{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:45:11Z","timestamp":1790397911415,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["FAPESP 2016\/05237-7."],"award-info":[{"award-number":["FAPESP 2016\/05237-7."]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.earlhumdev.2019.06.005","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T07:12:31Z","timestamp":1560841951000},"page":"23-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Can parental consanguinity be a risk factor for the occurrence of nonsyndromic oral cleft?"],"prefix":"10.1016","volume":"135","author":[{"given":"Carolina Maia","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carolina de Moraes","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds Bernardes de","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucimara Teixeira das","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1590\/S1678-77572012000100003","article-title":"Rehabilitative treatment of cleft lip and palate: experience of the Hospital for Rehabilitation of Craniofacial Anomalies\/USP (HRAC\/USP)\u2014part 1: overall aspects","volume":"20","author":"Freitas","year":"2012","journal-title":"J. Appl. Oral Sci."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0010","first-page":"19","article-title":"Study of patients with cleft lip and palate with consanguineous parents","volume":"77","author":"de Aquino","year":"2011","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0015","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1600-0722.2008.00574.x","article-title":"Genes causing clefting syndromes as candidates for non-syndromic cleft lip with or without cleft palate: a family-based association study","volume":"116","author":"Scapoli","year":"2008","journal-title":"Eur. J. Oral Sci."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0020","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1177\/0022034517722761","article-title":"Candidate genes for nonsyndromic cleft palate detected by exome sequencing","volume":"96","author":"Hoebel","year":"2017","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/odi.12292","article-title":"Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and\/or palate development","volume":"21","author":"Bezerra","year":"2015","journal-title":"Oral Dis."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/1055665618774019","article-title":"Proportion of orofacial clefts attributable to recognized risk factors","volume":"56","author":"Raut","year":"2019","journal-title":"Cleft Palate-Craniofacial J"},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/1807-3107bor-2018.vol32.0024","article-title":"Risk factors and comorbidities in Brazilian patients with orofacial clefts","volume":"32","author":"Silva","year":"2018","journal-title":"Braz. Oral Res."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0040","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/ajmg.a.34432","article-title":"Consanguinity and occurrence of cleft lip\/palate: a hospital-based registry study in Riyadh","volume":"158A","author":"Ravichandran","year":"2012","journal-title":"Am. J. Med. Genet. Part A."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0045","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/1096-8628(20010722)102:1<36::AID-AJMG1394>3.0.CO;2-M","article-title":"Parental consanguinity in specific types of congenital anomalies","volume":"102","author":"Rittler","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0050","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.earlhumdev.2010.08.003","article-title":"The impact of consanguinity on neonatal and infant health","volume":"86","author":"Bittles","year":"2010","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0055","first-page":"681","article-title":"Consanguinity and pregnancy outcome among rural pregnant women of Belgaum district","volume":"3","author":"Metgud","year":"2012","journal-title":"Natl. J. Community Med."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0060","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/gte.2007.0093","article-title":"The prevalence of consanguineous marriages in an underserved area in Lebanon and its association with congenital anomalies","volume":"12","author":"Kanaan","year":"2008","journal-title":"Genet. Test."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0065","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.15537\/smj.2015.9.11823","article-title":"Birth prevalence of non-syndromic orofacial clefts in Saudi Arabia and the effects of parental consanguinity","volume":"36","author":"Sabbagh","year":"2015","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0070","first-page":"366","article-title":"Parental cigarette smoking, transforming growth factor-alpha gene variant and the risk of orofacial cleft in Iranian infants","volume":"19","author":"Ebadifar","year":"2016","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0075","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12687-011-0072-y","article-title":"Consanguineous marriages","volume":"3","author":"Hamamy","year":"2012","journal-title":"J. Community Genet."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0080","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/ajmg.a.34036","article-title":"Genetic contribution for non-syndromic cleft lip with or without cleft palate (NS CL\/P) in different regions of Brazil and implications for association studies","volume":"155","author":"Brito","year":"2011","journal-title":"Am. J. Med. Genet. Part A."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0085","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1597\/1545-1569_2002_039_0093_gftdaa_2.0.co_2","article-title":"Guidelines for the design and analysis of studies on nonsyndromic cleft lip and cleft palate in humans: summary report from a workshop of the international consortium for oral clefts genetics","volume":"39","author":"Mitchell","year":"2002","journal-title":"Cleft Palate-Craniofacial J"},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijporl.2017.07.020","article-title":"The risk ratio for development of hereditary sensorineural hearing loss in consanguineous marriage offspring","volume":"101","author":"Sanyelbhaa","year":"2017","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0095","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-018-1090-8","article-title":"Environmental exposures and the risk of multiple sclerosis in Saudi Arabia","volume":"18","author":"Al Wutayd","year":"2018","journal-title":"BMC Neurol."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0100","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1590\/S1806-83242009000100006","article-title":"Oral clefts, consanguinity, parental tobacco and alcohol use: a case-control study in Rio de Janeiro, Brazil","volume":"23","author":"Leite","year":"2009","journal-title":"Braz. Oral Res."},{"key":"10.1016\/j.earlhumdev.2019.06.005_bb0105","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1597\/06-246.1","article-title":"Pattern of cleft lip and palate in hospital-based population in Saudi Arabia: retrospective study","volume":"45","author":"Aljohar","year":"2008","journal-title":"Cleft Palate-Craniofacial J"}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378219303093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378219303093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T21:41:46Z","timestamp":1568929306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378219303093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":21,"alternative-id":["S0378378219303093"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2019.06.005","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Can parental consanguinity be a risk factor for the occurrence of nonsyndromic oral cleft?","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2019.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}