{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:39:24Z","timestamp":1776109164703,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Metabolic Syndrome: Clinical Research &amp; Reviews"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.dsx.2022.102501","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T18:14:04Z","timestamp":1652724844000},"page":"102501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mitochondrial ATP6 and ND3 genes are associated with type 2 diabetic peripheral neuropathy"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-0380","authenticated-orcid":false,"given":"Devi","family":"Kasinathan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Matrougui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santhini","family":"Elango","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souad","family":"Belmandani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balaji","family":"Srinivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthikeyan","family":"Muthusamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhu","family":"Narayanasamy Marimuthu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dsx.2022.102501_bib1","first-page":"16","article-title":"Diabetic polyneuropathy. Risk factors, patterns of presentation, diagnosis, and treatment","volume":"58","author":"Poncelet","year":"2003","journal-title":"Geriatrics"},{"key":"10.1016\/j.dsx.2022.102501_bib2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mce.2008.05.015","article-title":"Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes","volume":"297","author":"Mulder","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.dsx.2022.102501_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.diabres.2013.12.015","article-title":"Novel mutations in ATPase 8, ND1 and ND5 genes associated with peripheral neuropathy of diabetes","volume":"103","author":"Santhini","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.dsx.2022.102501_bib4","first-page":"37","article-title":"Prevalence and clinical characterization of mitochondrial ND-1 gene G3316A mutation in type II diabetes of Karaikudi population, Genes","volume":"38","author":"Devi","year":"2016","journal-title":"Genomics"},{"key":"10.1016\/j.dsx.2022.102501_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by Thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.dsx.2022.102501_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal Biochem"},{"key":"10.1016\/j.dsx.2022.102501_bib7","article-title":"Oxidative stress level in the testes of mice and rats during nickel intoxication","author":"Eugenia","year":"2012","journal-title":"Sci World J"},{"key":"10.1016\/j.dsx.2022.102501_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rats lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.dsx.2022.102501_bib9","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.dsx.2022.102501_bib10","first-page":"1730","article-title":"Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.dsx.2022.102501_bib11","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the auto oxidation of epinephrine and a simple assay of superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.dsx.2022.102501_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","article-title":"A\u00a0spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalyse","volume":"195","author":"Beers","year":"1952","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.dsx.2022.102501_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2337\/diabetes.54.1.8","article-title":"Deficiency of sub-sarcolemmal mitochondria in obesity and type 2 diabetes","volume":"54","author":"Ritov","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.dsx.2022.102501_bib14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1177\/11.1.102","article-title":"Microdetermination of cytochrome oxidase in rat tissues by the oxidation on N-phenyl-p-phenylene diamine or ascorbic acid","volume":"11","author":"Pearl","year":"1963","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.dsx.2022.102501_bib15","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A\u00a0simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.dsx.2022.102501_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/13779","article-title":"Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA","volume":"23","author":"Andrews","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.dsx.2022.102501_bib17","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1136\/bmj.302.6786.1178","article-title":"Importance of maternal history of non-insulin dependent diabetic patients","volume":"302","author":"Alcolado","year":"1999","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.dsx.2022.102501_bib18","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1089\/ars.2009.2531","article-title":"Mitochondrial dysfunction in diabetes: from molecular mechanism to functional significance and therapeutic opportunities","volume":"12","author":"William","year":"2010","journal-title":"Antioxid Redox Biol"},{"key":"10.1016\/j.dsx.2022.102501_bib19","first-page":"637","article-title":"Mitochondrial dynamics in type 2 diabetes: pathophysiological implications","author":"Susana","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.dsx.2022.102501_bib20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jbt.10058","article-title":"Diabetes, oxidative stress, and antioxidants: a review","volume":"17","author":"Maritim","year":"2003","journal-title":"J\u00a0Biochem Mol Toxicol"},{"key":"10.1016\/j.dsx.2022.102501_bib21","first-page":"261","article-title":"The role of oxidative stress and endothelial injury in diabetic neuropathy and neuropathic pain","volume":"31","author":"Ozkul","year":"2010","journal-title":"Neuroendocrinol Lett"},{"key":"10.1016\/j.dsx.2022.102501_bib22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/cbf.2808","article-title":"Evaluation of oxidative stress markers and vascular risk factors in patients with diabetic peripheral neuropathy","volume":"30","author":"El Boghdady","year":"2012","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.dsx.2022.102501_bib23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2337\/diab.45.2.113","article-title":"Mitochondria and diabetes: genetic, biochemical, and clinical implications of the cellular energy circuit","volume":"45","author":"Gerbitz","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.dsx.2022.102501_bib24","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.diabres.2007.01.052","article-title":"Genetic factors related to mitochondrial function and risk of diabetes mellitus","volume":"77","author":"Cho","year":"2007","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.dsx.2022.102501_bib25","doi-asserted-by":"crossref","first-page":"865","DOI":"10.2337\/diacare.24.5.865","article-title":"Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients","volume":"24","author":"Song","year":"2001","journal-title":"Diabetes Care"}],"container-title":["Diabetes &amp; Metabolic Syndrome: Clinical Research &amp; Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402122001151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402122001151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:18:16Z","timestamp":1761729496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871402122001151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S1871402122001151"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2022.102501","relation":{},"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial ATP6 and ND3 genes are associated with type 2 diabetic peripheral neuropathy","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dsx.2022.102501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Diabetes India. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102501"}}