{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:16:25Z","timestamp":1764936985077,"version":"build-2065373602"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.dsx.2018.04.023","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T12:35:46Z","timestamp":1523363746000},"page":"813-818","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Insulin related lipodystrophic lesions and hypoglycemia: Double standards?"],"prefix":"10.1016","volume":"12","author":[{"given":"Sandro","family":"Gentile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felice","family":"Strollo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Della Corte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampiero","family":"Marino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Guarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dsx.2018.04.023_bib0005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.diabet.2013.05.006","article-title":"Prevalence and risk factors of lipohypertrophy in insulin-injecting patients with diabetes","volume":"39","author":"Blanco","year":"2013","journal-title":"Diabetes Metab."},{"issue":"October 5","key":"10.1016\/j.dsx.2018.04.023_bib0010","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1507\/endocrj.52.623","article-title":"Insulin-induced lipohypertrophy: report of a case with histopathology","volume":"52","author":"Fujikura","year":"2005","journal-title":"Endocr. J."},{"key":"10.1016\/j.dsx.2018.04.023_bib0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00592-009-0172-x","article-title":"Metabolic consequences of incorrect insulin administration techniques in aging subjects with diabetes","volume":"48","author":"Gentile","year":"2011","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.dsx.2018.04.023_bib0020","doi-asserted-by":"crossref","first-page":"1486e92","DOI":"10.2337\/dc16-0610","article-title":"Insulin injection into lipohypertrophic tissue: blunted and more variable insulin absorption and action and impaired postprandial glucose control","volume":"39","author":"Famulla","year":"2016","journal-title":"Diabetes Care"},{"issue":"May 5","key":"10.1016\/j.dsx.2018.04.023_bib0025","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1186\/s40064-016-1978-y","article-title":"AMD-OSDI Italian injection technique study group. A suitable palpation technique allows to identify skin lipohypertrophic lesions in insulin-treated people with diabetes","volume":"5","author":"Gentile","year":"2016","journal-title":"Springerplus"},{"issue":"9","key":"10.1016\/j.dsx.2018.04.023_bib0030","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.mayocp.2016.06.010","article-title":"New insulin delivery recommendations","volume":"91","author":"Frid","year":"2016","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.dsx.2018.04.023_bib0035","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1089\/152091502320798312","article-title":"Variability of insulin absorption and insulin action","volume":"4","author":"Heinemann","year":"2002","journal-title":"Diabetes Technol. Ther."},{"issue":"July 4","key":"10.1016\/j.dsx.2018.04.023_bib0040","first-page":"145","article-title":"Optimizing insulin injection technique and its effect on blood glucose 1control","volume":"1","author":"Grassi","year":"2014","journal-title":"J. Clin. Transl. Endocrinol."},{"issue":"1","key":"10.1016\/j.dsx.2018.04.023_bib0045","doi-asserted-by":"crossref","first-page":"24","DOI":"10.17140\/DROJ-2-126","article-title":"On behalf of AMD-OSDI Italian study group On injection techniques. Unexplained hypoglycaemia and large glycaemic variability: skin lipohypertrophy as a predictive sign","volume":"2","author":"Strollo","year":"2016","journal-title":"Diabetes Res. Open J."},{"issue":"Suppl. 1","key":"10.1016\/j.dsx.2018.04.023_bib0050","article-title":"Standards of medical care in diabetes 2018: lifestyle management","volume":"41","author":"American Diabetes Association","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2018.04.023_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2018.02.005","article-title":"On behalf of Italian study group On injection techniques. Skin complications of insulin injections: a case presentation and a possible explanation of hypoglycaemia","author":"Gentile","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"October 10","key":"10.1016\/j.dsx.2018.04.023_bib0060","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s12325-013-0066-8","article-title":"Improvement of glycemic control by re-education in insulin injection technique in patients with diabetes mellitus","volume":"30","author":"Nakatani","year":"2013","journal-title":"Adv Ther."},{"issue":"June 3","key":"10.1016\/j.dsx.2018.04.023_bib0065","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s13300-017-0243-x","article-title":"Indian injection technique study: population characteristics and injection practices","volume":"8","author":"Kalra","year":"2017","journal-title":"Diabetes Ther"},{"key":"10.1016\/j.dsx.2018.04.023_bib0070","article-title":"AMD-OSDI consensus on injection techniques for people with diabetes mellitus","volume":"2","author":"Gentile","year":"2016","journal-title":"Med. Clin. Rev."},{"issue":"April","key":"10.1016\/j.dsx.2018.04.023_bib0075","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.diabres.2017.01.020","article-title":"UK lipohypertrophy interventional study","volume":"126","author":"Smith","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"November 11","key":"10.1016\/j.dsx.2018.04.023_bib0080","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1089\/dia.2017.0165","article-title":"An effective intervention for diabetic lipohypertrophy: results of a randomized, controlled, prospective multicenter study in France","volume":"19","author":"Campinos","year":"2017","journal-title":"Diabetes Technol. Ther."},{"year":"2014","series-title":"Reportsurveyon lipodistrophyes. AMD\u2013OSDI study group on injection techniques","key":"10.1016\/j.dsx.2018.04.023_bib0085"},{"key":"10.1016\/j.dsx.2018.04.023_bib0090","doi-asserted-by":"crossref","first-page":"1308e14","DOI":"10.1016\/j.jdiacomp.2016.05.026","article-title":"Accumulation of severe hypoglycemia at weekends and in warm seasons in patients with type 1 diabetes but not with type 2 diabetes","volume":"30","author":"Holstein","year":"2016","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.dsx.2018.04.023_bib0095","series-title":"Optimize insulin delivery to help improve your patients\u2019 lives and reduce the burden of care","article-title":"Forum for injection technique & therapy expert recommendations. Rome, Italy","author":"FITTER","year":"2015"},{"issue":"344","key":"10.1016\/j.dsx.2018.04.023_bib0100","article-title":"Incidence and correlates of hypoglycemia in type 2 diabetes. The Hypos-1 study","volume":"5","author":"Giorda","year":"2014","journal-title":"J. Diabetes Metab."},{"issue":"March 3","key":"10.1016\/j.dsx.2018.04.023_bib0105","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.numecd.2016.10.005","article-title":"On behalf of theHYPOS-1 study group of AMD. Healthcare resource use, direct and indirect costs of hypoglycemia in type 1 and type 2 diabetes, and nationwide projections. Results of the HYPOS-1 study","volume":"27","author":"Giorda","year":"2017","journal-title":"Nutr. Metab. Cardiovasc. Dis."}],"container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187140211830081X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187140211830081X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:04:19Z","timestamp":1761728659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187140211830081X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S187140211830081X"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2018.04.023","relation":{},"ISSN":["1871-4021"],"issn-type":[{"type":"print","value":"1871-4021"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insulin related lipodystrophic lesions and hypoglycemia: Double standards?","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dsx.2018.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}