{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:27:02Z","timestamp":1791937622606,"version":"4.3.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.earlhumdev.2008.11.006","type":"journal-article","created":{"date-parts":[[2009,1,7]],"date-time":"2009-01-07T09:15:22Z","timestamp":1231319722000},"page":"73-76","source":"Crossref","is-referenced-by-count":21,"title":["Clinical aspects of induced hypothermia in full term neonates with perinatal asphyxia"],"prefix":"10.1016","volume":"85","author":[{"given":"Floris","family":"Groenendaal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke J.","family":"Brouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.earlhumdev.2008.11.006_bib1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib2","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic\u2013ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib3","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","author":"Jacobs","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib4","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1542\/peds.2007-3310","article-title":"Hypothermia: an evolving treatment for neonatal hypoxic ischemic encephalopathy","volume":"121","author":"Gunn","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1053\/siny.1999.0119","article-title":"Selection of babies for intervention after birth asphyxia","volume":"5","author":"Groenendaal","year":"2000","journal-title":"Semin Neonatol"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000084096","article-title":"Severe umbilical cord acidemia and neurological outcome in preterm and full-term neonates","volume":"88","author":"Lavrijsen","year":"2005","journal-title":"Biol Neonate"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib7","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress; a clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch Neurol"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1651-2227.1997.tb08581.x","article-title":"The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome","volume":"86","author":"Thompson","year":"1997","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib9","doi-asserted-by":"crossref","first-page":"F19","DOI":"10.1136\/fn.81.1.F19","article-title":"Amplitude integrated EEG at 3 and 6\u00a0hours after birth in fullterm neonates with hypoxic\u2013ischaemic encephalopathy","volume":"81","author":"Toet","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1055\/s-2000-7496","article-title":"MR patterns of hypoxic\u2013ischemic brain damage after prenatal, perinatal or postnatal asphyxia","volume":"31","author":"Sie","year":"2000","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib11","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1542\/peds.2004-0222","article-title":"Diffusion-weighted magnetic resonance imaging in term perinatal brain injury: a comparison with site of lesion and time from birth","volume":"114","author":"Rutherford","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib12","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1203\/00006450-200104000-00024","article-title":"Effective selective head cooling during posthypoxic hypothermia in newborn piglets","volume":"49","author":"Thoresen","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib13","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0140-6736(08)61329-X","article-title":"Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trial","volume":"372","author":"Robertson","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1203\/00006450-200109000-00017","article-title":"Twenty-four hours of mild hypothermia in unsedated newborn pigs starting after a severe global hypoxic\u2013ischemic insult is not neuroprotective","volume":"50","author":"Thoresen","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.clp.2006.06.012","article-title":"Mechanisms of injury to the newborn brain","volume":"33","author":"Fritz","year":"2006","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib16","first-page":"123","article-title":"Blood gas values during hypothermia in asphyxiated full term neonates","author":"Groenendaal","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib17","doi-asserted-by":"crossref","first-page":"e844","DOI":"10.1542\/peds.2007-1987","article-title":"Elevated morphine concentrations in neonates treated with morphine and prolonged hypothermia for hypoxic ischemic encephalopathy","volume":"121","author":"Roka","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jpeds.2007.06.003","article-title":"Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy","volume":"152","author":"Gunn","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib19","doi-asserted-by":"crossref","first-page":"F380","DOI":"10.1136\/adc.2004.067520","article-title":"Neuropsychological and educational problems at school age associated with neonatal encephalopathy","volume":"90","author":"Marlow","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000143723","article-title":"Long-term pharmacologic neuroprotection after birth asphyxia: where do we stand?","volume":"94","author":"van Bel","year":"2008","journal-title":"Neonatology"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib21","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1542\/peds.102.4.885","article-title":"Selective head cooling in newborn infants after perinatal asphyxia: a safety study","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2008.11.006_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pediatrneurol.2004.06.014","article-title":"Moderate hypothermia in neonatal encephalopathy: efficacy outcomes","volume":"32","author":"Eicher","year":"2005","journal-title":"Pediatr Neurol"}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378208006294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378208006294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T15:20:51Z","timestamp":1545492051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378208006294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0378378208006294"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2008.11.006","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}