{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:24:58Z","timestamp":1792027498524,"version":"4.4.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","earlyhumandevelopment.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.earlhumdev.2016.12.007","type":"journal-article","created":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T11:45:25Z","timestamp":1482061525000},"page":"41-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Cardiac biomarkers and haemodynamically significant patent ductus arteriosus in preterm infants"],"prefix":"10.1016","volume":"105","author":[{"given":"Dany E.","family":"Weisz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afif","family":"El-Khuffash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0005","doi-asserted-by":"crossref","DOI":"10.1136\/archdischild-2014-306214","article-title":"Reflections of the changes in patent ductus arteriosus management during the last 10years","author":"El-Khuffash","year":"2016","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0010","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.jpeds.2015.09.028","article-title":"A patent ductus arteriosus severity score predicts chronic lung disease or death before discharge","volume":"167","author":"El-Khuffash","year":"2015","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00431-012-1851-0","article-title":"Functional echocardiography in staging for ductal disease severity: role in predicting outcomes","volume":"172","author":"Sehgal","year":"2013","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0020","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/01.RES.62.2.191","article-title":"Atrial stretch, not pressure, is the principal determinant controlling the acute release of atrial natriuretic factor","volume":"62","author":"Edwards","year":"1988","journal-title":"Circ. Res."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0025","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1210\/jcem-66-3-605","article-title":"Identification and plasma concentrations of the N-terminal fragment of proatrial natriuretic factor in man","volume":"66","author":"Sundsfjord","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0030","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/01.PCC.0000224998.97784.A3","article-title":"A review of the natriuretic hormone system's diagnostic and therapeutic potential in critically ill children","volume":"7","author":"Costello","year":"2006","journal-title":"Pediatr. Crit. Care Med."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0035","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1373\/clinchem.2005.048892","article-title":"N-terminal pro-B-type natriuretic peptide concentrations in mothers just before delivery, in cord blood, and in newborns","volume":"51","author":"Bar-Oz","year":"2005","journal-title":"Clin. Chem."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0040","doi-asserted-by":"crossref","first-page":"F74","DOI":"10.1136\/adc.2009.158683","article-title":"Cord blood, perinatal BNP values in term and preterm newborns","volume":"95","author":"Mannarino","year":"2010","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0045","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/jp.2008.21","article-title":"Cardiac troponin T and N-terminal-pro-B type natriuretic peptide reflect myocardial function in preterm infants","volume":"28","author":"El-Khuffash","year":"2008","journal-title":"J. Perinatol."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0050","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1542\/peds.112.4.896","article-title":"Plasma concentrations of aminoterminal pro atrial natriuretic peptide and aminoterminal pro brain natriuretic peptide in healthy neonates: marked and rapid increase after birth","volume":"112","author":"Mir","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.earlhumdev.2008.05.008","article-title":"Correlation between cord blood, perinatal BNP values and echocardiographic parameters in healthy Italian newborns","volume":"85","author":"Mannarino","year":"2009","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0060","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.earlhumdev.2010.04.003","article-title":"BNP concentrations and cardiovascular adaptation in preterm and fullterm newborn infants","volume":"86","author":"Mannarino","year":"2010","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0065","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1542\/peds.2005-1387","article-title":"Longitudinal changes of brain-type natriuretic peptide in preterm neonates","volume":"117","author":"da Graca","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0070","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000330411","article-title":"Plasma C-terminal pro-endothelin-1 and the natriuretic pro-peptides NT-proBNP and MR-proANP in very preterm infants with patent ductus arteriosus","volume":"101","author":"Letzner","year":"2012","journal-title":"Neonatology"},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0075","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.earlhumdev.2014.03.002","article-title":"Cardiovascular biomarkers pro-atrial natriuretic peptide and pro-endothelin-1 to monitor ductus arteriosus evolution in very preterm infants","volume":"90","author":"Grass","year":"2014","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0080","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pharmthera.2004.04.004","article-title":"Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance","volume":"102","author":"Abassi","year":"2004","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0085","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1136\/hrt.2004.037762","article-title":"Diagnostic accuracy of B type natriuretic peptide and amino terminal proBNP in the emergency diagnosis of heart