{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:12:58Z","timestamp":1768684378909,"version":"3.49.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Education, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR20922\/MED\/122\/37\/2016"],"award-info":[{"award-number":["BT\/PR20922\/MED\/122\/37\/2016"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR4530\/MED\/30\/715\/2012"],"award-info":[{"award-number":["BT\/PR4530\/MED\/30\/715\/2012"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013416","name":"Indian Institute of Science Education and Research Kolkata","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Disorders"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.dscb.2021.100021","type":"journal-article","created":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T09:45:47Z","timestamp":1630835147000},"page":"100021","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["DJ-1-Nrf2 axis is activated upon murine \u03b2-coronavirus infection in the CNS"],"prefix":"10.1016","volume":"4","author":[{"given":"Soumya","family":"Kundu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fareeha","family":"Saadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sourodip","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisha Rose","family":"Antony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineeth A.","family":"Raveendran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithila Ashok","family":"Kamble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucky","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Burrows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debnath","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganes C.","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayasri Das","family":"Sarma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.dscb.2021.100021_bib0001","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1128\/JVI.00017-08","article-title":"Coronavirus Infection Modulates the Unfolded Protein Response and Mediates Sustained Translational Repression","volume":"82","author":"Bechill","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.dscb.2021.100021_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2012.00293","article-title":"Virus-induced ER stress and the unfolded protein response","volume":"3","author":"Zhang","year":"2012","journal-title":"Front. Plant Sci."},{"issue":"3","key":"10.1016\/j.dscb.2021.100021_bib0003","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41579-018-0118-9","article-title":"Origin and evolution of pathogenic coronaviruses","volume":"17","author":"Cui","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"issue":"2","key":"10.1016\/j.dscb.2021.100021_bib0004","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/rna.8.2.15013","article-title":"Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity","volume":"8","author":"Denison","year":"2011","journal-title":"RNA Biol."},{"issue":"6483","key":"10.1016\/j.dscb.2021.100021_bib0005","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.abb2507","article-title":"Cryo-EM structure of the 2019-nCoV spike in the pre-fusion conformation","volume":"367","author":"Wrapp","year":"2020","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.dscb.2021.100021_bib0006","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","article-title":"Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein","volume":"181","author":"Walls","year":"2020","journal-title":"Cell"},{"issue":"6965","key":"10.1016\/j.dscb.2021.100021_bib0007","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"Li","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.dscb.2021.100021_bib0008","series-title":"Coronaviruses: Methods and Protocols","first-page":"1","article-title":"Coronaviruses: An Overview of Their Replication and Pathogenesis","author":"Fehr","year":"2015"},{"issue":"14","key":"10.1016\/j.dscb.2021.100021_bib0009","doi-asserted-by":"crossref","first-page":"8124","DOI":"10.1128\/JVI.00626-13","article-title":"Upregulation of CHOP\/GADD153 during coronavirus infectious bronchitis virus infection modulates apoptosis by restricting activation of the extracellular signal-regulated kinase pathway","volume":"87","author":"Liao","year":"2013","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.dscb.2021.100021_bib0010","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.1128\/JVI.79.10.6180-6193.2005","article-title":"Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E","volume":"79","author":"Tang","year":"2005","journal-title":"J. Virol."},{"issue":"20","key":"10.1016\/j.dscb.2021.100021_bib0011","doi-asserted-by":"crossref","first-page":"10981","DOI":"10.1128\/JVI.01033-07","article-title":"The coronavirus spike protein induces endoplasmic reticulum stress and up-regulation of intracellular chemokine mRNA concentrations","volume":"81","author":"Versteeg","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.dscb.2021.100021_bib0012","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.virusres.2014.09.016","article-title":"Coronavirus-induced ER stress response and its involvement in regulation of coronavirus-host interactions","volume":"194","author":"Fung","year":"2014","journal-title":"Virus Res."