{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:31:17Z","timestamp":1791660677961,"version":"4.3.4"},"reference-count":78,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Metabolic Syndrome: Clinical Research &amp; Reviews"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.dsx.2022.102591","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T13:06:45Z","timestamp":1660136805000},"page":"102591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Type-2 diabetes mellitus-associated cancer risk: In pursuit of understanding the possible link"],"prefix":"10.1016","volume":"16","author":[{"given":"Srinivasa Rao","family":"Vulichi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Runthala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaraju","family":"Begari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Rupak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Rao","family":"Chunduri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Kapur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Appa Rao","family":"Chippada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durga Srinivasa Murthy","family":"Sistla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dsx.2022.102591_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/789174","article-title":"Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms","author":"Arcidiacono","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"10.1016\/j.dsx.2022.102591_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/msj.20167","article-title":"Type 2 diabetes and cancer: what is the connection?","volume":"77","author":"Cannata","year":"2010","journal-title":"MSJM (Mt Sinai J Med)"},{"key":"10.1016\/j.dsx.2022.102591_bib3","article-title":"How diabetes can increase cancer risk: DNA damaged by high blood sugar","year":"2019","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.dsx.2022.102591_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11892-012-0356-6","article-title":"The link between insulin resistance, diabetes, and cancer","volume":"13","author":"Orgel","year":"2013","journal-title":"Curr Diabetes Rep"},{"key":"10.1016\/j.dsx.2022.102591_bib5","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2337\/dc10-0666","article-title":"Diabetes and Cancer: a consensus report","volume":"33","author":"Giovannucci","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dsx.2022.102591_bib6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.diabres.2018.03.002","article-title":"Epidemiological dimensions of the association between type 2 diabetes and cancer: a review of observational studies","volume":"143","author":"Sacerdote","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"issue":"12","key":"10.1016\/j.dsx.2022.102591_bib7","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.trecan.2019.10.012","article-title":"The metabolic interplay between cancer and other diseases","volume":"5","author":"Le","year":"2019","journal-title":"Trends Cancer"},{"key":"10.1016\/j.dsx.2022.102591_bib8","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.2337\/db16-1477","article-title":"Diabetes, pancreatogenic diabetes, and pancreatic cancer","volume":"66","author":"Andersen","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.dsx.2022.102591_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.600824","article-title":"Type 2 diabetes, obesity, and cancer share some common and critical pathways","volume":"10","author":"Rahman","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.dsx.2022.102591_bib10","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s00125-010-1796-7","article-title":"Diabetes, prediabetes and cancer mortality","volume":"53","author":"Zhou","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.dsx.2022.102591_bib11","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/ans.12877","article-title":"Influence of diabetes mellitus on mortality of breast cancer patients","volume":"85","author":"Zhou","year":"2015","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.dsx.2022.102591_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2020.108552","article-title":"Annual glycemic variations and risk of cancer among Chinese patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai","volume":"171","author":"Xu","year":"2021","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.dsx.2022.102591_bib13","article-title":"Diabetes and risk of cancer","volume":"2013","author":"Habib","year":"2013","journal-title":"ISRN Oncol"},{"issue":"2","key":"10.1016\/j.dsx.2022.102591_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrclinonc.2016.120","article-title":"obesity, diabetes, and anti-diabetic drugs: is the fog clearing?","volume":"14","author":"Klil-Drori","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"issue":"8","key":"10.1016\/j.dsx.2022.102591_bib15","first-page":"31","article-title":"PPAR-\u0393 as antineoplastic agents in cancers with dysregulated IGF Axis","volume":"22","author":"Vella","year":"2017","journal-title":"Front Endocrinol"},{"issue":"1","key":"10.1016\/j.dsx.2022.102591_bib16","first-page":"3","article-title":"Insulin-like growth factors and their binding proteins: biological actions","volume":"16","author":"Jones","year":"1995","journal-title":"Endocr Rev"},{"key":"10.1016\/j.dsx.2022.102591_bib17","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.nu.11.070191.002141","article-title":"Nutritional regulation of IGF-I and IGF binding proteins","volume":"11","author":"Clemmons","year":"1991","journal-title":"Annu Rev Nutr"},{"issue":"5","key":"10.1016\/j.dsx.2022.102591_bib18","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41574-020-0329-9","article-title":"Insulin-PI3K signaling: an evolutionarily insulated metabolic driver of