{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:45:59Z","timestamp":1785257159127,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.earlhumdev.2006.05.003","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T11:44:37Z","timestamp":1150976677000},"page":"77-85","source":"Crossref","is-referenced-by-count":13,"title":["Inhaled nitric oxide treatment inhibits neuronal injury after meconium aspiration in piglets"],"prefix":"10.1016","volume":"83","author":[{"given":"Minna","family":"Aaltonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Soukka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri","family":"Halkola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmo","family":"Jalonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Kalimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma E.","family":"Holopainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka O.","family":"K\u00e4\u00e4p\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.earlhumdev.2006.05.003_bib1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0031-3955(05)70025-0","article-title":"Meconium-stained amniotic fluid and the meconium aspiration syndrome. An update","volume":"45","author":"Cleary","year":"1998","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.earlhumdev.2006.05.003_bib2","series-title":"Fetal and neonatal brain injury. Mechanisms, management and the risks of practice","first-page":"612","article-title":"Meconium staining and the meconium aspiration syndrome","author":"Wiswell","year":"2003"},{"issue":"2","key":"10.1016\/j.earlhumdev.2006.05.003_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ppul.1950160205","article-title":"Meconium aspiration syndrome: physiological and inflammatory changes in a newborn piglet model","volume":"16","author":"Davey","year":"1993","journal-title":"Pediatr Pulmonol"},{"issue":"2","key":"10.1016\/j.earlhumdev.2006.05.003_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/(SICI)1099-0496(199802)25:2<107::AID-PPUL6>3.0.CO;2-K","article-title":"Meconium aspiration induces a concentration-dependent pulmonary hypertensive response in newborn piglets","volume":"25","author":"Holopainen","year":"1998","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"10.1016\/j.earlhumdev.2006.05.003_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/archpedi.1985.02140030027020","article-title":"Persistent fetal circulation. Neurodevelopmental outcome","volume":"139","author":"Sell","year":"1985","journal-title":"Am J Dis Child"},{"issue":"6","key":"10.1016\/j.earlhumdev.2006.05.003_bib6","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0022-3476(95)70197-4","article-title":"Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn","volume":"126","author":"Kinsella","year":"1995","journal-title":"J Pediatr"},{"issue":"5","key":"10.1016\/j.earlhumdev.2006.05.003_bib7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.earlhumdev.2005.03.011","article-title":"Meconium aspiration induces oxidative injury in the hippocampus of newborn piglets","volume":"81","author":"Aaltonen","year":"2005","journal-title":"Early Hum Dev"},{"issue":"9","key":"10.1016\/j.earlhumdev.2006.05.003_bib8","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1056\/NEJM199702273360901","article-title":"Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. The Neonatal Inhaled Nitric Oxide Study Group","volume":"336","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.earlhumdev.2006.05.003_bib9","series-title":"Fetal and neonatal brain injury. Mechanisms, management and the risks of practice","first-page":"636","article-title":"Meconium staining and the meconium aspiration syndrome","author":"Van Meurs","year":"2003"},{"issue":"8","key":"10.1016\/j.earlhumdev.2006.05.003_bib10","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1097\/00003246-199508000-00013","article-title":"Cerebral hemodynamics and distribution of left ventricular output during inhalation of nitric oxide","volume":"23","author":"Rosenberg","year":"1995","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.earlhumdev.2006.05.003_bib11","doi-asserted-by":"crossref","first-page":"F30","DOI":"10.1136\/fn.80.1.F30","article-title":"Cerebral blood flow during treatment for pulmonary hypertension","volume":"80","author":"Kusuda","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"4","key":"10.1016\/j.earlhumdev.2006.05.003_bib12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-2001-15502","article-title":"Cerebral blood flow velocity acutely decreases in newborns who respond to inhaled nitric oxide","volume":"18","author":"Day","year":"2001","journal-title":"Am J Perinatol"},{"issue":"8","key":"10.1016\/j.earlhumdev.2006.05.003_bib13","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/BF03019384","article-title":"Inhaled nitric oxide in 2003: a review of its mechanisms of action","volume":"50","author":"Wang","year":"2003","journal-title":"Can J Anaesth"},{"issue":"3","key":"10.1016\/j.earlhumdev.2006.05.003_bib14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1203\/01.PDR.0000049514.02607.03","article-title":"Asphyxia aggravates systemic hypotension but not pulmonary hypertension in piglets with meconium aspiration","volume":"53","author":"Aaltonen","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1016\/j.earlhumdev.2006.05.003_bib15","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1080\/08035250510042816","article-title":"Meconium aspiration induces neuronal injury in piglets","volume":"94","author":"Aaltonen","year":"2005","journal-title":"Acta