{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:38:21Z","timestamp":1774330701350,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.earlhumdev.2023.105815","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T02:16:19Z","timestamp":1688350579000},"page":"105815","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Evaluation of neurovascular coupling during neuroprotective therapies: A single site HEAL ancillary study"],"prefix":"10.1016","volume":"183","author":[{"given":"Lina F.","family":"Chalak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivas","family":"Kota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra E.","family":"Juul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne W.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.earlhumdev.2023.105815_bb0005","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1056\/NEJMoa2119660","article-title":"Trial of erythropoietin for hypoxic-ischemic encephalopathy in newborns","volume":"387","author":"Wu","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.pediatrneurol.2005.10.015","article-title":"Translational stroke research in the developing brain","volume":"34","author":"Vexler","year":"2006","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0015","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1161\/STROKEAHA.107.483008","article-title":"Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia\/ischemia in rats","volume":"38","author":"Iwai","year":"2007","journal-title":"Stroke."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0020","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1111\/j.1471-4159.2007.04684.x","article-title":"Systemically delivered erythropoietin transiently enhances adult hippocampal neurogenesis","volume":"102","author":"Ransome","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0025","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ana.21068","article-title":"Sustained neocortical neurogenesis after neonatal hypoxic\/ischemic injury","volume":"61","author":"Yang","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0030","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1159\/000486820","article-title":"High-dose erythropoietin for asphyxia and encephalopathy (HEAL): a randomized controlled trial - background, aims, and study protocol","volume":"113","author":"Juul","year":"2018","journal-title":"Neonatology."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0035","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fnins.2015.00040","article-title":"Blood-brain barrier dysfunction in disorders of the developing brain","volume":"9","author":"Moretti","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0040","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fneur.2013.00040","article-title":"The potential for bio-mediators and biomarkers in pediatric traumatic brain injury and neurocritical care","volume":"4","author":"Kochanek","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0045","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.earlhumdev.2014.06.010","article-title":"Serum biomarkers to evaluate the integrity of the neurovascular unit","volume":"90","author":"Mir","year":"2014","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0050","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.earlhumdev.2014.06.013","article-title":"The \u201cneurovascular unit approach\u201d to evaluate mechanisms of dysfunctional autoregulation in asphyxiated newborns in the era of hypothermia therapy","volume":"90","author":"Chalak","year":"2014","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0055","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jpeds.2013.10.067","article-title":"Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy","volume":"164","author":"Chalak","year":"2014","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0060","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.earlhumdev.2014.06.011","article-title":"Introduction. A \u201cneurovascular unit\u201d approach in newborns with HIE: can we improve outcomes?","volume":"90","author":"Chalak","year":"2014","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0065","doi-asserted-by":"crossref","first-page":"45958","DOI":"10.1038\/srep45958","article-title":"Novel wavelet real time analysis of neurovascular coupling in neonatal encephalopathy","volume":"7","author":"Chalak","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0070","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/s41390-020-0992-5","article-title":"Regional heterogeneity of cerebral hemodynamics in mild neonatal encephalopathy measured with multichannel near-infrared spectroscopy","volume":"89","author":"Tian","year":"2021","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0075","doi-asserted-by":"crossref","first-page":"9183","DOI":"10.1038\/s41598-020-66227-y","article-title":"Rigor of neurovascular coupling (NVC) assessment in newborns using different amplitude EEG algorithms","volume":"10","author":"Das","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2021.106593","article-title":"EEG phase-amplitude coupling to stratify encephalopathy severity in the developing brain","volume":"214","author":"Wang","year":"2022","journal-title":"Comput. Methods Prog. Biomed."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0085","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1469-8749.1997.tb07414.x","article-title":"Development and reliability of a system to classify gross motor function in children with cerebral palsy","volume":"39","author":"Palisano","year":"1997","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0090","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jpeds.2008.04.013","article-title":"An algorithm for identifying and classifying cerebral palsy in young children","volume":"153","author":"Kuban","year":"2008","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0095","doi-asserted-by":"crossref","first-page":"9426","DOI":"10.1038\/s41598-021-88849-6","article-title":"Neurovascular coupling (NVC) in newborns using processed EEG versus amplitude-EEG","volume":"11","author":"Das","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2020.105716","article-title":"WU-NEAT: a clinically validated, open-source MATLAB toolbox for limited-channel neonatal EEG analysis","volume":"196","author":"Vesoulis","year":"2020","journal-title":"Comput. Methods Prog. Biomed."