{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:19:40Z","timestamp":1769001580809,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.dsx.2021.06.010","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T13:10:55Z","timestamp":1623244255000},"page":"102173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Therapeutic outcomes evaluation of adjuvant hyperbaric oxygen therapy for non-healing diabetic foot ulcers among sudanese patients"],"prefix":"10.1016","volume":"15","author":[{"given":"Ethar Mohamedalfatih","family":"Fadol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayat Mohamed","family":"Suliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashier","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safa A.","family":"Abdalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wadah J.A.","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elwasila M.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7453-5724","authenticated-orcid":false,"given":"Iman Hassan","family":"Abdoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dsx.2021.06.010_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-018-4711-2","article-title":"Global trends in diabetes complications: a review of current evidence","volume":"62","author":"Harding","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.dsx.2021.06.010_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232395","article-title":"Economic evaluations considering costs and outcomes of diabetic foot ulcer infections: a systematic review","volume":"15","author":"Woods","year":"2020","journal-title":"PloS One"},{"key":"10.1016\/j.dsx.2021.06.010_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/07853890.2016.1231932","article-title":"Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis (dagger)","volume":"49","author":"Zhang","year":"2017","journal-title":"Ann Med"},{"key":"10.1016\/j.dsx.2021.06.010_bib4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s11892-019-1212-8","article-title":"Epidemiology of peripheral neuropathy and lower extremity disease in diabetes","author":"Hicks","year":"2019","journal-title":"Curr Diabetes Rep"},{"key":"10.1016\/j.dsx.2021.06.010_bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/trstmh\/try124","article-title":"The double burden of diabetes and global infection in low and middle-income countries","volume":"113","author":"Dunachie","year":"2019","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.dsx.2021.06.010_bib6","doi-asserted-by":"crossref","DOI":"10.1177\/2042018819860071","article-title":"Prevalence, risk factors, and glycaemic control of type 2 diabetes mellitus in eastern Sudan: a community-based study","volume":"10","author":"Omar","year":"2019","journal-title":"Therapeutic advances in endocrinology and metabolism"},{"key":"10.1016\/j.dsx.2021.06.010_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21037\/atm.2017.07.01","article-title":"Prevalence of diabetic foot ulceration and associated risk factors: an old and still major public health problem in Khartoum, Sudan?","volume":"5","author":"Almobarak","year":"2017","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.dsx.2021.06.010_bib8","doi-asserted-by":"crossref","DOI":"10.4314\/sjms.v4i2.44898","article-title":"Diabetic septic foot in Omdurman teaching hospital","volume":"4","author":"Adam","year":"2009","journal-title":"Sudan journal of Medical Sciences"},{"key":"10.1016\/j.dsx.2021.06.010_bib9","first-page":"216","article-title":"Pattern, management and outcome of diabetic foot in Wad Medani teaching hospital from january to december 2016","volume":"54","author":"SaadEldein","year":"2018","journal-title":"Sudan Med J"},{"key":"10.1016\/j.dsx.2021.06.010_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/nyas.13569","article-title":"Update on management of diabetic foot ulcers","volume":"1411","author":"Everett","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.dsx.2021.06.010_bib11","doi-asserted-by":"crossref","first-page":"e3284","DOI":"10.1002\/dmrr.3284","article-title":"Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review","volume":"36","author":"Vas","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.dsx.2021.06.010_bib12","first-page":"6245758","article-title":"The efficacy and safety of acellular matrix therapy for diabetic foot ulcers: a meta-analysis of randomized clinical trials","volume":"2020","author":"Huang","year":"2020","journal-title":"J\u00a0Diabetes Res"},{"key":"10.1016\/j.dsx.2021.06.010_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jcws.2010.04.001","article-title":"Hyperbaric oxygen therapy","volume":"2","author":"Shah","year":"2010","journal-title":"The journal of the American College of Certified Wound Specialists"},{"key":"10.1016\/j.dsx.2021.06.010_bib14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2147\/IJGM.S172460","article-title":"Hypoxia and hyperbaric oxygen therapy: a review","volume":"11","author":"Choudhury","year":"2018","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.dsx.2021.06.010_bib15","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.biopha.2018.10.142","article-title":"Hyperbaric oxygen therapy: antimicrobial mechanisms and clinical application for infections","volume":"109","author":"Memar","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.dsx.2021.06.010_bib16","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/WON.0000000000000374","article-title":"Adjunctive hyperbaric oxygen therapy for healing of chronic diabetic foot ulcers: a randomized controlled trial","volume":"44","author":"Chen","year":"2017","journal-title":"J\u00a0Wound, Ostomy Cont Nurs"},{"key":"10.1016\/j.dsx.2021.06.010_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.fas.2009.06.002","article-title":"Treatment