{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:29:20Z","timestamp":1786987760566,"version":"build-2736575974"},"reference-count":77,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.dsx.2024.103068","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T19:43:30Z","timestamp":1719603810000},"page":"103068","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Unique metabolomics characteristics for distinguishing cirrhosis related to different liver diseases: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"18","author":[{"given":"Liu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zicheng","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenshen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lexin","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.dsx.2024.103068_bib1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S2468-1253(19)30349-8","article-title":"The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990\u20132017: a systematic analysis for the global burden of disease study 2017","volume":"5","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.dsx.2024.103068_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver","volume":"70","author":"Asrani","year":"2019","journal-title":"J Hepatol"},{"issue":"10308","key":"10.1016\/j.dsx.2024.103068_bib3","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver cirrhosis","volume":"398","author":"Gin\u00e8s","year":"2021","journal-title":"Lancet"},{"issue":"18","key":"10.1016\/j.dsx.2024.103068_bib4","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1001\/jama.2023.5997","article-title":"Diagnosis and management of cirrhosis and its complications: a review","volume":"329","author":"Tapper","year":"2023","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.dsx.2024.103068_bib5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13244-024-01692-x","article-title":"Determining the ideal measurement site and respiratory condition for liver transient elastography: toward clinical practice standardization","volume":"15","author":"Huang","year":"2024","journal-title":"Insights Imaging"},{"issue":"4","key":"10.1016\/j.dsx.2024.103068_bib6","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jhep.2011.01.031","article-title":"Serum metabolomics reveals \u03b3-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease","volume":"55","author":"Soga","year":"2011","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.dsx.2024.103068_bib7","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1021\/acs.jproteome.0c00852","article-title":"Bile acid profiles are distinct among patients with different etiologies of chronic liver disease","volume":"20","author":"Sang","year":"2021","journal-title":"J Proteome Res"},{"issue":"24","key":"10.1016\/j.dsx.2024.103068_bib8","first-page":"S0168","article-title":"Opportunities and barriers in omics-based biomarker discovery for steatotic liver diseases","volume":"28","author":"Thiele","year":"2024","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.dsx.2024.103068_bib9","article-title":"Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury","volume":"11","author":"Li","year":"2021","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.dsx.2024.103068_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12944-017-0551-1","article-title":"Free fatty acids profile among lean, overweight and obese non-alcoholic fatty liver disease patients: a case-control study","volume":"16","author":"Feng","year":"2017","journal-title":"Lipids Health"},{"issue":"7","key":"10.1016\/j.dsx.2024.103068_bib11","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.3390\/biomedicines10071669","article-title":"Plasma metabolomics and machine learning-driven novel diagnostic signature for non-alcoholic steatohepatitis","volume":"10","author":"Ji","year":"2022","journal-title":"Biomedicines"},{"issue":"10","key":"10.1016\/j.dsx.2024.103068_bib12","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1194\/jlr.M085613","article-title":"Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression","volume":"59","author":"Peng","year":"2018","journal-title":"J Lipid Res"},{"issue":"4","key":"10.1016\/j.dsx.2024.103068_bib13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bjd.18336","article-title":"Common methodological pitfalls and new developments in systematic review meta-analyses","volume":"181","author":"Leonardi-Bee","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.dsx.2024.103068_bib14","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.dsx.2024.103068_bib15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.dsx.2024.103068_bib16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jpsychires.2021.05.036","article-title":"A systematic review and meta-analysis of lipid metabolomic signatures of major depressive disorder","volume":"139","author":"Bharti","year":"2021","journal-title":"J