{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:04:04Z","timestamp":1778774644839,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.earlhumdev.2017.06.009","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T16:47:38Z","timestamp":1499359658000},"page":"42-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Maternal body mass index impacts fetal-placental size at birth and umbilical cord oxygen values with implications for regulatory mechanisms"],"prefix":"10.1016","volume":"112","author":[{"given":"Bryan S.","family":"Richardson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Ruttinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary K.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy R.H.","family":"Regnault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbra","family":"de Vrijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0005","first-page":"61","article-title":"Is maternal underweight really a risk factor for adverse pregnancy outcome? A population-based study in London","volume":"108","author":"Sebire","year":"2001","journal-title":"BJOG"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0010","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/S0002-9378(03)00860-3","article-title":"Low maternal weight, failure to thrive in pregnancy, and adverse pregnancy outcomes","volume":"189","author":"Ehrenberg","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0015","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/2047-783X-14-5-216","article-title":"Impact of maternal body mass index on neonatal outcome","volume":"14","author":"Kalk","year":"2009","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0020","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3109\/14767058.2011.575905","article-title":"Abnormal maternal body mass index and obstetric and neonatal outcome","volume":"25","author":"Sebasti\u00e1n Manzanares","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0025","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s00404-012-2403-6","article-title":"Prepregnancy body mass index and gestational weight gain with the outcome of pregnancy: a 13-year study of 292,568 cases in China","volume":"286","author":"Liu","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0030","article-title":"Maternal prepregnancy body mass index and gestational weight gain on pregnancy outcomes","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/plac.2000.0602","article-title":"Maternal food restriction reduces the exchange surface area and increases the barrier thickness of the placenta in the guinea-pig","volume":"22","author":"Roberts","year":"2001","journal-title":"Placenta"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0040","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.domaniend.2004.06.006","article-title":"Effect of nutrient intake during pregnancy on fetal and placental growth and vascular development","volume":"27","author":"Redmer","year":"2004","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20060339","article-title":"Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches","volume":"113","author":"Jansson","year":"2007","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0050","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1095\/biolreprod.110.084517","article-title":"Maternal undernutrition influences placental-fetal development","volume":"83","author":"Belkacemi","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1017\/S2040174412000529","article-title":"Placental transport in response to altered maternal nutrition","volume":"4","author":"Gaccioli","year":"2013","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0060","doi-asserted-by":"crossref","DOI":"10.1038\/pr.2017.92","article-title":"Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with evidence for chronic hypoxia","author":"Elias","year":"2017","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0065","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0143-4004(97)90000-X","article-title":"Oxygen and placental villous development: origins of fetal hypoxia","volume":"18","author":"Kingdom","year":"1997","journal-title":"Placenta"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0070","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1046\/j.1469-0705.2000.00208.x","article-title":"Umbilical vein blood flow in growth-restricted fetuses","volume":"16","author":"Ferrazzi","year":"2000","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0075","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0002-9378(88)90490-5","article-title":"Physiology and management of intrauterine growth retardation: a biologic approach with fetal blood sampling","volume":"159","author":"Cox","year":"1988","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0080","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1067\/mob.2001.116686","article-title":"Fetal umbilical cord oxygen values and birth to placental weight ratio in relation to size at birth","volume":"185","author":"Lackman","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0085","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/sj.ijo.0801670","article-title":"Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London","volume":"25","author":"Sebire","year":"2001","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0090","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/AOG.0b013e3182245d49","article-title":"Effect of prepregnancy maternal overweight and obesity on pregnancy outcome","volume":"118","author":"Ovesen","year":"2011","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1096\/fj.08-116889","article-title":"High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57\/BL6 mice","volume":"23","author":"Jones","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0100","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1095\/biolreprod.113.109702","article-title":"Maternal overweight induced by a diet with high content of saturated fat activates placental mTOR and eIF2alpha signaling and increases fetal growth in