of diabetic foot infection with hyperbaric oxygen therapy","volume":"16","author":"Chen","year":"2010","journal-title":"Foot Ankle Surg"},{"key":"10.1016\/j.dsx.2021.06.010_bib18","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s10973-019-09129-0","article-title":"Evaluation of hyperbaric oxygen therapy effects in hard-to-heal wounds using thermal imaging and planimetry","volume":"141","author":"Englisz-Jurgielewicz","year":"2020","journal-title":"J\u00a0Therm Anal Calorim"},{"key":"10.1016\/j.dsx.2021.06.010_bib19","doi-asserted-by":"crossref","first-page":"998","DOI":"10.2337\/dc09-1754","article-title":"Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes","volume":"33","author":"L\u00f6ndahl","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2021.06.010_bib20","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1089\/wound.2016.0718","article-title":"Hyperbaric oxygen therapy: side effects defined and quantified","volume":"6","author":"Heyboer","year":"2017","journal-title":"Adv Wound Care"},{"key":"10.1016\/j.dsx.2021.06.010_bib21","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/dme.13975","article-title":"Systematic Review or Meta-analysis Systematic review and meta-analysis of clinical trials examining the effect of hyperbaric oxygen therapy in people with diabetes-related lower limb ulcers","volume":"36","author":"Golledge","year":"2019","journal-title":"Diabet Med"},{"key":"10.1016\/j.dsx.2021.06.010_bib22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.4103\/0970-0358.101309","article-title":"Hyperbaric oxygen and wound healing. Indian journal of plastic surgery","volume":"45","author":"Bhutani","year":"2012","journal-title":"official publication of the Association of Plastic Surgeons of India"},{"key":"10.1016\/j.dsx.2021.06.010_bib23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/1534734619829939","article-title":"Adjuvant hyperbaric oxygen therapy enhances healing of nonischemic diabetic foot ulcers compared with standard wound care alone","volume":"18","author":"Salama","year":"2019","journal-title":"Int J Low Extrem Wounds"},{"key":"10.1016\/j.dsx.2021.06.010_bib24","first-page":"1","article-title":"Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment","volume":"17","year":"2017","journal-title":"Ontario health technology assessment series"},{"key":"10.1016\/j.dsx.2021.06.010_bib25","first-page":"CD004123","article-title":"Hyperbaric oxygen therapy for chronic wounds","volume":"2015","author":"Kranke","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.dsx.2021.06.010_bib26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2337\/cd17-0119","article-title":"Standards of medical care in diabetes-2018 abridged for primary care providers","volume":"36","year":"2018","journal-title":"Clin Diabetes"},{"key":"10.1016\/j.dsx.2021.06.010_bib27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3399\/bjgp12X630232","article-title":"Management of hypertension in adults in primary care: NICE guideline","volume":"62","author":"McCormack","year":"2012","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.dsx.2021.06.010_bib28","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/0141076816688346","article-title":"Prevention and treatment of diabetic foot ulcers","volume":"110","author":"Lim","year":"2017","journal-title":"J\u00a0R Soc Med"},{"key":"10.1016\/j.dsx.2021.06.010_bib29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/1932296819849478","article-title":"Choosing a vibratory test to pair with semmes weinstein monofilament testing for evaluating lower extremity sensation in patients with diabetes: a comparison of three vibratory methodologies","volume":"14","author":"Raymond","year":"2020","journal-title":"Journal of diabetes science and technology"},{"key":"10.1016\/j.dsx.2021.06.010_bib30","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1001\/archsurg.135.6.627","article-title":"Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: a new paradigm in wound healing","volume":"135","author":"Brem","year":"2000","journal-title":"Arch Surg"},{"key":"10.1016\/j.dsx.2021.06.010_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-018-0327-2","article-title":"Mortality in patients with diabetic foot ulcer: a retrospective study of 513 cases from a single Centre in the Northern Territory of Australia","volume":"19","author":"Jeyaraman","year":"2019","journal-title":"BMC Endocr Disord"},{"key":"10.1016\/j.dsx.2021.06.010_bib32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13047-020-00383-2","article-title":"Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer","volume":"13","author":"Armstrong","year":"2020","journal-title":"J\u00a0Foot Ankle Res"},{"key":"10.1016\/j.dsx.2021.06.010_bib33","doi-asserted-by":"crossref","first-page":"46S","DOI":"10.1016\/j.jvs.2015.10.007","article-title":"A\u00a0systematic review and meta-analysis of adjunctive therapies in diabetic foot ulcers","volume":"63","author":"Elraiyah","year":"2016","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.dsx.2021.06.010_bib34","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2337\/dc15-2001","article-title":"Hyperbaric oxygen therapy does not reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb: a prospective, double-blind, randomized controlled clinical trial","volume":"39","author":"Fedorko","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2021.06.010_bib35","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-034058","article-title":"Risk of diabetic foot ulcer and its associated factors among Bangladeshi subjects: a multicentric cross-sectional study","volume":"10","author":"Banik","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.dsx.2021.06.010_bib36","first-page":"4106383","article-title":"Prevalence