Psychiatr Res"},{"issue":"5","key":"10.1016\/j.dsx.2024.103068_bib17","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2337\/dc15-2251","article-title":"Metabolomics in prediabetes and diabetes: a systematic review and meta-analysis","volume":"39","author":"Guasch-Ferr\u00e9","year":"2016","journal-title":"Diabetes Care"},{"issue":"7414","key":"10.1016\/j.dsx.2024.103068_bib18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.dsx.2024.103068_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2217\/bmm.13.150","article-title":"Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children","volume":"8","author":"Bhattacharyya","year":"2014","journal-title":"Biomarkers Med"},{"issue":"4","key":"10.1016\/j.dsx.2024.103068_bib20","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/cts.13009","article-title":"A metabolomic analysis of thiol response for standard and modified N-acetyl cysteine treatment regimens in patients with acetaminophen overdose","volume":"14","author":"Dear","year":"2021","journal-title":"Clin Transl Sci"},{"issue":"7","key":"10.1016\/j.dsx.2024.103068_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131010","article-title":"Comparison of bile acids and acetaminophen protein adducts in children and adolescents with acetaminophen toxicity","volume":"10","author":"James","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.dsx.2024.103068_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/cts.12425","article-title":"Exploration of biomarkers for amoxicillin\/clavulanate-induced liver injury: multi-omics approaches","volume":"10","author":"Lee","year":"2017","journal-title":"Clin Transl Sci"},{"issue":"31","key":"10.1016\/j.dsx.2024.103068_bib23","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000016717","article-title":"Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury","volume":"98","author":"Ma","year":"2019","journal-title":"Medicine (Baltim)"},{"issue":"9","key":"10.1016\/j.dsx.2024.103068_bib24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/metabo10090355","article-title":"Plasma lipid profiling of three types of drug-induced liver injury in Japanese patients: a preliminary study","volume":"10","author":"Saito","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.dsx.2024.103068_bib25","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3390\/metabo11120852","article-title":"Targeted metabolomics analysis of bile acids in patients with idiosyncratic drug-induced liver injury","volume":"11","author":"Xie","year":"2021","journal-title":"Metabolites"},{"issue":"16","key":"10.1016\/j.dsx.2024.103068_bib26","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.3748\/wjg.v22.i16.4191","article-title":"Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: a biomarker corroboration study","volume":"22","author":"Cox","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.dsx.2024.103068_bib27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jchromb.2015.12.011","article-title":"Phospholipidomic identification of potential serum biomarkers in dengue fever, hepatitis B and hepatitis C using liquid chromatography-electrospray ionization-tandem mass spectrometry","volume":"1009\u20131010","author":"Khedr","year":"2016","journal-title":"J Chromatogr, B: Anal Technol Biomed Life Sci"},{"issue":"3","key":"10.1016\/j.dsx.2024.103068_bib28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11306-018-1326-z","article-title":"Omega-6-derived oxylipin changes in serum of patients with hepatitis B virus-related liver diseases","volume":"14","author":"Lu","year":"2018","journal-title":"Metabolomics"},{"issue":"8","key":"10.1016\/j.dsx.2024.103068_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104988","article-title":"Serum sphingolipids reflect the severity of chronic HBV infection and predict the mortality of HBV-acute-on-chronic liver failure","volume":"9","author":"Qu","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.dsx.2024.103068_bib30","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13073-016-0318-8","article-title":"Metabolic characterization of the natural progression of chronic hepatitis B","volume":"8","author":"Schoeman","year":"2016","journal-title":"Genome Med"},{"issue":"10","key":"10.1016\/j.dsx.2024.103068_bib31","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.4155\/bio-2018-0319","article-title":"Quantification of serum purine metabolites for distinguishing patients with hepatitis B from hepatocellular carcinoma","volume":"11","author":"Zhang","year":"2019","journal-title":"Bioanalysis"},{"issue":"2","key":"10.1016\/j.dsx.2024.103068_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029531","article-title":"A switch in hepatic cortisol metabolism across the spectrum of non-alcoholic fatty liver