{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:29:37Z","timestamp":1786987777008,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","earlyhumandevelopment.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.earlhumdev.2015.10.017","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T08:16:47Z","timestamp":1448353007000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Cerebral blood flow and oximetry response to blood transfusion in relation to chronological age in preterm infants"],"prefix":"10.1016","volume":"97","author":[{"given":"J.","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.S.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Aladangady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.earlhumdev.2015.10.017_bb0005","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jpeds.2009.02.026","article-title":"Effects of transfusions in extremely low birth weight infants: a retrospective study","volume":"155","author":"Valieva","year":"2009","journal-title":"J Pediatr"},{"key":"10.1016\/j.earlhumdev.2015.10.017_bb0010","unstructured":"Aladangady N, Asamoah F, Banerjee J. Blood Transfusion and Short Term Outcomes in Premature Infants. E-PAS2014:4113252 [Internet]. 2014 29.12.14."},{"issue":"3","key":"10.1016\/j.earlhumdev.2015.10.017_bb0015","article-title":"Red blood cell transfusions are independently associated with intra-hospital mortality in very low birth weight preterm infants","volume":"159","author":"dos Santos","year":"2011","journal-title":"J Pediatr 2011"},{"issue":"9","key":"10.1016\/j.earlhumdev.2015.10.017_bb0020","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1111\/j.1537-2995.2011.03081.x","article-title":"Red blood cell transfusion of preterm neonates with a Grade 1 intraventricular hemorrhage is associated with extension to a Grade 3 or 4 hemorrhage","volume":"51","author":"Baer","year":"2011","journal-title":"Transfusion"},{"issue":"6","key":"10.1016\/j.earlhumdev.2015.10.017_bb0025","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1542\/peds.2004-1884","article-title":"Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants","volume":"115","author":"Bell","year":"2005","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.earlhumdev.2015.10.017_bb0030","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jpeds.2006.05.011","article-title":"The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants","volume":"149","author":"Kirpalani","year":"2006","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.earlhumdev.2015.10.017_bb0035","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1542\/peds.2008-0338","article-title":"Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion","volume":"123","author":"Whyte","year":"2009","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.earlhumdev.2015.10.017_bb0040","doi-asserted-by":"crossref","first-page":"F352","DOI":"10.1136\/adc.2009.163592","article-title":"Cerebral tissue oxygen saturation and extraction in preterm infants before and after blood transfusion","volume":"95","author":"van Hoften","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"6","key":"10.1016\/j.earlhumdev.2015.10.017_bb0045","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1055\/s-0030-1247598","article-title":"Packed red blood cell transfusion increases regional cerebral and splanchnic tissue oxygen saturation in anemic symptomatic preterm infants","volume":"27","author":"Bailey","year":"2010","journal-title":"Am J Perinatol"},{"issue":"4","key":"10.1016\/j.earlhumdev.2015.10.017_bb0050","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/jp.2012.108","article-title":"Changes in regional tissue oxygenation saturation and desaturations after red blood cell transfusion in preterm infants","volume":"33","author":"Seidel","year":"2013","journal-title":"J Perinatol"},{"issue":"3","key":"10.1016\/j.earlhumdev.2015.10.017_bb0055","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1542\/peds.84.3.412","article-title":"Assessing the need for transfusion of premature infants and role of hematocrit, clinical signs, and erythropoietin level","volume":"84","author":"Keyes","year":"1989","journal-title":"Pediatrics"},{"issue":"11","key":"10.1016\/j.earlhumdev.2015.10.017_bb0060","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1046\/j.1537-2995.2002.00208.x","article-title":"Guidelines for assessing appropriateness of pediatric transfusion","volume":"42","author":"Roseff","year":"2002","journal-title":"Transfusion"},{"key":"10.1016\/j.earlhumdev.2015.10.017_bb0065","series-title":"Transfusion of prematures (TOP) trial: does a liberal red blood cell transfusion strategy improve neurologically-intact survival of extremely-low-birth-weight infants as compared to a restrictive