{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:48:02Z","timestamp":1788454082983,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.earlhumdev.2019.05.020","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T23:42:21Z","timestamp":1559778141000},"page":"6-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review"],"prefix":"10.1016","volume":"135","author":[{"given":"I.","family":"Viel-Theriault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.B.","family":"Fell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Grynspan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Redpath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Thampi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.earlhumdev.2019.05.020_bb0005","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1542\/peds.2013-2927","article-title":"Role of guidelines on length of therapy in chorioamnionitis and neonatal sepsis","volume":"133","author":"Kiser","year":"2014","journal-title":"Pediatrics"},{"issue":"8","key":"10.1016\/j.earlhumdev.2019.05.020_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001502","article-title":"Risk of early-onset neonatal infection with maternal infection or colonization: a global systematic review and meta-analysis","volume":"10","author":"Chan","year":"2013","journal-title":"PLoS Med."},{"issue":"4","key":"10.1016\/j.earlhumdev.2019.05.020_bb0015","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD010976","article-title":"Antibiotic regimens for management of intra-amniotic infection","author":"Chapman","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"issue":"2","key":"10.1016\/j.earlhumdev.2019.05.020_bb0020","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1542\/peds.2005-3083","article-title":"Risk factors for invasive, early-onset Escherichia coli infections in the era of widespread intrapartum antibiotic use","volume":"118","author":"Schrag","year":"2006","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.earlhumdev.2019.05.020_bb0025","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/1471-0528.12892","article-title":"Maternal sepsis incidence, aetiology and outcome for mother and fetus: a prospective study","volume":"122","author":"Knowles","year":"2015","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"issue":"5","key":"10.1016\/j.earlhumdev.2019.05.020_bb0030","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/INF.0000000000001473","article-title":"Clinical and microbiologic characteristics of early-onset sepsis among very low birth weight infants","volume":"36","author":"Mukhopadhyay","year":"2017","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.earlhumdev.2019.05.020_bb0035","first-page":"152","article-title":"Are postnatal ampicillin levels actually related to the duration of intrapartum antibiotic prophylaxis prior to delivery? A pharmacokinetic study in 120 neonates","author":"Berardi","year":"2017","journal-title":"Arch. Dis. Child."},{"issue":"3","key":"10.1016\/j.earlhumdev.2019.05.020_bb0040","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/adc.2010.187732","article-title":"Early, prolonged use of postnatal antibiotics increased the risk of necrotising enterocolitis","volume":"95","author":"Cotton","year":"2010","journal-title":"Arch. Dis. Child. Educ. Pract. Ed."},{"issue":"3","key":"10.1016\/j.earlhumdev.2019.05.020_bb0045","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jpeds.2011.02.035","article-title":"Antibiotic exposure in the newborn intensive care unit and the risk of necrotizing enterocolitis","volume":"159","author":"Alexander","year":"2011","journal-title":"J. Pediatr."},{"issue":"3","key":"10.1016\/j.earlhumdev.2019.05.020_bb0050","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2018-2286","article-title":"Duration of initial empirical antibiotic therapy and outcomes in very low birth weight infants","volume":"143","author":"Ting","year":"2019","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.earlhumdev.2019.05.020_bb0055","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jpeds.2011.05.033","article-title":"Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants","volume":"159","author":"Kuppala","year":"2011","journal-title":"J. Pediatr."},{"issue":"3","key":"10.1016\/j.earlhumdev.2019.05.020_bb0060","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1128\/JCM.02064-06","article-title":"Comparison of BACTEC PLUS blood culture media to BacT\/alert FA blood culture media for detection of bacterial pathogens in samples containing therapeutic levels of antibiotics","volume":"45","author":"Flayhart","year":"2007","journal-title":"J. Clin. Microbiol."},{"issue":"1","key":"10.1016\/j.earlhumdev.2019.05.020_bb0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0732-8893(02)00480-7","article-title":"Detection of group B streptococcal bacteremia in simulated intrapartum antimicrobial prophylaxis","volume":"45","author":"Hsu","year":"2003","journal-title":"Diagn. Microbiol. Infect. Dis."