disease","volume":"7","author":"Ahmed","year":"2012","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.dsx.2024.103068_bib33","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.3390\/ijms23147830","article-title":"Laparoscopic sleeve gastrectomy in patients with severe obesity restores adaptive responses leading to nonalcoholic steatohepatitis","volume":"23","author":"Cabr\u00e9","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.dsx.2024.103068_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138889","article-title":"Adipose tissue dysfunction and altered systemic amino acid metabolism are associated with non-alcoholic fatty liver disease","volume":"10","author":"Cheng","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.dsx.2024.103068_bib35","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.diabet.2018.09.003","article-title":"Clinical and metabolic characterization of obese subjects without non-alcoholic fatty liver: a targeted metabolomics approach","volume":"45","author":"Feldman","year":"2019","journal-title":"Diabetes Metab"},{"issue":"11","key":"10.1016\/j.dsx.2024.103068_bib36","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1007\/s10620-015-3776-8","article-title":"Altered bile acid metabolome in patients with nonalcoholic steatohepatitis","volume":"60","author":"Ferslew","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dsx.2024.103068_bib37","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.abb.2017.04.009","article-title":"Adrenic acid as an inflammation enhancer in non-alcoholic fatty liver disease","volume":"623\u2013624","author":"Horas","year":"2017","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"10.1016\/j.dsx.2024.103068_bib38","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/hep.28899","article-title":"Metabolic profiling of fatty liver in young and middle-aged adults: cross-sectional and prospective analyses of the young Finns study","volume":"65","author":"Kaikkonen","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.dsx.2024.103068_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103661","article-title":"The altered serum lipidome and its diagnostic potential for non-alcoholic fatty liver (NAFL)-associated hepatocellular carcinoma","volume":"73","author":"Lewinska","year":"2021","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.dsx.2024.103068_bib40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1194\/jlr.P055640","article-title":"Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis","volume":"56","author":"Loomba","year":"2015","journal-title":"J Lipid Res"},{"issue":"7","key":"10.1016\/j.dsx.2024.103068_bib41","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1111\/liv.12769","article-title":"Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans","volume":"35","author":"M\u00e4nnist\u00f6","year":"2015","journal-title":"Liver Int"},{"issue":"4","key":"10.1016\/j.dsx.2024.103068_bib42","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/hep.32427","article-title":"Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles","volume":"76","author":"Mart\u00ednez-Arranz","year":"2022","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.dsx.2024.103068_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsec\/fiu002","article-title":"Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease","volume":"91","author":"Michail","year":"2015","journal-title":"FEMS Microbiol Ecol"},{"issue":"5","key":"10.1016\/j.dsx.2024.103068_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151829","article-title":"Bile acids and dysbiosis in non-alcoholic fatty liver disease","volume":"11","author":"Mouzaki","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.dsx.2024.103068_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154457","article-title":"Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression","volume":"116","author":"Nimer","year":"2021","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.dsx.2024.103068_bib46","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/hep.29359","article-title":"The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids","volume":"67","author":"Puri","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.dsx.2024.103068_bib47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cca.2017.08.022","article-title":"Metabonomics screening of serum identifies pyroglutamate as a diagnostic biomarker for nonalcoholic steatohepatitis","volume":"473","author":"Qi","year":"2017","journal-title":"Clin Chim Acta"},{"issue":"11","key":"10.1016\/j.dsx.2024.103068_bib48","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3390\/metabo11110737","article-title":"Aqueous metabolite trends for the progression of nonalcoholic fatty liver disease in female bariatric surgery patients by targeted 1H-NMR metabolomics","volume":"11","author":"Robinson","year":"2021","journal-title":"Metabolites"},{"issue":"3","key":"10.1016\/j.dsx.2024.103068_bib49","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000131","article-title":"Altered