{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:30:06Z","timestamp":1786987806989,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007311","name":"Cleveland Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007311","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Early Human Development"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.earlhumdev.2024.106163","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T21:41:15Z","timestamp":1732311675000},"page":"106163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Retrospective study of left and right ventricular strain mechanics among neonates undergoing therapeutic hypothermia for neonatal encephalopathy"],"prefix":"10.1016","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9977-5583","authenticated-orcid":false,"given":"Justin B.","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenivas","family":"Karnati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Sammour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukmini","family":"Komarlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.earlhumdev.2024.106163_bb0005","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum. Dev."},{"issue":"4","key":"10.1016\/j.earlhumdev.2024.106163_bb0010","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jamapediatrics.2014.3269","article-title":"Hypoxic-ischemic encephalopathy: a review for the clinician","volume":"169","author":"Douglas-Escobar","year":"2015","journal-title":"JAMA Pediatr."},{"issue":"6","key":"10.1016\/j.earlhumdev.2024.106163_bb0015","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.earlhumdev.2010.05.009","article-title":"Obstetric aspects of hypoxic ischemic encephalopathy","volume":"86","author":"Kumar","year":"2010","journal-title":"Early Hum. Dev."},{"issue":"9359","key":"10.1016\/j.earlhumdev.2024.106163_bb0020","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(03)12658-X","article-title":"Origin and timing of brain lesions in term infants with neonatal encephalopathy","volume":"361","author":"Cowan","year":"2003","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.earlhumdev.2024.106163_bb0025","doi-asserted-by":"crossref","first-page":"F257","DOI":"10.1136\/adc.2003.047985","article-title":"Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy: population based study","volume":"90","author":"Pierrat","year":"2005","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"issue":"3","key":"10.1016\/j.earlhumdev.2024.106163_bb0030","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jpeds.2009.03.040","article-title":"Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic-ischemic brain injury","volume":"155","author":"Glass","year":"2009","journal-title":"J. Pediatr."},{"issue":"2","key":"10.1016\/j.earlhumdev.2024.106163_bb0035","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes","volume":"371","author":"Azzopardi","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106163_bb0040","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"2013","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"issue":"7","key":"10.1016\/j.earlhumdev.2024.106163_bb0045","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/0883073819828625","article-title":"Current practice of therapeutic hypothermia for mild hypoxic ischemic encephalopathy","volume":"34","author":"Saw","year":"2019","journal-title":"J. Child Neurol."},{"issue":"4","key":"10.1016\/j.earlhumdev.2024.106163_bb0050","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/adc.2011.214205","article-title":"Cardiovascular dysfunction in infants with neonatal encephalopathy","volume":"97","author":"Armstrong","year":"2012","journal-title":"Arch. Dis. Child."},{"issue":"Suppl. 1","key":"10.1016\/j.earlhumdev.2024.106163_bb0055","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41390-018-0075-z","article-title":"Application of neonatologist performed echocardiography in the assessment and management of neonatal heart failure unrelated to congenital heart disease","volume":"84","author":"Levy","year":"2018","journal-title":"Pediatr. Res."},{"issue":"9","key":"10.1016\/j.earlhumdev.2024.106163_bb0060","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s004310051192","article-title":"Myocardial ischaemia in neonates with perinatal asphyxia. Electrocardiographic, echocardiographic and enzymatic correlations","volume":"158","author":"Barberi","year":"1999","journal-title":"Eur. J. Pediatr."},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106163_bb0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000084067","article-title":"Usefulness of cardiac troponin T and echocardiography in the diagnosis of hypoxic myocardial injury of full-term neonates","volume":"88","author":"Szymankiewicz","year":"2005","journal-title":"Biol. Neonate"},{"issue":"5","key":"10.1016\/j.earlhumdev.2024.106163_bb0070","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s00246-010-9661-5","article-title":"Myocardial performance in asphyxiated full-term infants assessed by Doppler tissue imaging","volume":"31","author":"Matter","year":"2010","journal-title":"Pediatr. Cardiol."