{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:16:25Z","timestamp":1789503385073,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100005709","name":"Hellenic Endocrine Society, Greece","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005709","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.dsx.2020.07.049","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T02:47:51Z","timestamp":1597114071000},"page":"1571-1577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Nonalcoholic fatty liver disease in males with low testosterone concentrations"],"prefix":"10.1016","volume":"14","author":[{"given":"Stergios A.","family":"Polyzos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Mousiolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4482-4410","authenticated-orcid":false,"given":"Gesthimani","family":"Mintziori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios G.","family":"Goulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.dsx.2020.07.049_bib1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.dsx.2020.07.049_bib2","first-page":"127","article-title":"The multi-hit process and the antagonistic roles of tumor necrosis factor-alpha and adiponectin in nonalcoholic fatty liver disease","volume":"13","author":"Polyzos","year":"2009","journal-title":"Hippokratia"},{"key":"10.1016\/j.dsx.2020.07.049_bib3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and nonalcoholic fatty liver disease: from pathophysiology to therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.dsx.2020.07.049_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154203","article-title":"Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis","author":"Polyzos","year":"2020","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.dsx.2020.07.049_bib5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A\u00a0new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J\u00a0Hepatol"},{"issue":"7","key":"10.1016\/j.dsx.2020.07.049_bib6","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dsx.2020.07.049_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154318","article-title":"Making progress in nonalcoholic fatty liver disease (NAFLD) as we are transitioning from the era of NAFLD to dys-metabolism associated fatty liver disease (DAFLD)","author":"Polyzos","year":"2020","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.dsx.2020.07.049_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.23736\/S0391-1977.16.02576-1","article-title":"Endocrine and metabolic disorders interplaying with non-alcoholic fatty liver disease","volume":"42","author":"Polyzos","year":"2017","journal-title":"Minerva Endocrinol"},{"issue":"2","key":"10.1016\/j.dsx.2020.07.049_bib9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.23736\/S0391-1977.16.02570-0","article-title":"Hypogonadism and non-alcoholic fatty liver disease","volume":"42","author":"Mintziori","year":"2017","journal-title":"Minerva Endocrinol"},{"issue":"11","key":"10.1016\/j.dsx.2020.07.049_bib10","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.3390\/ijms20112841","article-title":"NAFLD in some common endocrine diseases: prevalence, pathophysiology, and principles of diagnosis and management","volume":"20","author":"Lonardo","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.dsx.2020.07.049_bib11","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1002\/hep.22252","article-title":"Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor","volume":"47","author":"Lin","year":"2008","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.dsx.2020.07.049_bib12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2337\/db14-0249","article-title":"5 alpha-Reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents","volume":"64","author":"Livingstone","year":"2015","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.dsx.2020.07.049_bib13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1179\/2045772314Y.0000000288","article-title":"Low testosterone and non-alcoholic fatty liver disease: evidence for their independent association in men with chronic spinal cord injury","volume":"39","author":"Barbonetti","year":"2016","journal-title":"J\u00a0Spinal Cord Med"},{"key":"10.1016\/j.dsx.2020.07.049_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-230X-12-69","article-title":"A\u00a0low level of serum total testosterone is independently associated with nonalcoholic fatty liver disease","volume":"12","author":"Kim","year":"2012","journal-title":"BMC Gastroenterol"},{"issue":"11","key":"10.1016\/j.dsx.2020.07.049_bib15","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1111\/liv.13735","article-title":"Serum testosterone and non-alcoholic fatty liver disease in men and women in the US","volume":"38","author":"Yim","year":"2018","journal-title":"Liver Int"},{"issue":"2","key":"10.1016\/j.dsx.2020.07.049_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.metabol.2013.10.010","article-title":"Necessity for timely noninvasive diagnosis of nonalcoholic fatty liver disease","volume":"63","author":"Polyzos","year":"2014","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.dsx.2020.07.049_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.metabol.2010.09.003","article-title":"Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"60","author":"Polyzos","year":"2011","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.dsx.2020.07.049_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.metabol.2013.09.013","article-title":"Irisin in patients with nonalcoholic fatty liver disease","volume":"63","author":"Polyzos","year":"2014","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.dsx.2020.07.049_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00125-015-3769-3","article-title":"Circulating leptin in non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"59","author":"Polyzos","year":"2015","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.dsx.2020.07.049_bib20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S1665-2681(19)31316-X","article-title":"Adipocytokines and cytokeratin-18 in patients with nonalcoholic fatty liver disease - introduction of CHA index","volume":"12","author":"Polyzos","year":"2013","journal-title":"Ann Hepatol"},{"issue":"10","key":"10.1016\/j.dsx.2020.07.049_bib21","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A\u00a0critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.dsx.2020.07.049_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"issue":"7","key":"10.1016\/j.dsx.2020.07.049_bib23","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.dsx.2020.07.049_bib24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.dld.2009.08.002","article-title":"Hepatic