{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:34:29Z","timestamp":1789623269132,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.dsx.2012.05.013","type":"journal-article","created":{"date-parts":[[2012,7,7]],"date-time":"2012-07-07T06:30:15Z","timestamp":1341642615000},"page":"207-211","source":"Crossref","is-referenced-by-count":16,"title":["Plasma adiponectin levels in women with polycystic ovary syndrome: Impact of Metformin treatment in a case\u2013control study"],"prefix":"10.1016","volume":"6","author":[{"given":"Shilpi","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishat","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dsx.2012.05.013_bib0005","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199509283331307","article-title":"Polycystic ovary syndrome","volume":"333","author":"Frank","year":"1995","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.dsx.2012.05.013_bib0010","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.dsx.2012.05.013_bib0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1210\/jcem-50-1-113","article-title":"Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease","volume":"50","author":"Burghen","year":"1990","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-2007-1016376","article-title":"Molecular mechanisms of insulin resistance in polycystic ovary syndrome","volume":"12","author":"Dunaif","year":"1994","journal-title":"Seminars in Reproductive Endocrinology"},{"key":"10.1016\/j.dsx.2012.05.013_bib0025","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1210\/jc.77.6.1636","article-title":"Normal basal and insulin stimulated fuel metabolism in lean women with the polycystic ovary syndrome","volume":"77","author":"Ovesen","year":"1993","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0030","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jc.86.5.1930","article-title":"Hypoadiponectinaemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia","volume":"86","author":"Weyer","year":"2001","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0035","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocrine Reviews"},{"key":"10.1016\/j.dsx.2012.05.013_bib0040","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1055\/s-2002-34785","article-title":"Adiponectin\u2014its role in metabolism and beyond","volume":"34","author":"Stefan","year":"2002","journal-title":"Hormone and Metabolic Research"},{"key":"10.1016\/j.dsx.2012.05.013_bib0045","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.2337\/dc05-1801","article-title":"Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome","volume":"29","author":"Hara","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2012.05.013_bib0050","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2337\/diabetes.55.01.06.db05-1105","article-title":"Adiponectin multimeric complexes and the metabolic syndrome trait cluster","volume":"55","author":"Lara-Castro","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.dsx.2012.05.013_bib0055","doi-asserted-by":"crossref","first-page":"18073","DOI":"10.1074\/jbc.M414231200","article-title":"Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes","volume":"280","author":"Xu","year":"2005","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.dsx.2012.05.013_bib0060","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.metabol.2008.03.019","article-title":"Low serum adiponectin level as a predictor of impaired glucose regulation and type 2 diabetes mellitus in a middle-aged Finnish population","volume":"57","author":"Jalovaara","year":"2008","journal-title":"Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0065","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.atherosclerosis.2007.12.033","article-title":"Factors contributing to the risk of cardiovascular disease reflected by plasma adiponectin: data from the coronary risk factors for atherosclerosis in women (CORA) study","volume":"200","author":"Zyriax","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.dsx.2012.05.013_bib0070","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1210\/jc.2004-1965","article-title":"Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulinresistant women with polycystic ovary syndrome","volume":"90","author":"Ortega-Gonzalez","year":"2005","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1210\/jc.85.1.89","article-title":"Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial","volume":"85","author":"Moghetti","year":"2000","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0080","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/humrep\/16.8.1625","article-title":"Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial","volume":"16","author":"Ng","year":"2001","journal-title":"Human Reproduction"},{"key":"10.1016\/j.dsx.2012.05.013_bib0085","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1093\/humrep\/dem271","article-title":"Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomized, double-blinded, placebo-controlled cross-over trial","volume":"22","author":"Trolle","year":"2007","journal-title":"Human Reproduction"},{"key":"10.1016\/j.dsx.2012.05.013_bib0090","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1210\/jc.2007-1549","article-title":"Glucose intolerance in polycystic ovary syndrome\u2013a position statement of the Androgen Excess Society","volume":"92","author":"Salley","year":"2007","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0095","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1210\/jc.2002-022033","article-title":"Adiponectin levels in women with polycystic ovary syndrome","volume":"88","author":"Orio","year":"2003","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0100","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/humrep\/deh013","article-title":"Are serum adiponectin levels really reduced in obese women with polycystic ovary syndrome?","volume":"19","author":"Orio","year":"2004","journal-title":"Human Reproduction"},{"key":"10.1016\/j.dsx.2012.05.013_bib0105","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1210\/jc.87.6.2764","article-title":"Decreased plasma adiponectin concentrations in women with dyslipidemia","volume":"87","author":"Matsubara","year":"2002","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0110","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1161\/01.ATV.20.6.1595","article-title":"Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients","volume":"20","author":"Hotta","year":"2000","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.dsx.2012.05.013_bib0115","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0140-6736(03)12255-6","article-title":"Adiponectin and protection against type 2 diabetes mellitus","volume":"361","author":"Spranger","year":"2003","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.dsx.2012.05.013_bib0120","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.2337\/diabetes.51.10.2964","article-title":"Low plasma adiponectin concentrations do not predict weight gain in humans","volume":"51","author":"Vozarova","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.dsx.2012.05.013_bib0125","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1210\/jc.2007-1834","article-title":"Impact of obesity on the risk for polycystic ovary syndrome","volume":"93","author":"Yildiz","year":"2008","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0130","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1210\/jcem-50-1-113","article-title":"Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease","volume":"50","author":"Burghen","year":"1980","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0135","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/humrep\/deh010","article-title":"Serum and adipocyte resistin in polycystic ovary syndrome with insulin resistance","volume":"19","author":"Seow","year":"2004","journal-title":"Human Reproduction"},{"key":"10.1016\/j.dsx.2012.05.013_bib0140","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0015-0282(02)03111-4","article-title":"Insulin resistance, polycystic ovary syndrome and diabetes mellitus","volume":"77","author":"Ovalle","year":"2002","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.dsx.2012.05.013_bib0145","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1210\/jc.2003-030219","article-title":"Glucose-to-insulin ratio rather than sex hormone-binding globulin and adiponectin levels is the best predictor of insulin resistance in non-obese women with polycystic ovary syndrome","volume":"88","author":"Ducluzeau","year":"2003","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.dsx.2012.05.013_bib0150","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1056\/NEJM199602293340906","article-title":"Metformin","volume":"334","author":"Bailey","year":"1996","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.dsx.2012.05.013_bib0155","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/09513590701192529","article-title":"Metformin in normal-weight hirsute women with polycystic ovary syndrome with normal insulin sensitivity","volume":"23","author":"Marcondes","year":"2007","journal-title":"Gynecological Endocrinology"},{"key":"10.1016\/j.dsx.2012.05.013_bib0160","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1210\/jc.2007-0441","article-title":"Insulin sensitivity after metformin suspension in normal-weight women with polycystic ovary syndrome","volume":"92","author":"Palomba","year":"2007","journal-title":"The Journal of Clinical Endocrinology and Metabolism"}],"container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402112000756?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402112000756?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T17:34:35Z","timestamp":1561916075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871402112000756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S1871402112000756"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2012.05.013","relation":{},"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}