{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T11:15:44Z","timestamp":1763810144275,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.earlhumdev.2019.104909","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T20:08:46Z","timestamp":1574194126000},"page":"104909","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The spectrum of bilirubin neurotoxicity in term and near-term babies with hyperbilirubinemia: Does outcome improve with time?"],"prefix":"10.1016","volume":"140","author":[{"given":"Sarah S.","family":"ElTatawy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esraa A.","family":"Elmazzahy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira M.","family":"El Shennawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan A.","family":"Madani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem","family":"Abou Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman F.","family":"Iskander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.earlhumdev.2019.104909_bb0005","doi-asserted-by":"crossref","first-page":"e190858","DOI":"10.1001\/jamanetworkopen.2019.0858","article-title":"Rates of extreme neonatal hyperbilirubinemia and kernicterus in children and adherence to national guidelines for screening, diagnosis, and treatment in Sweden","volume":"2","author":"Alk\u00e9n","year":"2019","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.earlhumdev.2019.104909_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/1119-3077.173703","article-title":"The burden and management of neonatal jaundice in Nigeria: a scoping review of the literature","volume":"19","author":"Olusanya","year":"2016","journal-title":"Niger. J. Clin. Pract."},{"issue":"1","key":"10.1016\/j.earlhumdev.2019.104909_bb0015","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12519-018-0200-4","article-title":"Characteristics and outcome of newborn admitted with acute bilirubin encephalopathy to a tertiary neonatal intensive care unit","volume":"15","author":"Helal","year":"2019","journal-title":"World J. Pediatr."},{"issue":"1","key":"10.1016\/j.earlhumdev.2019.104909_bb0020","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.siny.2014.12.003","article-title":"Impact of bilirubin induced neurologic dysfunction on neurodevelopmental outcomes","volume":"20","author":"CJ1","year":"2015","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0025","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0022-3476(05)82056-6","article-title":"New Ballard score, expanded to include extremely premature infants","volume":"119","author":"Ballard","year":"1991","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0030","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1038\/jp.2008.211","article-title":"Clinical report from the pilot USA kernicterus registry (1992 to 2004)","author":"Johnson","year":"2009","journal-title":"J. Perinatol."},{"issue":"1","key":"10.1016\/j.earlhumdev.2019.104909_bb0035","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"114","author":"American Academy of Pediatrics","year":"2004","journal-title":"Pediatrics"},{"year":"1993","series-title":"Bayley Scales of Infant Development","author":"Bayley","key":"10.1016\/j.earlhumdev.2019.104909_bb0040"},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0045","doi-asserted-by":"crossref","first-page":"209e23","DOI":"10.1242\/dmm.004135","article-title":"Deficient forward transduction and enhanced reverse transduction in the alpha tectorin C1509G human hearing loss mutation","volume":"3","author":"Xia","year":"2010","journal-title":"Dis. Model. Mech."},{"issue":"3","key":"10.1016\/j.earlhumdev.2019.104909_bb0050","first-page":"199","article-title":"The neurological sequelae of neonatal hyperbilirubinemia: definitions, diagnosis and treatmentof the kernicterus spectrum disorders (KSDs)","volume":"13","author":"Le Pichon","year":"2017","journal-title":"Curr. Pediatr. Rev."},{"issue":"4","key":"10.1016\/j.earlhumdev.2019.104909_bb0055","first-page":"599","article-title":"Hyperbilirubinemia in the term newborn","volume":"65","author":"Porter","year":"2002","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0060","doi-asserted-by":"crossref","unstructured":"Iskander I1, Gamaleldin R, Kabbani M. Root causes for late presentation of severe neonatal hyperbilirubinaemia in Egypt. East Mediterr. Health J.. 2012 Aug;18(8):882\u20137.","DOI":"10.26719\/2012.18.8.882"},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0065","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000357378","article-title":"Neonatal hemolytic jaundice: morphologic features of erythrocytes that will help you diagnose the underlying condition","volume":"105","author":"Christensen","year":"2014","journal-title":"Neonatology"},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0070","series-title":"Care of the Jaundiced Neonate","first-page":"1","article-title":"Genetics of neonatal jaundice","author":"Watchko","year":"2012"},{"issue":"2","key":"10.1016\/j.earlhumdev.2019.104909_bb0075","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s12098-011-0501-2","article-title":"Association between peak serum bilirubin and neurodevelopmental outcomes in term babies with hyperbilirubinemia","volume":"79","author":"Arun Babu","year":"2012","journal-title":"Indian J. Pediatr."},{"issue":"5","key":"10.1016\/j.earlhumdev.2019.104909_bb0080","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/pr.2013.28","article-title":"Neurodevelopment after moderate hyperbilirubinemia at term","volume":"73","author":"Lunsing","year":"2013","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0085","doi-asserted-by":"crossref","first-page":"773e9","DOI":"10.1542\/peds.112.4.773","article-title":"National Institute of Child Health and Human Development Neonatal Research Network. Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants","volume":"112","author":"Oh","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0090","doi-asserted-by":"crossref","first-page":"872e8","DOI":"10.1542\/peds.2010-0052","article-title":"Neonatal jaundice, autism, and other disorders of psychological development","volume":"126","author":"Maimburg","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0095","doi-asserted-by":"crossref","first-page":"157e63","DOI":"10.1016\/j.siny.2009.12.004","article-title":"Chronic bilirubin encephalopathy. Diagnosis and outcome","volume":"15","author":"Shapiro","year":"2010","journal-title":"Semin. Fetal Neonatal Med."},{"issue":"9","key":"10.1016\/j.earlhumdev.2019.104909_bb0100","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1016\/j.ridd.2013.06.019","article-title":"Prenatal, perinatal and neonatal risk factors of autism specterum disorders: a comprehensive epidemiological assessment from India","volume":"34","author":"Mamidala","year":"2013","journal-title":"Res. Dev. Disabil."},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0105","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.7717\/peerj.294","article-title":"Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates - a 30 year prospective follow-up study","volume":"2","author":"Hokkanen","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0110","first-page":"3e13","article-title":"Hyperbilirubinemia: subcortical mechanisms of cognitive and behavioral dysfunction","volume":"48","author":"Koziol","year":"2013","journal-title":"PediatrNeurol"},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0115","doi-asserted-by":"crossref","first-page":"117e33","DOI":"10.1016\/j.neuroscience.2013.05.021","article-title":"Auditory critical periods: a review from system's perspective","volume":"247","author":"Kral","year":"2013","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.earlhumdev.2019.104909_bb0120","doi-asserted-by":"crossref","first-page":"e925","DOI":"10.1542\/peds.2011-0206","article-title":"Risk factors for neurotoxicity in newborns with severe neonatal hyperbilirubinemia","volume":"128","author":"Gamaleldin","year":"2011","journal-title":"Pediatrics"},{"issue":"18","key":"10.1016\/j.earlhumdev.2019.104909_bb0125","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1056\/NEJMoa054244","article-title":"Jaundice and Infant Feeding Study Team. Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter or more","volume":"354","author":"Newman","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jpeds.2016.12.079","article-title":"Prediction of 3- to 5-months outcomes from signs of acute bilirubin toxicity in newborn infants","volume":"183","author":"El Houchi","year":"2017","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0135","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fncel.2012.00022","article-title":"Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining","volume":"6","author":"Palmela","year":"2012","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0140","doi-asserted-by":"crossref","first-page":"663e675","DOI":"10.1016\/j.nbd.2010.08.010","article-title":"Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation","volume":"40","author":"Silva","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.earlhumdev.2019.104909_bb0145","first-page":"162","article-title":"Auditory impairment in infants at risk for bilirubin induced neurologic dysfunction","volume":"35","author":"Shapiro","year":"2011","journal-title":"SeminPerinatol"},{"issue":"1","key":"10.1016\/j.earlhumdev.2019.104909_bb0150","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.siny.2014.12.006","article-title":"Audiologic impairment associated with bilirubin-induced neurologic damage","volume":"20","author":"Olds","year":"2015","journal-title":"Semin. Fetal Neonatal Med."},{"issue":"99","key":"10.1016\/j.earlhumdev.2019.104909_bb0155","first-page":"195","article-title":"Risk factors for sensorineural hearing loss in neonatal hyperbilirubinemia","volume":"30","author":"Boskabadi","year":"2018","journal-title":"Iran. J. Otorhinolaryngol."},{"issue":"1","key":"10.1016\/j.earlhumdev.2019.104909_bb0160","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12887-015-0355-2","article-title":"A modified bilirubin-induced neurologic dysfunction (BIND-M) algorithm is useful in evaluating severity of jaundice in a resource-limited setting","volume":"15","author":"Radmacher","year":"2015","journal-title":"BMC Pediatr."},{"issue":"2","key":"10.1016\/j.earlhumdev.2019.104909_bb0165","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00405-010-1363-3","article-title":"Reversible auditory brainstem responses screening failures in high risk neonates","volume":"268","author":"Psarommatis","year":"2011","journal-title":"Eur. Arch. Otorhinolaryngol."}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378219302853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378219302853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T01:58:35Z","timestamp":1759888715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378219302853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":33,"alternative-id":["S0378378219302853"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2019.104909","relation":{},"ISSN":["0378-3782"],"issn-type":[{"type":"print","value":"0378-3782"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The spectrum of bilirubin neurotoxicity in term and near-term babies with hyperbilirubinemia: Does outcome improve with time?","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2019.104909","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104909"}}