{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:33:00Z","timestamp":1791621180677,"version":"4.3.4"},"reference-count":75,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Metabolic Syndrome: Clinical Research &amp; Reviews"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.dsx.2020.06.006","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T02:47:19Z","timestamp":1591670839000},"page":"867-875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Skeletal muscle \u2013 A bystander or influencer of metabolic syndrome?"],"prefix":"10.1016","volume":"14","author":[{"given":"Gina L.","family":"Richter-Stretton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3679-7712","authenticated-orcid":false,"given":"Andrew S.","family":"Fenning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca K.","family":"Vella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.dsx.2020.06.006_bib1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1186\/1471-2458-13-681","article-title":"Area-level socioeconomic characteristics and incidence of metabolic syndrome: a prospective cohort study","volume":"13","author":"Ngo","year":"2013","journal-title":"BMC Publ Health"},{"issue":"6","key":"10.1016\/j.dsx.2020.06.006_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.tem.2016.03.012","article-title":"Blood-based biomarkers for metabolic syndrome","volume":"27","author":"O\u2019Neill","year":"2016","journal-title":"Trends Endocrinol Metabol"},{"key":"10.1016\/j.dsx.2020.06.006_bib3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ypmed.2016.04.006","article-title":"A\u00a0metabolic syndrome severity score: a tool to quantify cardio-metabolic risk factors","volume":"88","author":"Wiley","year":"2016","journal-title":"Prev Med"},{"issue":"4","key":"10.1016\/j.dsx.2020.06.006_bib4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tcm.2015.10.004","article-title":"Metabolic syndrome update","volume":"26","author":"Grundy","year":"2016","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.dsx.2020.06.006_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ypmed.2016.05.012","article-title":"Home-based lifestyle intervention for rural adults improves metabolic syndrome parameters and cardiovascular risk factors: a randomised controlled trial","volume":"89","author":"Blackford","year":"2016","journal-title":"Prev Med"},{"issue":"10","key":"10.1016\/j.dsx.2020.06.006_bib6","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.nut.2016.03.005","article-title":"Pathophysiology of metabolic syndrome: the onset of natural recovery on withdrawal of a high-carbohydrate, high-fat diet","volume":"32","author":"Hazarika","year":"2016","journal-title":"Nutrition"},{"issue":"9","key":"10.1016\/j.dsx.2020.06.006_bib7","doi-asserted-by":"crossref","first-page":"7691","DOI":"10.3390\/nu7095360","article-title":"Green and black cardamom in a diet-induced rat model of metabolic syndrome","volume":"7","author":"Bhaswant","year":"2015","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.dsx.2020.06.006_bib8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/hep.21641","article-title":"Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa\/fa rats","volume":"46","author":"Gary-Bobo","year":"2007","journal-title":"Hepatology"},{"issue":"12","key":"10.1016\/j.dsx.2020.06.006_bib9","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1681\/ASN.2006080944","article-title":"Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors","volume":"17","author":"Nagase","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.dsx.2020.06.006_bib10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00418-004-0678-9","article-title":"Hyperglycemia-induced oxidative stress in diabetic complications","volume":"122","author":"King","year":"2004","journal-title":"Histochem Cell Biol"},{"issue":"1","key":"10.1016\/j.dsx.2020.06.006_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2009.07.031","article-title":"Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome","volume":"314","author":"Maury","year":"2010","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"10.1016\/j.dsx.2020.06.006_bib12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2010.12.006","article-title":"Oxidative stress, insulin signaling, and diabetes","volume":"50","author":"Rains","year":"2011","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"10.1016\/j.dsx.2020.06.006_bib13","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1152\/ajpregu.00561.2007","article-title":"Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species","volume":"294","author":"Wei","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7","key":"10.1016\/j.dsx.2020.06.006_bib14","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1017\/S0007114515005528","article-title":"A\u00a0mitochondrial-targeted ubiquinone modulates muscle lipid profile and improves mitochondrial respiration in obesogenic diet-fed rats","volume":"115","author":"Coudray","year":"2016","journal-title":"Br J Nutr"},{"issue":"6","key":"10.1016\/j.dsx.2020.06.006_bib15","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.2337\/diabetes.50.6.1324","article-title":"GLUT4 is reduced in slow muscle fibers of type 2 diabetic patients","volume":"50","author":"Gaster","year":"2001","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.dsx.2020.06.006_bib16","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.2337\/diabetes.51.10.2944","article-title":"Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes","volume":"51","author":"Kelley","year":"2002","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.dsx.2020.06.006_bib17","doi-asserted-by":"crossref","first-page":"895","DOI":"10.2337\/diacare.29.04.06.dc05-1854","article-title":"Altered fiber distribution and fiber-specific glycolytic and oxidative enzyme activity in skeletal