rats","volume":"89","author":"Gaccioli","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0105","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1210\/jc.2012-2667","article-title":"Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies","volume":"98","author":"Jansson","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2014.08.009","article-title":"Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers","volume":"212","author":"Acosta","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0115","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1148\/radiology.181.1.1887021","article-title":"In utero analysis of fetal growth: a sonographic weight standard","volume":"181","author":"Hadlock","year":"1991","journal-title":"Radiology"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0120","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1067\/mob.2001.111719","article-title":"The risks of spontaneous preterm delivery and perinatal mortality in relation to size at birth according to fetal versus neonatal growth standards","volume":"184","author":"Lackman","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0125","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/01.ede.0000198470.26932.9a","article-title":"Combined effects of prepregnancy body mass index and weight gain during pregnancy on the risk of preterm delivery","volume":"17","author":"Dietz","year":"2006","journal-title":"Epidemiology"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0130","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/01.AOG.0000425667.10377.60","article-title":"ACOG committee opinion no. 549: obesity in pregnancy","volume":"121","author":"American College of Obstetricians and Gynecologists","year":"2013","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0135","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/j.1471-0528.1994.tb13581.x","article-title":"Umbilical cord blood gas analysis at delivery: a time for quality data","volume":"101","author":"Westgate","year":"1994","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0140","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.placenta.2014.04.019","article-title":"Obstetric conditions and the placental weight ratio","volume":"35","author":"Macdonald","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0145","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1136\/bmj.312.7028.410","article-title":"Maternal nutrition in early and late pregnancy in relation to placental and fetal growth","volume":"312","author":"Godfrey","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0150","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1203\/00006450-199810000-00013","article-title":"Influence of restricted maternal nutrition in early to mid gestation on placental and fetal development at term in sheep","volume":"44","author":"Heasman","year":"1998","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0155","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/1933719115602773","article-title":"Maternal Nutrient Restriction in Guinea Pigs as an Animal Model for Inducing Fetal Growth Restriction","volume":"23","author":"Elias","year":"2016","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0160","series-title":"Maternal-Fetal Medicine","article-title":"Placental respiratory gas exchange and fetal oxygenation","author":"Meschia","year":"2014"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0165","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/oxfordjournals.bmb.a070437","article-title":"Morphometry of the human placenta","volume":"22","author":"Aherne","year":"1966","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0170","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0143-4004(88)90072-0","article-title":"Intrauterine growth retardation: morphometry of the microvillous membrane of the human placenta","volume":"9","author":"Teasdale","year":"1988","journal-title":"Placenta"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0175","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0002-9378(94)90081-7","article-title":"Intrapartum fetal pulse oximetry: fetal oxygen saturation trends during labor and relation to delivery outcome","volume":"171","author":"Dildy","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0180","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/0002-9378(73)90066-5","article-title":"Fetal and neonatal biochemistry and Apgar scores","volume":"117","author":"Modanlou","year":"1973","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0185","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0002-9378(98)70441-7","article-title":"Fetal oxygen saturation and fractional extraction at birth and the relationship to measures of acidosis","volume":"178","author":"Richardson","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0190","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/bmj.294.6579.1051","article-title":"Prenatal asphyxia, hyperlacticaemia, hypoglycaemia, and erythroblastosis in growth retarded fetuses","volume":"294","author":"Soothill","year":"1987","journal-title":"Br. Med. J."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0195","series-title":"Pediatrics and Perinatology: The Scientific Basis","first-page":"228","article-title":"Fetal physiology","author":"Richardson","year":"1996"},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0200","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"Barker","year":"2004","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.earlhumdev.2017.06.009_bb0205","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1152\/physiol.00050.2005","article-title":"Intrauterine programming of physiological systems: causes and consequences","volume":"21","author":"Fowden","year":"2006","journal-title":"Physiology (Bethesda)"}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378217301731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378217301731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T14:35:38Z","timestamp":1602426938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378217301731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":41,"alternative-id":["S0378378217301731"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2017.06.009","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal body mass index impacts fetal-placental size at birth and umbilical cord oxygen values with implications for regulatory mechanisms","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2017.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}