{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:04:53Z","timestamp":1772114693506,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Research and Society Services Directorate"},{"DOI":"10.13039\/501100006378","name":"Universitas Indonesia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006378","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Polyclinic of Dental and Oral Disease Cipto Mangunkusumo National Referral Hospital (CMH), Jakarta, Indonesia"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.dsx.2019.05.012","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:07:12Z","timestamp":1558483632000},"page":"2176-2182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["The influence of diabetes and or periodontitis on inflammation and adiponectin level"],"prefix":"10.1016","volume":"13","author":[{"given":"Dyah","family":"Purnamasari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anandhara I.","family":"Khumaedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuniarti","family":"Soeroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siti","family":"Marhamah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.dsx.2019.05.012_bib1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2337\/db09-9028","article-title":"From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus","volume":"58","author":"DeFronzo","year":"2009","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.dsx.2019.05.012_bib2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1902\/jop.2010.100285","article-title":"Periodontitis prevalence and severity in Indonesians with type 2 diabetes","volume":"82","author":"Susanto","year":"2011","journal-title":"J\u00a0Periodontol [Internet]"},{"issue":"2","key":"10.1016\/j.dsx.2019.05.012_bib3","first-page":"98","article-title":"Prevalensi periodontitis pada pasien diabetes mellitus ( Studi observasional di poliklinik penyakit dalam RSUP Dr . Sardjito ) progresif . Bakteri dan produknya memiliki peran prevalensi periodontitis pada pasien","volume":"3","author":"Sari","year":"2017","journal-title":"DM khususnya yang datang ke poliklinik pen"},{"key":"10.1016\/j.dsx.2019.05.012_bib4","series-title":"The global burden of disease: 2004 update","first-page":"146","author":"World Health Organization","year":"2008"},{"issue":"1","key":"10.1016\/j.dsx.2019.05.012_bib5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1902\/annals.2001.6.1.125","article-title":"Periodontitis and diabetes interrelationships: role of inflammation","volume":"6","author":"Iacopino","year":"2001","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.dsx.2019.05.012_bib6","first-page":"1","article-title":"Hyporesponsiveness to the anti-inflammatory action of interleukin-10 in type 2 diabetes","author":"Barry","year":"2016","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.dsx.2019.05.012_bib7","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1590\/S0100-879X2006005000143","article-title":"Neutrophil function and metabolism in individuals with diabetes mellitus","volume":"40","author":"Alba-Loureiro","year":"2007","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.dsx.2019.05.012_bib8","first-page":"210","volume":"vol. 3","author":"Emor","year":"2015"},{"issue":"2","key":"10.1016\/j.dsx.2019.05.012_bib9","doi-asserted-by":"crossref","first-page":"362","DOI":"10.2337\/dc09-S340","article-title":"Adipocytokines and insulin resistance","volume":"32","author":"Esteve","year":"2009","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.dsx.2019.05.012_bib10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/gene.2011.14","article-title":"State of the union between metabolism and the immune system in type 2 diabetes","volume":"12","author":"Nikolajczyk","year":"2011","journal-title":"Genes Immun [Internet]"},{"issue":"55","key":"10.1016\/j.dsx.2019.05.012_bib11","first-page":"21","article-title":"Periodontitis and type II diabetes: a two-way relationship","volume":"11","author":"Preshaw","year":"2012","journal-title":"Int J Evid Based Healthc"},{"issue":"1","key":"10.1016\/j.dsx.2019.05.012_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2016-000260","article-title":"Systemic inflammatory responses in patients with type 2 diabetes with chronic periodontitis","volume":"4","author":"Mesia","year":"2016","journal-title":"BMJ Open Diabetes Res Care"},{"key":"10.1016\/j.dsx.2019.05.012_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6296854","article-title":"Influence of type 2 diabetes on prevalence of key periodontal pathogens, salivary Matrix metalloproteinases, and bone remodeling markers in Sudanese adults with and without chronic periodontitis","author":"Mohamed","year":"2016","journal-title":"Int J Dentistry"},{"issue":"1","key":"10.1016\/j.dsx.2019.05.012_bib14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol [Internet]"},{"issue":"January","key":"10.1016\/j.dsx.2019.05.012_bib15","first-page":"1","author":"Straka","year":"2008","journal-title":"Periodontitis and Diabetes Mellitus"},{"issue":"8","key":"10.1016\/j.dsx.2019.05.012_bib16","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1902\/jop.2006.050459","article-title":"Diabetes mellitus and periodontal diseases","volume":"77","author":"Mealey","year":"2006","journal-title":"J\u00a0Periodontol [Internet]"},{"key":"10.1016\/j.dsx.2019.05.012_bib17","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1600-051X.2006.00929.x","article-title":"Type 2 diabetes and risk for periodontal disease\u202f: a role for dental health awareness","volume":"33","author":"Jansson","year":"2006","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.dsx.2019.05.012_bib18","series-title":"A\u00a0comparative study on serum leptin and adiponectin levels in periodontitis patients with and without diabetes Mellitus Type 2","first-page":"2","author":"Al-azawy","year":"2014"},{"issue":"5","key":"10.1016\/j.dsx.2019.05.012_bib19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4103\/0972-124X.201694","article-title":"Tumor necrosis factor-\u03b1, interleukin-4 and -6 in the serum of health, chronic periodontitis, and type 2 diabetes mellitus","volume":"20","author":"Acharya","year":"2017","journal-title":"Indian Soc Periodontol"},{"issue":"4","key":"10.1016\/j.dsx.2019.05.012_bib20","first-page":"8","article-title":"Evaluation of serum interleukin - 10 levels as a predictor of glycemic alteration in chronic periodontitis and type 2 diabetes mellitus","volume":"19","author":"Acharya","year":"2015","journal-title":"J\u00a0Indian Soc Periodontol"},{"issue":"1","key":"10.1016\/j.dsx.2019.05.012_bib21","first-page":"6","article-title":"Association of TNF-\u0391, IL-1\u03b2 with chronic periodontitis and type 2 diabetes mellitus","volume":"6","author":"Ertugrul","year":"2017","journal-title":"J\u00a0Dent Heal Oral Disord Ther [Internet"},{"key":"10.1016\/j.dsx.2019.05.012_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4801418","article-title":"Cytokine profile in chronic periodontitis patients with and without obesity: a systematic review and meta-analysis","author":"Akram","year":"2016","journal-title":"Dis Markers"},{"issue":"5","key":"10.1016\/j.dsx.2019.05.012_bib23","first-page":"ZC48","article-title":"Association between gingival crevicular fluid leptin levels and periodontal status - a biochemical study on Indian patients","volume":"9","author":"Selvarajan","year":"2015","journal-title":"J\u00a0Clin Diagn Res [Internet]"},{"issue":"Specialissue","key":"10.1016\/j.dsx.2019.05.012_bib24","article-title":"Gingival crevicular fluid levels of resistin and adiponectin in chronic periodontitis with type 2 diabetes mellitus","volume":"9","author":"Natalina","year":"2016","journal-title":"J\u00a0Int Dent Med Res"},{"issue":"6","key":"10.1016\/j.dsx.2019.05.012_bib25","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1600-051X.2007.01078.x","article-title":"Gingival crevicular fluid and serum leptin: their relationship to periodontal health and disease","volume":"34","author":"Karthikeyan","year":"2007","journal-title":"J\u00a0Clin Periodontol"},{"issue":"3","key":"10.1016\/j.dsx.2019.05.012_bib26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00005-015-0357-7","article-title":"Inflammatory markers change with age , but do not fall beyond reported normal ranges","volume":"64","author":"Czarkowska-paczek","year":"2016","journal-title":"Arch Immunol Ther Exp"},{"issue":"9","key":"10.1016\/j.dsx.2019.05.012_bib27","first-page":"935","article-title":"Adipocytokines , fat distribution , and insulin resistance in elderly men and women","volume":"59","author":"Zoico","year":"2004","journal-title":"J\u00a0Gerontol"},{"key":"10.1016\/j.dsx.2019.05.012_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/497324","article-title":"Gender differences in fat distribution and inflammatory markers among arabs","author":"Farooq","year":"2013","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.dsx.2019.05.012_bib29","first-page":"268","volume":"vol. 57","author":"Oda","year":"2008"},{"key":"10.1016\/j.dsx.2019.05.012_bib30","series-title":"Serum ratio of leptin to adiponectin in patients with chronic periodontitis and type 2 diabetes Mellitus","first-page":"1","author":"Jing Ling","year":"2014"},{"key":"10.1016\/j.dsx.2019.05.012_bib31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/ajcn\/83.2.461S","article-title":"Obesity and the role of adipose tissue in inflammation and metabolism 1\u2013 4","volume":"83","author":"Greenberg","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.dsx.2019.05.012_bib32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4236\/ojemd.2012.22002","article-title":"Correlation between obesity and inflammation in cardiovascular diseases \u2014 evaluation of leptin and inflammatory cytokines","volume":"2","author":"Erusan","year":"2012","journal-title":"Open J Endocr Metab Dis"},{"issue":"1","key":"10.1016\/j.dsx.2019.05.012_bib33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.5005\/jp-journals-10031-1031","article-title":"Prevalence and severity of periodontal disease in type II diabetes mellitus ( noninsulin-dependent diabetes mellitus ) patients in gulbarga , Karnataka , India\u202f: an epidemiological study","volume":"3","author":"Patil","year":"2013","journal-title":"J\u00a0Contemp Dent"},{"issue":"1","key":"10.1016\/j.dsx.2019.05.012_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.5507\/bp.2013.098","article-title":"Severity of periodontal disease in adult patients with diabetes mellitus","volume":"158","author":"Pranckeviciene","year":"2014","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"issue":"1","key":"10.1016\/j.dsx.2019.05.012_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/0972-124X.107470","article-title":"Prevalence