failure","volume":"91","author":"Mueller","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0090","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0140-6736(00)02060-2","article-title":"Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations","volume":"355","author":"Troughton","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0095","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1161\/01.CIR.0000130845.38133.8F","article-title":"Plasma brain natriuretic peptide to detect preclinical ventricular systolic or diastolic dysfunction: a community-based study","volume":"109","author":"Redfield","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0100","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1161\/01.CIR.0000054164.99881.00","article-title":"Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan Heart Failure Trial (Val-HeFT)","volume":"107","author":"Anand","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0105","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1651-2227.2004.tb02958.x","article-title":"Clinical signs of heart failure are associated with increased levels of natriuretic peptide types B and A in children with congenital heart defects or cardiomyopathy","volume":"93","author":"Westerlind","year":"2004","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0110","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1651-2227.2004.tb02984.x","article-title":"N-terminal pro-B-type natriuretic peptide: reference plasma levels from birth to adolescence. Elevated levels at birth and in infants and children with heart diseases","volume":"93","author":"Nir","year":"2004","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0115","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/eurheartj\/ehi773","article-title":"B-type natriuretic peptide in paediatric patients with congenital heart disease","volume":"27","author":"Koch","year":"2006","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0120","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jpeds.2005.10.039","article-title":"Prognostic value of plasma N-terminal pro-brain natriuretic peptide in children with congenital heart defects and open-heart surgery","volume":"148","author":"Gessler","year":"2006","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0125","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1399-3046.2005.00365.x","article-title":"Cardiac function in children post-orthotopic liver transplantation: echocardiographic parameters and biochemical markers of subclinical cardiovascular damage","volume":"9","author":"Shalev","year":"2005","journal-title":"Pediatr. Transplant."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0130","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1542\/peds.2004-0525","article-title":"Brain-type natriuretic peptide in the diagnosis and management of persistent pulmonary hypertension of the newborn","volume":"114","author":"Reynolds","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0135","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1055\/s-0035-1548540","article-title":"B-type natriuretic peptide: biomarker of persistent pulmonary hypertension of the newborn?","volume":"32","author":"Shah","year":"2015","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0140","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpeds.2011.06.038","article-title":"B-type natriuretic peptide and rebound during treatment for persistent pulmonary hypertension","volume":"160","author":"Vijlbrief","year":"2012","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0145","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1111\/apa.12273","article-title":"B-type natriuretic peptide for assessment of haemodynamically significant patent ductus arteriosus in premature infants","volume":"102","author":"Mine","year":"2013","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0150","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000343034","article-title":"Can early B-type natriuretic peptide assays predict symptomatic patent ductus arteriosus in extremely low birth weight infants?","volume":"103","author":"Lee","year":"2013","journal-title":"Neonatology"},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0155","doi-asserted-by":"crossref","first-page":"F421","DOI":"10.1136\/adc.2007.119701","article-title":"N-terminal pro-B-type natriuretic peptide as a marker of ductal haemodynamic significance in preterm infants: a prospective observational study","volume":"92","author":"El-Khuffash","year":"2007","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0160","doi-asserted-by":"crossref","first-page":"F257","DOI":"10.1136\/adc.2007.120691","article-title":"N-terminal pro-B-type natriuretic peptide: a measure of significant patent ductus arteriosus","volume":"93","author":"Farombi-Oghuvbu","year":"2008","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0165","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000440940","article-title":"Longitudinal assessment of left and right myocardial function in preterm infants using strain and strain rate imaging","volume":"109","author":"James","year":"2016","journal-title":"Neonatology"},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0170","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1159\/000334826","article-title":"Urinary NT-proBNP, NGAL, and H-FABP may predict hemodynamic relevance of patent ductus arteriosus in very low birth weight infants","volume":"101","author":"Tosse","year":"2012","journal-title":"Neonatology"},{"issue":"2465","key":"10.1016\/j.earlhumdev.2016.12.007_bb0175","article-title":"Reference values for N-terminal pro-B-type natriuretic peptide in umbilical cord blood","volume":"50","author":"Bakker","year":"2004","journal-title":"Clin. Chem."