},{"key":"10.1016\/j.dscb.2021.100021_bib0013","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fmicb.2014.00296","article-title":"Coronavirus infection, ER stress, apoptosis and innate immunity","volume":"5","author":"Fung","year":"2014","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.dscb.2021.100021_bib0014","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3201\/eid1002.030913","article-title":"Ultrastructural characterization of SARS coronavirus","volume":"10","author":"Goldsmith","year":"2004","journal-title":"Emerg. Infect. Dis."},{"issue":"12","key":"10.1016\/j.dscb.2021.100021_bib0015","doi-asserted-by":"crossref","first-page":"5927","DOI":"10.1128\/JVI.02501-05","article-title":"Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex","volume":"80","author":"Snijder","year":"2006","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.dscb.2021.100021_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/v8070184","article-title":"Regulation of stress responses and translational control by coronavirus","volume":"8","author":"Fung","year":"2016","journal-title":"Viruses"},{"issue":"3","key":"10.1016\/j.dscb.2021.100021_bib0017","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/ars.2014.5851","article-title":"Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease","volume":"21","author":"Cao","year":"2014","journal-title":"Antioxid. Redox. Signal"},{"issue":"14","key":"10.1016\/j.dscb.2021.100021_bib0018","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1093\/jxb\/ery040","article-title":"Interplay between the unfolded protein response and reactive oxygen species: a dynamic duo","volume":"69","author":"Ozgur","year":"2018","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.dscb.2021.100021_bib0019","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1574-695X.2006.00045.x","article-title":"Severe acute respiratory syndrome coronavirus 3C-like protease-induced apoptosis","volume":"46","author":"Wen","year":"2006","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"18","key":"10.1016\/j.dscb.2021.100021_bib0020","doi-asserted-by":"crossref","first-page":"9279","DOI":"10.1128\/JVI.00659-06","article-title":"Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein","volume":"80","author":"Chan","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.dscb.2021.100021_bib0021","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: immunity, inflammation and intervention","author":"Tay","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.dscb.2021.100021_bib0022","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1038\/s41467-020-18764-3","article-title":"SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate","volume":"11","author":"Olagnier","year":"2020","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.dscb.2021.100021_bib0023","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1134\/S0006297920070111","article-title":"Transcription Factor Nrf2 as a potential therapeutic target for prevention of cytokine storm in COVID-19 patients","volume":"85","author":"Zinovkin","year":"2020","journal-title":"Biochemistry (Moscow)"},{"issue":"2","key":"10.1016\/j.dscb.2021.100021_bib0024","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1006\/bbrc.1997.6132","article-title":"DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras","volume":"231","author":"Nagakubo","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"29","key":"10.1016\/j.dscb.2021.100021_bib0025","doi-asserted-by":"crossref","first-page":"10244","DOI":"10.1073\/pnas.0708518105","article-title":"RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways","volume":"105","author":"van der Brug","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A,"},{"key":"10.1016\/j.dscb.2021.100021_bib0026","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1750-1326-4-12","article-title":"Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains","volume":"4","author":"Baulac","year":"2009","journal-title":"Mol. Neurodegener."},{"issue":"3","key":"10.1016\/j.dscb.2021.100021_bib0027","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1385\/JMN:29:3:215","article-title":"Role of DJ-1 in Parkinson's disease","volume":"29","author":"Lev","year":"2006","journal-title":"J. Mol. Neurosci."},{"issue":"8","key":"10.1016\/j.dscb.2021.100021_bib0028","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.freeradbiomed.2010.07.013","article-title":"Nrf2 and DJ1 are consistently up-regulated in inflammatory multiple sclerosis lesions","volume":"49","author":"van Horssen","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"41","key":"10.1016\/j.dscb.2021.100021_bib0029","doi-asserted-by":"crossref","first-page":"15091","DOI":"10.1073\/pnas.0607260103","article-title":"DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2","volume":"103","author":"Clements","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U S A,"},{"issue":"3","key":"10.1016\/j.dscb.2021.100021_bib0030","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.freeradbiomed.2004.10.013","article-title":"Gene expression profiling of NRF2-mediated protection against oxidative injury","volume":"38","author":"Cho","year":"2005","journal-title":"Free Radical Biol. Med."