCR2-tethered CAR-NK cells","volume":"32","author":"Yoon","year":"2024","journal-title":"Mol. Ther. Oncol."},{"key":"10.1016\/j.drup.2026.101465_bib173","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.989881","article-title":"Biomimetic nanoparticles for tumor immunotherapy","volume":"10","author":"Yu","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.drup.2026.101465_bib174","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","article-title":"Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy","volume":"170","author":"Yu","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.drup.2026.101465_bib175","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1021\/acscentsci.9b01139","article-title":"Size-tunable strategies for a tumor targeted drug delivery system","volume":"6","author":"Yu","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.drup.2026.101465_bib176","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12943-019-1065-4","article-title":"METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer","volume":"18","author":"Yue","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib177","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3892\/ol.2021.12639","article-title":"Autophagy is a double-edged sword in the therapy of colorectal cancer","volume":"21","author":"Zhang","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.drup.2026.101465_bib178","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","article-title":"Ferroptosis in cancer therapy: a novel approach to reversing drug resistance","volume":"21","author":"Zhang","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.drup.2026.101465_bib179","doi-asserted-by":"crossref","DOI":"10.1021\/acsnano.8b05200","article-title":"Erythrocyte membrane cloaked metal\u2013organic framework nanoparticle as biomimetic nanoreactor for starvation-activated colon cancer therapy","author":"Zhang","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.drup.2026.101465_bib180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biomaterials.2018.01.007","article-title":"NIR-responsive cancer cytomembrane-cloaked carrier-free nanosystems for highly efficient and self-targeted tumor drug delivery","volume":"159","author":"Zhang","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.drup.2026.101465_bib181","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12951-021-01221-8","article-title":"Charge reversal nano-systems for tumor therapy","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.drup.2026.101465_bib182","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1021\/acs.nanolett.7b05263","article-title":"Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy","volume":"18","author":"Zhang","year":"2018","journal-title":"Nano Lett."},{"key":"10.1016\/j.drup.2026.101465_bib183","first-page":"751","article-title":"Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment","volume":"17","author":"Zhang","year":"2022","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.drup.2026.101465_bib184","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.18632\/oncotarget.14012","article-title":"Mechanisms of resistance to anti-EGFR therapy in colorectal cancer","volume":"8","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.drup.2026.101465_bib185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cell.2020.02.001","article-title":"Targeting strategies for tissue-specific drug delivery","volume":"181","author":"Zhao","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.drup.2026.101465_bib186","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41551-019-0423-2","article-title":"Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy","volume":"3","author":"Zheng","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.drup.2026.101465_bib187","doi-asserted-by":"crossref","first-page":"761","DOI":"10.7150\/thno.85917","article-title":"Engineered bacterial outer membrane vesicles: a versatile bacteria-based weapon against gastrointestinal tumors","volume":"14","author":"Zheng","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.drup.2026.101465_bib188","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s13046-021-02130-2","article-title":"Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies","volume":"40","author":"Zhou","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.drup.2026.101465_bib189","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.drup.2026.101465_bib190","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.2174\/011574888X287102240101060146","article-title":"Mesenchymal stem cells target gastric cancer and deliver epirubicin via tunneling nanotubes for enhanced chemotherapy","volume":"19","author":"Zhou","year":"2024","journal-title":"Curr. Stem Cell. Res. Ther."},{"key":"10.1016\/j.drup.2026.101465_bib191","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.omto.2022.12.002","article-title":"A cancer cell membrane coated, doxorubicin and microRNA co-encapsulated nanoplatform for colorectal cancer theranostics","volume":"28","author":"Zhu","year":"2022","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.drup.2026.101465_bib192","doi-asserted-by":"crossref","first-page":"7471","DOI":"10.7150\/thno.59953","article-title":"Nano-immunotherapy for each stage of cancer cellular immunity: which, why, and what?","volume":"11","author":"Zuo","year":"2021","journal-title":"Theranostics"}],"container-title":["Drug Resistance Updates"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764626001160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1368764626001160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:12:29Z","timestamp":1789787549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1368764626001160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":192,"alternative-id":["S1368764626001160"],"URL":"https:\/\/doi.org\/10.1016\/j.drup.2026.101465","relation":{},"ISSN":["1368-7646"],"issn-type":[{"value":"1368-7646","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomimetic delivery systems for overcoming drug resistance in gastrointestinal cancers","name":"articletitle","label":"Article Title"},{"value":"Drug Resistance Updates","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drup.2026.101465","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101465"}}