},{"issue":"8","key":"10.1016\/j.earlhumdev.2019.05.020_bb0070","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2165\/00003088-200443080-00001","article-title":"Human placenta","volume":"43","author":"Syme","year":"2004","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.earlhumdev.2019.05.020_bb0075","first-page":"1","article-title":"Prevention of perinatal group B streptococcal disease","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","journal-title":"Mmwr"},{"issue":"3","key":"10.1016\/j.earlhumdev.2019.05.020_bb0080","article-title":"Recommendations for the prevention of perinatal group B streptococcal (GBS) disease","volume":"128","author":"American Academy of Pediatrics","year":"2011","journal-title":"Pediatrics"},{"issue":"7","key":"10.1016\/j.earlhumdev.2019.05.020_bb0085","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3109\/14767058.2014.934804","article-title":"Intrapartum GBS screening and antibiotic prophylaxis: a European consensus conference","volume":"28","author":"Di Renzo","year":"2015","journal-title":"J. Matern. Neonatal Med."},{"issue":"9","key":"10.1016\/j.earlhumdev.2019.05.020_bb0090","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S1701-2163(16)30157-8","article-title":"The prevention of early-onset neonatal group B streptococcal disease","volume":"26","author":"Money","year":"2004","journal-title":"J. Obstet. Gynaecol. Canada"},{"issue":"2","key":"10.1016\/j.earlhumdev.2019.05.020_bb0095","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/1753-0407.12288","article-title":"Decreased placental and transcellular permeation of cefuroxime in pregnant women with diabetes","volume":"8","author":"Lalic-Popovic","year":"2016","journal-title":"J. Diabetes"},{"issue":"2","key":"10.1016\/j.earlhumdev.2019.05.020_bb0100","first-page":"84","article-title":"Placental structure, function and drug transfer","volume":"15","author":"Griffiths","year":"2015","journal-title":"Contin. Educ. Anaesth. Crit. Care Pain"},{"key":"10.1016\/j.earlhumdev.2019.05.020_bb0105","series-title":"Pr\u00e9cis de pharmacologie. Les Presses de l'Universit\u00e9 de Montr\u00e9al","author":"Beaulieu","year":"2015"},{"issue":"2","key":"10.1016\/j.earlhumdev.2019.05.020_bb0110","first-page":"170","article-title":"Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy","volume":"200","author":"Allegaert","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.earlhumdev.2019.05.020_bb0115","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/pch\/pxx023","article-title":"Management of term infants at increased risk for early-onset bacterial sepsis","volume":"22","author":"Jefferies","year":"2017","journal-title":"Paediatr. Child Health"},{"key":"10.1016\/j.earlhumdev.2019.05.020_bb0120","series-title":"Performance Standards for Antimicrobial Susceptibility Testing","author":"Clinical and Laboratory Standards Insitute","year":"2006"},{"issue":"1","key":"10.1016\/j.earlhumdev.2019.05.020_bb0125","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijgo.2014.10.018","article-title":"Vaginal group B streptococcus status during intrapartum antibiotic prophylaxis","volume":"129","author":"Scasso","year":"2015","journal-title":"Int. J. Gynecol. Obstet."},{"issue":"2","key":"10.1016\/j.earlhumdev.2019.05.020_bb0130","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/AOG.0b013e31817d0246","article-title":"Duration of intrapartum prophylaxis and concentration of penicillin g in fetal serum at delivery","volume":"112","author":"Barber","year":"2008","journal-title":"Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.earlhumdev.2019.05.020_bb0135","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2165\/00003088-199528030-00005","article-title":"Placental transfer of drugs administered to the mother","volume":"28","author":"Pacifici","year":"1995","journal-title":"Clin. Pharmacokinet."},{"issue":"4 I","key":"10.1016\/j.earlhumdev.2019.05.020_bb0140","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S0002-9378(96)80035-4","article-title":"Ampicillin for neonatal group B streptococcal prophylaxis: how rapidly can bactericidal concentrations be achieved?","volume":"175","author":"Bloom","year":"1996","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.earlhumdev.2019.05.020_bb0145","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ajog.2005.07.098","article-title":"Optimal timing of ampicillin administration to pregnant women for establishing bactericidal levels in the prophylaxis of group B Streptococcus","volume":"194","author":"Colombo","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2019.05.020_bb0150","series-title":"Antibiotic Concentration in Maternal Blood, Cord Blood, and Placental Membranes in Chorioamnionitis","first-page":"124","author":"Bawdon","year":"1988"},{"issue":"6","key":"10.1016\/j.earlhumdev.2019.05.020_bb0155","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0029-7844(01)01629-5","article-title":"Maternal and transplacental pharmacokinetics of cefazolin","volume":"98","author":"Fiore","year":"2001","journal-title":"Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.earlhumdev.2019.05.020_bb0160","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1365-2710.2007.00864.x","article-title":"Influence of pregnancy on ceftriaxone, cefazolin and gentamicin pharmacokinetics in caesarean vs. non-pregnant sectioned women","volume":"32","author":"Popovic","year":"2007","journal-title":"J. Clin. Pharm. Ther."