{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:22:22Z","timestamp":1769577742687,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","earlyhumandevelopment.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.earlhumdev.2015.09.008","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T19:41:07Z","timestamp":1445974867000},"page":"695-700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Cellular and humoral coagulation profiles and occurrence of IVH in VLBW and ELWB infants"],"prefix":"10.1016","volume":"91","author":[{"given":"Perrine","family":"Duppr\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni Z.","family":"Giannopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig","family":"Gortner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Nunold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Wagenpfeil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Geisel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0005","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.earlhumdev.2005.07.007","article-title":"Victorian Infant Collaborative Study Group: neurodevelopmental sequelae of intraventricular haemorrhage at 8years of age in a regional cohort of ELBW\/very preterm infants","volume":"81","author":"Sherlock","year":"2005","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0010","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S1474-4422(08)70294-1","article-title":"Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances","volume":"8","author":"Volpe","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0015","first-page":"489","article-title":"Prospective risk factor monitoring reduces intracranial hemorrhage rates in preterm infants","volume":"110","author":"Schmid","year":"2013","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0020","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1055\/s-0029-1214237","article-title":"Severe intraventricular hemorrhage in preterm infants: comparison of risk factors and short-term neonatal morbidities between grade 3 and grade 4 intraventricular hemorrhage","volume":"26","author":"Sarkar","year":"2009","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0025","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.clp.2008.07.014","article-title":"The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate","volume":"35","author":"McCrea","year":"2008","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0030","doi-asserted-by":"crossref","first-page":"F319","DOI":"10.1136\/fn.88.4.F319","article-title":"Effects of gestational age and prenatal and perinatal events on the coagulation status in premature infants","volume":"88","author":"Salonvaara","year":"2003","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0035","doi-asserted-by":"crossref","first-page":"e590","DOI":"10.1542\/peds.111.5.e590","article-title":"Risk factors for intraventricular hemorrhage in very low birth weight premature infants: a retrospective case-control study","volume":"111","author":"Linder","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0040","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/jp.2011.182","article-title":"The coagulation system of extremely preterm infants: influence of perinatal risk factors on coagulation","volume":"32","author":"Poralla","year":"2012","journal-title":"J Perinatol"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0045","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jpeds.2013.02.030","article-title":"Indomethacin prophylaxis to prevent intraventricular hemorrhage: association between incidence and timing of drug administration","volume":"163","author":"Mirza","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0050","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.earlhumdev.2013.08.025","article-title":"Neonatal transfusion","volume":"89","author":"Kelly","year":"2013","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0055","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000329925","article-title":"Platelet transfusion in the neonatal intensive care unit: benefits, risks, alternatives","volume":"100","author":"Christensen","year":"2011","journal-title":"Neonatology"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0060","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/trf.12322","article-title":"Reference intervals for common coagulation tests of preterm infants","volume":"54","author":"Christensen","year":"2014","journal-title":"Transfusion"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0065","doi-asserted-by":"crossref","first-page":"F77","DOI":"10.1136\/adc.2009.162156","article-title":"Need for consensus in interpreting coagulation profile in preterm neonates","volume":"95","author":"Vasudevan","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0070","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000365135","article-title":"Evidence-based advances in transfusion practice in neonatal intensive care units","volume":"106","author":"Christensen","year":"2014","journal-title":"Neonatology"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0075","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000353366","article-title":"Laboratory coagulation parameters in extremely premature infants born earlier than 27 gestational weeks upon admission to a neonatal intensive care unit","volume":"104","author":"Neary","year":"2013","journal-title":"Neonatology"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0080","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3233\/NPM-2011-2715","article-title":"Decreased fibrinogen levels are associated with severe intraventricular hemorrhage in very low birth weight infants","volume":"4","author":"White","year":"2011","journal-title":"J Neonatal-Perinatal Med"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0085","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/j.1471-0528.1984.tb03679.x","article-title":"Intraventricular haemorrhage\u2014timing of occurrence and relationship to perinatal events","volume":"91","author":"Beverley","year":"1984","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0090","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1111\/j.1537-2995.2009.02328.x","article-title":"Coagulopathy screening and early plasma treatment for the prevention of intraventricular hemorrhage in preterm infants","volume":"49","author":"Dani","year":"2009","journal-title":"Transfusion"},{"issue":"9022","key":"10.1016\/j.earlhumdev.2015.09.008_bb0095","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0140-6736(95)12506-X","article-title":"Randomised trial of prophylactic early fresh-frozen plasma or gelatin or glucose in preterm babies: outcome at 2years","volume":"348","author":"Northern Neonatal Nursing Initiative Trial Group","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0100","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(11)60986-0","article-title":"Avoidance of mechanical ventilation by surfactant treatment of spontaneously breathing preterm infants (AMV): an open-label, randomised, controlled trial","volume":"378","author":"G\u00f6pel","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0105","author":"National Healthcare Safety Network DoHQP"},{"issue":"4","key":"10.1016\/j.earlhumdev.2015.09.008_bb0110","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2013.02.007","article-title":"Optimizing the definition of intrauterine growth restriction: the multicenter prospective PORTO Study","volume":"208","author":"Unterscheider","year":"2013","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.earlhumdev.2015.09.008_bb0115","first-page":"210","article-title":"New percentile values for the anthropometric dimensions of singleton neonates: analysis of perinatal survey data of 2007\u20132011 from all 16 states of Germany]","volume":"218","author":"Voigt","year":"2014","journal-title":"Z Geburtshilfe Neonatol"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0120","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm","volume":"92","author":"Papile","year":"1978","journal-title":"J Pediatr"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0125","doi-asserted-by":"crossref","first-page":"F12","DOI":"10.1136\/archdischild-2013-304705","article-title":"Antenatal steroid exposure and outcomes of very premature infants: a regional cohort study","volume":"99","author":"Wong","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0135","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/MBC.0b013e3283551145","article-title":"Does risk-based coagulation screening predict intraventricular haemorrhage in extreme premature infants?","volume":"23","author":"Tran","year":"2012","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0140","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000341266","article-title":"Elevated Interleukin-6 concentration and alterations of the coagulation system are associated with the development of intraventricular hemorrhage in extremely preterm infants","volume":"102","author":"Poralla","year":"2012","journal-title":"Neonatology"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0145","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1111\/j.1537-2995.2009.02253.x","article-title":"Testing platelet mass versus platelet count to guide platelet transfusions in the neonatal intensive care unit","volume":"49","author":"Gerday","year":"2009","journal-title":"Transfusion"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0150","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.siny.2011.07.001","article-title":"Developmental hemostasis: primary hemostasis and evaluation of platelet function in neonates","volume":"16","author":"Strauss","year":"2011","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0155","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood.V72.5.1651.1651","article-title":"Development of the human coagulation system in the healthy premature infant","volume":"72","author":"Andrew","year":"1988","journal-title":"Blood"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0160","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1055\/s-2007-994529","article-title":"Coagulation studies in very low-birth weight infants","volume":"11","author":"Seguin","year":"1994","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1542\/peds.74.1.26","article-title":"Role of coagulopathy in newborn intracranial hemorrhage","volume":"74","author":"McDonald","year":"1984","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0170","doi-asserted-by":"crossref","first-page":"F77","DOI":"10.1136\/adc.2009.162156","article-title":"Need for consensus in interpreting coagulation profile in preterm neonates","volume":"95","author":"Vasudevan","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0175","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0022-3476(82)80766-X","article-title":"Platelet dysfunction and coagulopathy in intraventricular hemorrhage in the premature infant","volume":"100","author":"Setzer","year":"1982","journal-title":"J Pediatr"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0180","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3109\/14767050903229614","article-title":"Coagulation abnormalities and severe intraventricular hemorrhage in extremely low birth weight infants","volume":"23","author":"Piotrowski","year":"2010","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0185","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0049-3848(90)90033-9","article-title":"Blood coagulation findings and the efficacy of factor XIII concentrate in premature infants with intracranial hemorrhages","volume":"57","author":"Shirahata","year":"1990","journal-title":"Thromb Res"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0190","first-page":"CD002055","article-title":"Early volume expansion for prevention of morbidity and mortality in very preterm infants","volume":"2","author":"Osborn","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"issue":"Suppl. 1","key":"10.1016\/j.earlhumdev.2015.09.008_bb0195","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0049-3848(13)70018-5","article-title":"Intraventricular hemorrhage in preterm infants and coagulation\u2014ambivalent perspectives?","volume":"131","author":"Kuperman","year":"2013","journal-title":"Thromb Res"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0200","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1182\/asheducation.V2012.1.450.3798660","article-title":"The conundrum of neonatal coagulopathy","author":"Revel-Vilk","year":"2012","journal-title":"Hematology"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0205","doi-asserted-by":"crossref","first-page":"R239","DOI":"10.1186\/cc10488","article-title":"Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review","volume":"15","author":"Kozek-Langenecker","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0210","doi-asserted-by":"crossref","first-page":"F423","DOI":"10.1136\/archdischild-2011-301142","article-title":"The preterm infant with thrombosis","volume":"97","author":"Bhat","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.earlhumdev.2015.09.008_bb0215","first-page":"w13954","article-title":"Non-neurological, steroid-related adverse events in very low birth weight infants: a prospective audit","volume":"144","author":"R\u00f6hr","year":"2014","journal-title":"Swiss Med Wkly"}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378215001917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378215001917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T15:21:22Z","timestamp":1653405682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378215001917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0378378215001917"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2015.09.008","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular and humoral coagulation profiles and occurrence of IVH in VLBW and ELWB infants","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2015.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}