},{"issue":"50","key":"10.1016\/j.dscb.2021.100021_bib0031","doi-asserted-by":"crossref","first-page":"19303","DOI":"10.1074\/jbc.RA118.003376","article-title":"NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells","volume":"293","author":"Paul","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.dscb.2021.100021_bib0032","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41419-019-1354-2","article-title":"DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.dscb.2021.100021_bib0033","doi-asserted-by":"crossref","first-page":"27362","DOI":"10.1038\/srep27362","article-title":"Divergence and Conservation of the Major UPR Branch IRE1-bZIP Signaling Pathway across","volume":"6","author":"Zhang","year":"2016","journal-title":"Eukaryotes. Sci. Rep."},{"key":"10.1016\/j.dscb.2021.100021_bib0034","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/109239","article-title":"A mechanism of virus-induced demyelination","volume":"2010","author":"Das Sarma","year":"2010","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"issue":"2","key":"10.1016\/j.dscb.2021.100021_bib0035","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s13365-013-0188-4","article-title":"Microglia-mediated neuroinflammation is an amplifier of virus-induced neuropathology","volume":"20","author":"Das Sarma","year":"2014","journal-title":"J. Neurovirol."},{"issue":"17","key":"10.1016\/j.dscb.2021.100021_bib0036","doi-asserted-by":"crossref","first-page":"8882","DOI":"10.1128\/JVI.00920-08","article-title":"Experimental Optic Neuritis Induced by a Demyelinating Strain of Mouse Hepatitis Virus","volume":"82","author":"Shindler","year":"2008","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.dscb.2021.100021_bib0037","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2051-5960-2-3","article-title":"SIRT1 Activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease","volume":"2","author":"Khan","year":"2014","journal-title":"Acta Neuropathol.Commun."},{"key":"10.1016\/j.dscb.2021.100021_bib0038","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00548-20","article-title":"CD4 deficiency causes poliomyelitis and axonal blebbing in murine coronavirus induced neuro-inflammation","author":"Chakravarty","year":"2020","journal-title":"J. Virol."},{"issue":"33","key":"10.1016\/j.dscb.2021.100021_bib0039","doi-asserted-by":"crossref","first-page":"10272","DOI":"10.1523\/JNEUROSCI.1975-09.2009","article-title":"Mechanisms of primary axonal damage in a viral model of multiple sclerosis","volume":"29","author":"Das Sarma","year":"2009","journal-title":"The J. Neurosci."},{"issue":"5","key":"10.1016\/j.dscb.2021.100021_bib0040","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/13550280260422686","article-title":"Enhanced green fluorescent protein expression may be used to monitor murine coronavirus spread in vitro and in the mouse central nervous system","volume":"8","author":"Das Sarma","year":"2002","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.dscb.2021.100021_bib0041","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2105-9-40","article-title":"I-TASSER server for protein 3D structure prediction","volume":"9","author":"Zhang","year":"2008","journal-title":"BMC Bioinformatics"},{"issue":"2","key":"10.1016\/j.dscb.2021.100021_bib0042","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: High performance molecular stimulations through multi-level parallelism from laptops to supercomputers","volume":"1","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.dscb.2021.100021_bib0043","unstructured":"Delano, W.L., PyMOL: An Open-Source Molecular Graphics Tool. 2002."},{"issue":"Web Server issue","key":"10.1016\/j.dscb.2021.100021_bib0044","doi-asserted-by":"crossref","first-page":"W235","DOI":"10.1093\/nar\/gkp287","article-title":"3D-DART: a DNA structure modeling server","volume":"37","author":"van Dijk","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.dscb.2021.100021_bib0045","doi-asserted-by":"crossref","first-page":"W425","DOI":"10.1093\/nar\/gkv493","article-title":"NPDock: a web server for protein-nucleic acid docking","volume":"43","author":"Tuszynska","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dscb.2021.100021_bib0046","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.3389\/fimmu.2018.02541","article-title":"Interplay between the unfolded protein response and immune function in the development of neurodegenerative diseases","volume":"9","author":"Garcia-Gonzalez","year":"2018","journal-title":"Front Immunol."},{"issue":"5","key":"10.1016\/j.dscb.2021.100021_bib0047","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/13550280260422686","article-title":"Enhanced green fluorescent protein expression may be used to monitor murine coronavirus spread in vitro and in the mouse central nervous system","volume":"8","author":"Das Sarma","year":"2002","journal-title":"J. Neurovirol."