steatosis index: a simple screening tool reflecting nonalcoholic fatty liver disease","volume":"42","author":"Lee","year":"2010","journal-title":"Dig Liver Dis"},{"issue":"1","key":"10.1016\/j.dsx.2020.07.049_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12944-019-0986-7","article-title":"Triglycerides to high-density lipoprotein cholesterol ratio as a surrogate for nonalcoholic fatty liver disease: a cross-sectional study","volume":"18","author":"Fan","year":"2019","journal-title":"Lipids Health Dis"},{"issue":"7","key":"10.1016\/j.dsx.2020.07.049_bib26","first-page":"477","article-title":"APRI: a simple bedside marker for advanced fibrosis that can avoid liver biopsy in patients with NAFLD\/NASH","volume":"101","author":"Kruger","year":"2011","journal-title":"S\u00a0Afr Med J"},{"issue":"9","key":"10.1016\/j.dsx.2020.07.049_bib27","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1136\/gut.2010.216077","article-title":"Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease","volume":"59","author":"McPherson","year":"2010","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.dsx.2020.07.049_bib28","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/hep.21496","article-title":"The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD","volume":"45","author":"Angulo","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.dsx.2020.07.049_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/andr.12770","article-title":"European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males","author":"Corona","year":"2020","journal-title":"Andrology"},{"issue":"6","key":"10.1016\/j.dsx.2020.07.049_bib30","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/cen.12360","article-title":"Low serum sex hormone-binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients","volume":"80","author":"Hua","year":"2014","journal-title":"Clin Endocrinol"},{"issue":"9","key":"10.1016\/j.dsx.2020.07.049_bib31","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1097\/MEG.0000000000000408","article-title":"Nonalcoholic fatty liver disease and alteration in semen quality and reproductive hormones","volume":"27","author":"Li","year":"2015","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.dsx.2020.07.049_bib32","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/jgh.12935","article-title":"Prediction of prevalent but not incident non-alcoholic fatty liver disease by levels of serum testosterone","volume":"30","author":"Seo","year":"2015","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.dsx.2020.07.049_bib33","doi-asserted-by":"crossref","first-page":"382","DOI":"10.5604\/01.3001.0009.8593","article-title":"Testosterone, sex hormone-binding globulin and nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"16","author":"Jaruvongvanich","year":"2017","journal-title":"Ann Hepatol"},{"issue":"3","key":"10.1016\/j.dsx.2020.07.049_bib34","first-page":"573","article-title":"Liver disease in men undergoing androgen deprivation therapy for prostate cancer","volume":"200","author":"Gild","year":"2018","journal-title":"J\u00a0Urol"},{"issue":"3","key":"10.1016\/j.dsx.2020.07.049_bib35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1055\/s-0029-1202774","article-title":"Improvement of the metabolic syndrome and of non-alcoholic liver steatosis upon treatment of hypogonadal elderly men with parenteral testosterone undecanoate","volume":"118","author":"Haider","year":"2010","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"12","key":"10.1016\/j.dsx.2020.07.049_bib36","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1507\/endocrj.EJ17-0225","article-title":"Free testosterone concentration is inversely associated with markers of liver fibrosis in men with type 2 diabetes mellitus","volume":"64","author":"Miyauchi","year":"2017","journal-title":"Endocr J"},{"issue":"3","key":"10.1016\/j.dsx.2020.07.049_bib37","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1365-2265.2010.03804.x","article-title":"Accuracy of calculated free testosterone formulae in men","volume":"73","author":"Ly","year":"2010","journal-title":"Clin Endocrinol"},{"issue":"3","key":"10.1016\/j.dsx.2020.07.049_bib38","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/BF03401306","article-title":"Sex steroids and sex hormone-binding globulin in postmenopausal women with nonalcoholic fatty liver disease","volume":"12","author":"Polyzos","year":"2013","journal-title":"Hormones (Athens)"},{"issue":"4","key":"10.1016\/j.dsx.2020.07.049_bib39","doi-asserted-by":"crossref","first-page":"519","DOI":"10.14310\/horm.2002.1493","article-title":"Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: assessment of non-invasive indices predicting hepatic steatosis and fibrosis","volume":"13","author":"Polyzos","year":"2014","journal-title":"Hormones (Athens)"},{"issue":"10","key":"10.1016\/j.dsx.2020.07.049_bib40","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1093\/humrep\/deu198","article-title":"The striking similarities in the metabolic associations of female androgen excess and male androgen deficiency","volume":"29","author":"Escobar-Morreale","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.dsx.2020.07.049_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.steroids.2018.04.004","article-title":"Possible mechanisms underlying fatty liver in a rat model of male hypogonadism: a protective role for testosterone","volume":"135","author":"Sakr","year":"2018","journal-title":"Steroids"},{"issue":"5","key":"10.1016\/j.dsx.2020.07.049_bib42","doi-asserted-by":"crossref","first-page":"G825","DOI":"10.1152\/ajpgi.00145.2011","article-title":"Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition","volume":"301","author":"Charlton","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402120302976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402120302976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:21:58Z","timestamp":1761729718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871402120302976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S1871402120302976"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2020.07.049","relation":{},"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonalcoholic fatty liver disease in males with low testosterone concentrations","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dsx.2020.07.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}