{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:24:24Z","timestamp":1785583464042,"version":"3.56.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.dsx.2017.08.014","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T18:19:08Z","timestamp":1503685148000},"page":"51-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["An observational study of vitamin b12 levels and peripheral neuropathy profile in patients of diabetes mellitus on metformin therapy"],"prefix":"10.1016","volume":"12","author":[{"given":"Kamesh","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Rohatgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"September (8)","key":"10.1016\/j.dsx.2017.08.014_bib0005","first-page":"557","article-title":"He effect of a nonabsorbed oral antibiotic (Rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial","volume":"145","author":"Pimentel","year":"2016","journal-title":"Ann Intern Med"},{"issue":"February (1)","key":"10.1016\/j.dsx.2017.08.014_bib0010","article-title":"The spectrum of diabetic neuropathies","volume":"13","author":"Tracy","year":"2008","journal-title":"Phys Med Rehabil Clin N Am"},{"issue":"December (2)","key":"10.1016\/j.dsx.2017.08.014_bib0015","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.3390\/nu5125031","article-title":"Neuroenhancement with vitamin B12-underestimated neurological significance","volume":"5","author":"Gr\u00f6ber","year":"2013","journal-title":"Nutrients"},{"issue":"November (3)","key":"10.1016\/j.dsx.2017.08.014_bib0020","article-title":"Neurological, Hematological and Dermatological Manifestations of Vitamin Deficiency Secondary to Pernicious Anemia","volume":"19","author":"Ismail","year":"2015","journal-title":"Case Rep Lit Rev"},{"issue":"March (5)","key":"10.1016\/j.dsx.2017.08.014_bib0025","first-page":"979","article-title":"Vitamin B12 deficiency","volume":"67","author":"Oh","year":"2003","journal-title":"Am Fam Phys"},{"issue":"January (1)","key":"10.1016\/j.dsx.2017.08.014_bib0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4066\/AMJ.2014.1979","article-title":"The current state of diabetes mellitus in India","volume":"7","author":"Kaveeshwar","year":"2014","journal-title":"Australas Med J"},{"issue":"February (2)","key":"10.1016\/j.dsx.2017.08.014_bib0035","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/nure.12001","article-title":"How prevalent is vitamin B(12) deficiency among vegetarians?","volume":"71","author":"Pawlak","year":"2013","journal-title":"Nutr Rev"},{"issue":"June (5763)","key":"10.1016\/j.dsx.2017.08.014_bib0040","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/bmj.2.5763.685","article-title":"Vitamin-B12 status of patients on long-term metformin therapy","volume":"2","author":"Tomkin","year":"1971","journal-title":"Br Med J"},{"issue":"October (18)","key":"10.1016\/j.dsx.2017.08.014_bib0045","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1001\/archinte.166.18.1975","article-title":"Risk factors of vitamin B(12) deficiency in patients receiving metformin","volume":"166","author":"Ting","year":"2006","journal-title":"Arch Intern Med"},{"issue":"July (7)","key":"10.1016\/j.dsx.2017.08.014_bib0050","first-page":"780","article-title":";Effect of metformin on plasma homocysteine, vitamin B12 and folic acid: a cross-sectional study in patients with type 2 diabetes mellitus","volume":"87","author":"Pongchaidecha","year":"2004","journal-title":"J Med Assoc Thai"},{"issue":"March (2)","key":"10.1016\/j.dsx.2017.08.014_bib0055","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jdiacomp.2005.10.005","article-title":"Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin in patients with type 2 diabetes mellitus","volume":"21","author":"Sahin","year":"2007","journal-title":"J Diabetes Complications"},{"issue":"340","key":"10.1016\/j.dsx.2017.08.014_bib0060","doi-asserted-by":"crossref","first-page":"c2181","DOI":"10.1136\/bmj.c2181","article-title":"Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial","volume":"20","author":"de Jager","year":"2010","journal-title":"BMJ"},{"issue":"September (7)","key":"10.1016\/j.dsx.2017.08.014_bib0065","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/pdi.1619","article-title":"Metformin therapy and assessment for vitamin deficiency: is it necessary?","volume":"28","author":"Qureshi","year":"2011","journal-title":"Practical Diabetes"},{"issue":"January (1)","key":"10.1016\/j.dsx.2017.08.014_sbref0070","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0104-4230(11)70015-X","article-title":"Vitamin B12 in metformin-treated diabetic patients: a cross-sectional study in Brazil","volume":"57","author":"Nervo","year":"2011","journal-title":"Rev Assoc Med Bras"},{"key":"10.1016\/j.dsx.2017.08.014_oref0070","unstructured":"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21390459."},{"issue":"2","key":"10.1016\/j.dsx.2017.08.014_bib0075","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4158\/EP11009.OR","article-title":"Effect of metformin therapy on Vitamin D and vitamin B12 levels in patients with type 2 diabetes mellitus","volume":"18","author":"Kos","year":"2012","journal-title":"Endocr Pract"},{"issue":"November (6)","key":"10.1016\/j.dsx.2017.08.014_sbref0080","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/14746514040040060701","article-title":"Vitamin B12 status of patients treated with metformin: a cross-sectional cohort study","volume":"4","author":"Sparre Hermann","year":"2004","journal-title":"British J Diabetes Vasc Dis"},{"key":"10.1016\/j.dsx.2017.08.014_oref0080","unstructured":"http:\/\/dvd.sagepub.com\/content\/4\/6\/401."