{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:20:10Z","timestamp":1792070410066,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Children's National Inova Collaborative (CNICA) Research Program"},{"DOI":"10.13039\/100012416","name":"Inova Health System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.earlhumdev.2018.07.003","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T11:03:21Z","timestamp":1531825401000},"page":"11-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Autonomic nervous system depression at term in neurologically normal premature infants"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-526X","authenticated-orcid":false,"given":"Sarah B.","family":"Mulkey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Kota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Swisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hitchings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Metzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Larry","family":"Maxwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adre J.","family":"du Plessis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rathinaswamy","family":"Govindan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.earlhumdev.2018.07.003_bb0005","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.earlhumdev.2012.09.009","article-title":"The development of autonomic cardiovascular control is altered by preterm birth","volume":"89","author":"Yiallourou","year":"2013","journal-title":"Early Hum. Dev."},{"issue":"1","key":"10.1016\/j.earlhumdev.2018.07.003_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169442","article-title":"Routine magnetic resonance imaging at term-equivalent age detects brain injury in 25% of a contemporary cohort of very preterm infants","volume":"12","author":"Neubauer","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.earlhumdev.2018.07.003_bb0015","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10286-015-0298-6","article-title":"Altered autonomic control in preterm newborns with impaired neurological outcomes","volume":"25","author":"Thiriez","year":"2015","journal-title":"Clin. Auton. Res."},{"issue":"4","key":"10.1016\/j.earlhumdev.2018.07.003_bb0020","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1515\/JPM.2006.058","article-title":"Maturation of the autonomic nervous system: differences in heart rate variability in premature vs. term infants","volume":"34","author":"Longin","year":"2006","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.earlhumdev.2018.07.003_bb0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10286-004-0216-9","article-title":"Birth prematurity determines prolonged autonomic nervous system immaturity","volume":"14","author":"F; PHBJPVMCTGDGR","year":"2004","journal-title":"Clin. Auton. Res."},{"issue":"1","key":"10.1016\/j.earlhumdev.2018.07.003_bb0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12967-016-0879-8","article-title":"Early life programming of pain: focus on neuroimmune to endocrine communication","volume":"14","author":"Zouikr","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.earlhumdev.2018.07.003_bb0035","series-title":"The Critical Role of the Central Autonomic Nervous System in Fetal-neonatal Transition Seminars in Pediatric Neurology","author":"Mulkey","year":"2018"},{"key":"10.1016\/j.earlhumdev.2018.07.003_bb0040","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.5665\/sleep.5064","article-title":"The effect of gestational age at birth on post-term maturation of heart rate variability","volume":"38","author":"Fyfe","year":"2015","journal-title":"Sleep"},{"issue":"5","key":"10.1016\/j.earlhumdev.2018.07.003_bb0045","first-page":"1043","article-title":"Heart rate variability","volume":"93","author":"Electrophysiology TFotESoCtNASoP","year":"1996","journal-title":"Stand. Meas. Physiol. Interpret. Clin. Use"},{"issue":"4","key":"10.1016\/j.earlhumdev.2018.07.003_bb0050","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.smrv.2013.06.002","article-title":"The development of cardiovascular and cerebral vascular control in preterm infants","volume":"18","author":"Fyfe","year":"2014","journal-title":"Sleep Med. Rev."},{"issue":"1","key":"10.1016\/j.earlhumdev.2018.07.003_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/hrt.71.1.1","article-title":"Power spectrum analysis of heart rate variability: a tool to explore neural regulatory mechanisms","volume":"71","author":"Malliani","year":"1994","journal-title":"Br. Heart J."},{"issue":"9","key":"10.1016\/j.earlhumdev.2018.07.003_bb0060","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1088\/0967-3334\/37\/9\/1436","article-title":"Novel heart rate parameters for the assessment of autonomic nervous system function in premature infants","volume":"37","author":"Lucchini","year":"2016","journal-title":"Physiol. Meas."},{"key":"10.1016\/j.earlhumdev.2018.07.003_bb0065","series-title":"Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference","first-page":"2801","article-title":"A comparison of fetal and neonatal heart rate variability at similar post-menstrual ages","volume":"2008","author":"Padhye","year":"2008"},{"issue":"3","key":"10.1016\/j.earlhumdev.2018.07.003_bb0070","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000014209","article-title":"Heart rate variability in preterm brain-injured and very-low-birth-weight infants","volume":"77","author":"Hanna","year":"2000","journal-title":"Biol. Neonate"},{"issue":"10","key":"10.1016\/j.earlhumdev.2018.07.003_bb0075","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.earlhumdev.2008.04.010","article-title":"Autonomic cardiac control of very preterm newborns: a prolonged dysfunction","volume":"84","author":"Patural","year":"2008","journal-title":"Early Hum. Dev."},{"issue":"9","key":"10.1016\/j.earlhumdev.2018.07.003_bb0080","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.earlhumdev.2013.04.008","article-title":"Patent ductus arteriosus in preterm infants is associated with cardiac autonomic alteration and predominant parasympathetic stimulation","volume":"89","author":"Goudjil","year":"2013","journal-title":"Early Hum. Dev."