of diabetic foot ulcer and associated factors among adult diabetic patients on follow-up clinic at jimma medical center, southwest Ethiopia, 2019: an institutional-based cross-sectional study","volume":"2020","author":"Abdissa","year":"2020","journal-title":"Journal of diabetes research"},{"key":"10.1016\/j.dsx.2021.06.010_bib37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4103\/0970-9185.92444","article-title":"Evaluation of the efficacy of hyperbaric oxygen therapy in the management of chronic nonhealing ulcer and role of periwound transcutaneous oximetry as a predictor of wound healing response: a randomized prospective controlled trial","volume":"28","author":"Kaur","year":"2012","journal-title":"J\u00a0Anaesthesiol Clin Pharmacol"},{"key":"10.1016\/j.dsx.2021.06.010_bib38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.mayocp.2012.10.021","article-title":"Systematic review of the effectiveness of hyperbaric oxygenation therapy in the management of chronic diabetic foot ulcers","volume":"88","author":"Liu","year":"2013","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.dsx.2021.06.010_bib39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s13126-016-0321-y","article-title":"Evaluation of the role of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers: a prospective comparative study","volume":"88","author":"Munjewar","year":"2016","journal-title":"Hellenic Journal of Surgery"},{"key":"10.1016\/j.dsx.2021.06.010_bib40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2174\/1874192401812010080","article-title":"Hyperbaric oxygen therapy in ischaemic foot ulcers in type 2 diabetes: a clinical trial","volume":"12","author":"Perren","year":"2018","journal-title":"Open Cardiovasc Med J"},{"key":"10.1016\/j.dsx.2021.06.010_bib41","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1053\/j.jfas.2018.05.011","article-title":"Efficacy of hyperbaric oxygen therapy in diabetic foot ulcers based on wagner classification","volume":"57","author":"Erdo\u011fan","year":"2018","journal-title":"J\u00a0Foot Ankle Surg"},{"key":"10.1016\/j.dsx.2021.06.010_bib42","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jvs.2019.07.082","article-title":"A\u00a0systematic review and meta-analysis of hyperbaric oxygen therapy for diabetic foot ulcers with arterial insufficiency","volume":"71","author":"Brouwer","year":"2020","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.dsx.2021.06.010_bib43","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2337\/dc17-0654","article-title":"Hyperbaric oxygen therapy in the treatment of ischemic lower- extremity ulcers in patients with diabetes: results of the DAMO2CLES multicenter randomized clinical trial","volume":"41","author":"Santema","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2021.06.010_bib44","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.2337\/dc12-2160","article-title":"Lack of effectiveness of hyperbaric oxygen therapy for the treatment of diabetic foot ulcer and the prevention of amputation: a cohort study","volume":"36","author":"Margolis","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2021.06.010_bib45","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2337\/dc16-0105","article-title":"Comment on Fedorko et\u00a0al. Hyperbaric oxygen therapy does not reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb: a prospective, double-blind, randomized controlled clinical trial","volume":"39","author":"L\u00f6ndahl","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2021.06.010_bib46","first-page":"133","article-title":"Poorly designed research does not help clarify the role of hyperbaric oxygen in the treatment of chronic diabetic foot ulcers","volume":"46","author":"Mutluoglu","year":"2016","journal-title":"Diving and hyperbaric medicine"},{"key":"10.1016\/j.dsx.2021.06.010_bib47","doi-asserted-by":"crossref","first-page":"18980","DOI":"10.3402\/dfa.v3i0.18980","article-title":"Associated risk factors and management of chronic diabetic foot ulcers exceeding 6 months' duration","volume":"3","author":"Gubara Musa","year":"2012","journal-title":"Diabet Foot Ankle"},{"key":"10.1016\/j.dsx.2021.06.010_bib48","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1089\/wound.2018.0855","article-title":"Impact of hyperbaric oxygen on more advanced wagner grades 3 and 4 diabetic foot ulcers: matching therapy to specific wound conditions","volume":"7","author":"Ennis","year":"2018","journal-title":"Adv Wound Care"},{"key":"10.1016\/j.dsx.2021.06.010_bib49","doi-asserted-by":"crossref","first-page":"e3283","DOI":"10.1002\/dmrr.3283","article-title":"Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update)","volume":"36","author":"Rayman","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.dsx.2021.06.010_bib50","first-page":"205","article-title":"A\u00a0clinical practice guideline for the use of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers","volume":"42","author":"Huang","year":"2015","journal-title":"Undersea Hyper Med"}],"container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402121001910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402121001910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:16:52Z","timestamp":1761729412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871402121001910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1871402121001910"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2021.06.010","relation":{},"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic outcomes evaluation of adjuvant hyperbaric oxygen therapy for non-healing diabetic foot ulcers among sudanese patients","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dsx.2021.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102173"}}