and severity of periodontal disease in type 2 diabetes mellitus ( non \u2013 insulin - dependent diabetes mellitus ) patients in Bangalore city\u202f: an epidemiological study","volume":"17","author":"Apoorva","year":"2013","journal-title":"J\u00a0Indian Soc Periodontol"},{"key":"10.1016\/j.dsx.2019.05.012_bib36","first-page":"1902","article-title":"Diabetes, hyperglycemia, and inflammation in older individuals","volume":"29","author":"Rekeneire","year":"2006","journal-title":"Cardiovasc Metab risk"},{"key":"10.1016\/j.dsx.2019.05.012_bib37","first-page":"123","volume":"vol. 13","author":"Hyun","year":"2013"},{"key":"10.1016\/j.dsx.2019.05.012_bib38","series-title":"Effect of metformin on the expression of tumor necrosis factor- \u03b1 , Toll like receptors 2\/4 and C reactive protein in obese type-2 diabetic patients","first-page":"1377","author":"Andrews","year":"2012"},{"issue":"10","key":"10.1016\/j.dsx.2019.05.012_bib39","first-page":"786","article-title":"Original article Atorvastatin attenuates TNF-alpha production via heme oxygenase-1 pathway in LPS-stimulated RAW264.7 macrophages *","volume":"27","author":"Qiao","year":"2014","journal-title":"Biomed Environ Sci"},{"issue":"1\u20132","key":"10.1016\/j.dsx.2019.05.012_bib40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cca.2009.06.029","article-title":"Clinica Chimica Acta TNF- \u03b1\/IL-10 ratio and C-reactive protein as markers of the in fl ammatory response in CAD-prone North Indian patients with acute myocardial infarction","volume":"408","author":"Goswami","year":"2009","journal-title":"Clin Chim Acta [Internet]"},{"issue":"1","key":"10.1016\/j.dsx.2019.05.012_bib41","first-page":"164","article-title":"Study the role of proinflammatory and anti- inflammatory cytokines in Iraqi chronic periodontitis patients","volume":"24","author":"Shaker","year":"2012","journal-title":"J\u00a0Bagh Coll Dent"},{"key":"10.1016\/j.dsx.2019.05.012_bib42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/09629350123387","article-title":"Tumor necrosis factor- a\/interleukin-10 balance in normal and cystic fibrosis children","volume":"10","author":"Shmarina","year":"2001","journal-title":"Mediat Inflamm"},{"issue":"October","key":"10.1016\/j.dsx.2019.05.012_bib43","first-page":"1","article-title":"TnF- \u03b1\/il-10 ratio correlates with Burn severity and May serve as a risk Predictor of increased susceptibility to infections","volume":"4","author":"Tsurumi","year":"2016","journal-title":"Front Public Heal"},{"key":"10.1016\/j.dsx.2019.05.012_bib44","series-title":"Periodontal Inflammation\u202f: from gingivitis to systemic Disease\u202f?","first-page":"155","author":"Panagakos","year":"2011"},{"issue":"10","key":"10.1016\/j.dsx.2019.05.012_bib45","first-page":"462","article-title":"Periodontal disease\u202f: mechanisms of infection and inflammation and possible impact on miscellaneous systemic diseases and conditions","volume":"68","author":"Mohangi","year":"2013","journal-title":"J\u00a0South African Dent Assoviation"},{"issue":"1","key":"10.1016\/j.dsx.2019.05.012_bib46","first-page":"35","article-title":"Correlation of adipocytokines and oxidative stress in type 2 diabetes melltius and their association with degree of insulin resistance","volume":"5","author":"Das","year":"2016","journal-title":"Int J Basic Appl Physiol"},{"key":"10.1016\/j.dsx.2019.05.012_bib47","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1093\/ajcn\/86.5.1293","article-title":"Effects of long-term exercise and diet intervention on plasma","volume":"86","author":"Rokling-andersen","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.dsx.2019.05.012_bib48","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1161\/CIRCULATIONAHA.108.833574","article-title":"Associations of physical activity with inflammatory factors , adipocytokines , and metabolic syndrome in middle-aged and older Chinese people","volume":"119","author":"Yu","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.dsx.2019.05.012_bib49","first-page":"323","article-title":"Relationship of obesity with periodontitis among patients attending a dental college in Chennai\u202f: a cross-sectional survey","author":"Francis","year":"2017","journal-title":"J\u00a0Indian Assoc Public Heal Dent"},{"key":"10.1016\/j.dsx.2019.05.012_bib50","first-page":"1","article-title":"Waist circumference and waist-to-height ratio are associated with periodontal pocketing \u2014 results of the Health 2000 Survey","author":"Kangas","year":"2017","journal-title":"BMC Oral Health"}],"container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187140211930284X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187140211930284X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T17:40:12Z","timestamp":1569174012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187140211930284X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S187140211930284X"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2019.05.012","relation":{},"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The influence of diabetes and or periodontitis on inflammation and adiponectin level","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dsx.2019.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}