{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:04:53Z","timestamp":1778695493083,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.earlhumdev.2024.106147","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T15:09:39Z","timestamp":1731856179000},"page":"106147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Is neutrophil to lymphocyte ratio an accurate predictor of neonatal sepsis in premature infants?"],"prefix":"10.1016","volume":"200","author":[{"given":"Rachel","family":"Binny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despina","family":"Kotsanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Buttery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Korman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.earlhumdev.2024.106147_bb0005","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/tropej\/fmu038","article-title":"Late-onset sepsis in very low birth weight infants: a Brazilian Neonatal Research Network Study","volume":"60","author":"de Souza Rugolo","year":"2014","journal-title":"J. Trop. Pediatr."},{"issue":"2","key":"10.1016\/j.earlhumdev.2024.106147_bb0010","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/INF.0000000000000024","article-title":"Clinical and laboratory factors that predict death in very low birth weight infants presenting with late-onset sepsis","volume":"33","author":"Levit","year":"2014","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0015","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0140-6736(14)61698-6","article-title":"Global, regional and national causes of child mortality in 2000\u201313, with projections to inform post-2015 priorities: an updated systematic analysis","volume":"31","author":"Liu","year":"2015","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.earlhumdev.2024.106147_bb0020","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/INF.0000000000002558","article-title":"Neonatal outcomes following culture-negative late-onset sepsis among preterm infants","volume":"39","author":"Jiang","year":"2020","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0025","doi-asserted-by":"crossref","first-page":"e00089","DOI":"10.1128\/CMR.00089-17","article-title":"Emerging technologies for molecular diagnosis of sepsis","volume":"31","author":"Sinha","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"issue":"4","key":"10.1016\/j.earlhumdev.2024.106147_bb0030","first-page":"487","article-title":"Late-onset sepsis in preterm infants: update on strategies for therapy and prevention","volume":"13","author":"Pammi","year":"2015","journal-title":"Expert Rev. Anti Infect. Ther."},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106147_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/tropej\/fmu079","article-title":"Challenges in the diagnosis and management of neonatal sepsis","volume":"61","author":"Zea-Vera","year":"2015","journal-title":"J. Trop. Pediatr."},{"issue":"03","key":"10.1016\/j.earlhumdev.2024.106147_bb0040","doi-asserted-by":"crossref","first-page":"e20162845","DOI":"10.1542\/peds.2016-2845","article-title":"Variation in sepsis evaluation across a national network of nurseries","volume":"139","author":"Mukhopadhyay","year":"2017","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.earlhumdev.2024.106147_bb0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.4103\/JETS.JETS_72_17","article-title":"The eminence of neutrophil-lymphocyte count ratio in predicting bacteremia for community-acquired infections at an emergency medicine department in a tertiary care setting","volume":"11","author":"Manohar","year":"2018","journal-title":"J. Emerg. Trauma Shock"},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0050","doi-asserted-by":"crossref","first-page":"1983455","DOI":"10.1155\/2022\/1983455","article-title":"The neutrophil to lymphocyte ratio in poststroke infection: a systematic review and meta-analysis","volume":"2022","author":"Khanzadeh","year":"2022","journal-title":"Dis. Markers"},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106147_bb0055","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.amjsurg.2019.04.018","article-title":"Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguished between complicated and uncomplicated appendicitis: a systematic review and meta-analysis","volume":"219","author":"Hajibandeh","year":"2020","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0060","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.clineuro.2019.03.012","article-title":"Peripheral blood neutrophil-to-lymphocyte ratio in preterm infants with intraventricular hemorrhage","volume":"180","author":"Stein","year":"2019","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0065","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fped.2019.00464","article-title":"High neutrophil-to-lymphocyte ratio is an early predictor of bronchopulmonary dysplasia","volume":"7","author":"Sun","year":"2019","journal-title":"Front. Pediatr."},{"issue":"4","key":"10.1016\/j.earlhumdev.2024.106147_bb0070","doi-asserted-by":"crossref","first-page":"e229","DOI":"10.1097\/MPH.0000000000001059","article-title":"The value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for detecting early-onset neonatal sepsis","volume":"40","author":"Can","year":"2018","journal-title":"J. Pediatr. Hematol. Oncol."},{"issue":"6","key":"10.1016\/j.earlhumdev.2024.106147_bb0075","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3345\/kjp.2018.06723","article-title":"Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis","volume":"62","author":"Wilar","year":"2019","journal-title":"Korean J. Pediatr."},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0080","doi-asserted-by":"crossref","first-page":"F257","DOI":"10.1136\/archdischild-2014-306213","article-title":"Late-onset neonatal sepsis: recent developments","volume":"100","author":"Dong","year":"2015","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"issue":"5","key":"10.1016\/j.earlhumdev.2024.106147_bb0085","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/archdischild-2022-324977","article-title":"Late-onset sepsis in very preterm infants in Norway in 2009\u20132018: a population-based study","volume":"108","author":"Huncikova","year":"2023","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"issue":"7","key":"10.1016\/j.earlhumdev.2024.106147_bb0090","doi-asserted-by":"crossref","first-page":"e200593","DOI":"10.1001\/jamapediatrics.2020.0593","article-title":"Early-onset neonatal sepsis 2015 to 2017, the rise of Escherichia coli, and the need for novel prevention strategies","volume":"174","author":"Stoll","year":"2020","journal-title":"JAMA Pediatr."