Paediatr"},{"issue":"1","key":"10.1016\/j.earlhumdev.2006.05.003_bib16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF02259131","article-title":"Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death","volume":"88","author":"Deshpande","year":"1992","journal-title":"Exp Brain Res"},{"issue":"2","key":"10.1016\/j.earlhumdev.2006.05.003_bib17","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0003-2697(83)90019-2","article-title":"Assay method for myeloperoxidase in human polymorphonuclear leukocytes","volume":"132","author":"Suzuki","year":"1983","journal-title":"Anal Biochem"},{"issue":"3","key":"10.1016\/j.earlhumdev.2006.05.003_bib18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/PL00005054","article-title":"Antioxidant properties of the triphenylethylene antiestrogen drug toremifene","volume":"356","author":"Ahotupa","year":"1997","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"10.1016\/j.earlhumdev.2006.05.003_bib19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0076-6879(84)05038-2","article-title":"Comparative studies on different methods of malonaldehyde determination","volume":"105","author":"Bird","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.earlhumdev.2006.05.003_bib20","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1039\/an9588300670","article-title":"A scheme for the colorimetric determination of microgram amounts of thiols","volume":"83","author":"Saville","year":"1958","journal-title":"Analyst"},{"issue":"1","key":"10.1016\/j.earlhumdev.2006.05.003_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum Dev"},{"issue":"2","key":"10.1016\/j.earlhumdev.2006.05.003_bib22","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/cvr\/15.2.108","article-title":"Adaptation of the pulmonary circulation to extra-uterine life in the pig and its relevance to the human infant","volume":"15","author":"Haworth","year":"1981","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.earlhumdev.2006.05.003_bib23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/bja\/86.2.267","article-title":"Renal effects of inhaled nitric oxide in humans","volume":"86","author":"Wraight","year":"2001","journal-title":"Br J Anaesth"},{"issue":"11","key":"10.1016\/j.earlhumdev.2006.05.003_bib24","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1172\/JCI2736","article-title":"Inhaled NO as a viable antiadhesive therapy for ischemia\/reperfusion injury of distal microvascular beds","volume":"101","author":"Fox-Robichaud","year":"1998","journal-title":"J Clin Invest"},{"issue":"16","key":"10.1016\/j.earlhumdev.2006.05.003_bib25","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1073\/pnas.89.16.7674","article-title":"Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin","volume":"89","author":"Stamler","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.earlhumdev.2006.05.003_bib26","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000244322","article-title":"Inhalation of nitric oxide: effect on cerebral hemodynamics and activity, and antioxidant status in the newborn lamb","volume":"69","author":"Lopes Cardozo","year":"1996","journal-title":"Biol Neonate"},{"issue":"10","key":"10.1016\/j.earlhumdev.2006.05.003_bib27","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1651-2227.1999.tb01004.x","article-title":"Nitric oxide inhalation inhibits pulmonary apoptosis but not inflammatory injury in porcine meconium aspiration","volume":"88","author":"Holopainen","year":"1999","journal-title":"Acta Paediatr"},{"issue":"6","key":"10.1016\/j.earlhumdev.2006.05.003_bib28","doi-asserted-by":"crossref","first-page":"H1783","DOI":"10.1152\/ajpheart.2000.278.6.H1783","article-title":"Inhaled NO reduces leukocyte-endothelial cell interactions and myocardial dysfunction in endotoxemic rats","volume":"278","author":"Neviere","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"10.1016\/j.earlhumdev.2006.05.003_bib29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1203\/00006450-199705000-00001","article-title":"Reperfusion injury as the mechanism of brain damage after perinatal asphyxia","volume":"41","author":"Fellman","year":"1997","journal-title":"Pediatr Res"},{"issue":"2 Pt 2","key":"10.1016\/j.earlhumdev.2006.05.003_bib30","first-page":"H676","article-title":"Inhaled NO impacts vascular but not extravascular compartments in postischemic peripheral organs","volume":"277","author":"Kubes","year":"1999","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1016\/j.earlhumdev.2006.05.003_bib31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0163-7258(99)00044-3","article-title":"Nitric oxide in the lung: therapeutic and cellular mechanisms of action","volume":"84","author":"Weinberger","year":"1999","journal-title":"Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.earlhumdev.2006.05.003_bib32","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1067\/mpd.2002.122730","article-title":"Neurodevelopmental and medical outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide","volume":"140","author":"Lipkin","year":"2002","journal-title":"J Pediatr"}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378206001496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378206001496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T14:02:39Z","timestamp":1555682559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378206001496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0378378206001496"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2006.05.003","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}