strategy","author":"Kirpalani","year":"2012"},{"key":"10.1016\/j.earlhumdev.2015.10.017_bb0070","first-page":"48","article-title":"Long-term outcome in relationship to neonatal transfusion volume in extremely premature infants: a comparative cohort study","volume":"11","author":"von Lindern","year":"2011","journal-title":"BMC Pediatr 2011"},{"issue":"2","key":"10.1016\/j.earlhumdev.2015.10.017_bb0075","first-page":"161","article-title":"Cerebral autoregulation","volume":"2","author":"Paulson","year":"1990","journal-title":"Cerebrovasc Brain Metab Rev"},{"issue":"1","key":"10.1016\/j.earlhumdev.2015.10.017_bb0080","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s001340000712","article-title":"The value of capillary whole blood lactate for blood transfusion requirements in anaemia of prematurity","volume":"27","author":"Frey","year":"2001","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.earlhumdev.2015.10.017_bb0085","first-page":"246","article-title":"A randomized trial to develop criteria for administering erythrocyte transfusions to anemic preterm infants 1 to 3months of age","volume":"9","author":"Ross","year":"1989","journal-title":"J Perinatol"},{"issue":"12","key":"10.1016\/j.earlhumdev.2015.10.017_bb0090","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.earlhumdev.2006.09.020","article-title":"Assessment and support of the preterm circulation","volume":"82","author":"Evans","year":"2006","journal-title":"Early Hum Dev"},{"issue":"3","key":"10.1016\/j.earlhumdev.2015.10.017_bb0095","doi-asserted-by":"crossref","first-page":"F182","DOI":"10.1136\/fn.82.3.F182","article-title":"Superior vena cava flow in newborn infants: a novel marker of systemic blood flow","volume":"82","author":"Kluckow","year":"2000","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"4","key":"10.1016\/j.earlhumdev.2015.10.017_bb0100","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1542\/peds.112.4.838","article-title":"Hemodynamic changes in anemic premature infants: are we allowing the hematocrits to fall too low?","volume":"112","author":"Alkalay","year":"2003","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.earlhumdev.2015.10.017_bb0105","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1542\/peds.2005-3197","article-title":"Poor circulation, early brain injury, and the potential role of Red cell transfusion in premature newborns","volume":"117","author":"Andersen","year":"2006","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.earlhumdev.2015.10.017_bb0110","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000101063","article-title":"Use of tissue oxygenation index and fractional tissue oxygen extraction as non-invasive parameters for cerebral oxygenation. A validation study in piglets","volume":"92","author":"Naulaers","year":"2007","journal-title":"Neonatology"},{"key":"10.1016\/j.earlhumdev.2015.10.017_bb0115","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1136\/adc.67.4_Spec_No.407","article-title":"Plethysmographic validation of near infrared spectroscopic monitoring of cerebral blood volume","volume":"67","author":"Wickramasinghe","year":"1992","journal-title":"Arch Dis Child"},{"issue":"1","key":"10.1016\/j.earlhumdev.2015.10.017_bb0120","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1203\/01.PDR.0000099775.87684.FB","article-title":"A new method for the measurement of cerebral blood volume and total circulating blood volume using near infrared spatially resolved spectroscopy and indocyanine green: application and validation in neonates","volume":"55","author":"Leung","year":"2004","journal-title":"Pediatr Res"},{"issue":"3","key":"10.1016\/j.earlhumdev.2015.10.017_bb0125","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1542\/neo.10-3-e121","article-title":"Bedside cerebral monitoring to predict neurodevelopmental outcomes","volume":"10","author":"Chock","year":"2009","journal-title":"NeoReviews"},{"key":"10.1016\/j.earlhumdev.2015.10.017_bb0130","unstructured":"Pickler G. Cerebral oxygenation to guide supplemental oxygen (COSGOD) clinicaltrial.gov2013 [cited 2015 25.03.15]. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02017691]. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02017691."