{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:30:08Z","timestamp":1770895808348,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.earlhumdev.2011.12.030","type":"journal-article","created":{"date-parts":[[2012,2,18]],"date-time":"2012-02-18T10:47:11Z","timestamp":1329562031000},"page":"583-587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association between neonatal iron overload and early human brain development in premature infants"],"prefix":"10.1016","volume":"88","author":[{"given":"Sanjiv B.","family":"Amin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.earlhumdev.2011.12.030_bb0005","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1203\/00006450-200008000-00003","article-title":"Perinatal iron deficiency and the developing brain","volume":"48","author":"Lozoff","year":"2000","journal-title":"Pediatr Res"},{"issue":"2","key":"10.1016\/j.earlhumdev.2011.12.030_bb0010","doi-asserted-by":"crossref","first-page":"614S","DOI":"10.1093\/ajcn\/85.2.614S","article-title":"Nutrition and the developing brain: nutrient priorities and measurement","volume":"85","author":"Georgieff","year":"2007","journal-title":"Am J Clin Nutr"},{"issue":"5 Pt 2","key":"10.1016\/j.earlhumdev.2011.12.030_bb0015","doi-asserted-by":"crossref","first-page":"99R","DOI":"10.1203\/01.PDR.0000160542.69840.0F","article-title":"Controversial nutrients that potentially affect preterm neurodevelopment: essential fatty acids and iron","volume":"57","author":"Georgieff","year":"2005","journal-title":"Pediatr Res"},{"issue":"3","key":"10.1016\/j.earlhumdev.2011.12.030_bb0020","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jpeds.2009.09.049","article-title":"In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response","volume":"156","author":"Amin","year":"2010","journal-title":"J Pediatr"},{"issue":"12","key":"10.1016\/j.earlhumdev.2011.12.030_bb0025","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/sj.jp.7211178","article-title":"Iron status and neurobehavioral development of premature infants","volume":"24","author":"Armony-Sivan","year":"2004","journal-title":"J Perinatol"},{"issue":"6","key":"10.1016\/j.earlhumdev.2011.12.030_bb0030","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1203\/01.pdr.0000127021.38207.62","article-title":"Iron deficiency alters auditory recognition memory in newborn infants of diabetic mothers","volume":"55","author":"Siddappa","year":"2004","journal-title":"Pediatr Res"},{"issue":"2","key":"10.1016\/j.earlhumdev.2011.12.030_bb0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1067\/mpd.2002.120688","article-title":"Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age","volume":"140","author":"Tamura","year":"2002","journal-title":"J Pediatr"},{"issue":"2\u20133","key":"10.1016\/j.earlhumdev.2011.12.030_bb0040","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF03033799","article-title":"Neuroprotective strategies in Parkinson's disease: protection against progressive nigral damage induced by free radicals","volume":"2","author":"Chiueh","year":"2000","journal-title":"Neurotox Res"},{"issue":"2","key":"10.1016\/j.earlhumdev.2011.12.030_bb0045","doi-asserted-by":"crossref","first-page":"F153","DOI":"10.1136\/adc.2006.108837","article-title":"Pathogenesis of cerebral white matter injury of prematurity","volume":"93","author":"Khwaja","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"3\u20134","key":"10.1016\/j.earlhumdev.2011.12.030_bb0050","first-page":"180","article-title":"Free radicals and brain damage in the newborn","volume":"79","author":"Buonocore","year":"2001","journal-title":"Biol Neonate"},{"issue":"1","key":"10.1016\/j.earlhumdev.2011.12.030_bb0055","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/01.rmr.0000245461.90406.ad","article-title":"Role of iron in neurodegenerative disorders","volume":"17","author":"Berg","year":"2006","journal-title":"Top Magn Reson Imaging"},{"issue":"7","key":"10.1016\/j.earlhumdev.2011.12.030_bb0060","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/jp.2008.22","article-title":"Iron metabolism and lipid peroxidation products in infants with hypoxic ischemic encephalopathy","volume":"28","author":"Shouman","year":"2008","journal-title":"J Perinatol"},{"issue":"4","key":"10.1016\/j.earlhumdev.2011.12.030_bb0065","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.pneurobio.2009.01.003","article-title":"Periventricular white matter damage in the hypoxic neonatal brain: role of microglial cells","volume":"87","author":"Kaur","year":"2009","journal-title":"Prog Neurobiol"},{"issue":"1","key":"10.1016\/j.earlhumdev.2011.12.030_bb0070","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/ars.2009.2668","article-title":"Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities","volume":"12","author":"Adibhatla","year":"2010","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"10.1016\/j.earlhumdev.2011.12.030_bb0075","doi-asserted-by":"crossref","first-page":"F101","DOI":"10.1136\/fn.84.2.F101","article-title":"Hepatic iron storage in very low birthweight infants after multiple blood