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2021.102856","article-title":"Wavelet-based neurovascular coupling can predict brain abnormalities in neonatal encephalopathy","volume":"32","author":"Das","year":"2021","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0110","doi-asserted-by":"crossref","first-page":"561","DOI":"10.5194\/npg-11-561-2004","article-title":"Application of the cross wavelet transform and wavelet coherence to geophysical time series","volume":"11","author":"Grinsted","year":"2004","journal-title":"Nonlinear Process. Geophys."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0115","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/biom.13184","article-title":"Robustness of ANCOVA in randomized trials with unequal randomization","volume":"76","author":"Bartlett","year":"2020","journal-title":"Biometrics."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0120","first-page":"1","article-title":"Risk of seizures in neonates with hypoxic-ischemic encephalopathy receiving hypothermia plus erythropoietin or placebo","author":"Glass","year":"2022","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1113\/jphysiol.1890.sp000321","article-title":"On the regulation of the blood-supply of the brain","volume":"11","author":"Roy","year":"1890","journal-title":"J. Physiol."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0130","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41582-022-00703-z","article-title":"The neurovascular unit and systemic biology in stroke - implications for translation and treatment","volume":"18","author":"Tiedt","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0135","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00401-022-02452-1","article-title":"Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke","volume":"144","author":"Spitzer","year":"2022","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0140","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000457833","article-title":"New wavelet neurovascular bundle for bedside evaluation of cerebral autoregulation and neurovascular coupling in newborns with hypoxic-ischemic encephalopathy","volume":"39","author":"Chalak","year":"2017","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0145","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.earlhumdev.2014.06.009","article-title":"Non-invasive assessment of neonatal brain oxygen metabolism: a review of newly available techniques","volume":"90","author":"Liu","year":"2014","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0150","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pediatrneurol.2015.11.010","article-title":"Cerebral hemodynamics in asphyxiated newborns undergoing hypothermia therapy: pilot findings using a multiple-time-scale analysis","volume":"55","author":"Chalak","year":"2016","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0155","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.nicl.2016.01.020","article-title":"Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic-ischemic encephalopathy","volume":"11","author":"Tian","year":"2016","journal-title":"NeuroImage Clin."},{"issue":"1","key":"10.1016\/j.earlhumdev.2023.105815_bb0160","first-page":"45958","article-title":"Scientific reports 2017","volume":"7","author":"Chalak","year":"2017"},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0165","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/STROKEAHA.111.000104","article-title":"Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke","volume":"44","author":"Gonzalez","year":"2013","journal-title":"Stroke."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0170","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.nbd.2010.01.015","article-title":"Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke","volume":"38","author":"Osredkar","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0175","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1203\/pdr.0b013e31805341dc","article-title":"Pharmacokinetics of high-dose recombinant erythropoietin in plasma and brain of neonatal rats","volume":"61","author":"Statler","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0180","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1152\/jappl.1996.80.1.140","article-title":"Erythropoietin pharmacokinetics in premature infants: developmental, nonlinearity, and treatment effects","volume":"80","author":"Widness","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0185","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0022-3476(05)83559-0","article-title":"Single-dose pharmacokinetics of recombinant human erythropoietin in preterm infants after intravenous and subcutaneous administration","volume":"122","author":"Brown","year":"1993","journal-title":"J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2023.105815_bb0190","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jpeds.2013.10.084","article-title":"Feasibility and safety of erythropoietin for neuroprotection after perinatal arterial ischemic stroke","volume":"164","author":"Benders","year":"2014","journal-title":"J. Pediatr."}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378223001111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378223001111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T02:22:31Z","timestamp":1759890151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378223001111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":38,"alternative-id":["S0378378223001111"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2023.105815","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of neurovascular coupling during neuroprotective therapies: A single site HEAL ancillary study","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2023.105815","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105815"}}