{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:42:05Z","timestamp":1777650125100,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Metabolic Syndrome: Clinical Research &amp; Reviews"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.dsx.2018.06.022","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T21:51:09Z","timestamp":1530049869000},"page":"1045-1050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The association between fetuin-A and testosterone levels and markers of arterial stiffness in Saudi subjects with type 2 diabetes mellitus"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-247X","authenticated-orcid":false,"given":"Tarek Mohamed","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"El Askary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.dsx.2018.06.022_bib0005","doi-asserted-by":"crossref","first-page":"444","DOI":"10.4239\/wjd.v5.i4.444","article-title":"Type 2 diabetes and cardiovascular disease: have all risk factors the same strength?","volume":"5","author":"Mart\u00edn-Tim\u00f3n","year":"2014","journal-title":"World J Diabetes"},{"key":"10.1016\/j.dsx.2018.06.022_bib0010","series-title":"IDF diabetes atlas","author":"International Diabetes Federation","year":"2017"},{"key":"10.1016\/j.dsx.2018.06.022_bib0015","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJM199807233390404","article-title":"Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction","volume":"339","author":"Haffner","year":"1998","journal-title":"N Engl J Med"},{"issue":"24","key":"10.1016\/j.dsx.2018.06.022_bib0020","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1161\/CIRCULATIONAHA.116.022194","article-title":"Atherosclerotic cardiovascular disease and heart failure in type 2 diabetes \u2013 mechanisms, management, and clinical considerations","volume":"133","author":"Low Wang","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.dsx.2018.06.022_bib0025","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2337\/diacare.29.04.06.dc05-1938","article-title":"Alpha2-Heremans-Schmid glycoprotein\/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans","volume":"29","author":"Stefan","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2018.06.022_bib0030","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1172\/JCI17202","article-title":"The serum protein alpha 2-Heremans-Schmid glycoprotein\/fetuin-A is a systemically acting inhibitor of ectopic calcification","volume":"112","author":"Schafer","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.dsx.2018.06.022_bib0035","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1365-2265.2011.04070.x","article-title":"Serum fetuin-A concentrations are elevated in subjects with impaired glucose tolerance and newly diagnosed type 2 diabetes","volume":"75","author":"Ou","year":"2011","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.dsx.2018.06.022_bib0040","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2337\/dc10-0788","article-title":"Fetuin-A levels are increased in patients with type 2 diabetes and peripheral arterial disease","volume":"34","author":"Lorant","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2018.06.022_bib0045","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1475-2840-9-48","article-title":"Associations of fetuin-A levels with vascular disease in type 2 diabetes patients with early diabetic nephropathy","volume":"9","author":"Roos","year":"2010","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.dsx.2018.06.022_bib0050","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1210\/jc.2004-0804","article-title":"Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes","volume":"89","author":"Dhindsa","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.dsx.2018.06.022_bib0055","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.2337\/dc08-0851","article-title":"Testosterone concentration in young patients with diabetes","volume":"31","author":"Chandel","year":"2008","journal-title":"Diabetes Care"},{"issue":"9","key":"10.1016\/j.dsx.2018.06.022_bib0060","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.metabol.2007.04.011","article-title":"Relationship between low serum endogenous androgen concentrations and arterial stiffness in men with type 2 diabetes mellitus","volume":"56","author":"Fukui","year":"2007","journal-title":"Metabolism"},{"key":"10.1016\/j.dsx.2018.06.022_bib0065","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","article-title":"Expert consensus document on arterial stiffness: methodological issues and clinical applications","volume":"27","author":"Laurent","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.dsx.2018.06.022_bib0070","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000097034","article-title":"Mannheim carotid intima-media thickness consensus (2004\u20132006). An update on behalf of the advisory board of the 3rd and 4th watching the risk symposium, 13th and 15th European stroke conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006","volume":"23","author":"Touboul","year":"2007","journal-title":"Cerebrovas Dis"},{"key":"10.1016\/j.dsx.2018.06.022_bib0075","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedwald formula","year":"1972","journal-title":"Clin Chem"},{"issue":"2","key":"10.1016\/j.dsx.2018.06.022_bib0080","doi-asserted-by":"crossref","first-page":"128","DOI":"10.5551\/jat.32979","article-title":"Brachial-Ankle PWV: current status and future directions as a useful marker in the management of cardiovascular disease and\/or cardiovascular risk factors","volume":"23","author":"Tomiyama","year":"2016","journal-title":"J Atheroscler Thromb"},{"issue":"1","key":"10.1016\/j.dsx.2018.06.022_bib0085","doi-asserted-by":"crossref","DOI":"10.1186\/s12872-017-0481-x","article-title":"Red blood cell distribution width and carotid intima-media thickness in patients with metabolic syndrome","volume":"17","author":"Ren","year":"2017","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.dsx.2018.06.022_bib0090","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0303-7207(00)00237-9","article-title":"Alpha2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor","volume":"164","author":"Mathews","year":"2000","journal-title":"Mol Cell Endocrinol"},{"issue":"March (3)","key":"10.1016\/j.dsx.2018.06.022_bib0095","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jdiacomp.2016.11.006","article-title":"Association of plasma fetuin-a levels with peripheral arterial disease and lower extremity arterial calcification in subjects with type 2 diabetes mellitus","volume":"31","author":"Eleftheriadou","year":"2017","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.dsx.2018.06.022_bib0100","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1159\/000363022","article-title":"Sex hormones regulate hepatic fetuin expression in male and female rats","volume":"34","author":"Kim","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.dsx.2018.06.022_bib0105","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","article-title":"Use and abuse of HOMA modeling","volume":"27","author":"Wallace","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2018.06.022_bib0110","doi-asserted-by":"crossref","first-page":"31496","DOI":"10.1074\/jbc.272.50.31496","article-title":"Cloning and targeted deletion of the mouse fetuin gene","volume":"272","author":"Jahnen-Dechent","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.dsx.2018.06.022_bib0115","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bbrc.2006.09.071","article-title":"Fetuin-null mice are protected against obesity and insulin resistance associated with aging","volume":"350","author":"Mathews","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.dsx.2018.06.022_bib0120","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.2337\/diabetes.51.8.2450","article-title":"Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene","volume":"51","author":"Mathews","year":"2002","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.dsx.2018.06.022_bib0125","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s40618-017-0697-8","article-title":"The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies","volume":"41","author":"Roshanzamir","year":"2018","journal-title":"J Endocrinol Invest."