},{"issue":"4","key":"10.1016\/j.earlhumdev.2024.106147_bb0095","doi-asserted-by":"crossref","first-page":"e22338","DOI":"10.1002\/jcla.22338","article-title":"Can neutrophil to lymphocyte ratio predict late-onset sepsis in preterm infants?","volume":"32","author":"Alkan Ozdemir","year":"2018","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0100","doi-asserted-by":"crossref","first-page":"e018092","DOI":"10.1136\/bmjopen-2017-018092","article-title":"Diagnostic markers of acute infections in infants aged 1 week to 3\u00a0months: a retrospective cohort study","volume":"8","author":"Hamiel","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0105","first-page":"908326","article-title":"The utility of peripheral blood leucocyte ratios as biomarkers in neonatal sepsis: a systematic review and meta-analysis","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Pediatr."},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106147_bb0110","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1186\/s12879-023-08800-0","article-title":"Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis","volume":"23","author":"Chen","year":"2023","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106147_bb0115","first-page":"e12891","article-title":"The utility of the neutrophil-lymphocyte ratio as an early diagnostic marker in neonatal sepsis","volume":"13","author":"Panda","year":"2021","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106147_bb0120","doi-asserted-by":"crossref","first-page":"64","DOI":"10.5935\/0103-507X.20190010","article-title":"Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study. Raz\u00e3o neutr\u00f3filo-linf\u00f3cito no diagn\u00f3stico precoce de sepse em unidade de terapia intensiva: um estudo de caso-controle","volume":"31","author":"Martins","year":"2019","journal-title":"Rev. Bras. Ter. Intensiva"},{"issue":"3","key":"10.1016\/j.earlhumdev.2024.106147_bb0125","doi-asserted-by":"crossref","first-page":"144","DOI":"10.14238\/pi51.3.2011.144-8","article-title":"Incidence and factors associated with mortality of neonatal sepsis","volume":"51","author":"Kardana","year":"2011","journal-title":"Paediatr. Indones."},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0130","series-title":"Report of the Australian and New Zealand Neonatal Network 2019","author":"Chow","year":"2021"},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0135","series-title":"ANZNN 2020 Data Dictionary","author":"Australian and New Zealand Neonatal Network","year":"2020"},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106147_bb0140","doi-asserted-by":"crossref","first-page":"F51","DOI":"10.1136\/archdischild-2015-310165","article-title":"Decreasing infection in neonatal intensive care units through quality improvement","volume":"102","author":"Bowen","year":"2017","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"issue":"7","key":"10.1016\/j.earlhumdev.2024.106147_bb0145","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1515\/jpm-2019-0016","article-title":"The value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) parameters in analysis with fetal malnutrition neonates","volume":"47","author":"Can","year":"2019","journal-title":"J. Perinat. Med."},{"issue":"9","key":"10.1016\/j.earlhumdev.2024.106147_bb0150","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/INF.0000000000001568","article-title":"Late-onset neonatal sepsis\u2014a 10-year review from North Queensland, Australia","volume":"36","author":"Gowda","year":"2017","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"9","key":"10.1016\/j.earlhumdev.2024.106147_bb0155","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1097\/INF.0000000000002408","article-title":"Gram-negative late-onset sepsis in extremely low birth weight infants is emerging in the Netherlands despite quality improvement programs and antibiotic stewardship!","volume":"38","author":"Ran","year":"2019","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"9","key":"10.1016\/j.earlhumdev.2024.106147_bb0160","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.cmi.2018.03.030","article-title":"Contaminants in blood cultures: importance, implications, interpretation and prevention","volume":"24","author":"Darg\u00e8re","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0165","doi-asserted-by":"crossref","first-page":"E41","DOI":"10.1542\/peds.102.4.e41","article-title":"Serial serum C-reactive protein levels in the diagnosis of neonatal infection","volume":"102","author":"Benitz","year":"1998","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106147_bb0170","doi-asserted-by":"crossref","first-page":"F76","DOI":"10.1136\/archdischild-2013-303984","article-title":"Value of a single C-reactive protein measurement at 18\u00a0h of age","volume":"99","author":"Lacaze-Masmonteil","year":"2014","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0175","series-title":"Neonatal Blood Culture Collection Procedure (Monash Newborn Services) Clinical Practice Guidelines 2021","author":"Binny","year":"2021"},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0180","author":"Clinical Excellence Commission"},{"issue":"2","key":"10.1016\/j.earlhumdev.2024.106147_bb0185","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.cmi.2019.10.006","article-title":"The correct blood volume for paediatric blood cultures: a conundrum?","volume":"26","author":"Huber","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"issue":"6","key":"10.1016\/j.earlhumdev.2024.106147_bb0190","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1136\/archdischild-2019-318080","article-title":"The practice of blood volume submitted for culture in a neonatal intensive care unit","volume":"105","author":"Singh","year":"2020","journal-title":"Arch. Dis. Child. Neonatal Ed."},{"key":"10.1016\/j.earlhumdev.2024.106147_bb0195","series-title":"Neonatology: Management, Procedures, On-call Problems, Disease and Drugs","first-page":"865","article-title":"Sepsis","author":"Bany-Mohammed","year":"2013"}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378224002160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378224002160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T16:36:11Z","timestamp":1734021371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378224002160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":39,"alternative-id":["S0378378224002160"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2024.106147","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is neutrophil to lymphocyte ratio an accurate predictor of neonatal sepsis in premature infants?","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2024.106147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106147"}}