cancer","volume":"16","author":"Hopkins","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.dsx.2022.102591_bib19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","article-title":"The PI3K pathway in human disease","volume":"170","author":"Fruman","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.dsx.2022.102591_bib20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.124.3215.269","article-title":"On respiratory impairment in cancer cells","volume":"124","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.dsx.2022.102591_bib21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cell.2008.08.021","article-title":"Cancer cell metabolism: Warburg and beyond","volume":"134","author":"Hsu","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.dsx.2022.102591_bib22","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature07782","article-title":"Tumors with PI3K activation are resistant to dietary restriction","volume":"458","author":"Kalaany","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.dsx.2022.102591_bib23","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/35035131","article-title":"Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase","volume":"407","author":"Simoncini","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.dsx.2022.102591_bib24","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1210\/me.2004-0093","article-title":"Thyroid hormone induces rapid activation of Akt\/protein kinase B mammalian target of rapamycin-p70SK cascade through phosphatidylinositol 3-kinase in human fibroblasts","volume":"19","author":"Cao","year":"2005","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.dsx.2022.102591_bib25","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1158\/1535-7163.MCT-10-0318","article-title":"Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for co-targeting IGF-1R and IR in cancer","volume":"9","author":"Buck","year":"2010","journal-title":"Mol Cancer Therapeut"},{"key":"10.1016\/j.dsx.2022.102591_bib26","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1056\/NEJMra1704560","article-title":"Phosphatidylinositol 3- kinase, growth disorders and cancer","volume":"379","author":"Gonclaves","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.dsx.2022.102591_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40170-019-0203-1","article-title":"SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia","volume":"7","author":"Nasiri","year":"2019","journal-title":"Cancer Metabol"},{"key":"10.1016\/j.dsx.2022.102591_bib28","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-018-0343-4","article-title":"Suppression of insulin feedback enhances the efficacy of PI3K inhibitors","volume":"560","author":"Hopkins","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.dsx.2022.102591_bib29","series-title":"Hyperglycemia","first-page":"1","author":"Mouri","year":"2019"},{"issue":"9","key":"10.1016\/j.dsx.2022.102591_bib30","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.3390\/cancers11091402","article-title":"Hyperglycemia associated metabolic and molecular alterations in cancer risk, progression, treatment, and mortality","volume":"11","author":"Ramteke","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.dsx.2022.102591_bib31","first-page":"14","article-title":"Reactive oxygen species: role in the development of cancer and various chronic conditions","volume":"5","author":"Waris","year":"2006","journal-title":"J\u00a0Carcinog"},{"key":"10.1016\/j.dsx.2022.102591_bib32","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3109\/10409238.2013.875514","article-title":"Interplay between DNA repair and inflammation, and link to cancer","volume":"49","author":"Kidane","year":"2014","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.dsx.2022.102591_bib33","series-title":"Diabetes can increase cancer risk. Here's how.\" SciTechDaily. SciTechDaily","year":"2019"},{"key":"10.1016\/j.dsx.2022.102591_bib34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/ncrna5010030","article-title":"Increased extracellular matrix protein production in chronic diabetic complications: implications of non-coding RNAs","volume":"5","author":"Biswas","year":"2019","journal-title":"Non-Coding RNA"},{"key":"10.1016\/j.dsx.2022.102591_bib35","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1167\/iovs.13-13221","article-title":"Aberrant expression of long noncoding RNAs in early diabetic retinopathy","volume":"55","author":"Yan","year":"2014","journal-title":"Investig. Opthalmol. Vis. Sci"},{"key":"10.1016\/j.dsx.2022.102591_bib36","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1167\/iovs.16-20569","article-title":"ANRIL: a regulator of VEGF in diabetic retinopathy","volume":"58","author":"Thomas","year":"2017","journal-title":"Invesgit. Opthalmol. Vis. Sci"},{"key":"10.1016\/j.dsx.2022.102591_bib37","first-page":"38","article-title":"The role of long non-coding RNA ANRIL in the carcinogenesis of oral cancer by targeting miR-125a. Biomed","volume":"103","author":"Chai","year":"2018","journal-title":"Pharma"},{"key":"10.1016\/j.dsx.2022.102591_bib38","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.biopha.2017.09.107","article-title":"Long non-coding RNA ANRIL promotes carcinogenesis via sponging miR-199a in triple-negative breast cancer","volume":"96","author":"Xu","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.dsx.2022.102591_bib39","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3727\/096504017X14953948675449","article-title":"Long noncoding RNA ANRIL promotes cervical cancer development by acting as a sponge of miR-186","volume":"26","author":"Zhang","year":"2018","journal-title":"Oncol Res"},{"key":"10.1016\/j.dsx.2022.102591_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/npre.2008.1567.1","article-title":"Effect of hyperglycemia on inflammatory markers in patients with Type 2 