muscle of patients with type 2 diabetes","volume":"29","author":"Oberbach","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2020.06.006_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/635146","article-title":"Genetic dissection of the physiological role of skeletal muscle in metabolic syndrome","volume":"2014","author":"Hagiwara","year":"2014","journal-title":"New J Sci"},{"issue":"6","key":"10.1016\/j.dsx.2020.06.006_bib19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/jdi.12365","article-title":"Sarcopenia and diabetes: hyperglycemia is a risk factor for age-associated muscle mass and functional reduction","volume":"6","author":"Umegaki","year":"2015","journal-title":"J\u00a0Diabetes Invest"},{"issue":"11","key":"10.1016\/j.dsx.2020.06.006_bib20","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.3390\/nu4111664","article-title":"Insulinotropic and muscle protein synthetic effects of branched-chain amino acids: potential therapy for type 2 diabetes and sarcopenia","volume":"4","author":"Manders","year":"2012","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.dsx.2020.06.006_bib21","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s10522-015-9626-4","article-title":"The impact of obesity on skeletal muscle strength and structure through adolescence to old age","volume":"17","author":"Tomlinson","year":"2016","journal-title":"Biogerontology"},{"issue":"5","key":"10.1016\/j.dsx.2020.06.006_bib22","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jelekin.2011.07.006","article-title":"Fat mass limits lower-extremity relative strength and maximal walking performance in older women","volume":"21","author":"LaRoche","year":"2011","journal-title":"J\u00a0Electromyogr Kinesiol"},{"key":"10.1016\/j.dsx.2020.06.006_bib23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.freeradbiomed.2017.05.018","article-title":"Overweight in elderly people induces impaired autophagy in skeletal muscle","volume":"110","author":"Potes","year":"2017","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"10.1016\/j.dsx.2020.06.006_bib24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/07853890600888413","article-title":"The metabolic syndrome: role of skeletal muscle metabolism","volume":"38","author":"Stump","year":"2006","journal-title":"Ann Med"},{"issue":"11","key":"10.1016\/j.dsx.2020.06.006_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080152","article-title":"Dietary fat influences the expression of contractile and metabolic genes in rat skeletal muscle","volume":"8","author":"Mizunoya","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.dsx.2020.06.006_bib26","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1210\/jc.2010-2532","article-title":"Impaired muscle AMPK activation in the metabolic syndrome may attenuate improved insulin action after exercise training","volume":"96","author":"Layne","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.dsx.2020.06.006_bib27","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1210\/jc.2012-3876","article-title":"Slow-twitch fiber proportion in skeletal muscle correlates with insulin responsiveness","volume":"98","author":"Stuart","year":"2013","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.dsx.2020.06.006_bib28","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2337\/diabetes.50.4.817","article-title":"Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity","volume":"50","author":"He","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.dsx.2020.06.006_bib29","first-page":"81","article-title":"Skeletal muscle SIRTI and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise","volume":"5","author":"Williams","year":"2012","journal-title":"Appl Clin Genet"},{"issue":"1","key":"10.1016\/j.dsx.2020.06.006_bib30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2337\/diabetes.54.1.8","article-title":"Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes","volume":"54","author":"Ritov","year":"2005","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.dsx.2020.06.006_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2337\/db09-0591","article-title":"Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function","volume":"59","author":"Karakelides","year":"2010","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.dsx.2020.06.006_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.imr.2013.09.004","article-title":"Exercise and obesity-induced insulin resistance in skeletal muscle","volume":"2","author":"Kwak","year":"2013","journal-title":"Integr Med Res"},{"issue":"3","key":"10.1016\/j.dsx.2020.06.006_bib33","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1172\/JCI37048","article-title":"Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans","volume":"119","author":"Anderson","year":"2009","journal-title":"J\u00a0Clin Invest"},{"issue":"5","key":"10.1016\/j.dsx.2020.06.006_bib34","doi-asserted-by":"crossref","first-page":"E882","DOI":"10.1152\/ajpendo.00769.2007","article-title":"Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete\u2019s paradox revisited","volume":"294","author":"Dub\u00e9","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.dsx.2020.06.006_bib35","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1210\/jcem.86.12.8075","article-title":"Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes","volume":"86","author":"Goodpaster","year":"2001","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.dsx.2020.06.006_bib36","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI25102","article-title":"Inflammation, stress, and diabetes","volume":"115","author":"Wellen","year":"2005","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"10.1016\/j.dsx.2020.06.006_bib37","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1152\/japplphysiol.00006.2008","article-title":"Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons","volume":"105","author":"Lambert","year":"2008","journal-title":"J\u00a0Appl