},{"issue":"Pt 9","key":"10.1016\/j.dscb.2021.100021_bib0048","first-page":"2124","article-title":"ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1","volume":"126","author":"Duplan","year":"2013","journal-title":"J. Cell Sci."},{"issue":"12","key":"10.1016\/j.dscb.2021.100021_bib0049","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nrn.2016.140","article-title":"Keeping it in check: chronic viral infection and antiviral immunity in the brain","volume":"17","author":"Miller","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.dscb.2021.100021_bib0050","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-1-14","article-title":"Microglia and neuroinflammation: a pathological perspective","volume":"1","author":"Streit","year":"2004","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.dscb.2021.100021_bib0051","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.virol.2003.09.023","article-title":"Differential regulation of innate and adaptive immune responses in viral encephalitis","volume":"318","author":"Rempel","year":"2004","journal-title":"Virology"},{"issue":"20","key":"10.1016\/j.dscb.2021.100021_bib0052","doi-asserted-by":"crossref","first-page":"9829","DOI":"10.1128\/JVI.01199-08","article-title":"Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages\/microglia","volume":"82","author":"Roth-Cross","year":"2008","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.dscb.2021.100021_bib0053","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1128\/JVI.78.7.3398-3406.2004","article-title":"Coronavirus neuro-virulence correlates with the ability of the virus to induce pro-inflammatory cytokine signals from astrocytes and microglia","volume":"78","author":"Li","year":"2004","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.dscb.2021.100021_bib0054","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s11064-018-2504-0","article-title":"Microglia polarization and endoplasmic reticulum stress in chronic social defeat stress induced depression mouse","volume":"43","author":"Tang","year":"2018","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.dscb.2021.100021_bib0055","doi-asserted-by":"crossref","first-page":"14931","DOI":"10.1038\/s41598-019-51481-6","article-title":"Endoplasmic reticulum stress differentially modulates the IL-6 family of cytokines in murine astrocytes and macrophages","volume":"9","author":"Sanchez","year":"2019","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.dscb.2021.100021_bib0056","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1089\/ars.2013.5745","article-title":"Redox control of microglial function: molecular mechanisms and functional significance","volume":"21","author":"Rojo","year":"2014","journal-title":"Antioxid. Redox Sig."},{"issue":"87","key":"10.1016\/j.dscb.2021.100021_bib0057","article-title":"Astrocytes do not forfeit their neuro-protective roles after surviving intense oxidative stress","volume":"12","author":"Bhatia","year":"2019","journal-title":"Front. Mol. Neurosci."},{"issue":"10","key":"10.1016\/j.dscb.2021.100021_bib0058","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.freeradbiomed.2009.08.003","article-title":"DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders","volume":"47","author":"Kahle","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.dscb.2021.100021_bib0059","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1089\/ars.2010.3481","article-title":"The role of cysteine oxidation in DJ-1 function and dysfunction","volume":"15","author":"Wilson","year":"2011","journal-title":"Antioxid. Redox. Signal"},{"issue":"7","key":"10.1016\/j.dscb.2021.100021_bib0060","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(01)00611-0","article-title":"XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor","volume":"107","author":"Yoshida","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.dscb.2021.100021_bib0061","doi-asserted-by":"crossref","unstructured":"Fung, T.S. and D.X. Liu, Coronavirus infection, ER stress, apoptosis and innate immunity. 2014. 5(296).","DOI":"10.3389\/fmicb.2014.00296"}],"container-title":["Brain Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666459321000202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666459321000202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:03:10Z","timestamp":1762992190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666459321000202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":61,"alternative-id":["S2666459321000202"],"URL":"https:\/\/doi.org\/10.1016\/j.dscb.2021.100021","relation":{},"ISSN":["2666-4593"],"issn-type":[{"value":"2666-4593","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DJ-1-Nrf2 axis is activated upon murine \u03b2-coronavirus infection in the CNS","name":"articletitle","label":"Article Title"},{"value":"Brain Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dscb.2021.100021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100021"}}