},{"issue":"2","key":"10.1016\/j.earlhumdev.2024.106163_bb0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1651-2227.2007.00104.x","article-title":"Is serum troponin T a useful marker of myocardial damage in newborn infants with perinatal asphyxia?","volume":"96","author":"Costa","year":"2007","journal-title":"Acta paediatrica (Oslo, Norway\u202f: 1992)"},{"issue":"5","key":"10.1016\/j.earlhumdev.2024.106163_bb0080","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.earlhumdev.2014.01.014","article-title":"The myocardial function during and after whole-body therapeutic hypothermia for hypoxic-ischemic encephalopathy, a cohort study","volume":"90","author":"Nestaas","year":"2014","journal-title":"Early Hum. Dev."},{"issue":"4","key":"10.1016\/j.earlhumdev.2024.106163_bb0085","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.braindev.2007.08.008","article-title":"Reduction in cerebral blood flow volume in infants complicated with hypoxic ischemic encephalopathy resulting in cerebral palsy","volume":"30","author":"Fukuda","year":"2008","journal-title":"Brain and Development"},{"issue":"16","key":"10.1016\/j.earlhumdev.2024.106163_bb0090","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1080\/14767058.2017.1338256","article-title":"Impacts of therapeutic hypothermia on cardiovascular hemodynamics in newborns with hypoxic-ischemic encepha- lopathy: a case control study using echocardiography","volume":"31","author":"Yoon","year":"2018","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.earlhumdev.2024.106163_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2023.113585","article-title":"Left ventricular function and dimensions are altered early in infants developing brain injury in the setting of neonatal encephalopathy","volume":"261","author":"Elias","year":"2023","journal-title":"J. Pediatr."},{"issue":"9","key":"10.1016\/j.earlhumdev.2024.106163_bb0100","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1017\/S1047951122002839","article-title":"Altered biventricular function in neonatal hypoxic-ischaemic encephalopathy: a case-control echocardiographic study","volume":"33","author":"Altit","year":"2023","journal-title":"Cardiol. Young"},{"issue":"4","key":"10.1016\/j.earlhumdev.2024.106163_bb0105","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/echo.12131","article-title":"Speckle tracking echocardiography in pediatric and congenital heart disease","volume":"30","author":"Forsey","year":"2013","journal-title":"Echocardiography"},{"issue":"4","key":"10.1016\/j.earlhumdev.2024.106163_bb0110","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.echo.2008.12.007","article-title":"Quantification of regional left and right ventricular deformation indices in healthy neonates by using strain rate and strain imaging","volume":"22","author":"Pena","year":"2009","journal-title":"Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography."},{"issue":"10","key":"10.1016\/j.earlhumdev.2024.106163_bb0115","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.echo.2013.06.005","article-title":"Feasibility and reproducibility of systolic right ventricular strain measurement by speckle-tracking echocardiography in pre- mature infants","volume":"26","author":"Levy","year":"2013","journal-title":"Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography."},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106163_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1047951109991314","article-title":"Longitudinal strain and strain rate by tissue Doppler are more sensitive indices than fractional shortening for assessing the reduced myocardial function in asphyxiated neonates","volume":"21","author":"Nestaas","year":"2011","journal-title":"Cardiol. Young"},{"issue":"8","key":"10.1016\/j.earlhumdev.2024.106163_bb0125","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.ultrasmedbio.2013.03.024","article-title":"Left ventricular longitudinal strain and strain rate measured by 2-D speckle tracking echocardiography in neonates during whole-body hypothermia","volume":"39","author":"Czernik","year":"2013","journal-title":"Ultrasound Med. Biol."},{"issue":"10","key":"10.1016\/j.earlhumdev.2024.106163_bb0130","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1164\/rccm.201903-0583OC","article-title":"Impaired right ventricular performance is associated with adverse outcome after hypoxic ischemic encephalopathy","volume":"200","author":"Giesinger","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.earlhumdev.2024.106163_bb0135","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1476-7120-11-34","article-title":"Speckle tracking derived strain in infants with severe perinatal asphyxia: a comparative case control study","volume":"11","author":"Sehgal","year":"2013","journal-title":"Cardiovasc. Ultrasound"},{"issue":"10","key":"10.1016\/j.earlhumdev.2024.106163_bb0140","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch. Neurol."