Physiol"},{"issue":"7","key":"10.1016\/j.dsx.2020.06.006_bib38","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1210\/jc.2007-2223","article-title":"Interleukin-6 markedly decreases skeletal muscle protein turnover and increases nonmuscle amino acid utilization in healthy individuals","volume":"93","author":"Van Hall","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.dsx.2020.06.006_bib39","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00125-010-1865-y","article-title":"Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance","volume":"53","author":"Matthews","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.dsx.2020.06.006_bib40","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.dsx.2020.06.006_bib41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"10.1016\/j.dsx.2020.06.006_bib42","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/japplphysiol.00080.2007","article-title":"Role of myokines in exercise and metabolism","volume":"103","author":"Pedersen","year":"2007","journal-title":"J\u00a0Appl Physiol"},{"issue":"4","key":"10.1016\/j.dsx.2020.06.006_bib43","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1152\/japplphysiol.00164.2004","article-title":"The anti-inflammatory effect of exercise","volume":"98","author":"Petersen","year":"2005","journal-title":"J\u00a0Appl Physiol"},{"issue":"3","key":"10.1016\/j.dsx.2020.06.006_bib44","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/01.CIR.104.3.342","article-title":"Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase","volume":"104","author":"Duplain","year":"2001","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.dsx.2020.06.006_bib45","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1161\/HYPERTENSIONAHA.107.089391","article-title":"Isolated systolic hypertension is characterized by increased aortic stiffness and endothelial dysfunction","volume":"50","author":"Wallace","year":"2007","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.dsx.2020.06.006_bib46","doi-asserted-by":"crossref","first-page":"R1124","DOI":"10.1152\/ajpregu.00239.2003","article-title":"Impaired skeletal muscle perfusion in obese Zucker rats","volume":"285","author":"Frisbee","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"4","key":"10.1016\/j.dsx.2020.06.006_bib47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4066\/AMJ.2015.2293","article-title":"Muscular strength, aerobic capacity, and adipocytokines in obese youth after resistance training: a pilot study","volume":"8","author":"Shultz","year":"2015","journal-title":"Australas Med J"},{"issue":"8","key":"10.1016\/j.dsx.2020.06.006_bib48","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.apmr.2005.01.007","article-title":"The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus","volume":"86","author":"Cauza","year":"2005","journal-title":"Arch Phys Med Rehabil"},{"issue":"1","key":"10.1016\/j.dsx.2020.06.006_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1758-5996-1-27","article-title":"Resistance exercise training lowers HbA1c more than aerobic training in adults with type 2 diabetes","volume":"1","author":"Bweir","year":"2009","journal-title":"Diabetol Metab Syndrome"},{"issue":"1","key":"10.1016\/j.dsx.2020.06.006_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.7150\/ijms.4.19","article-title":"Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes","volume":"4","author":"Brooks","year":"2007","journal-title":"Int J Med Sci"},{"issue":"1","key":"10.1016\/j.dsx.2020.06.006_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00421-004-1255-6","article-title":"Regulation of mTOR by amino acids and resistance exercise in skeletal muscle","volume":"94","author":"Deldicque","year":"2005","journal-title":"Eur J Appl Physiol"},{"issue":"2","key":"10.1016\/j.dsx.2020.06.006_bib52","doi-asserted-by":"crossref","first-page":"E392","DOI":"10.1152\/ajpendo.00582.2007","article-title":"Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle","volume":"294","author":"Dreyer","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"23","key":"10.1016\/j.dsx.2020.06.006_bib53","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00441-17","article-title":"MTORC1 regulates both general autophagy and mitophagy induction after oxidative phosphorylation uncoupling","volume":"37","author":"Bartolom\u00e9","year":"2017","journal-title":"Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.dsx.2020.06.006_bib54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: from growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Zoncu","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"10.1016\/j.dsx.2020.06.006_bib55","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tcb.2007.07.009","article-title":"ROS, mitochondria and the regulation of autophagy","volume":"17","author":"Scherz-Shouval","year":"2007","journal-title":"Trends Cell Biol"},{"issue":"1\u20132","key":"10.1016\/j.dsx.2020.06.006_bib56","first-page":"1","article-title":"Iron metabolism and autophagy: a poorly explored relationship that has important consequences for health and disease","volume":"77","author":"Krishan","year":"2015","journal-title":"Nagoya J Med Sci"},{"issue":"6","key":"10.1016\/j.dsx.2020.06.006_bib57","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.cell.2014.11.006","article-title":"Metabolic control of autophagy","volume":"159","author":"Galluzzi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.dsx.2020.06.006_bib58","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cotox.2017.10.006","article-title":"Reciprocity in ROS and autophagic signaling","volume":"7","author":"Wilbe","year":"2018","journal-title":"Curr Opin