},{"issue":"October (6)","key":"10.1016\/j.dsx.2017.08.014_sbref0085","article-title":"Increases total serum homocysteine levels in non-diabetic male patients with coronary heart disease","volume":"57","author":"Carlsen","year":"1997","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.dsx.2017.08.014_oref0085","unstructured":"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9350072."},{"issue":"November (5)","key":"10.1016\/j.dsx.2017.08.014_bib0090","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1046\/j.1365-2796.2003.01213.x","article-title":"Borger van der Burg B, et al. Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial","volume":"254","author":"Wulffel\u00e9","year":"2003","journal-title":"J Intern Med"},{"issue":"June (9)","key":"10.1016\/j.dsx.2017.08.014_bib0095","article-title":"Induces reductions in plasma cobalamin and haptocorrin bound cobalamin levels in elderly diabetic patients","volume":"43","author":"Leung","year":"2010","journal-title":"Clin Biochem"},{"issue":"September (5)","key":"10.1016\/j.dsx.2017.08.014_bib0100","article-title":"The prevalence of vitamin B(12) deficiency in patients with type 2 diabetes: a cross-sectional study","volume":"22","author":"Pflipsen","year":"2009","journal-title":"J Am Board Fam Med"},{"issue":"2","key":"10.1016\/j.dsx.2017.08.014_bib0105","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2337\/dc11-1582","article-title":"Association of biochemical B12 deficiency with metformin therapy and vitamin B12 supplements the national health and nutrition examination survey, 1999-2006","volume":"35","author":"Reinstatler","year":"2012","journal-title":"Diabetes Care"},{"issue":"October","key":"10.1016\/j.dsx.2017.08.014_bib0110","article-title":"Prevalence of vitamin deficiency in patients of type 2 diabetes mellitus on metformin: a case control study from Pakistan","volume":"16","author":"Iftikhar","year":"2013","journal-title":"Pan Afr Med J"},{"issue":"January (1)","key":"10.1016\/j.dsx.2017.08.014_bib0115","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2337\/dc09-0606","article-title":"Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy","volume":"33","author":"Wile","year":"2010","journal-title":"Diabetes Care"},{"issue":"March (3)","key":"10.1016\/j.dsx.2017.08.014_bib0120","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/SMJ.0b013e3181ce0e4d","article-title":"Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy","volume":"103","author":"Bell","year":"2010","journal-title":"South Med J"},{"issue":"September (9)","key":"10.1016\/j.dsx.2017.08.014_bib0125","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2337\/diacare.23.9.1227","article-title":"Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin","volume":"23","author":"Bauman","year":"2000","journal-title":"Diabetes Care"},{"issue":"October (4)","key":"10.1016\/j.dsx.2017.08.014_bib0130","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4103\/0022-3859.123143","article-title":"Association of deficiency and clinical neuropathy with metformin use in type 2 diabetes patients","volume":"59","author":"Singh","year":"2013","journal-title":"J Postgrad Med"},{"issue":"1","key":"10.1016\/j.dsx.2017.08.014_bib0135","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3121\/cmr.2012.1112","article-title":"Laboratory evaluation for vitamin B12 deficiency: the case for cascade testing","volume":"11","author":"Berg","year":"2013","journal-title":"Clin Med Res"},{"issue":"3","key":"10.1016\/j.dsx.2017.08.014_bib0140","doi-asserted-by":"crossref","first-page":"447b","DOI":"10.1001\/archinte.130.3.447b","article-title":"Nerve conduction velocity","volume":"130","author":"Kraft","year":"1972","journal-title":"Arch Intern Med"},{"issue":"11","key":"10.1016\/j.dsx.2017.08.014_bib0145","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.2337\/diacare.25.11.2048","article-title":"Validation of the Toronto clinical scoring system for diabetic polyneuropathy","volume":"25","author":"Bril","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2017.08.014_bib0150","first-page":"717","article-title":"Diabetes care in India?current status","volume":"49","author":"Raheja","year":"2001","journal-title":"J Ass Phys India"},{"key":"10.1016\/j.dsx.2017.08.014_bib0155","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/bmj.297.6648.587","article-title":"High prevalence of diabetes in an urban population in South India","volume":"297","author":"Ramachandran","year":"1988","journal-title":"Br Med J"},{"key":"10.1016\/j.dsx.2017.08.014_bib0160","first-page":"64","article-title":"A study of the prevalence of serum vitamin B12 and folic acid deficiency in western maharashtra","author":"Mahajan Sanket","year":"2016","journal-title":"J Family Med Primary Care"},{"key":"10.1016\/j.dsx.2017.08.014_bib0165","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2251-6581-12-17","article-title":"Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?","volume":"12","author":"Kibirige","year":"2013","journal-title":"J Diabetes Metab Dis"},{"issue":"7","key":"10.1016\/j.dsx.2017.08.014_bib0170","article-title":"Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes","volume":"29","author":"Sun-Hye","year":"2016","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.dsx.2017.08.014_bib0175","unstructured":"Braza M, Hanley J, Bhatla A, Martinez M. Prevalence of Vitamin B12 Deficiency in Hispanic Patients with Type 2 Diabetes Mellitus (DM) on Long Term Metformin-Is It Associated with Peripheral Neuropathy (PN). InDIABETES 2009 Jun 1 (Vol. 58, pp. A153-A153). 