transfusions","volume":"84","author":"Ng","year":"2001","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"4","key":"10.1016\/j.earlhumdev.2011.12.030_bb0080","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/sj.jp.7200522","article-title":"The role of high-dose oral iron supplementation during erythropoietin therapy for anemia of prematurity","volume":"21","author":"Bader","year":"2001","journal-title":"J Perinatol"},{"issue":"1","key":"10.1016\/j.earlhumdev.2011.12.030_bb0085","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jpeds.2005.08.052","article-title":"Iron sulfate supplementation decreases zinc protoporphyrin to heme ratio in premature infants","volume":"148","author":"Miller","year":"2006","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.earlhumdev.2011.12.030_bb0090","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpeds.2007.02.016","article-title":"Oxidative stress markers and antioxidant status after oral iron supplementation to very low birth weight infants","volume":"151","author":"Braekke","year":"2007","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.earlhumdev.2011.12.030_bb0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.clp.2008.09.013","article-title":"Iron therapy for preterm infants","volume":"36","author":"Rao","year":"2009","journal-title":"Clin Perinatol"},{"issue":"2","key":"10.1016\/j.earlhumdev.2011.12.030_bb0100","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0009-9120(94)00080-F","article-title":"Evaluation of the Technicon Immuno I random access immunoassay analyzer and calculation of pediatric reference ranges for endocrine tests, T-uptake, and ferritin","volume":"28","author":"Murthy","year":"1995","journal-title":"Clin Biochem"},{"issue":"4","key":"10.1016\/j.earlhumdev.2011.12.030_bb0105","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1542\/peds.106.4.707","article-title":"Venous and arterial hematologic profiles of very low birth weight infants. European Multicenter rhEPO Study Group","volume":"106","author":"Obladen","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2011.12.030_bb0110","article-title":"In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response","author":"Amin","year":"2009","journal-title":"J Pediatr"},{"issue":"4","key":"10.1016\/j.earlhumdev.2011.12.030_bb0115","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1469-8749.2008.02025.x","article-title":"A systematic review of the clinimetric properties of neuromotor assessments for preterm infants during the first year of life","volume":"50","author":"Spittle","year":"2008","journal-title":"Dev Med Child Neurol"},{"issue":"5","key":"10.1016\/j.earlhumdev.2011.12.030_bb0120","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.2307\/1129673","article-title":"Correction for prematurity and its consequences for the assessment of the very low birth weight infant","volume":"54","author":"Siegel","year":"1983","journal-title":"Child Dev"},{"issue":"2","key":"10.1016\/j.earlhumdev.2011.12.030_bb0125","first-page":"171","article-title":"Serum ferritin","volume":"10","author":"Worwood","year":"1979","journal-title":"CRC Crit Rev Clin Lab Sci"},{"issue":"5","key":"10.1016\/j.earlhumdev.2011.12.030_bb0130","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1542\/peds.75.5.976","article-title":"American Academy of Pediatrics Committee on Nutrition: nutritional needs of low-birth-weight infants","volume":"75","year":"1985","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.earlhumdev.2011.12.030_bb0135","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1542\/peds.2004-1884","article-title":"Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants","volume":"115","author":"Bell","year":"2005","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.earlhumdev.2011.12.030_bb0140","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1542\/peds.2004-2247","article-title":"Neurodevelopmental outcomes of extremely low birth weight infants <32weeks' gestation between 1993 and 1998","volume":"116","author":"Vohr","year":"2005","journal-title":"Pediatrics"},{"issue":"7","key":"10.1016\/j.earlhumdev.2011.12.030_bb0145","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.bbagen.2008.09.010","article-title":"Iron overload following red blood cell transfusion and its impact on disease severity","volume":"1790","author":"Ozment","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.earlhumdev.2011.12.030_bb0150","doi-asserted-by":"crossref","first-page":"F188","DOI":"10.1136\/fn.84.3.F188","article-title":"Blood transfusion increases radical promoting non-transferrin bound iron in preterm infants","volume":"84","author":"Hirano","year":"2001","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"1","key":"10.1016\/j.earlhumdev.2011.12.030_bb0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1042\/bj2430055","article-title":"Release of iron from ferritin by xanthine oxidase. Role of the superoxide radical","volume":"243","author":"Bolann","year":"1987","journal-title":"Biochem J"},{"issue":"1","key":"10.1016\/j.earlhumdev.2011.12.030_bb0160","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s004310050551","article-title":"Blood transfusion and