{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:17:17Z","timestamp":1780373837151,"version":"3.54.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Metabolic Syndrome: Clinical Research &amp; Reviews"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.dsx.2018.11.005","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T02:01:51Z","timestamp":1541210511000},"page":"492-495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased insulin requirement may contribute to risk of obesity in children and young people with Type 1 Diabetes Mellitus"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6325-146X","authenticated-orcid":false,"given":"Louise J.","family":"Apperley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-0541","authenticated-orcid":false,"given":"Sze May","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.dsx.2018.11.005_bib1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1530\/EJE-14-0522","article-title":"BMI is an important driver of beta-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children","volume":"172","author":"Lauria","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.dsx.2018.11.005_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1891\/0739-6686.31.47","article-title":"Overweight and obesity in youth with type 1 diabetes","volume":"31","author":"Minges","year":"2013","journal-title":"Annu Rev Nurs Res"},{"key":"10.1016\/j.dsx.2018.11.005_bib3","series-title":"National paediatric diabetes Audit 2016-17: care processes and outcomes","year":"2018"},{"issue":"7","key":"10.1016\/j.dsx.2018.11.005_bib4","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1464-5491.2012.03698.x","article-title":"Estimating the current and future costs of Type 1 and Type 2 diabetes in the UK, including direct health costs and indirect societal and productivity costs","volume":"29","author":"Hex","year":"2012","journal-title":"Diabet Med"},{"issue":"5","key":"10.1016\/j.dsx.2018.11.005_bib5","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1210\/js.2017-00044","article-title":"Body mass index and incident type 1 and type 2 diabetes in children and young adults: a retrospective cohort study","volume":"1","author":"Abbasi","year":"2017","journal-title":"J\u00a0Endocr Soc"},{"issue":"4","key":"10.1016\/j.dsx.2018.11.005_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175728","article-title":"Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study","volume":"12","author":"Channanath","year":"2017","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.dsx.2018.11.005_bib7","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s001250100548","article-title":"The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes","volume":"44","author":"Wilkin","year":"2001","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.dsx.2018.11.005_bib8","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.2337\/dc06-2578","article-title":"Relationship between BMI and age at diagnosis of type 1 diabetes in a Mediterranean area in the period of 1990-2004","volume":"30","author":"Gimenez","year":"2007","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.dsx.2018.11.005_bib9","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/ijo.2009.97","article-title":"The accelerator hypothesis: a review of the evidence for insulin resistance as the basis for type I as well as type II diabetes","volume":"33","author":"Wilkin","year":"2009","journal-title":"Int J Obes (Lond)"},{"issue":"2","key":"10.1016\/j.dsx.2018.11.005_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1464-5491.2004.01368.x","article-title":"Increasing body weight predicts the earlier onset of insulin-dependant diabetes in childhood: testing the 'accelerator hypothesis'","volume":"22","author":"Betts","year":"2005","journal-title":"Diabet Med"},{"issue":"5","key":"10.1016\/j.dsx.2018.11.005_bib11","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2337\/dc16-2331","article-title":"Excess BMI in childhood: a modifiable risk factor for type 1 diabetes development?","volume":"40","author":"Ferrara","year":"2017","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.dsx.2018.11.005_bib12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1177\/1932296815572681","article-title":"Relationship between Basal insulin requirement and body mass index in children and adults with type 1 diabetes on insulin pump therapy","volume":"9","author":"Deeb","year":"2015","journal-title":"J\u00a0Diabetes Sci Technol"},{"issue":"16","key":"10.1016\/j.dsx.2018.11.005_bib13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/pedi.12219","article-title":"The influence of age, gender, insulin dose, BMI, and blood pressure on metabolic control in young patients with type 1 diabetes","volume":"8","author":"Akesson","year":"2015","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.dsx.2018.11.005_bib14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.diabres.2017.01.012","article-title":"Correlates of overweight and obesity in 5529 adolescents with type 1 diabetes: the T1D Exchange Clinic Registry","volume":"126","author":"Minges","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.dsx.2018.11.005_bib15","article-title":"Lipid disorders in type 1 diabetes, type 1 diabetes - complications, pathogenesis, and alternative treatments","author":"Verg\u00e8s","year":"2011","journal-title":"Intech"},{"key":"10.1016\/j.dsx.2018.11.005_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.epag.2015.03.001","article-title":"Dyslipidemia in type 1 diabetes mellitus: relation to diabetes duration, glycaemic control, body habitus, dietary intake and other epidemiological risk factors","author":"Mona","year":"2015","journal-title":"Egypt Pediatr Assoc Gazette"},{"issue":"1","key":"10.1016\/j.dsx.2018.11.005_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4103\/ijem.IJEM_217_17","article-title":"Lipid profile in relation to glycemic control in type 1 diabetes children and adolescents in Bangladesh","volume":"22","author":"Zabeen","year":"2018","journal-title":"Indian J Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.dsx.2018.11.005_bib18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jdiacomp.2015.11.016","article-title":"Obesity and glycemic control in patients with diabetes mellitus: analysis of physician electronic health records in the US from 2009-2011","volume":"30","author":"Bae","year":"2016","journal-title":"J\u00a0Diabet Complicat"},{"key":"10.1016\/j.dsx.2018.11.005_bib19","doi-asserted-by":"crossref","DOI":"10.1210\/er.2017-00191","article-title":"Obesity in type 1 diabetes: pathophysiology, clinical impact and mechanisms","author":"Corbin","year":"2018","journal-title":"Endocr Rev"},{"key":"10.1016\/j.dsx.2018.11.005_bib20","article-title":"Intensive multidisciplinary weight management in patients with type 1 diabetes and obesity: a one-year retrospective matched cohort study","author":"Mottalib","year":"2018","journal-title":"Diabetes Obes Metabol"}],"container-title":["Diabetes &amp; Metabolic Syndrome: Clinical Research &amp; Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402118304442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402118304442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T16:01:36Z","timestamp":1605369696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871402118304442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S1871402118304442"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2018.11.005","relation":{},"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased insulin requirement may contribute to risk of obesity in children and young people with Type 1 Diabetes Mellitus","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dsx.2018.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}