},{"key":"10.1016\/j.dsx.2018.06.022_bib0130","doi-asserted-by":"crossref","first-page":"468","DOI":"10.2337\/diacare.29.02.06.dc05-1484","article-title":"Association of serum fetuin-A with insulin resistance in type 2 diabetic and nondiabetic subjects","volume":"29","author":"Mori","year":"2006","journal-title":"Diabetes Care."},{"key":"10.1016\/j.dsx.2018.06.022_bib0135","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/nm.2851","article-title":"Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance","volume":"18","author":"Pal","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.dsx.2018.06.022_bib0140","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1530\/EJE-08-0813","article-title":"Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients","volume":"160","author":"Chen","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.dsx.2018.06.022_bib0145","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1161\/CIRCULATIONAHA.111.072751","article-title":"Association of fetuin-A with incident diabetes mellitus in community-living older adults: the cardiovascular health study","volume":"125","author":"Ix","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.dsx.2018.06.022_bib0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/ATVBAHA.107.147538","article-title":"Fatty liver: a novel component of the metabolic syndrome","volume":"28","author":"Kotronen","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.dsx.2018.06.022_bib0155","first-page":"266","article-title":"Elevated fetuin \u2013 A level associated with an atherogenic lipid profile in type 2 diabetes","volume":"43","author":"Khalil","year":"2013","journal-title":"Int J Pharm Sci Rev Res"},{"issue":"5","key":"10.1016\/j.dsx.2018.06.022_bib0160","doi-asserted-by":"crossref","first-page":"826","DOI":"10.5114\/aoms.2012.31616","article-title":"Fetuin-A levels in obesity: differences in relation to metabolic syndrome and correlation with clinical and laboratory variables","volume":"8","author":"Ismail","year":"2012","journal-title":"Arch Med Sci"},{"issue":"2","key":"10.1016\/j.dsx.2018.06.022_bib0165","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.metabol.2010.01.026","article-title":"Plasma fetuin-A concentrations in young and older high- and low-active men","volume":"60","author":"Jenkins","year":"2011","journal-title":"Metabolism"},{"key":"10.1016\/j.dsx.2018.06.022_bib0170","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.regpep.2008.12.001","article-title":"Fetuin-A and arterial stiffness in patients with normal kidney function","volume":"154","author":"Roos","year":"2009","journal-title":"Regul Pept"},{"key":"10.1016\/j.dsx.2018.06.022_bib0175","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2265.2006.02716.x","article-title":"Association of serum fetuin-A with carotid arterial stiffness","volume":"66","author":"Mori","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.dsx.2018.06.022_bib0180","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1471-2369-14-122","article-title":"Associations of fetuin-a and osteoprotegerin with arterial stiffness and early atherosclerosis in chronic hemodialysis patients","volume":"14","author":"Pateinakis","year":"2013","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.dsx.2018.06.022_bib0185","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1042\/CS20090631","article-title":"Vascular calcification in chronic kidney disease","volume":"119","author":"Covic","year":"2010","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.dsx.2018.06.022_bib0190","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0140-6736(03)12710-9","article-title":"Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study","volume":"361","author":"Ketteler","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.dsx.2018.06.022_bib0195","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/hr.2012.136","article-title":"Subclinical atherosclerosis and fetuin-A plasma levels in essential hypertensive patients","volume":"36","author":"Guarneri","year":"2013","journal-title":"Hypertens Res"},{"key":"10.1016\/j.dsx.2018.06.022_bib0200","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/j.jacc.2011.08.035","article-title":"The associations of fetuin-A with subclinical cardiovascular disease in community-dwelling persons: the Rancho Bernardo Study","volume":"58","author":"Ix","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.dsx.2018.06.022_bib0205","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2006.08.052","article-title":"Association of high alpha2-Heremans-Schmid glycoprotein\/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass","volume":"195","author":"Fiore","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.dsx.2018.06.022_bib0210","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1053\/j.ajkd.2008.10.046","article-title":"Serum fetuin a in hemodialysis: a link between derangement of calcium-phosphorus homeostasis and progression of atherosclerosis?","volume":"53","author":"Pertosa","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.dsx.2018.06.022_bib0215","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2174\/187221411799015372","article-title":"Fetuin-A: a multifunctional protein","volume":"5","author":"Mori","year":"2011","journal-title":"Recent Pat Endocr Metab Immune Drug Discov"}],"container-title":["Diabetes &amp; Metabolic Syndrome: Clinical Research &amp; Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402118302546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402118302546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T10:14:46Z","timestamp":1604484886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871402118302546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S1871402118302546"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2018.06.022","relation":{},"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association between fetuin-A and testosterone levels and markers of arterial stiffness in Saudi subjects with type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dsx.2018.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}