1701N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA: AMER DIABETES ASSOC."},{"issue":"13","key":"10.1016\/j.dsx.2017.08.014_bib0180","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1475-2891-13-55","article-title":"Nutritional profile of indian vegetarian diets?the indian migration study (IMS)","volume":"4","author":"Shridhar","year":"2014","journal-title":"Nutr J"},{"issue":"Mar (5)","key":"10.1016\/j.dsx.2017.08.014_bib0185","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/ejcn.2014.46","article-title":"Babatunde T.)The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature","volume":"68","author":"Pawlak","year":"2014","journal-title":"Eur J ClinNutr."},{"key":"10.1016\/j.dsx.2017.08.014_bib0190","unstructured":"Javid P, Christensen E., UgeskrLaeger [Vegetarians are at high risk of vitamin B12 deficiency].2016 Jan 4;178 (1). pii: V06150484. Danish."},{"key":"10.1016\/j.dsx.2017.08.014_bib0195","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/1474651412454924","article-title":"An observational study of the effect ofmetformin on B12 status and peripheral neuropathy","volume":"12","author":"Dunstan","year":"2012","journal-title":"Br J Diabetes Vasc Dis"},{"key":"10.1016\/j.dsx.2017.08.014_bib0200","unstructured":"Liu F, Mao JP, Yan X.Zhong Nan Da XueXueBao Yi Xue Ban. Toronto clinical scoring system in diabetic peripheral neuropathy]. 2008 Dec;33(12):1137-41."},{"issue":"April (2)","key":"10.1016\/j.dsx.2017.08.014_bib0205","first-page":"15","article-title":"Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin","volume":"52","author":"Biemans","year":"2014","journal-title":"ActaDiabetol"},{"issue":"June","key":"10.1016\/j.dsx.2017.08.014_bib0210","first-page":"386","article-title":"Vitamin B12 deficiency and elevated folate levels: an unusual cause of generalized tonic-Clonic seizure","volume":"16","author":"Lubana","year":"2015","journal-title":"Am J Case Rep"},{"issue":"March (2)","key":"10.1016\/j.dsx.2017.08.014_bib0215","first-page":"9","article-title":"Hematological manifestations related to cobalamin deficiency in elderly patients","volume":"19","author":"Andr\u00e8s","year":"2007","journal-title":"Eur J Intern Med"},{"issue":"11","key":"10.1016\/j.dsx.2017.08.014_bib0220","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/ajh.20996","article-title":"Green PH. Anemia in celiac disease is multifactorial in etiology","volume":"82","author":"Harper","year":"2007","journal-title":"Am J Hematol"},{"issue":"1","key":"10.1016\/j.dsx.2017.08.014_bib0225","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1365-2257.2006.00755.x","article-title":"Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency","volume":"28","author":"Andr\u00e8s","year":"2006","journal-title":"Clin Lab Haematol"},{"key":"10.1016\/j.dsx.2017.08.014_bib0230","first-page":"2319","article-title":"Hematological parameters versus serum vitamin b 12 levels in the diagnosis of vitamin B 12 deficiency neurological deficits","author":"Dr. Akash","year":"2017","journal-title":"Int J Sci Res"},{"issue":"June (3)","key":"10.1016\/j.dsx.2017.08.014_bib0235","first-page":"337","article-title":"[Hematological and neurological compromisedue to vitamin B12 deficit in infant of a vegetarian mother: case report]","volume":"85","author":"Bravo","year":"2014","journal-title":"Rev Chil Pediatr"},{"issue":"September","key":"10.1016\/j.dsx.2017.08.014_bib0240","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1186\/s13104-015-1437-9","article-title":"B12 deficiency withneurological manifestations in the absence of anaemia","volume":"8","author":"Ralapanawa","year":"2015","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.dsx.2017.08.014_bib0245","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1056\/NEJMcp1113996","article-title":"Clinical practice. vitamin B12 deficiency","volume":"368","author":"Stabler","year":"2013","journal-title":"N Engl J Med"}],"container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402117302874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402117302874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T09:21:17Z","timestamp":1535448077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871402117302874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1871402117302874"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2017.08.014","relation":{},"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An observational study of vitamin b12 levels and peripheral neuropathy profile in patients of diabetes mellitus on metformin therapy","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dsx.2017.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}