microbiota diversity and bile acid signaling in cirrhotic and noncirrhotic NASH-HCC","volume":"11","author":"Sydor","year":"2020","journal-title":"Clin Transl Gastroenterol"},{"issue":"1","key":"10.1016\/j.dsx.2024.103068_bib50","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41467-020-20422-7","article-title":"Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma","volume":"12","author":"Behary","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.dsx.2024.103068_bib51","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/liv.14256","article-title":"Metabolomics and microbial composition increase insight into the impact of dietary differences in cirrhosis","volume":"40","author":"Cox","year":"2020","journal-title":"Liver Int"},{"issue":"12","key":"10.1016\/j.dsx.2024.103068_bib52","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.4254\/wjh.v7.i12.1701","article-title":"(1) H nuclear magnetic resonance spectroscopy-based metabonomic study in patients with cirrhosis and hepatic encephalopathy","volume":"7","author":"Dabos","year":"2015","journal-title":"World J Hepatol"},{"key":"10.1016\/j.dsx.2024.103068_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/bjbs.2021.10191","article-title":"Value of bile acids in diagnosing hepatitis C virus-induced liver cirrhosis and hepatocellular carcinoma","volume":"79","author":"Khalil","year":"2022","journal-title":"Br J Biomed Sci"},{"issue":"3","key":"10.1016\/j.dsx.2024.103068_bib54","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/ijc.28706","article-title":"NMR and LC\/MS-based global metabolomics to identify serum biomarkers differentiating hepatocellular carcinoma from liver cirrhosis","volume":"135","author":"Liu","year":"2014","journal-title":"Int J Cancer"},{"issue":"5","key":"10.1016\/j.dsx.2024.103068_bib55","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1053\/j.gastro.2020.12.008","article-title":"Integrated multiomics reveals glucose use reprogramming and identifies a novel hexokinase in alcoholic hepatitis","volume":"160","author":"Massey","year":"2021","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.dsx.2024.103068_bib56","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s11011-016-9904-0","article-title":"Urinary metabolic profiling by (1)H NMR spectroscopy in patients with cirrhosis may discriminate overt but not covert hepatic encephalopathy","volume":"32","author":"McPhail","year":"2017","journal-title":"Metab Brain Dis"},{"issue":"7","key":"10.1016\/j.dsx.2024.103068_bib57","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1872-034X.2011.00964.x","article-title":"Comparison of the metabolic profiling of hepatitis B virus-infected cirrhosis and alcoholic cirrhosis patients by using (1) H NMR-based metabonomics","volume":"42","author":"Qi","year":"2012","journal-title":"Hepatol Res"},{"issue":"4","key":"10.1016\/j.dsx.2024.103068_bib58","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.dld.2011.10.025","article-title":"Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: a pilot study","volume":"44","author":"Trottier","year":"2012","journal-title":"Dig Liver Dis"},{"issue":"2","key":"10.1016\/j.dsx.2024.103068_bib59","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/hep.31256","article-title":"Circulating extracellular vesicles carrying sphingolipid cargo for the diagnosis and dynamic risk profiling of alcoholic hepatitis","volume":"73","author":"Sehrawat","year":"2021","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.dsx.2024.103068_bib60","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.nut.2014.03.016","article-title":"Ammonia and amino acid profiles in liver cirrhosis: effects of variables leading to hepatic encephalopathy","volume":"31","author":"Holecek","year":"2015","journal-title":"Nutrition"},{"issue":"3","key":"10.1016\/j.dsx.2024.103068_bib61","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1872-034X.2007.00268.x","article-title":"Measurement of serum branched-chain amino acids to tyrosine ratio level is useful in a prediction of a change of serum albumin level in chronic liver disease","volume":"38","author":"Suzuki","year":"2008","journal-title":"Hepatol Res"},{"issue":"4","key":"10.1016\/j.dsx.2024.103068_bib62","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1872-034X.2009.00614.x","article-title":"Amino acid imbalance in patients with chronic liver diseases","volume":"40","author":"Michitaka","year":"2010","journal-title":"Hepatol Res"},{"issue":"2","key":"10.1016\/j.dsx.2024.103068_bib63","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jhep.2005.03.017","article-title":"Enterohepatic transport of bile salts and genetics of