Diabetes","author":"Goyal","year":"2008","journal-title":"Nat. Precede"},{"key":"10.1016\/j.dsx.2022.102591_bib41","first-page":"406","article-title":"Inflammation and cancer. Encycl","volume":"4","author":"Kumar","year":"2016","journal-title":"Immunobiology"},{"key":"10.1016\/j.dsx.2022.102591_bib42","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1080\/08820139.2018.1480031","article-title":"Hyperglycemia affects the expression of inflammatory genes in peripheral blood mononuclear cells of patients with type 2 diabetes","volume":"47","author":"Akbari","year":"2018","journal-title":"Immunol Invest"},{"key":"10.1016\/j.dsx.2022.102591_bib43","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41586-018-0350-5","article-title":"Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer","volume":"559","author":"Wu","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.dsx.2022.102591_bib44","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0014-5793(97)01314-8","article-title":"Glucose regulates the promoter activity of aldolase A and pyruvate kinase M2 via dephosphorylation of Sp1","volume":"417","author":"Schafer","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.dsx.2022.102591_bib45","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.cmet.2019.02.005","article-title":"High glucose triggers nucleotide imbalance through O-GlcNAcylation of key enzymes and induces KRAS mutation in pancreatic cells","volume":"29","author":"Hu","year":"2019","journal-title":"Cell Metabol"},{"key":"10.1016\/j.dsx.2022.102591_bib46","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nrm.2017.22","article-title":"Protein O-GlcNAcylation: emerging mechanisms and functions","volume":"18","author":"Yang","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.dsx.2022.102591_bib47","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fendo.2013.00099","article-title":"A\u00a0new cancer hallmark?","volume":"4","author":"Fardini","year":"2013","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.dsx.2022.102591_bib48","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1038\/s41598-019-42153-6","article-title":"O-GlcNActransferase inhibition differentially affects breast cancer subtypes","volume":"9","author":"Barkovskaya","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.dsx.2022.102591_bib49","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41419-018-0522-0","article-title":"O-GlcNAc elevation through activation of the hexosamine biosynthetic pathway enhances cancer cell chemoresistance","volume":"9","author":"Liu","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.dsx.2022.102591_bib50","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-77736-8_1","article-title":"Glucose metabolism in cancer","volume":"1063","author":"Bose","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.dsx.2022.102591_bib51","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.cell.2012.01.058","article-title":"Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism","volume":"149","author":"Ying","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.dsx.2022.102591_bib52","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-3-319-77736-8_5","article-title":"The intricate metabolism of pancreatic cancers","volume":"1063","author":"Camelo","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.dsx.2022.102591_bib53","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-3-319-77736-8_7","article-title":"Non-Hodgkin lymphoma metabolism","volume":"1063","author":"Kirsch","year":"2018","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"10.1016\/j.dsx.2022.102591_bib54","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: mechanism of cellular energy sensing and restoration of metabolic balance","volume":"66","author":"Gracia","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.dsx.2022.102591_bib55","article-title":"AMPK activation: a therapeutic target for type 2 diabetes?","author":"Coughlan","year":"2014","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"7","key":"10.1016\/j.dsx.2022.102591_bib56","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41573-019-0019-2","article-title":"AMP-activated protein kinase: the current landscape for drug development","volume":"18","author":"Steinberg","year":"2019","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"10.1016\/j.dsx.2022.102591_bib57","doi-asserted-by":"crossref","first-page":"E175","DOI":"10.1152\/ajpendo.00453.2005","article-title":"Thiazolidinediones can rapidly activate AMP- activated protein kinase in mammalian tissues","volume":"291","author":"LeBrasseur","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.dsx.2022.102591_bib58","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317697576","article-title":"Down-regulation of adenosine monophosphate-activated protein kinase activity: a driver of cancer","volume":"39","author":"He","year":"2017","journal-title":"Tumour Biol"},{"key":"10.1016\/j.dsx.2022.102591_bib59","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/BJ20150122","article-title":"Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex\u00a0vivo through inhibition of de novo lipogenesis","volume":"469","author":"Brien","year":"2015","journal-title":"Biochem J"},{"key":"10.1016\/j.dsx.2022.102591_bib60","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.molmet.2016.08.014","article-title":"The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration","volume":"5","author":"Villani","year":"2016","journal-title":"Mol Metabol"},{"key":"10.1016\/j.dsx.2022.102591_bib61","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.molcel.2005.03.027","article-title":"AMP-activated protein kinase induces a p53-dependent metabolic