chronic lung disease in preterm infants","volume":"156","author":"Cooke","year":"1997","journal-title":"Eur J Pediatr"},{"issue":"6","key":"10.1016\/j.earlhumdev.2011.12.030_bb0165","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s004310050641","article-title":"Blood transfusion. Iron load and retinopathy of prematurity","volume":"156","author":"Hesse","year":"1997","journal-title":"Eur J Pediatr"},{"issue":"4","key":"10.1016\/j.earlhumdev.2011.12.030_bb0170","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0022-3476(97)70058-1","article-title":"High iron status in very low birth weight infants is associated with an increased risk of retinopathy of prematurity","volume":"131","author":"Inder","year":"1997","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.earlhumdev.2011.12.030_bb0175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-3782(01)00115-3","article-title":"The role of blood transfusions and iron intake on retinopathy of prematurity","volume":"62","author":"Dani","year":"2001","journal-title":"Early Hum Dev"},{"issue":"8","key":"10.1016\/j.earlhumdev.2011.12.030_bb0180","doi-asserted-by":"crossref","first-page":"627","DOI":"10.7326\/0003-4819-138-8-200304150-00008","article-title":"Serum ferritin level predicts advanced hepatic fibrosis among U.S. patients with phenotypic hemochromatosis","volume":"138","author":"Morrison","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.earlhumdev.2011.12.030_bb0185","doi-asserted-by":"crossref","DOI":"10.1007\/s12072-009-9144-z","article-title":"The global burden of iron overload","author":"Wood","year":"2009","journal-title":"Hepatol Int"},{"key":"10.1016\/j.earlhumdev.2011.12.030_bb0190","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1182\/asheducation-2003.1.40","article-title":"Iron deficiency and overload","author":"Beutler","year":"2003","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"2","key":"10.1016\/j.earlhumdev.2011.12.030_bb0195","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.taap.2004.06.021","article-title":"Iron metabolism and toxicity","volume":"202","author":"Papanikolaou","year":"2005","journal-title":"Toxicol Appl Pharmacol"},{"issue":"3","key":"10.1016\/j.earlhumdev.2011.12.030_bb0200","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0955-3886(00)00089-8","article-title":"Transfusional iron overload and chelation therapy with deferoxamine and deferiprone (L1)","volume":"23","author":"Kontoghiorghes","year":"2000","journal-title":"Transfus Sci"},{"issue":"3","key":"10.1016\/j.earlhumdev.2011.12.030_bb0205","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0955-3886(00)00087-4","article-title":"The importance of non-transferrin bound iron in disorders of iron metabolism","volume":"23","author":"Breuer","year":"2000","journal-title":"Transfus Sci"},{"issue":"1","key":"10.1016\/j.earlhumdev.2011.12.030_bb0210","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1067\/mpd.2002.119626","article-title":"Prognostic value of the neurologic optimality score at 9 and 18months in preterm infants born before 31weeks' gestation","volume":"140","author":"Frisone","year":"2002","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.earlhumdev.2011.12.030_bb0215","doi-asserted-by":"crossref","first-page":"F111","DOI":"10.1136\/adc.2005.073262","article-title":"Usefulness of an early neurofunctional assessment in predicting neurodevelopmental outcome in very low birthweight infants","volume":"91","author":"Picciolini","year":"2006","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"12","key":"10.1016\/j.earlhumdev.2011.12.030_bb0220","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1111\/j.1651-2227.2000.tb02776.x","article-title":"Early motor development of premature infants with birthweight less than 2000grams","volume":"89","author":"Pedersen","year":"2000","journal-title":"Acta Paediatr"},{"issue":"4","key":"10.1016\/j.earlhumdev.2011.12.030_bb0225","first-page":"215","article-title":"Early identification of cerebral palsy in high risk infants","volume":"25","author":"Burns","year":"1989","journal-title":"Aust Paediatr J"},{"issue":"12","key":"10.1016\/j.earlhumdev.2011.12.030_bb0230","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.3945\/jn.108.094888","article-title":"Research needed to strengthen science and programs for the control of iron deficiency and its consequences in young children","volume":"138","author":"Stoltzfus","year":"2008","journal-title":"J Nutr"}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378211004002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378211004002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T01:55:39Z","timestamp":1759888539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378211004002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0378378211004002"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2011.12.030","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between neonatal iron overload and early human brain development in premature infants","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2011.12.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}