},{"issue":"5","key":"10.1016\/j.earlhumdev.2024.106163_bb0145","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.echo.2010.03.019","volume":"23","author":"Lopez","year":"2010","journal-title":"Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography"},{"issue":"4","key":"10.1016\/j.earlhumdev.2024.106163_bb0150","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2012-001636","article-title":"Myocardial performance assessment in neonates by one-segment strain and strain rate analysis by tissue Doppler - a quality improvement cohort study","volume":"2","author":"Nestaas","year":"2012","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.earlhumdev.2024.106163_bb0155","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommen- dations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"European Heart Journal-Cardiovascular Imaging"},{"issue":"3","key":"10.1016\/j.earlhumdev.2024.106163_bb0160","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1017\/S104795111200011X","article-title":"Is myocardial performance index useful in differential diagnosis of moderate and severe hypoxic-ischaemic encephalopathy? A serial Doppler echocardiographic evaluation","volume":"22","author":"Karaarslan","year":"2012","journal-title":"Cardiol. Young"},{"key":"10.1016\/j.earlhumdev.2024.106163_bb0165","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jpeds.2019.11.030","article-title":"Is it time for a randomized controlled trial of hypothermia for mild hypoxic-ischemic encephalopathy?","volume":"220","author":"Chawla","year":"2020","journal-title":"J. Pediatr."},{"issue":"3","key":"10.1016\/j.earlhumdev.2024.106163_bb0170","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1071\/RD9950451","article-title":"Ultrastructural and functional features of the developing mammalian heart: a brief overview","volume":"7","author":"Smolich","year":"1995","journal-title":"Reprod. Fertil. Dev."},{"issue":"12","key":"10.1016\/j.earlhumdev.2024.106163_bb0175","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0002-9149(99)80419-6","article-title":"Noninvasive assessment of myocardial contractility, preload, and afterload in healthy newborn infants","volume":"75","author":"Rowland","year":"1995","journal-title":"Am. J. Cardiol."},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106163_bb0180","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0033-0620(72)90006-0","article-title":"The intrinsic physiologic properties of the developing heart","volume":"15","author":"Friedman","year":"1972","journal-title":"Prog. Cardiovasc. Dis."},{"issue":"7","key":"10.1016\/j.earlhumdev.2024.106163_bb0185","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/hrt.2004.047399","article-title":"Response of the fetal heart to changes in load: from hyperplasia to heart failure","volume":"91","author":"Gardiner","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.earlhumdev.2024.106163_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2018.04.051","article-title":"Cardio-pulmonary adaptation during first day of life in human neonates","volume":"200","author":"Jain","year":"2018","journal-title":"J. Pediatr."},{"issue":"1","key":"10.1016\/j.earlhumdev.2024.106163_bb0195","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000440940","article-title":"Longitudinal assessment of left and right myocardial function in preterm infants using strain and strain rate imaging","volume":"109","author":"James","year":"2016","journal-title":"Neonatology"},{"issue":"5","key":"10.1016\/j.earlhumdev.2024.106163_bb0200","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/echo.12716","article-title":"Effects of frame rate on two-dimensional speckle tracking-derived measurements of myocardial deformation in premature infants","volume":"32","author":"Sanchez","year":"2015","journal-title":"Echocardiography"},{"issue":"11","key":"10.1016\/j.earlhumdev.2024.106163_bb0205","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.echo.2013.06.021","article-title":"Effects of therapeutic hypothermia on left ventricular function assessed by ultrasound imaging","volume":"26","author":"Espinoza","year":"2013","journal-title":"Journal of the American Society of Echocardiography\u202f: official publication of the American Society of Echocardiography."},{"issue":"3","key":"10.1016\/j.earlhumdev.2024.106163_bb0210","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1542\/peds.2004-1587","article-title":"Hemodynamics among neonates with hypoxic-ischemic encephalopathy during whole-body hypothermia and passive rewarming","volume":"117","author":"Gebauer","year":"2006","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.earlhumdev.2024.106163_bb0215","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3233\/NPM-1853","article-title":"Cardiac adaptation in asphyxiated infants treated with therapeutic hypothermia","volume":"12","author":"Sehgal","year":"2019","journal-title":"J. Neonatal-Perinatal Med."}],"container-title":["Early Human Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378224002329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378378224002329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T11:36:27Z","timestamp":1734003387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378378224002329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":43,"alternative-id":["S0378378224002329"],"URL":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2024.106163","relation":{},"ISSN":["0378-3782"],"issn-type":[{"value":"0378-3782","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retrospective study of left and right ventricular strain mechanics among neonates undergoing therapeutic hypothermia for neonatal encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Early Human Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.earlhumdev.2024.106163","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106163"}}