checkpoint","volume":"18","author":"Jones","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.dsx.2022.102591_bib62","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.devcel.2009.01.005","article-title":"AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development","volume":"16","author":"Dasgupta","year":"2009","journal-title":"Dev Cell"},{"key":"10.1016\/j.dsx.2022.102591_bib63","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ncb1537","article-title":"The energy sensing LKB1-AMPK pathway regulates p27 (kip1) phosphorylation mediating the decision to enter autophagy or apoptosis","volume":"9","author":"Liang","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.dsx.2022.102591_bib64","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.cmet.2015.09.009","article-title":"Identification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate prediction","volume":"22","author":"Schaffer","year":"2015","journal-title":"Cell Metabol"},{"key":"10.1016\/j.dsx.2022.102591_bib65","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.lfs.2019.04.039","article-title":"Role of AMPK and its molecular intermediates in subjugating cancer survival mechanism","volume":"227","author":"Thirupati","year":"2019","journal-title":"Life Sci"},{"key":"10.1016\/j.dsx.2022.102591_bib66","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/febs.13139","article-title":"ATP- citrate lyase regulates cellular senescence via an AMPK- and p53- dependent pathway","author":"Lee","year":"2015","journal-title":"FEBS J"},{"key":"10.1016\/j.dsx.2022.102591_bib67","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng1531","article-title":"Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer","volume":"37","author":"Fraga","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.dsx.2022.102591_bib68","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1158\/1541-7786.MCR-15-0068","article-title":"Dissecting the dual role of AMPK in cancer: from experimental to human studies","volume":"13","author":"Zadra","year":"2015","journal-title":"Mol Cancer. Res"},{"key":"10.1016\/j.dsx.2022.102591_bib69","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2013.05.017","article-title":"Cellular fatty acid metabolism and cancer","volume":"18","author":"Currie","year":"2013","journal-title":"Cell Metabol"},{"issue":"2","key":"10.1016\/j.dsx.2022.102591_bib70","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.molcel.2020.09.018","article-title":"Phosphorylation of PDHA by AMPK drives TCA cycle to promote cancer metastasis","volume":"80","author":"Cai","year":"2020","journal-title":"Mol Cell"},{"key":"10.1016\/j.dsx.2022.102591_bib71","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.breast.2016.08.014","article-title":"High expressions of LDHA and AMPK as prognostic biomarkers for breast cancer","volume":"30","author":"Huang","year":"2016","journal-title":"Breast J"},{"key":"10.1016\/j.dsx.2022.102591_bib72","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.yexcr.2019.04.006","article-title":"KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming","volume":"379","author":"Zhang","year":"2019","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.dsx.2022.102591_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110821","article-title":"Sodium-glucose co-transporter- 2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK\/mTOR pathway","volume":"132","author":"Zhou","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.dsx.2022.102591_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112190","article-title":"The induction of AMPK-dependent autophagy leads to P53 degradation and affects cell growth and migration in kidney cancer cells","volume":"395","author":"Patergnani","year":"2020","journal-title":"Exp Cell Res"},{"issue":"3","key":"10.1016\/j.dsx.2022.102591_bib75","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ccell.2020.05.022","article-title":"SETD2 restricts prostate cancer metastasis by integrating EZH2 and AMPK signaling pathways","volume":"38","author":"Yuan","year":"2020","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.dsx.2022.102591_bib76","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.dsx.2016.09.009","article-title":"Activation of the receptor for advanced glycation end products and consequences on health","volume":"11","author":"Wautier","year":"2017","journal-title":"Diabetes Metabol Syndr"},{"key":"10.1016\/j.dsx.2022.102591_bib77","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.2174\/1381612825666190130145549","article-title":"Role of advanced glycation end products in carcinogenesis and their therapeutic implications","volume":"24","author":"Schroter","year":"2018","journal-title":"Curr Pharmaceut Des"},{"issue":"11","key":"10.1016\/j.dsx.2022.102591_bib78","first-page":"878","article-title":"Cancer risk among patients with type 2 diabetes: a real-world study in Shanghai, China","volume":"11","author":"Qi","year":"2019","journal-title":"J\u00a0Diabetes"}],"container-title":["Diabetes &amp; Metabolic Syndrome: Clinical Research &amp; Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402122002053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402122002053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:19:17Z","timestamp":1761729557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871402122002053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":78,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S1871402122002053"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2022.102591","relation":{},"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Type-2 diabetes mellitus-associated cancer risk: In pursuit of understanding the possible link","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dsx.2022.102591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Diabetes India. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102591"}}