{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:09:44Z","timestamp":1779296984435,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.earlhumdev.2021.105467","type":"journal-article","created":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T10:34:41Z","timestamp":1631356481000},"page":"105467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Early extubation is associated with shorter duration of mechanical ventilation and lower incidence of bronchopulmonary dysplasia"],"prefix":"10.1016","volume":"163","author":[{"given":"Fanny","family":"S\u00f6derstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"\u00c5gren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Sindelar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.earlhumdev.2021.105467_bb0005","doi-asserted-by":"crossref","first-page":"e370","DOI":"10.2741\/1060","article-title":"Pathogenesis, pathology and pathophysiology of pulmonary sequelae of bronchopulmonary dysplasia in premature infants","volume":"8","author":"Bhandari","year":"2003","journal-title":"Front. Biosci. J. Virtual Libr."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0010","first-page":"6","article-title":"How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and \u201ctomorrow\u201d","author":"Nelin","year":"2017","journal-title":"F1000Research"},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0015","doi-asserted-by":"crossref","first-page":"319","DOI":"10.5935\/0103-507X.20130054","article-title":"Ventilator-induced lung injury in preterm infants","volume":"25","author":"Carvalho","year":"2013","journal-title":"Rev. Bras. Ter. Intensiva"},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0020","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jpeds.2018.01.043","article-title":"Bronchopulmonary dysplasia: executive summary of a workshop","volume":"197","author":"Higgins","year":"2018","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0025","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM196702162760701","article-title":"Pulmonary disease following respirator therapy of hyaline-membrane disease","volume":"276","author":"WHJr","year":"1967","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0030","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","article-title":"Bronchopulmonary dysplasia","volume":"163","author":"Jobe","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0035","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1203\/00006450-199912000-00007","article-title":"The new BPD: an arrest of lung development","volume":"46","author":"Jobe","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0040","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1053\/j.semperi.2006.05.002","article-title":"Definitions and diagnostic criteria for bronchopulmonary dysplasia","volume":"30","author":"Bancalari","year":"2006","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0045","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41390-018-0167-9","article-title":"The definition of bronchopulmonary dysplasia: an evolving dilemma","volume":"84","author":"Ibrahim","year":"2018","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jpeds.2016.10.082","article-title":"Interdisciplinary care of children with severe bronchopulmonary dysplasia","volume":"181","author":"Abman","year":"2017","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0055","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1164\/rccm.201812-2348OC","article-title":"The diagnosis of bronchopulmonary dysplasia in very preterm infants. An evidence-based approach","volume":"200","author":"Jensen","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0060","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1164\/rccm.201907-1342OC","article-title":"Characterization of disease phenotype in very preterm infants with severe bronchopulmonary dysplasia","volume":"201","author":"Wu","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0065","first-page":"1","article-title":"Established severe BPD: is there a way out? Change of ventilatory paradigms","author":"Sindelar","year":"2021","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0070","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3233\/NPM-15814061","article-title":"Early extubation attempts reduce length of stay in extremely preterm infants even if re-intubation is necessary","volume":"8","author":"Robbins","year":"2015","journal-title":"J. Neonatal-Perinat. Med."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0075","doi-asserted-by":"crossref","first-page":"F305","DOI":"10.1136\/adc.2007.129890","article-title":"A trial of spontaneous breathing to determine the readiness for extubation in very low birth weight infants: a prospective evaluation","volume":"93","author":"Kamlin","year":"2008","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0080","doi-asserted-by":"crossref","first-page":"e907","DOI":"10.1542\/peds.2008-1647","article-title":"Implementation of a respiratory therapist-driven protocol for neonatal ventilation: impact on the premature population","volume":"123","author":"Hermeto","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0085","doi-asserted-by":"crossref","first-page":"F428","DOI":"10.1136\/archdischild-2015-308549","article-title":"International survey on periextubation practices in extremely preterm infants","volume":"100","author":"Al-Mandari","year":"2015","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0090","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/ppul.20726","article-title":"A randomized trial of delayed extubation for the reduction of reintubation in extremely preterm infants","volume":"43","author":"Danan","year":"2008","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0095","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jpeds.2017.04.050","article-title":"Markers of successful extubation in extremely preterm infants, and morbidity after failed extubation","volume":"189","author":"Chawla","year":"2017","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0100","doi-asserted-by":"crossref","first-page":"F89","DOI":"10.1136\/archdischild-2017-313878","article-title":"Predictors of extubation readiness in preterm infants: a systematic review and meta-analysis","volume":"104","author":"Shalish","year":"2019","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0105","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1001\/jamapediatrics.2015.2401","article-title":"Effects of multiple ventilation courses and duration of mechanical ventilation on respiratory outcomes in extremely low-birth-weight infants","volume":"169","author":"Jensen","year":"2015","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/ppul.25383","article-title":"Prediction of extubation readiness using lung ultrasound in preterm infants","author":"Soliman","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/14767050410001668239","article-title":"Spontaneous minute ventilation is a predictor of extubation failure in extremely-low-birth-weight infants","volume":"15","author":"Ventol","year":"2004","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0120","first-page":"55","article-title":"The FiO2 is associated with the successful extubation of mechanically ventilated neonates","volume":"1","author":"Shepherd","year":"2011","journal-title":"Res. Rep. Neonatol."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0125","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jpeds.2018.09.062","article-title":"The impact of time interval between extubation and reintubation on death or bronchopulmonary dysplasia in extremely preterm infants","volume":"205","author":"Shalish","year":"2019","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0130","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/sj.jp.7210886","article-title":"Usefulness of the minute ventilation test in predicting successful extubation in newborn infants: a randomized controlled trial","volume":"23","author":"Gillespie","year":"2003","journal-title":"J. Perinatol."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0135","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41372-018-0300-y","article-title":"Reduced rate of treated retinopathy of prematurity after implementing lower oxygen saturation targets","volume":"39","author":"S\u00f6derstr\u00f6m","year":"2019","journal-title":"J. Perinatol."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0140","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1001\/archopht.123.7.991","article-title":"The international classification of retinopathy of prematurity revisited","volume":"123","author":"International Committee for the Classification of Retinopathy of Prematurity","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0145","unstructured":"National Quality Registry for Neonatal Care (SNQ) - Nationella Kvalitetsregister n.d. http:\/\/kvalitetsregister.se\/englishpages\/findaregistry\/registerarkivenglish\/nationalqualityregistryforneonatalcaresnq.2191.html (accessed April 19, 2018)."},{"key":"10.1016\/j.earlhumdev.2021.105467_bb0150","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41372-019-0495-6","article-title":"Early versus delayed extubation in extremely preterm neonates: a retrospective cohort study","volume":"40","author":"Mukerji","year":"2020","journal-title":"J. Perinatol."}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378221001663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378221001663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T02:06:51Z","timestamp":1759889211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378221001663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":30,"alternative-id":["S0378378221001663"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2021.105467","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early extubation is associated with shorter duration of mechanical ventilation and lower incidence of bronchopulmonary dysplasia","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2021.105467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105467"}}