},{"issue":"9","key":"10.1016\/j.earlhumdev.2019.05.020_bb0165","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1128\/JCM.01781-14","article-title":"Antimicrobial susceptibilities of group B streptococcus isolates from prenatal screening samples","volume":"52","author":"Berg","year":"2014","journal-title":"J. Clin. Microbiol."},{"issue":"11","key":"10.1016\/j.earlhumdev.2019.05.020_bb0170","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/jp.2016.122","article-title":"Transplacental passage of clindamycin from mother to neonate","volume":"36","author":"Wear","year":"2016","journal-title":"J. Perinatol."},{"issue":"5","key":"10.1016\/j.earlhumdev.2019.05.020_bb0175","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1128\/AAC.01017-09","article-title":"Pharmacokinetics of clindamycin in pregnant women in the peripartum period","volume":"54","author":"Muller","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"issue":"23","key":"10.1016\/j.earlhumdev.2019.05.020_bb0180","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1056\/NEJM197306072882307","article-title":"Transplacental passage of erythromycin and clindamycin","volume":"288","author":"Philipson","year":"1973","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.earlhumdev.2019.05.020_bb0185","doi-asserted-by":"crossref","first-page":"33","DOI":"10.17772\/gp\/1896","article-title":"The placental transfer of erythromycin in human pregnancies with group B streptococcal infection","volume":"86","author":"Bulska","year":"2015","journal-title":"Ginekol. Pol."},{"issue":"3","key":"10.1016\/j.earlhumdev.2019.05.020_bb0190","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1067\/mob.2003.171","article-title":"Placental passage of clarithromycin surpasses other macrolide antibiotics","volume":"188","author":"Witt","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.earlhumdev.2019.05.020_bb0195","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1067\/mob.2003.141","article-title":"Maternal and transplacental pharmacokinetics of azithromycin","volume":"188","author":"Ramsey","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"352","key":"10.1016\/j.earlhumdev.2019.05.020_bb0200","first-page":"e1","article-title":"Transplacental passage of vancomycin from mother to neonate","volume":"210","author":"Onwuchuruba","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"8","key":"10.1016\/j.earlhumdev.2019.05.020_bb0205","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1080\/14767058.2017.1306049","article-title":"Transplacental passage of vancomycin","volume":"31","author":"Towers","year":"2018","journal-title":"J. Matern. Neonatal Med."},{"issue":"5","key":"10.1016\/j.earlhumdev.2019.05.020_bb0210","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/01.AOG.0000260388.78339.b6","article-title":"Transplacental passage of vancomycin in noninfected term pregnant women","volume":"109","author":"Laiprasert","year":"2007","journal-title":"Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.earlhumdev.2019.05.020_bb0215","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/10647440400009821","article-title":"Transplacental passage of vancomycin in the ex vivo human perfusion model","volume":"12","author":"Hnat","year":"2004","journal-title":"Infect. Dis. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.earlhumdev.2019.05.020_bb0220","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/01.AOG.0000151106.87930.1a","article-title":"High compared with standard gentamicin dosing for chorioamnionitis: a comparison of maternal and fetal serum drug levels","volume":"105","author":"Locksmith","year":"2005","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.earlhumdev.2019.05.020_bb0225","article-title":"Ampicillin and gentamycin in the treatment of fetal intrauterine infection","volume":"8","author":"Creatsas","year":"1980","journal-title":"J. Perinatol."},{"issue":"4","key":"10.1016\/j.earlhumdev.2019.05.020_bb0230","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2012.06.064","article-title":"Transplacental transfer of vancomycin and telavancin","volume":"207","author":"Nanovskaya","year":"2012","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378219300799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378219300799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T01:56:37Z","timestamp":1759888597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378219300799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":46,"alternative-id":["S0378378219300799"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2019.05.020","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2019.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}