},{"issue":"6","key":"10.1016\/j.earlhumdev.2015.10.017_bb0135","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1203\/PDR.0b013e3182176d85","article-title":"Cerebral tissue oxygenation and regional oxygen saturation can be used to study cerebral autoregulation in prematurely born infants","volume":"69","author":"Caicedo","year":"2011","journal-title":"Pediatr Res"},{"key":"10.1016\/j.earlhumdev.2015.10.017_bb0140","doi-asserted-by":"crossref","first-page":"g7635","DOI":"10.1136\/bmj.g7635","article-title":"Cerebral near infrared spectroscopy oximetry in extremely preterm infants: phase II randomised clinical trial","volume":"350","author":"Hyttel-Sorensen","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.earlhumdev.2015.10.017_bb0145","author":"Lemmers"},{"key":"10.1016\/j.earlhumdev.2015.10.017_bb0150","author":"Pickler"},{"issue":"9","key":"10.1016\/j.earlhumdev.2015.10.017_bb0155","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1651-2227.2002.tb02881.x","article-title":"Effect of blood transfusions on cerebral haemodynamics in preterm infants","volume":"91","author":"Dani","year":"2002","journal-title":"Acta Paediatr"},{"issue":"4","key":"10.1016\/j.earlhumdev.2015.10.017_bb0160","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2141.2004.04815.x","article-title":"Transfusion guidelines for neonates and older children","volume":"124","author":"Gibson","year":"2004","journal-title":"Br J Haematol"},{"issue":"6","key":"10.1016\/j.earlhumdev.2015.10.017_bb0165","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/j.1537-2995.2009.02575.x","article-title":"Blood transfusions increase cerebral, splanchnic, and renal oxygenation in anemic preterm infants","volume":"50","author":"Dani","year":"2010","journal-title":"Transfusion"},{"issue":"1","key":"10.1016\/j.earlhumdev.2015.10.017_bb0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/jp.2010.71","article-title":"Normal cerebral, renal and abdominal regional oxygen saturations using near-infrared spectroscopy in preterm infants","volume":"31","author":"McNeill","year":"2011","journal-title":"J Perinatol"},{"issue":"4","key":"10.1016\/j.earlhumdev.2015.10.017_bb0175","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000151642","article-title":"Monitoring neonatal regional cerebral oxygen saturation in clinical practice: value and pitfalls","volume":"94","author":"van Bel","year":"2008","journal-title":"Neonatology"},{"issue":"1","key":"10.1016\/j.earlhumdev.2015.10.017_bb0180","doi-asserted-by":"crossref","first-page":"F45","DOI":"10.1136\/fn.71.1.F45","article-title":"Effects of red cell transfusion on cardiac output and blood flow velocities in cerebral and gastrointestinal arteries in premature infants","volume":"71","author":"Nelle","year":"1994","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"4","key":"10.1016\/j.earlhumdev.2015.10.017_bb0185","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s004310050606","article-title":"The effect of blood transfusion and haemodilution on cerebral oxygenation and haemodynamics in newborn infants investigated by near infrared spectrophotometry","volume":"156","author":"Liem","year":"1997","journal-title":"Eur J Pediatr"},{"issue":"1","key":"10.1016\/j.earlhumdev.2015.10.017_bb0190","first-page":"86","article-title":"Neonatal red blood cell transfusions: searching for better guidelines","volume":"9","author":"Kasat","year":"2011","journal-title":"Blood Transfus"},{"issue":"4","key":"10.1016\/j.earlhumdev.2015.10.017_bb0195","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0095-5108(18)30030-7","article-title":"Blood pressure measurements in the newborn","volume":"26","author":"Nuntnarumit","year":"1999","journal-title":"Clin Perinatol"},{"issue":"4","key":"10.1016\/j.earlhumdev.2015.10.017_bb0200","doi-asserted-by":"crossref","first-page":"F249","DOI":"10.1136\/adc.2010.191023","article-title":"Acute physiological effects of packed red blood cell transfusion in preterm infants with different degrees of anaemia","volume":"96","author":"Fredrickson","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed 2010"},{"issue":"10","key":"10.1016\/j.earlhumdev.2015.10.017_bb0205","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1111\/trf.12670","article-title":"Biomarkers to decide red blood cell transfusion in newborn infants","volume":"54","author":"Banerjee","year":"2014","journal-title":"Transfusion"},{"issue":"9","key":"10.1016\/j.earlhumdev.2015.10.017_bb0210","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1460-9592.2008.02647.x","article-title":"Measuring circulating blood volume in newborn infants using pulse dye densitometry and indocyanine green","volume":"18","author":"Aladangady","year":"2008","journal-title":"Paediatr Anaesth"}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378215300384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378215300384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T19:56:08Z","timestamp":1653594968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378215300384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":42,"alternative-id":["S0378378215300384"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2015.10.017","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebral blood flow and oximetry response to blood transfusion in relation to chronological age in preterm infants","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2015.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}