Toxicol"},{"issue":"12","key":"10.1016\/j.dsx.2020.06.006_bib59","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrendo.2014.171","article-title":"Branched-chain amino acids in metabolic signalling and insulin resistance","volume":"10","author":"Lynch","year":"2014","journal-title":"Nat Rev Endocrinol"},{"issue":"11","key":"10.1016\/j.dsx.2020.06.006_bib60","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.2337\/dc09-0264","article-title":"Excessive loss of skeletal muscle mass in older adults with type 2 diabetes","volume":"32","author":"Park","year":"2009","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.dsx.2020.06.006_bib61","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1753-4887.2011.00443.x","article-title":"Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes","volume":"69","author":"Leenders","year":"2011","journal-title":"Nutr Rev"},{"issue":"3","key":"10.1016\/j.dsx.2020.06.006_bib62","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s13539-012-0068-4","article-title":"Role and potential mechanisms of anabolic resistance in sarcopenia","volume":"3","author":"Haran","year":"2012","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"7","key":"10.1016\/j.dsx.2020.06.006_bib63","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.2337\/dc09-2310","article-title":"Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS)","volume":"33","author":"Kim","year":"2010","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.dsx.2020.06.006_bib64","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2337\/dc14-1166","article-title":"Hyperglycemia predicts persistently lower muscle strength with aging","volume":"38","author":"Kalyani","year":"2015","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.dsx.2020.06.006_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112718","article-title":"Metabolic syndrome, sarcopenia and role of sex and age: cross sectional analysis of Kashiwa cohort study","volume":"9","author":"Ishii","year":"2014","journal-title":"PloS One"},{"issue":"6","key":"10.1016\/j.dsx.2020.06.006_bib66","doi-asserted-by":"crossref","first-page":"458","DOI":"10.4093\/dmj.2013.37.6.458","article-title":"Relative skeletal muscle mass is associated with development of metabolic syndrome","volume":"37","author":"Park","year":"2013","journal-title":"Diabetes Metab J"},{"issue":"10","key":"10.1016\/j.dsx.2020.06.006_bib67","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ejcn.2012.43","article-title":"Adverse effects of coexistence of sarcopenia and metabolic syndrome in Japanese women","volume":"66","author":"Sanada","year":"2012","journal-title":"Eur J Clin Nutr"},{"issue":"12","key":"10.1016\/j.dsx.2020.06.006_bib68","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1038\/oby.2006.267","article-title":"Effect of sarcopenia on cardiovascular disease risk factors in obese postmenopausal women","volume":"14","author":"Aubertin-Leheudre","year":"2006","journal-title":"Obesity"},{"issue":"4","key":"10.1016\/j.dsx.2020.06.006_bib69","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2337\/diabetes.51.4.1066","article-title":"Increased glucocorticoid receptor expression in human skeletal muscle cells may contribute to the pathogenesis of the metabolic syndrome","volume":"51","author":"Whorwood","year":"2002","journal-title":"Diabetes"},{"issue":"31","key":"10.1016\/j.dsx.2020.06.006_bib70","doi-asserted-by":"crossref","first-page":"12587","DOI":"10.1073\/pnas.0705408104","article-title":"The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome","volume":"104","author":"Petersen","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.dsx.2020.06.006_bib71","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1056\/NEJMoa031314","article-title":"Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes","volume":"350","author":"Petersen","year":"2004","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.dsx.2020.06.006_bib72","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.2337\/db06-0783","article-title":"Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients","volume":"56","author":"Befroy","year":"2007","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.dsx.2020.06.006_bib73","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1172\/JCI25151","article-title":"Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents","volume":"115","author":"Morino","year":"2005","journal-title":"J\u00a0Clin Invest"},{"issue":"5708","key":"10.1016\/j.dsx.2020.06.006_bib74","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1126\/science.1108177","article-title":"Cardiovascular risk factors emerge after artificial selection for low aerobic capacity","volume":"307","author":"Wisl\u00f8ff","year":"2005","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.dsx.2020.06.006_bib75","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1249\/01.mss.0000175865.17614.74","article-title":"Association of muscular strength with incidence of metabolic syndrome in men","volume":"37","author":"Jurca","year":"2005","journal-title":"Med Sci Sports Exerc"}],"container-title":["Diabetes &amp; Metabolic Syndrome: Clinical Research &amp; Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402120301752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402120301752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:19:53Z","timestamp":1761729593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871402120301752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":75,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S1871402120301752"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2020.06.006","relation":{},"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skeletal muscle \u2013 A bystander or influencer of metabolic syndrome?","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dsx.2020.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}