cholestasis","volume":"43","author":"Pauli-Magnus","year":"2005","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.dsx.2024.103068_bib64","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41572-019-0105-0","article-title":"Drug-induced liver injury","volume":"5","author":"Andrade","year":"2019","journal-title":"Nat Rev Dis Prim"},{"issue":"1","key":"10.1016\/j.dsx.2024.103068_bib65","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12876-018-0842-7","article-title":"Taurocholic acid is an active promoting factor, not just a biomarker of progression of liver cirrhosis: evidence from a human metabolomic study and in vitro experiments","volume":"18","author":"Liu","year":"2018","journal-title":"BMC Gastroenterol"},{"issue":"8","key":"10.1016\/j.dsx.2024.103068_bib66","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.cgh.2023.02.005","article-title":"New treatment paradigms in primary biliary cholangitis","volume":"21","author":"Levy","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.dsx.2024.103068_bib67","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.dsx.2024.103068_bib68","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1089\/ars.2017.7338","article-title":"Metabolism, nutrition, and redox signaling of hydroxyproline","volume":"30","author":"Wu","year":"2019","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.dsx.2024.103068_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2023.103532","article-title":"Comparison of surface-enhanced Raman spectral data sets of filtrate portions of serum samples of hepatitis B and Hepatitis C infected patients obtained by centrifugal filtration","volume":"42","author":"Nawaz","year":"2023","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"5","key":"10.1016\/j.dsx.2024.103068_bib70","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.jhep.2013.06.026","article-title":"Molecular MRI of collagen to diagnose and stage liver fibrosis","volume":"59","author":"Fuchs","year":"2013","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.dsx.2024.103068_bib71","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1053\/j.gastro.2011.01.040","article-title":"Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice","volume":"140","author":"Popov","year":"2011","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.dsx.2024.103068_bib72","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/cbin.11206","article-title":"Tripartite motif protein 52 (TRIM52) promoted fibrosis in LX-2 cells through PPM1A-mediated Smad2\/3 pathway","volume":"44","author":"Zhou","year":"2020","journal-title":"Cell Biol Int"},{"issue":"3","key":"10.1016\/j.dsx.2024.103068_bib81","first-page":"367","article-title":"Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR\/LXR-mediated P2X7R\/NLRP3\/NF-kappaB pathway activation","volume":"14","author":"Bao","year":"2022","journal-title":"Chin Herb Med"},{"issue":"11","key":"10.1016\/j.dsx.2024.103068_bib73","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.3390\/nu10111586","article-title":"Advanced liver fibrosis is independently associated with palmitic acid and insulin levels in patients with non-alcoholic fatty liver disease","volume":"10","author":"Cansan\u00e7\u00e3o","year":"2018","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.dsx.2024.103068_bib74","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/s41575-021-00502-9","article-title":"Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests","volume":"18","author":"Masoodi","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.dsx.2024.103068_bib83","first-page":"421","article-title":"Cassiae Semen improves non-alcoholic fatty liver disease through autophagy-related pathway","volume":"15","author":"Ding","year":"2023","journal-title":"Chin Herb Med"},{"issue":"8","key":"10.1016\/j.dsx.2024.103068_bib75","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.cmet.2021.06.012","article-title":"FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption","volume":"33","author":"Clifford","year":"2021","journal-title":"Cell Metabol"}],"container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402124001292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871402124001292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T03:35:14Z","timestamp":1737776114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871402124001292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":77,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S1871402124001292"],"URL":"https:\/\/doi.org\/10.1016\/j.dsx.2024.103068","relation":{},"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unique metabolomics characteristics for distinguishing cirrhosis related to different liver diseases: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dsx.2024.103068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd on behalf of Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC).","name":"copyright","label":"Copyright"}],"article-number":"103068"}}