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0180","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.3109\/14767058.2014.880879","article-title":"Correlation analysis between echocardiographic flow pattern and N-terminal-pro-brain natriuretic peptide for early targeted treatment of patent ductus arteriosus","volume":"27","author":"Occhipinti","year":"2014","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0185","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1203\/PDR.0b013e3181799594","article-title":"B-type natriuretic peptide to predict ductus intervention in infants <28weeks","volume":"64","author":"Czernik","year":"2008","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0190","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/jp.2012.86","article-title":"Urinary NT-proBNP and ductal closure in preterm infants","volume":"33","author":"Czernik","year":"2013","journal-title":"J. Perinatol."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0195","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00246-011-0020-y","article-title":"Early NT-proBNP is able to predict spontaneous closure of patent ductus arteriosus in preterm neonates, but not the need of its treatment","volume":"32","author":"Martinovici","year":"2011","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0200","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/jp.2010.47","article-title":"How useful are B-type natriuretic peptide measurements for monitoring changes in patent ductus arteriosus shunt magnitude?","volume":"30","author":"Chen","year":"2010","journal-title":"J. Perinatol."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0205","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jpeds.2005.03.040","article-title":"The use of a bedside assay for plasma B-type natriuretic peptide as a biomarker in the management of patent ductus arteriosus in premature neonates","volume":"147","author":"Flynn","year":"2005","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0210","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4103\/2249-4847.96758","article-title":"NT-proBNP levels improve the ability of predicting a hemodynamically significant patent ductus arteriosus in very low-birth-weight infants","volume":"1","author":"Buddhe","year":"2012","journal-title":"J. Clin. Neonatol."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0215","doi-asserted-by":"crossref","first-page":"e255","DOI":"10.1542\/peds.2004-1837","article-title":"Utility of rapid B-type natriuretic peptide assay for diagnosis of symptomatic patent ductus arteriosus in preterm infants","volume":"115","author":"Choi","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0220","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/jp.2008.185","article-title":"N-terminal probrain natriuretic peptide and patent ductus arteriosus in preterm infants","volume":"29","author":"Nuntnarumit","year":"2009","journal-title":"J. Perinatol."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0225","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.1651-2227.2009.01315.x","article-title":"Early N-terminal pro-brain natriuretic peptide measurements predict clinically significant ductus arteriosus in preterm infants","volume":"98","author":"Ramakrishnan","year":"2009","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0230","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00431-014-2350-2","article-title":"Serial N-terminal pro-brain natriuretic peptide measurement as a predictor of significant patent ductus arteriosus in preterm infants beyond the first week of life","volume":"173","author":"Letshwiti","year":"2014","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0235","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jpeds.2009.12.045","article-title":"B-type natriuretic peptide predicts responses to indomethacin in premature neonates with patent ductus arteriosus","volume":"157","author":"Hsu","year":"2010","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0240","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/sj.jp.7211383","article-title":"Role of plasma B-type natriuretic peptide in screening for hemodynamically significant patent ductus arteriosus in preterm neonates","volume":"25","author":"Sanjeev","year":"2005","journal-title":"J. Perinatol."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0245","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s00246-009-9568-1","article-title":"N-terminal-pro-B-type natriuretic peptide in premature patent ductus arteriosus: a physiologic biomarker, but is it a clinical tool?","volume":"31","author":"Hammerman","year":"2010","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0250","doi-asserted-by":"crossref","first-page":"F178","DOI":"10.1136\/adc.2008.147587","article-title":"B-type natriuretic peptide concentrations to guide treatment of patent ductus arteriosus","volume":"94","author":"Attridge","year":"2009","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0255","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jpeds.2009.06.013","article-title":"Duration of indomethacin treatment of the preterm patent ductus arteriosus as directed by echocardiography","volume":"155","author":"Carmo","year":"2009","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2016.12.007_bb0260","doi-asserted-by":"crossref","DOI":"10.1136\/adc.2007.133140","article-title":"Biochemical markers may identify preterm infants with a patent ductus arteriosus at high risk of death or severe intraventricular haemorrhage","volume":"93","author":"El-Khuffash","year":"2008","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378216305710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378216305710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T16:20:21Z","timestamp":1536164421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378216305710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":52,"alternative-id":["S0378378216305710"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2016.12.007","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac biomarkers and haemodynamically significant patent ductus arteriosus in preterm infants","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2016.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}