},{"issue":"3","key":"10.1016\/j.earlhumdev.2018.07.003_bb0085","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.clp.2010.06.002","article-title":"Heart rate characteristics: physiomarkers for detection of late-onset neonatal sepsis","volume":"37","author":"Fairchild","year":"2010","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.earlhumdev.2018.07.003_bb0090","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.compbiomed.2017.05.033","article-title":"Identification of QRS complex in non-stationary electrocardiogram of sick infants","volume":"87","author":"Kota","year":"2017","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.earlhumdev.2018.07.003_bb0095","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.physa.2015.10.018","article-title":"A spike correction approach for variability analysis of heart rate in sick infants","volume":"444","author":"Govindan","year":"2016","journal-title":"Physica A"},{"issue":"1","key":"10.1016\/j.earlhumdev.2018.07.003_bb0100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1063\/1.166141","article-title":"Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series","volume":"5","author":"Peng","year":"1995","journal-title":"Chaos"},{"key":"10.1016\/j.earlhumdev.2018.07.003_bb0105","doi-asserted-by":"crossref","DOI":"10.1209\/0295-5075\/108\/40005","article-title":"Detrended fluctuation analysis of non-stationary cardiac beat-to-beat interval of sick infants","volume":"108","author":"Govindan","year":"2014","journal-title":"Europhys. Lett."},{"issue":"3","key":"10.1016\/j.earlhumdev.2018.07.003_bb0110","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/pr.2017.94","article-title":"Pattern of brain injury and depressed heart rate variability in newborns with hypoxic ischemic encephalopathy","volume":"82","author":"Metzler","year":"2017","journal-title":"Pediatr. Res."},{"issue":"2","key":"10.1016\/j.earlhumdev.2018.07.003_bb0115","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1203\/00006450-199308000-00005","article-title":"An estimate of fetal autonomic state by spectral analysis of fetal heart rate fluctuations","volume":"34","author":"Karin","year":"1993","journal-title":"Pediatr. Res."},{"issue":"1\u20132","key":"10.1016\/j.earlhumdev.2018.07.003_bb0120","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.autneu.2007.04.008","article-title":"Autonomic nervous system activity in premature and full-term infants from theoretical term to 7 years","volume":"136","author":"De Rogalski","year":"2007","journal-title":"Auton. Neurosci. Basic Clin."},{"issue":"2","key":"10.1016\/j.earlhumdev.2018.07.003_bb0125","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbi.2005.05.003","volume":"20","author":"Karrow","year":"2006","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.earlhumdev.2018.07.003_bb0130","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jpeds.2013.11.038","article-title":"Infection and other clinical correlates of abnormal heart rate characteristics in preterm infants","volume":"164","author":"Sullivan","year":"2014","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2018.07.003_bb0135","doi-asserted-by":"crossref","DOI":"10.1055\/s-0038-1639339","article-title":"Changes in autonomic tone in premature infants developing necrotizing enterocolitis","author":"Al-Shargabi","year":"2018","journal-title":"Am. J. Perinatol."},{"issue":"1","key":"10.1016\/j.earlhumdev.2018.07.003_bb0140","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000347101","article-title":"Heart rate variability and extubation readiness in extremely preterm infants","volume":"104","author":"Kaczmarek","year":"2013","journal-title":"Neonatology"},{"key":"10.1016\/j.earlhumdev.2018.07.003_bb0145","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.5665\/sleep.4980","article-title":"Preterm infants exhibit greater variability in cerebrovascular control than term infants","volume":"38","author":"Fyfe","year":"2015","journal-title":"Sleep"},{"issue":"3","key":"10.1016\/j.earlhumdev.2018.07.003_bb0150","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1164\/rccm.201601-0150LE","article-title":"Premature infants rehospitalized because of an apparent life-threatening event had distinctive autonomic developmental trajectories","volume":"194","author":"Nino","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.earlhumdev.2018.07.003_bb0155","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1542\/peds.2008-0253","article-title":"Altered heart rhythm dynamics in very low birth weight infants with impending intraventricular hemorrhage","volume":"123","author":"Tuzcu","year":"2009","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.earlhumdev.2018.07.003_bb0160","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/icd.688","article-title":"The early development of the autonomic nervous system provides a neural platform for social behavior: a polyvagal perspective","volume":"20","author":"Porges","year":"2011","journal-title":"Infant Child Dev."},{"issue":"18","key":"10.1016\/j.earlhumdev.2018.07.003_bb0165","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1161\/CIRCULATIONAHA.108.783902","article-title":"Cardiovascular stress hyperreactivity in babies of smokers and in babies born preterm","volume":"118","author":"Cohen","year":"2008","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.earlhumdev.2018.07.003_bb0170","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1067\/S0022-3476(03)00357-3","article-title":"Defining the nature of the cerebral abnormalities in the premature infant: a qualitative magnetic resonance imaging study","volume":"143","author":"Inder","year":"2003","journal-title":"J. Pediatr."}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378218301385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378218301385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T12:01:11Z","timestamp":1535112071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378218301385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":34,"alternative-id":["S0378378218301385"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2018.07.003","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autonomic nervous system depression at term in neurologically normal premature infants","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2018.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}